JP2000264820A - Composition for promoting hair growth - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition having high safety and excellent hair growth promoting actions and useful as medicines, cosmetics, etc., effective in improving depilation due to an aging change, etc., by including specific mucopolysaccharides, a hair growth promoter and a polyhydric alcohol. SOLUTION: This composition is obtained by including (A) one or more kinds selected from mucopolysaccharides which are preferably a heparin analogous substance (e.g. chondroitin sulfate) having sulfate groups, (B) a hair growth promoter which is preferably one or more kinds selected from an extract from Fungus Umbellatus, an acdysteroid, an extract from Crataegus cuneata, etc., and (C) a polyhydric alcohol which is preferably one or more kinds selected from polyethylene glycol 200-1,000, 1,3-butylene glycol and isoprene glycol. The amounts of the ingredients are preferably 0.05-5 wt.% of the ingredient A, 0.01-5 wt.% of the ingredient B and 5-30 wt.% of the ingredient C. The composition is useful as a hair tonic, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition for promoting hair growth, such as pharmaceuticals and cosmetics, which is highly safe and excellent in promoting hair growth.

[0002]

BACKGROUND OF THE INVENTION Maintaining abundant and black hair forever is what all men and women of all ages want to look young. However, aging phenomena, genetic predisposition,
Furthermore, due to social stress and the like, the hair gradually falls off, causing thinning and baldness. In order to prevent such alopecia, various manufacturers have been working hard to develop hair growth agents. As the ones that have been developed so far, extracts of crude drugs such as yokuinin, ginkgo and ginger, vitamin B, alloxazine, adenosine-3 ',
5'-cyclic monophosphate (c-AMP)
And so on.

[0003] However, the hair growth agents which have been developed so far may not have a sufficient hair growth promoting effect or may cause side effects such as skin irritation, and at present they are sufficiently effective and safe. Was not obtained. Therefore, there has been a demand for a hair restorer which has an excellent hair growth promoting action and is highly safe.

On the other hand, as substances having a moisturizing action, a blood flow improving action and an anti-inflammatory action, those already contained in the external composition for skin include heparin-like substances such as chondroitin polysulfate and ketalan polysulfate. However, no hair growth promoting composition containing such a heparin-like substance, a hair growth promoter and a polyhydric alcohol is known at all, and further a hair growth promoting composition containing such a component is not known. It is not known to be effective in preventing hair loss due to aging change, genetic predisposition or social stress, preventing thinning hair and promoting hair growth, and also effective in maintaining youthful hair Was.

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, has high safety, has an excellent hair growth promoting action, and has an object to improve hair loss accompanying age-related changes. An object of the present invention is to provide a composition for promoting hair growth such as pharmaceuticals and cosmetics which is effective for the hair.

[0006]

In view of such circumstances, the present inventors have high safety, have an excellent hair growth promoting action, and are effective in improving hair loss accompanying age-related changes and the like. As a result of intensive research efforts for compositions for promoting hair growth such as cosmetics,
Such a function was found in a hair growth promoting composition containing one or more selected from mucopolysaccharides having a sulfate group, a hair growth promoter and a polyhydric alcohol, and the invention was completed. It led to. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Mucopolysaccharide having a sulfate group which is an essential component of the composition for promoting hair growth of the present invention The composition for promoting hair growth of the present invention is prepared from mucopolysaccharide having a sulfate group. It is characterized by containing one or more selected ones. Examples of the mucopolysaccharide having a sulfate group include, for example, chondroitin sulfate and its salts, chondroitin sulfates such as dermatan sulfate and its salts, heparins, ketalan sulfate and its salts and chondroitin polysulfate, and ketalan polysulfate and its salts It preferably contains a heparin analog. The term "heparin-like substance" as used in the present invention means a general term for polysulfated mucopolysaccharides such as chondroitin polysulfate. Such a heparin-like substance can be obtained by sulphating mucopolysaccharide, or can be extracted and purified from the internal organs including the bronchi of animals such as cattle using an aqueous carrier. Since such heparin-like substances have been developed as raw materials for medicines and cosmetics, such commercially available products can also be used. The most preferable example of such a heparin-like substance is Heparinoid (registered trademark), which is a lung extract / purified product containing bovine bronchi, sold by Sankyo Pharma Co., Ltd. This is known to have an excellent moisturizing effect. In the composition for promoting hair growth of the present invention, only one of these mucopolysaccharides having a sulfate group may be contained.
It is also possible to incorporate more than one kind in combination. The preferred content of the mucopolysaccharide having a sulfate group is
0.001 to 10% by weight, more preferably 0.1 to 10% by weight.
0.5 to 5% by weight. This is because if the amount is too large, the effect may reach a plateau, and if the amount is too small, the effect may not be obtained.

(2) Hair-growth promoting agent which is an essential component of the hair-growth promoting composition of the present invention The hair-growth promoting composition of the present invention comprises one or more hair-growth promoting agents as essential components. It is characterized by containing as.
The hair growth promoter referred to in the present invention can be used as a cosmetic or a pharmaceutical by itself or by mixing and mixing necessary substances as needed. Hair growth promoter, prevention or improvement of hair loss,
A generic term for compounds having a hair growth promoting action, crude drug extracts, and the like. Preferred examples of such components include, for example, vitamin E nicotinate, ethinyl estradiol, ecdysteroid, chorei extract, bukuroyou extract, hawthorn extract, sansha extract, minoxidil and the like. , Hawthorn extract and Sansha extract are particularly preferred. The extract referred to in the present invention refers to a plant itself, a processed product obtained by drying and pulverizing the plant, an alcohol, an ester, a halogenated hydrocarbon, a polyhydric alcohol, and the like. It is a general term for an extract obtained by adding a solvent such as water, ketones, and water, an extract obtained by removing a solvent from the extract, and a fraction obtained by fractionating the extract. An extract and / or a solvent-removed product thereof is preferable. As the solvent, one or more kinds selected from water, alcohols and polyhydric alcohols can be preferably exemplified. This is because these solvents are preferable in terms of safety. The content of the hair growth promoter of the present invention is 0.001 to 10% by weight.
Is more preferable, and a more preferable content is 0.01 to 5% by weight. If the content is lower than the above range, a sufficient hair growth effect cannot be expected, and if the content is higher than the above range, the effect reaches a plateau and is not economical.

(3) Polyhydric alcohol which is an essential component of the composition for promoting hair growth of the present invention The composition for promoting hair growth of the present invention contains one or more polyhydric alcohols as essential components. It is characterized by doing. As the polyhydric alcohol mentioned here, specifically,
Preferred examples include ethylene glycol, polyethylene glycol, glycerin, propylene glycol, dipropylene glycol, diglycerin, 1,3 butylene glycol, isoprene glycol, erythritol, diethylene glycol, pentyl glycol, neopentyl glycol and the like.
00-1000, 1,3-butylene glycol and isoprene glycol are particularly preferred. The preferred content of the polyhydric alcohol in the composition for promoting hair growth of the present invention is,
0.1 to 70% by weight, more preferably 5 to 30% by weight.
When the amount is too large, side effects such as skin irritation may occur, while when the amount is too small, the hair growth promoting action may be weakened.

(4) Composition for Promoting Hair Growth of the Present Invention The composition for promoting hair growth of the present invention comprises one or more selected from mucopolysaccharides having a sulfate group and one or more hair growth promoting agents. It is characterized in that it contains at least one kind or at least two kinds of polyhydric alcohols. The hair growth promoting composition referred to in the present invention is a composition for promoting hair growth having an effect of preventing hair loss and the like and an effect of improving thinning and baldness, and is a generic term for cosmetics, pharmaceutical compositions, and the like. The dosage form of the composition for promoting hair growth of the present invention is not particularly limited as long as hair growth on hair and a hair growth promoting action can be expected.
Examples include those commonly used as cosmetics such as hair tonics, shampoos, rinses, pomades, hair lotions, hair creams, and hair treatments. The hair growth-promoting composition of the present invention can contain, in addition to the above essential components, optional components that are usually used in external skin compositions. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow and olive oil, higher alcohols such as cetanol and oleyl alcohol, and stearic acid. Fatty acids such as and oleic acid, nonionic surfactants, anionic surfactants,
Preferred examples include cationic surfactants, amphoteric surfactants, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, dyes, and powders. By treating these components according to a conventional method, the composition for promoting hair growth of the present invention can be produced.

Furthermore, as a user of the composition for promoting hair growth of the present invention, there is no particular limitation as long as the composition is concerned with local or whole-head hair loss, thin hair, or hairlessness, such as a circle. Can be targeted. Of these subjects, those which are preferably applied are chronic, specifically, normal hair loss, thinning hair, and hairlessness. That is, the composition for promoting hair growth of the present invention exerts excellent effects on hair loss, thinning hair, and hairlessness caused by acute hair cycle abnormalities such as alopecia areata, but normal hair loss, thinning hair, and no hair loss. It exerts an even better effect on hair.

[0012]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

Examples 1 to 10 A simple hair growth promoting composition was prepared according to the following formulation. That is, the ingredients were stirred at room temperature and solubilized to obtain a lotion. Polyethylene glycol 200 20 parts by weight Heparin-like substance * 0.5 parts by weight Hair growth promoter * 1 part by weight Water 78.5 parts by weight * Details are shown in Table 1.

[0014]

[Table 1]

<Example 11> Hair growth promoting action The hair growth promoting actions of the above Examples 1 to 10 and the following Comparative Examples were examined. The test animals consisted of 10 C3H mice (male, 7 weeks old) as one group.
The area of cm × 3 cm was shaved with a clipper and used for the test. 0.2 ml of each sample was applied to the shaved portion once a day, and the degree of hair growth of the test portion after 20 days was visually evaluated with respect to the control group in the following six steps. It was shown to. -: No hair growth is observed. -: The hair is slightly hairy. ±: Hard hairs are growing. +: About 50% of normal hair is growing. ++: Hard hair grows about 75% of normal. +++: Hard hair grows about 100% of normal. As Comparative Example 1, the cholay extract of Example 1 was replaced with water, as Comparative Example 2, the cholay extract of Example 2 was replaced with water, and as Comparative Example 3, the heparinoid of Example 1 was replaced with water. Comparative Example 4 in which the heparinoid of Example 3 was replaced with water. Comparative Example 5 in which the heparinoid of Example 5 was replaced with water. Comparative Example 6 in which the heparinoid of Example 7 was replaced with water. Example 7 in which the heparinoid of Example 9 was replaced by water, Comparative Example 8 in which the polyethylene glycol 200 of Example 1 was replaced by water, and Comparative Example 9 in which the polyethylene glycol 200 of Example 2 was replaced by water. As Comparative Example 10, the polyethylene glycol 200 of Example 3 was replaced with water, and as Comparative Example 11, the polyethylene glycol 200 of Example 4 was substituted. As the comparative example 12, the polyethylene glycol 200 of Example 5 was replaced with water, as Comparative Example 12, the polyethylene glycol 200 of Example 6 was replaced with water, as Comparative Example 13, and as the Comparative Example 14 as Example 7. Polyethylene glycol 200 replaced with water, Comparative Example 15 replaced polyethylene glycol 200 of Example 8 with water, Comparative Example 16 replaced polyethylene glycol 200 of Example 9 with water, Comparative Example 17 The polyethylene glycol 200 of Example 10 was replaced with water, and the control group was prepared by replacing the heparinoid, chorei extract and polyethylene glycol of Example 1 with water. Table 2 shows the results as points. This shows that the lotion which is the composition for promoting hair growth of the present invention promotes hair growth.

[0016]

[Table 2]

Example 11 A hair lotion was prepared according to the following formulation. That is, the ingredients are stirred at room temperature,
Solubilized to give a hair lotion. Polyethylene glycol 200 10 parts by weight Sunsha extract 1 part by weight Heparinoid 0.3 parts by weight L-menthol 0.2 parts by weight Ethanol 50 parts by weight Vitamin E 0.1 parts by weight Dipotassium glycyrrhizinate 0.1 parts by weight Methyl paraben 0.1 parts by weight Perfume 1 part by weight Water 37.2 parts by weight

Example 12 A hair lotion was prepared according to the following formulation. That is, the ingredients are stirred at room temperature,
Solubilized to give a hair lotion. Polyethylene glycol 200 10 parts by weight Ecdysterone 1 part by weight Heparinoid 0.3 part by weight L-menthol 0.2 part by weight Ethanol 50 part by weight Vitamin E 0.1 part by weight Dipotassium glycyrrhizinate 0.1 part by weight Methylparaben 0.1 part by weight Fragrance 1 part by weight water 37.2 parts by weight

Example 13 A hair lotion was prepared according to the following formulation. That is, the ingredients are stirred at room temperature,
Solubilized to give a hair lotion. Isoprene glycol 10 parts by weight Minoxidil 1 part by weight Heparinoid 0.3 part by weight L-menthol 0.2 part by weight Ethanol 50 part by weight Vitamin E 0.1 part by weight Dipotassium glycyrrhizinate 0.1 part by weight Methylparaben 0.1 part by weight Fragrance 1 Parts by weight water 37.2 parts by weight

Example 14 A hair tonic was prepared according to the following formulation. That is, the ingredients were stirred at room temperature and solubilized to obtain a hair tonic. Polyethylene glycol 400 10 parts by weight Vitamin E nicotinate 1 part by weight Chondroitin polysulfate 0.3 part by weight Pepper tincture 0.2 part by weight Ethanol 55 parts by weight Diphenhydramine hydrochloride 0.1 part by weight Placenta extract 0.1 part by weight Benzalkonium chloride 0 .1 parts by weight Fragrance 0.5 parts by weight Water 32.7 parts by weight

Example 15 A hair tonic was prepared according to the following formulation. That is, the ingredients were stirred at room temperature and solubilized to obtain a hair tonic. Polyethylene glycol 400 10 parts by weight 17-hydroxyecdysterone 1 part by weight Chondroitin polysulfate 0.3 part by weight Pepper tincture 0.2 part by weight Ethanol 55 parts by weight Diphenhydramine hydrochloride 0.1 part by weight Placenta extract 0.1 part by weight Benza chloride Ruconium 0.1 parts by weight Fragrance 0.5 parts by weight Water 32.7 parts by weight

Example 16 A hair tonic was prepared according to the following formulation. That is, the ingredients were stirred at room temperature and solubilized to obtain a hair tonic. Polyethylene glycol 400 10 parts by weight Sunsha extract 1 part by weight Chondroitin polysulfate 0.3 part by weight Pepper tincture 0.2 part by weight Ethanol 55 parts by weight Diphenhydramine hydrochloride 0.1 part by weight Placenta extract 0.1 part by weight Benzalkonium chloride 0. 1 part by weight Fragrance 0.5 part by weight Water 32.7 parts by weight

Example 17 A hair tonic was prepared according to the following formulation. That is, the ingredients were stirred at room temperature and solubilized to obtain a hair tonic. Polyethylene glycol 400 10 parts by weight Sunsha extract 1 part by weight Heparinoid 0.3 parts by weight Pepper tincture 0.2 parts by weight Ethanol 55 parts by weight Diphenhydramine hydrochloride 0.1 part by weight Placenta extract 0.1 part by weight Benzalkonium chloride 0.1 part by weight Parts Perfume 0.5 parts by weight Water 32.7 parts by weight

Example 18 A hair cream was obtained according to the following formulation. A and B were heated to 80 ° C., and B was gradually added to A to emulsify while stirring. Finally, C was added, and the mixture was cooled and stirred to obtain a hair cream. I Vaseline 7 parts by weight Beeswax 8 parts by weight Liquid paraffin 37 parts by weight POE (20) behenyl ether 3 parts by weight glyceryl monostearate 2 parts by weight Lo heparinoid 0.3 parts by weight 1,3 butylene glycol 10 parts by weight Minoxidil 1 part by weight Parts dipotassium glycyrrhizinate 0.1 part by weight diphemin hydramine hydrochloride 0.1 part by weight hibitene gluconate 0.1 part by weight water 31.3 parts by weight c fragrance 0.1 part by weight

Example 19 A hair cream was obtained according to the following formulation. A and B were heated to 80 ° C., and B was gradually added to A to emulsify while stirring. Finally, C was added, and the mixture was cooled and stirred to obtain a hair cream. I Vaseline 7 parts by weight Beeswax 8 parts by weight Liquid paraffin 37 parts by weight POE (20) behenyl ether 3 parts by weight glyceryl monostearate 2 parts by weight Lo chondroitin polysulfate 0.3 part by weight 1, 3 butylene glycol 10 parts by weight ethynyl Estradiol 1 part by weight Dipotassium glycyrrhizinate 0.1 part by weight Difemin hydramine hydrochloride 0.1 part by weight Hibitene gluconate 0.1 part by weight Water 31.3 parts by weight C Fragrance 0.1 part by weight

Example 20 A hair cream was obtained according to the following formulation. A and B were heated to 80 ° C., and B was gradually added to A to emulsify while stirring. Finally, C was added, and the mixture was cooled and stirred to obtain a hair cream. A Vaseline 7 parts by weight Beeswax 8 parts by weight Liquid paraffin 37 parts by weight POE (20) behenyl ether 3 parts by weight glyceryl monostearate 2 parts by weight Lo chondroitin polysulfate 0.3 parts by weight 1,3 butylene glycol 10 parts by weight Extract 1 part by weight Dipotassium glycyrrhizinate 0.1 part by weight Difemin hydramine hydrochloride 0.1 part by weight Hibitene gluconate 0.1 part by weight Water 31.3 parts by weight C Fragrance 0.1 part by weight

Example 21 A hair treatment was obtained according to the following formulation. A and B were heated to 80 ° C., and B was gradually added to A to emulsify while stirring. Finally, C was added and the mixture was cooled and stirred to obtain a hair treatment. Liquid paraffin 2 parts by weight Methyl polysiloxane (10 cs) 2 parts by weight Behenyl alcohol 4 parts by weight Lo heparinoid 0.3 part by weight Isoprene glycol 10 parts by weight Hawthorn extract 1 part by weight Stearyl trimethylammonium chloride 3.5 parts by weight Water 76 0.7 parts by weight C Spice 0.5 parts by weight

Example 22 A hair treatment was obtained according to the following formulation. A and B were heated to 80 ° C., and B was gradually added to A to emulsify while stirring. Finally, C was added and the mixture was cooled and stirred to obtain a hair treatment. Liquid paraffin 2 parts by weight Methyl polysiloxane (10 cs) 2 parts by weight Behenyl alcohol 4 parts by weight Lo chondroitin polysulfate 0.3 part by weight Isoprene glycol 10 parts by weight Chorei extract 1 part by weight Stearyl trimethylammonium chloride 3.5 parts by weight Parts 76.7 parts by weight of water c 0.5 parts by weight of fragrance

Example 23 A hair treatment was obtained according to the following formulation. A and B were heated to 80 ° C., and B was gradually added to A to emulsify while stirring. Finally, C was added and the mixture was cooled and stirred to obtain a hair treatment. Liquid paraffin 2 parts by weight Methyl polysiloxane (10 cs) 2 parts by weight Behenyl alcohol 4 parts by weight Lo chondroitin polysulfate 0.3 part by weight Polyethylene glycol 200 10 parts by weight Sansha extract 1 part by weight Stearyl trimethylammonium chloride 3.5 parts by weight Parts 76.7 parts by weight of water c 0.5 parts by weight of fragrance

<Example 24> Use test for thin hair Using the hair tonic shown in Example 16, a use test was performed to confirm the hair growth promoting action. That is, when five panelists suffering from thinning hair used the hair tonic of Example 16 for three months, three people had hard hair and a remarkable improvement effect was observed, and two people had no dandruff and a clear improvement effect. Was observed. This indicates that the composition for promoting hair growth of the present invention has an effect of improving hair thinning.

<Example 25> Use test for alopecia areata The use test was performed using the hair tonic shown in Example 16 to confirm the hair growth promoting action. That is, when five panelists suffering from alopecia areata used the hair tonic of Example 16 for three months, two had hard hair, a remarkable improvement effect was observed, and two had hairy hair. Significant improvement effect was recognized. This shows that the composition for promoting hair growth of the present invention is also effective for acute hair loss such as alopecia areata.

[0032]

Industrial Applicability The present invention can provide a composition for promoting hair growth such as cosmetics, which is highly safe and excellent in promoting hair growth.

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Claims (6)

[Claims] 1. A compound selected from mucopolysaccharides having a sulfate group.
A hair growth-promoting composition comprising at least one or more species, a hair growth-promoting agent, and a polyhydric alcohol. 2. The composition for promoting hair growth according to claim 1, wherein the composition contains a heparin-like substance as the mucopolysaccharide having a sulfate group. 3. A hair growth promoting agent, comprising: vitamin E nicotinate;
3. Hair growth according to claim 1 or 2, characterized in that it comprises one or more selected from ethinyl estradiol, ecdysteroid, chorei extract, boukuro extract, hawthorn extract and sunsha extract. Accelerating composition. 4. The polyhydric alcohol comprises one or more selected from the group consisting of polyethylene glycols 200 to 1000, 1,3 butylene glycol and isoprene glycol. The composition for promoting hair growth according to any one of the above. 5. A cosmetic according to claim 1, wherein the cosmetic is a cosmetic.
The composition for promoting hair growth according to any one of claims 4 to 4. 6. The method according to claim 1, wherein the drug is a pharmaceutical.
The composition for promoting hair growth according to any one of claims 4 to 4.