JPH07126128A - Cosmetic for hair - Google Patents

Abstract

PURPOSE:To obtain hair tonic or hair cosmetic which shows high safety guard by using the essence from Guavas seeds, as an active ingredient, having excellent hair development-accelerating action and white gray-improving action. CONSTITUTION:The seeds of Guavas, a kind of rose apple, whose fruits are commercially available in Japan, too, are pressed or extracted with an organic solvent to collect the essence. The essence is used as an active ingredient to prepare hair tonic or hair cosmetic. It can be used in the form of hair lotion, heir tonic, hair cream, hair treatment or shampoo or the like.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair-growth agent and a cosmetic for hair containing the same, and more particularly to a hair-growth containing guava seed essence and a cosmetic for hair containing the same.

[0002]

2. Description of the Related Art It has been a wish of all people, young and old, to maintain abundant and beautiful black hair forever. However, in today's stressful society such as social stress and interpersonal stress, such stress adversely affects hair, and the number of people who have hair-related troubles such as alopecia is uneasy every year. It is increasing to climb.

Reflecting such a situation, extracts of crude drugs such as Yokuinin, Ginkgo, and ginger, vitamin E, alloxazine, adenosine-3 ', 5'-cyclic monophosphate (c-AMP), etc. Has been developed as a hair restorer.

However, each of these hair restorers has a poor hair restorer action, and among others, like 101, which has become a boom until it comes to the China tour.
Some of them are unfavorable from a safety standpoint, such as causing side effects such as dermatitis, and at the present time, no one that can be put to practical use has been obtained. Therefore, it has been desired to develop a hair-growth agent having an excellent hair-growth action and safety.

On the other hand, regarding guava seed essence,
It was not known to have a hair-growing action.

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the above point of view, and provides a hair-growth agent having an excellent hair-growth effect and high safety, and a cosmetic composition for hair containing the same. This is an issue.

[0007]

[Means for Solving the Problems] In order to solve the above-mentioned problems, the present inventors have extensively screened the constituent components and extracts of plants using hair growth action as an index, and as a result, the constituent components of guava seeds. Was found to contain a substance having an excellent hair growth promoting action and a gray hair improving action, and completed the invention.

That is, the present invention relates to a hair-growth material comprising guava seed essence.

The present invention also relates to a cosmetic composition for hair, which contains a hair restorer composed of guava seed essence.

The present invention will be described in detail below.

The guava referred to in the present invention is a plant of the family Myrtaceae, and its fruits are widely marketed in Japan.
It is used for food. In the present invention, the essence of this guava seed is used as a hair restorer.

[0012] To obtain the essence from guava seeds, pressing or extraction may be performed. Pressing at room temperature,
The heating may be performed, but it is more efficient and preferable to perform the heating. The pressing may be performed using a normal pressing machine. In addition, although it is a method of extraction, the extraction may be performed in a usual manner using an organic solvent. That is, raw or dried guava seeds may be crushed or the like, an organic solvent in an amount of 1 to 100 times the amount thereof may be added, and the mixture may be immersed at room temperature for several days or at a temperature near the boiling point for several hours with stirring. Here, as the organic solvent, alcohols such as methanol and ethanol, ketones such as acetone and methyl ethyl ketone, nitriles such as acetonitrile, furans such as tetrahydrofuran, halogenated hydrocarbons such as chloroform and methylene chloride, diethyl ether. Examples thereof include one or more selected from ethers such as isopropyl ether and hydrocarbons such as normal hexane petroleum ether. The extraction may be batch type or continuous type. The extract thus obtained can be used as the hair restorer of the present invention by removing the solvent by concentration under reduced pressure or the like.

The guava seed essence thus obtained is very useful as a hair-growing agent because it has an excellent hair-growth action, white-hair improving action, and high safety, as shown in Examples below.

The hair cosmetic composition of the present invention contains the above-mentioned guava seed essence as a hair restorer.
The blending amount is 0.01 to 10% by weight based on the total amount of the cosmetic.
Is preferred. This is because if the blending amount is less than 0.01% by weight, a sufficient hair-growth effect cannot be expected, and if the blending amount exceeds 10% by weight, the effect reaches the ceiling and is not economical.

The dosage form of the cosmetic for hair of the present invention is not particularly limited, and for example, for hair tonic, shampoo, conditioner, pomade, hair lotion, hair cream, hair treatment, etc. The thing used as cosmetics is mentioned. These cosmetics may be manufactured according to a usual method.

The hair cosmetic composition of the present invention usually contains
Hydrocarbons, waxes, oils and fats, esters, higher fatty acids, higher alcohols, surfactants, fragrances, dyes, preservatives, antioxidants, UV absorbers, alcohols applied to hair cosmetics A class, a pH adjuster, various medicinal components and the like can be appropriately selected and blended. In addition to the guava seed essence, which is the hair-growing agent of the present invention, a hair-growing or hair-growing component may be added.

[0017]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.

Example 1. Production Example 1 1 kg of dried guava seeds was put into a press and gradually heated while being heated to 80 ° C. and pressed at 450 kg.
g of a pale yellow liquid was obtained.

Example 2. Production Example 2 After 1 Kg of dried guava seeds was finely crushed, 2 L of normal hexane was added, and the mixture was heated under reflux with stirring, filtered and concentrated under reduced pressure to obtain 131 g of a pale yellow liquid.

Example 3. Production Example 3 1 kg of dried guava seeds was finely crushed, 2 l of dichloromethane was added, and the mixture was heated under reflux with stirring, filtered,
Concentration under reduced pressure gave 145 g of a pale yellow liquid.

Example 4. Production Example 4 1 kg of dried guava seeds was finely crushed, 2 l of diethyl ether was added, the mixture was heated under reflux with stirring, filtered and concentrated under reduced pressure to obtain 152 g of a pale yellow liquid.

Embodiment 5. Production Example 5 1 kg of dried guava seeds was finely crushed, 2 l of acetone was added, the mixture was heated under reflux with stirring, filtered and concentrated under reduced pressure to obtain 104 g of a pale yellow liquid.

Example 6. Production Example 6 1 kg of guava seeds was finely crushed, 2 l of 50% ethanol / chloroform solution was added, the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 102 g of a pale yellow liquid.

Example 7. Production Example 7 1 kg of dried guava seeds was crushed into 50%
2 l of a normal hexane diethyl ether solution was added, heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 112 g of a pale yellow liquid.

Example 8. Acute toxicity Acute toxicity was examined using ICR mice (male, 5 weeks old, 25-35 g). That is, 1 g / Kg of the hair-growing agents of Production Examples 1 to 7 were orally administered to 6 animals per group. After administration 1
On the 4th day, life or death was judged and LD50 value was calculated. No deaths were observed in any of the animals, and therefore the LD50 value seems to be 1 g / Kg or more. From this, it can be seen that the hair restorer of the present invention is highly safe.

Example 9. Dermal irritation test (local toxicity test) 3c on the back of Hartley white guinea pigs with 6 animals per group
The hair was shaved on m squares, and the 10% liquid paraffin solutions of the hair-growing agents of Examples 1 to 7 were administered once a day for 5 days in 0.05 ml increments. Six days after the start of administration, the dermal irritation was evaluated according to the Japanese patch test standard (Japan Dermatological Association). That is,-: no reaction, ±: false positive reaction, +: positive reaction, +
+: It is a standard of reaction with edema. The results showed that all the animals showed no reaction. From this, it is understood that the hair restorers of Examples 1 to 7, which are the hair restorer of the present invention, are excellent in safety.

Example 10. Hair growth promoting action: The backs of C3H mice aged 10 weeks, 5 mice each in 1 group, were shaved in a 2 cm square, and the next day, ethanol solutions containing the hair-growth agents of Examples 1 to 7 at various concentrations as shown in Table 1 were added. As a comparative example, an ethanol solution containing 2% by weight of vitamin E,
As a control, ethanol was applied to the shaved part of each group of mice in an amount of 0.05 ml. After application 14
On the day, the level of hair growth was visually judged according to the following criteria. That is,-: same as hair growth of mice in control group, ±: slightly earlier than hair growth of mice in control group, +: obviously faster than hair growth of mice in control group, ++: It is a criterion that it is significantly faster than the hair growth of the mice in the control group. The results are shown in Table 1. From these results, it is clear that the hair restorer of the present invention is excellent in the hair growth promoting effect.

[0028]

[Table 1]

Example 11. Effect of improving gray hair The effect of improving gray hair was tested using B57 black mice mixed with gray hair of 1 year old. That is, to 10 mice per group, 0.1 ml of the test substance was continuously administered once a day for 30 days on one surface of the back. 7 days after administration, 1 gray hair per animal
0 hairs were removed and the number of blackened roots was counted. An ethanol solution containing 2% of the hair restorer of Examples 1 to 7 of the present invention was used as a sample, an ethanol solution containing 2% of vitamin E as a comparison, and ethanol was used as a control. The results are shown in Table 2. From this, it is understood that the hair restorer of the present invention has an excellent effect of improving gray hair.

[0030]

[Table 2]

Example 12 Formulation Example 1 (Hair lotion) The following formulation ingredients were weighed and stirred at room temperature to be solubilized to obtain a hair lotion. Hair restorer of Example 1 9 Menthol 0.2 Propylene glycol 5 Vitamin E 0.1 Diphenhydramine hydrochloride 0.1 Glycyrrhizin dipotassium 0.1 Methylparaben 0.2 Ethanol 50 Perfume 1 Purified water 34.3

Example 13 Formulation example 2 (hair tonic) The following formulation ingredients were weighed and stirred at room temperature to be solubilized to obtain a hair tonic. Hair restorer of Example 2 0.3 Vitamin E 0.2 Capsicum tincture 0.1 Ethanol 50.0 Propylene glycol 5 Vitamin B ₂ 0.1 Diphenhydramine hydrochloride 0.1 Placenta extract 0.1 Benzalkonium chloride 0.1 Fragrance 0.5 Purified water 43.5

Example 14 Formulation Example 3 (hair cream) A hair cream was prepared according to the following formulation. That is,
Each of A and B was heated and dissolved at 80 ° C., B was gradually added to A while stirring, and C was further added, followed by cooling to obtain a hair cream. (A) Vaseline 7 Bead wax 8 Liquid paraffin 37 POE (20) Behenyl ether 3 Glyceryl monostearate 2 (B) Hair restorer of Example 3 0.03 Propylene glycol 5 Diphenhydramine hydrochloride 0.1 Glycyrrhizin dipotassium 0.12 Hibitene gluco Nate 0.05 Purified water 42.6 (C) Perfume 0.1

Example 15 Formulation Example 4 (Hair Treatment) A hair treatment was prepared according to the following formulation. That is, each of A and B was heated and dissolved at 80 ° C., B was gradually added to A while stirring, and C was further added, followed by cooling to obtain a hair treatment. (A) Liquid paraffin 2 Methyl polysiloxane (10 cs) 2 Behenyl alcohol 4 (B) Hair growth agent of Example 4 0.5 Hair growth agent of Example 5 0.5 Stearyl trimethyl ammonium chloride 3.5 Propylene glycol 5 Purification Water 82 (C) Perfume 0.5

Example 16 Formulation example 5 (shampoo) The following formulation components were weighed, dissolved by heating at 80 ° C, and cooled to obtain a shampoo. Lauryl Sulfate Triethanolamine 15 Palm Oil Fatty Acid Diethanolamide 2 Propylene Glycol 5 Hair Growth Agent of Example 6 3 Hair Growth Agent of Example 7 2 Purified Water 72.5 Fragrance 0.5

[0036]

The hair-growing agent of the present invention is very useful because it has a high level of safety and has an excellent effect of promoting hair growth and an effect of improving gray hair.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Nobue Muramatsu Nobue Muramatsu 27 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa 1 Inside Yokohama Research Laboratory, Pola Chemical Industry Co., Ltd. (72) Masayoshi Yagi, 560, Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Polar Chemical Industry Co., Ltd. Totsuka Laboratory

Claims (4)

[Claims] 1. A hair restorer comprising guava seed essence. 2. The hair restorer according to claim 1, wherein the guava seed essence is an essence obtained by pressing guava seeds. 3. The guava seed essence is an essence obtained by extracting guava seed with an organic solvent.
The hair restorer described. 4. The hair-restoring agent according to claim 1 is 0.01
Hair cosmetics containing 10% by weight.