JPH0764747B2 - トロンビン製剤 - Google Patents

トロンビン製剤

Info

Publication number
JPH0764747B2
JPH0764747B2 JP61253900A JP25390086A JPH0764747B2 JP H0764747 B2 JPH0764747 B2 JP H0764747B2 JP 61253900 A JP61253900 A JP 61253900A JP 25390086 A JP25390086 A JP 25390086A JP H0764747 B2 JPH0764747 B2 JP H0764747B2
Authority
JP
Japan
Prior art keywords
thrombin
buffer
preparation
formulations
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP61253900A
Other languages
English (en)
Japanese (ja)
Other versions
JPS62106028A (ja
Inventor
ステイーブン・ビー・シルベーリング
ラツセル・ユー・ネスビツト
マーデイ・ビー・フオージ
Original Assignee
ワ−ナ−−ランバ−ト・コンパニ−
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25154936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH0764747(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ワ−ナ−−ランバ−ト・コンパニ− filed Critical ワ−ナ−−ランバ−ト・コンパニ−
Publication of JPS62106028A publication Critical patent/JPS62106028A/ja
Publication of JPH0764747B2 publication Critical patent/JPH0764747B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/22—Blood coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP61253900A 1985-10-28 1986-10-27 トロンビン製剤 Expired - Lifetime JPH0764747B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US791836 1985-10-28
US06/791,836 US4696812A (en) 1985-10-28 1985-10-28 Thrombin preparations

Publications (2)

Publication Number Publication Date
JPS62106028A JPS62106028A (ja) 1987-05-16
JPH0764747B2 true JPH0764747B2 (ja) 1995-07-12

Family

ID=25154936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61253900A Expired - Lifetime JPH0764747B2 (ja) 1985-10-28 1986-10-27 トロンビン製剤

Country Status (14)

Country Link
US (1) US4696812A (OSRAM)
EP (1) EP0221700B1 (OSRAM)
JP (1) JPH0764747B2 (OSRAM)
KR (1) KR870003793A (OSRAM)
AT (1) ATE83927T1 (OSRAM)
AU (1) AU586897B2 (OSRAM)
CA (1) CA1272128A (OSRAM)
DE (1) DE3687402T2 (OSRAM)
DK (1) DK512686A (OSRAM)
ES (1) ES2053442T3 (OSRAM)
GR (1) GR3006727T3 (OSRAM)
NZ (1) NZ217190A (OSRAM)
PH (1) PH23444A (OSRAM)
ZA (1) ZA868223B (OSRAM)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
ZA88227B (en) * 1987-01-28 1988-06-30 Warner-Lambert Company Thrombin preparations
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
JP2715104B2 (ja) * 1988-08-18 1998-02-18 株式会社ミドリ十字 トロンビン乾燥製剤
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
GB8903438D0 (en) * 1989-02-15 1989-04-05 May & Baker Ltd New compositions of matter
DK223389D0 (da) * 1989-05-05 1989-05-05 Ferrosan As Saarsvamp
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
DE69122376D1 (de) * 1991-03-28 1996-10-31 Warner Lambert Co Hochreine Thrombinzubereitung
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
JP3230713B2 (ja) * 1992-10-23 2001-11-19 トヨタ自動車株式会社 ピークトルク低減機構
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
RU2193897C2 (ru) * 1996-04-04 2002-12-10 Бакстер Акциенгезельшафт Гемостатическая губка, основанная на коллагене, способ ее получения, повязка для ран, включающая такую губку, и набор для приготовления повязки для ран
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
JP3927403B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3401162B2 (ja) * 1996-11-21 2003-04-28 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3927425B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AU7320300A (en) * 1999-09-27 2001-04-30 International Reagents Corporation Means of stabilizing thrombin and compositions
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
US8187625B2 (en) * 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
PL377477A1 (pl) 2002-12-11 2006-02-06 Ferrosan A/S Materiały na bazie żelatyny jako waciki
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
AR054637A1 (es) 2004-01-30 2007-07-11 Ferrosan As Aerosoles y composiciones hemostaticas
ES2313383T3 (es) * 2004-06-22 2009-03-01 Zymogenetics, Inc. Composiciones de trombina.
EP1786480B1 (en) 2004-07-09 2016-09-21 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
ATE533491T1 (de) * 2004-09-21 2011-12-15 Trobio Ab Stabilisierte protease zusammensetzungen enthaltend eine serinprotease, morpholin-derivate und reversible serinprotease- inhibitoren
ES2226587B1 (es) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US7341392B2 (en) * 2005-04-22 2008-03-11 Dofair Co., Ltd. Lock device in an articulated joint for a foldable ladder
KR101421750B1 (ko) * 2006-05-26 2014-07-22 박스터 헬쓰케어 에스에이 주입가능한 골 결함 충전제
ATE499120T1 (de) 2006-05-26 2011-03-15 Baxter Int Injizierbare fibrin-zusammensetzung zur knochenverstärkung
RU2009127718A (ru) * 2006-12-19 2011-01-27 Ферросан А/С (Dk) Раневой или тканевой перевязочный материал, содержащий молочнокислые бактерии
CN101558310B (zh) 2006-12-21 2013-05-08 积水医疗株式会社 含凝血酶的溶液中的α-凝血酶的稳定化方法
CA2682034C (en) * 2007-03-26 2015-01-27 Baxter International Inc. Injectable void filler for soft tissue augmentation
WO2008157304A2 (en) * 2007-06-15 2008-12-24 Zymogenetics, Inc. Stabilized thrombin compositions
JP5569398B2 (ja) 2008-02-29 2014-08-13 フェッローサン メディカル ディバイス エー／エス 止血および／または創傷治癒を促進するための装置
US10046081B2 (en) 2008-04-11 2018-08-14 The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. Electrospun dextran fibers and devices formed therefrom
EP2269594B1 (en) * 2008-04-16 2016-03-02 The Chemo-Sero-Therapeutic Research Institute Method of producing thrombin-immobilized bioabsorbable sheet preparation
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
BR112015030612B1 (pt) 2013-06-21 2020-07-21 Ferrosan Medical Devices A/S método para preparar uma composição seca
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
WO2016058612A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
CA2970710A1 (en) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CN104630325B (zh) * 2015-02-04 2018-03-02 上海长岛生物技术有限公司 一种液体型纤维蛋白原检测试剂及其制备方法
CN104569446A (zh) * 2015-02-04 2015-04-29 上海长岛生物技术有限公司 一种液体型凝血酶时间检测试剂及其制备方法
EP3316930B1 (en) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
CA3004734A1 (en) 2015-11-12 2017-06-18 St. Teresa Medical, Inc. A method of sealing a durotomy
WO2019089717A1 (en) 2017-11-02 2019-05-09 St. Teresa Medical, Inc. Fibrin sealant products
EP3790600B1 (en) 2018-05-09 2023-12-27 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
IL261190A (en) 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
IL262716A (en) * 2018-11-01 2018-11-29 Omrix Biopharmaceuticals Ltd Oxidized cellulose preparations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
US2532348A (en) * 1946-12-12 1950-12-05 Szent-Gyorgyi Albert Blood clotting preparation
JPS536483A (en) * 1976-07-02 1978-01-20 Tanabe Seiyaku Co Ltd Composition having enzymatic activity and its preparation
JPS5639782A (en) * 1979-09-04 1981-04-15 Dai Ichi Pure Chem Co Ltd Stabilization of thrombin
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
JPS628137A (ja) * 1985-07-05 1987-01-16 Konishiroku Photo Ind Co Ltd 情報記録装置

Also Published As

Publication number Publication date
EP0221700B1 (en) 1992-12-30
KR870003793A (ko) 1987-05-04
EP0221700A3 (en) 1987-08-26
EP0221700A2 (en) 1987-05-13
CA1272128A (en) 1990-07-31
DE3687402D1 (de) 1993-02-11
DK512686D0 (da) 1986-10-27
DK512686A (da) 1987-04-29
ZA868223B (en) 1987-07-29
DE3687402T2 (de) 1993-05-06
AU586897B2 (en) 1989-07-27
JPS62106028A (ja) 1987-05-16
ES2053442T3 (es) 1994-08-01
US4696812A (en) 1987-09-29
NZ217190A (en) 1989-05-29
PH23444A (en) 1989-08-07
AU6451786A (en) 1987-04-30
ATE83927T1 (de) 1993-01-15
GR3006727T3 (OSRAM) 1993-06-30

Similar Documents

Publication Publication Date Title
JPH0764747B2 (ja) トロンビン製剤
US4965203A (en) Purified thrombin preparations
US5595735A (en) Hemostatic thrombin paste composition
AU2008266094B2 (en) Stabilized thrombin compositions
US5281528A (en) Process for purified thromboplastin for ultra-pure thrombin preparation
EP0277096B1 (en) Improved thrombin preparations
JPH01193229A (ja) 抗血液凝固剤
KR20040058194A (ko) 보관이 안정한 피브리노겐 용액
EP0505604B1 (en) Highly purified thrombin preparation
US20030091559A1 (en) Storage-stable human fibrinogen solutions
US5525498A (en) Process for preparing an ultra-pure thrombin preparation
US20070014780A1 (en) Storage-stable human fibrinogen solutions
HUP0001841A2 (en) Use of tranexamic acid for the preparation of a human fibrinogen composition
JP3282834B2 (ja) 超高純度トロンビン調製物
AU642987B2 (en) Ultra-pure thrombin preparation
JPS60248621A (ja) 一本鎖組織プラスミノ−ゲンアクチベ−タ−の安定化方法
NZ237568A (en) Thrombin preparation with a specific activity of from 4000-11000 units per mg of protein
CA2039248A1 (en) Ultra-pure thrombin preparation
IE75378B1 (en) Highly purified thrombin preparation
JPWO2005034990A1 (ja) アンチトロンビンｉｉｉ含有止血用組成物

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term