JPH07108232B2 - ペプチド又は蛋白質の製造方法 - Google Patents
ペプチド又は蛋白質の製造方法Info
- Publication number
- JPH07108232B2 JPH07108232B2 JP2271880A JP27188090A JPH07108232B2 JP H07108232 B2 JPH07108232 B2 JP H07108232B2 JP 2271880 A JP2271880 A JP 2271880A JP 27188090 A JP27188090 A JP 27188090A JP H07108232 B2 JPH07108232 B2 JP H07108232B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- peptide
- protease
- arg
- dipeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2271880A JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
| EP91904654A EP0591524A1 (en) | 1990-10-09 | 1991-02-25 | Process for producing peptide or protein |
| PCT/JP1991/000239 WO1992006211A1 (en) | 1990-10-09 | 1991-02-25 | Process for producing peptide or protein |
| CA002070781A CA2070781A1 (en) | 1990-10-09 | 1991-02-25 | Method of producing peptides or proteins |
| US08/243,082 US5506120A (en) | 1990-10-09 | 1994-05-16 | Method of producing peptides or proteins as fusion proteins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2271880A JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04148694A JPH04148694A (ja) | 1992-05-21 |
| JPH07108232B2 true JPH07108232B2 (ja) | 1995-11-22 |
Family
ID=17506194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2271880A Expired - Lifetime JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5506120A (esLanguage) |
| EP (1) | EP0591524A1 (esLanguage) |
| JP (1) | JPH07108232B2 (esLanguage) |
| CA (1) | CA2070781A1 (esLanguage) |
| WO (1) | WO1992006211A1 (esLanguage) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2090969C (en) * | 1990-09-04 | 2001-08-21 | Russell Arthur Brierley | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| ATE220105T1 (de) * | 1991-04-01 | 2002-07-15 | Merck & Co Inc | Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FR2701953B1 (fr) * | 1993-02-22 | 1995-05-24 | Centre Nat Rech Scient | Protéine de fusion multi-VIP et procédé de préparation de VIP recombinant. |
| US6316004B1 (en) * | 1993-06-22 | 2001-11-13 | T. Tikhonenko | Chimeric somatostatin containing protein and encoding DNA, plasmids of expression, method for preparing chimeric protein, strain-producers, immunogenic composition, method for increasing the productivity of farm animals |
| US5888775A (en) * | 1994-04-29 | 1999-03-30 | Dade International Inc | Peptide synthesis and purification by fusion to penI protein or precipitation effective portion thereof |
| US6037145A (en) * | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
| ATE247129T1 (de) * | 1995-04-11 | 2003-08-15 | Merck & Co Inc | Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden |
| WO1996034958A1 (en) * | 1995-05-03 | 1996-11-07 | Biostar Inc. | Vasoactive intestinal peptide |
| US6037321A (en) * | 1995-05-03 | 2000-03-14 | Biostar Inc. | Fusion proteins comprising vasoactive intestinal peptide or PACAP |
| WO1997001627A1 (en) * | 1995-06-27 | 1997-01-16 | Igen International, Inc. | High-level expression and efficient recovery of ubiquitin fusion proteins from escherichia coli |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| US20080286228A1 (en) * | 1995-10-20 | 2008-11-20 | Tarantolo Stefano R | Compositions and methods for enhancing immune responses mediated by antigen-presenting cells |
| JP4125784B2 (ja) * | 1995-10-20 | 2008-07-30 | ユニバーシティ・オブ・ネブラスカ・ボード・オブ・リージェンツ | 抗原提示細胞により仲介される免疫応答を高めるための組成物および方法 |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US5935824A (en) * | 1996-01-31 | 1999-08-10 | Technologene, Inc. | Protein expression system |
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| KR100368073B1 (ko) * | 1999-03-09 | 2003-01-24 | 한국생명공학연구원 | 융합파트너를 이용한 재조합 단백질의 제조방법 |
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| JP4472998B2 (ja) * | 2002-04-22 | 2010-06-02 | ダウ グローバル テクノロジーズ インコーポレイティド | 低コストのペプチド製造 |
| ATE480624T1 (de) * | 2002-06-29 | 2010-09-15 | Korea Res Inst Of Bioscience | Yapsin-mangelmutantenstamm von hansenula polymorpha sowie verfahren zur herstellung rekombinanter proteine damit |
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| ES2567634T3 (es) | 2004-02-09 | 2016-04-25 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina |
| RU2369404C2 (ru) * | 2004-02-09 | 2009-10-10 | Хьюман Дженом Сайенсиз, Инк. | Слитые белки альбумина |
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| US4828994A (en) * | 1984-09-21 | 1989-05-09 | Genex Corporation | Bacillus strains with reduced extracellular protease levels |
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| JP2862870B2 (ja) * | 1986-09-12 | 1999-03-03 | 協和醗酵工業株式会社 | 新規ペプチド |
| DE3851117T2 (de) * | 1987-10-16 | 1995-03-30 | Genencor Int | Sequenzspezifische saure E.coli-Protease. |
| JPH0249585A (ja) * | 1988-08-12 | 1990-02-19 | M D Res Kk | 新規なプロテアーゼ |
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| JPH02271880A (ja) * | 1989-04-13 | 1990-11-06 | Suzuki Gakki Seisakusho:Kk | 呼吸器官鍛練器 |
-
1990
- 1990-10-09 JP JP2271880A patent/JPH07108232B2/ja not_active Expired - Lifetime
-
1991
- 1991-02-25 EP EP91904654A patent/EP0591524A1/en not_active Ceased
- 1991-02-25 WO PCT/JP1991/000239 patent/WO1992006211A1/ja not_active Ceased
- 1991-02-25 CA CA002070781A patent/CA2070781A1/en not_active Abandoned
-
1994
- 1994-05-16 US US08/243,082 patent/US5506120A/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Ｊ．Ｂａｃｔｅｒｉｏｌ．，Ｖｏｌ．１７０，Ｐ．５６２５−５６３２（１９８８） |
| Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，Ｖｏｌ．２６２，Ｎｏ．２０，Ｐ．９６１５−９６２０（１９８７） |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0591524A4 (esLanguage) | 1994-08-03 |
| JPH04148694A (ja) | 1992-05-21 |
| US5506120A (en) | 1996-04-09 |
| EP0591524A1 (en) | 1994-04-13 |
| CA2070781A1 (en) | 1992-04-10 |
| WO1992006211A1 (en) | 1992-04-16 |
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