JPH07108232B2 - ペプチド又は蛋白質の製造方法 - Google Patents

ペプチド又は蛋白質の製造方法

Info

Publication number
JPH07108232B2
JPH07108232B2 JP2271880A JP27188090A JPH07108232B2 JP H07108232 B2 JPH07108232 B2 JP H07108232B2 JP 2271880 A JP2271880 A JP 2271880A JP 27188090 A JP27188090 A JP 27188090A JP H07108232 B2 JPH07108232 B2 JP H07108232B2
Authority
JP
Japan
Prior art keywords
protein
peptide
protease
arg
dipeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2271880A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04148694A (ja
Inventor
浩明 山本
邦彦 山下
Original Assignee
エム・ディ・リサーチ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エム・ディ・リサーチ株式会社 filed Critical エム・ディ・リサーチ株式会社
Priority to JP2271880A priority Critical patent/JPH07108232B2/ja
Priority to PCT/JP1991/000239 priority patent/WO1992006211A1/ja
Priority to EP91904654A priority patent/EP0591524A1/en
Priority to CA002070781A priority patent/CA2070781A1/en
Publication of JPH04148694A publication Critical patent/JPH04148694A/ja
Priority to US08/243,082 priority patent/US5506120A/en
Publication of JPH07108232B2 publication Critical patent/JPH07108232B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2271880A 1990-10-09 1990-10-09 ペプチド又は蛋白質の製造方法 Expired - Lifetime JPH07108232B2 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2271880A JPH07108232B2 (ja) 1990-10-09 1990-10-09 ペプチド又は蛋白質の製造方法
PCT/JP1991/000239 WO1992006211A1 (en) 1990-10-09 1991-02-25 Process for producing peptide or protein
EP91904654A EP0591524A1 (en) 1990-10-09 1991-02-25 Process for producing peptide or protein
CA002070781A CA2070781A1 (en) 1990-10-09 1991-02-25 Method of producing peptides or proteins
US08/243,082 US5506120A (en) 1990-10-09 1994-05-16 Method of producing peptides or proteins as fusion proteins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2271880A JPH07108232B2 (ja) 1990-10-09 1990-10-09 ペプチド又は蛋白質の製造方法

Publications (2)

Publication Number Publication Date
JPH04148694A JPH04148694A (ja) 1992-05-21
JPH07108232B2 true JPH07108232B2 (ja) 1995-11-22

Family

ID=17506194

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2271880A Expired - Lifetime JPH07108232B2 (ja) 1990-10-09 1990-10-09 ペプチド又は蛋白質の製造方法

Country Status (5)

Country Link
US (1) US5506120A (online.php)
EP (1) EP0591524A1 (online.php)
JP (1) JPH07108232B2 (online.php)
CA (1) CA2070781A1 (online.php)
WO (1) WO1992006211A1 (online.php)

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US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
CA2090969C (en) * 1990-09-04 2001-08-21 Russell Arthur Brierley Production of insulin-like growth factor-1 in methylotrophic yeast cells
JPH06506117A (ja) * 1991-04-01 1994-07-14 メルク　エンド　カンパニー　インコーポレーテッド ピキア（Ｐｉｃｈｉａ）蛋白質分解活性に影響する遺伝子およびその使用
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2701953B1 (fr) * 1993-02-22 1995-05-24 Centre Nat Rech Scient Protéine de fusion multi-VIP et procédé de préparation de VIP recombinant.
EP0645454A3 (en) * 1993-06-22 1997-01-15 Vladimir Glebovich Lunin Chimeric somatostatin-containing protein and encoding DNA, immunogen compositions, and methods of increasing farm animal production.
US5888775A (en) * 1994-04-29 1999-03-30 Dade International Inc Peptide synthesis and purification by fusion to penI protein or precipitation effective portion thereof
US6037145A (en) * 1994-09-07 2000-03-14 Suntory Limited Process for production of protein
WO1996032468A2 (en) * 1995-04-11 1996-10-17 Merck & Co., Inc. Bioprocess for production of dipeptide based compounds
WO1996034958A1 (en) * 1995-05-03 1996-11-07 Biostar Inc. Vasoactive intestinal peptide
US6037321A (en) * 1995-05-03 2000-03-14 Biostar Inc. Fusion proteins comprising vasoactive intestinal peptide or PACAP
WO1997001627A1 (en) * 1995-06-27 1997-01-16 Igen International, Inc. High-level expression and efficient recovery of ubiquitin fusion proteins from escherichia coli
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
AU703120B2 (en) * 1995-10-20 1999-03-18 University Of Nebraska Board Of Regents Composition and methods for enhancing immune responses mediated by antigen-presenting cells
US20080286228A1 (en) * 1995-10-20 2008-11-20 Tarantolo Stefano R Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US5935824A (en) * 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
CA2198966C (en) * 1996-03-04 2011-06-21 Yuji Suzuki Method for cleaving chimeric protein using processing enzyme
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
GB9716790D0 (en) 1997-08-07 1997-10-15 Creative Peptides Sweden Ab Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof
KR100368073B1 (ko) * 1999-03-09 2003-01-24 한국생명공학연구원 융합파트너를 이용한 재조합 단백질의 제조방법
EP1274720A4 (en) 2000-04-12 2004-08-18 Human Genome Sciences Inc FUSION PROTEINS CONTAINING ALBUMIN
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
EP1463752A4 (en) 2001-12-21 2005-07-13 Human Genome Sciences Inc ALBUM INFUSION PROTEINS
US20080194481A1 (en) 2001-12-21 2008-08-14 Human Genome Sciences, Inc. Albumin Fusion Proteins
JP4472998B2 (ja) * 2002-04-22 2010-06-02 ダウ グローバル テクノロジーズ インコーポレイティド 低コストのペプチド製造
KR100496758B1 (ko) * 2002-06-29 2005-06-22 한국생명공학연구원 한세눌라 폴리모르파 앱신 유전자 결손 변이주 및 이를이용한 재조합 단백질 생산 방법
CN1747747B (zh) * 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
ES2398463T3 (es) * 2003-09-30 2013-03-19 Daiichi Sankyo Company, Limited Método de escisión de polipéptidos usando un mutante de la proteasa OmpT
RU2369404C2 (ru) * 2004-02-09 2009-10-10 Хьюман Дженом Сайенсиз, Инк. Слитые белки альбумина
JP5010923B2 (ja) * 2004-02-09 2012-08-29 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド アルブミン融合蛋白質
US8178495B2 (en) 2008-06-27 2012-05-15 Duke University Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
AU2007258609B2 (en) 2006-06-07 2013-01-24 Human Genome Sciences, Inc. Albumin fusion proteins
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
JP5801807B2 (ja) * 2009-08-14 2015-10-28 フェーズバイオ ファーマシューティカルズ，インコーポレイテッド 修飾された血管作動性腸管ペプチド
ES2669190T3 (es) 2011-06-06 2018-05-24 Phasebio Pharmaceuticals, Inc. Uso de péptidos intestinales vasoactivos modificados en el tratamiento de la hipertensión
WO2015172046A1 (en) 2014-05-08 2015-11-12 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
WO2016130518A2 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
JP2020513834A (ja) 2017-03-20 2020-05-21 ルピン・リミテッド ペプチドの発現および大規模生産

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SE8300693L (sv) * 1983-02-09 1984-08-10 Sven Lofdahl Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
US4703004A (en) * 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
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CA1260858A (en) * 1985-03-28 1989-09-26 Lawrence S. Cousens Expression using fused genes providing for protein product
JP2862870B2 (ja) * 1986-09-12 1999-03-03 協和醗酵工業株式会社 新規ペプチド
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JP2643968B2 (ja) * 1988-02-03 1997-08-25 サントリー株式会社 Ｋｅｘ２エンドプロテアーゼ及びその製造方法
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Ｊ．Ｂａｃｔｅｒｉｏｌ．，Ｖｏｌ．１７０，Ｐ．５６２５−５６３２（１９８８）
Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，Ｖｏｌ．２６２，Ｎｏ．２０，Ｐ．９６１５−９６２０（１９８７）

Also Published As

Publication number Publication date
US5506120A (en) 1996-04-09
WO1992006211A1 (en) 1992-04-16
CA2070781A1 (en) 1992-04-10
EP0591524A1 (en) 1994-04-13
EP0591524A4 (online.php) 1994-08-03
JPH04148694A (ja) 1992-05-21

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