JPH07108232B2 - ペプチド又は蛋白質の製造方法 - Google Patents
ペプチド又は蛋白質の製造方法Info
- Publication number
- JPH07108232B2 JPH07108232B2 JP2271880A JP27188090A JPH07108232B2 JP H07108232 B2 JPH07108232 B2 JP H07108232B2 JP 2271880 A JP2271880 A JP 2271880A JP 27188090 A JP27188090 A JP 27188090A JP H07108232 B2 JPH07108232 B2 JP H07108232B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- peptide
- protease
- arg
- dipeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2271880A JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
| PCT/JP1991/000239 WO1992006211A1 (en) | 1990-10-09 | 1991-02-25 | Process for producing peptide or protein |
| EP91904654A EP0591524A1 (en) | 1990-10-09 | 1991-02-25 | Process for producing peptide or protein |
| CA002070781A CA2070781A1 (en) | 1990-10-09 | 1991-02-25 | Method of producing peptides or proteins |
| US08/243,082 US5506120A (en) | 1990-10-09 | 1994-05-16 | Method of producing peptides or proteins as fusion proteins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2271880A JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04148694A JPH04148694A (ja) | 1992-05-21 |
| JPH07108232B2 true JPH07108232B2 (ja) | 1995-11-22 |
Family
ID=17506194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2271880A Expired - Lifetime JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5506120A (enExample) |
| EP (1) | EP0591524A1 (enExample) |
| JP (1) | JPH07108232B2 (enExample) |
| CA (1) | CA2070781A1 (enExample) |
| WO (1) | WO1992006211A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| JPH06500470A (ja) * | 1990-09-04 | 1994-01-20 | メルク エンド カンパニー インコーポレーテッド | メチロトローフ酵母細胞におけるインスリン様成長因子の産生 |
| AU661844B2 (en) * | 1991-04-01 | 1995-08-10 | Merck Sharp & Dohme Corp. | Genes which influence (pichia) proteolytic activity, and uses therefor |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FR2701953B1 (fr) * | 1993-02-22 | 1995-05-24 | Centre Nat Rech Scient | Protéine de fusion multi-VIP et procédé de préparation de VIP recombinant. |
| US6316004B1 (en) * | 1993-06-22 | 2001-11-13 | T. Tikhonenko | Chimeric somatostatin containing protein and encoding DNA, plasmids of expression, method for preparing chimeric protein, strain-producers, immunogenic composition, method for increasing the productivity of farm animals |
| US5888775A (en) * | 1994-04-29 | 1999-03-30 | Dade International Inc | Peptide synthesis and purification by fusion to penI protein or precipitation effective portion thereof |
| US6037145A (en) * | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
| AU5445596A (en) * | 1995-04-11 | 1996-10-30 | Merck & Co., Inc. | Bioprocess for production of dipeptide based compounds |
| WO1996034958A1 (en) * | 1995-05-03 | 1996-11-07 | Biostar Inc. | Vasoactive intestinal peptide |
| US6037321A (en) * | 1995-05-03 | 2000-03-14 | Biostar Inc. | Fusion proteins comprising vasoactive intestinal peptide or PACAP |
| AU6290496A (en) * | 1995-06-27 | 1997-01-30 | Igen International, Inc. | High-level expression and efficient recovery of ubiquitin fusion proteins from escherichia coli |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| DE69637571D1 (de) * | 1995-10-20 | 2008-08-07 | Univ Nebraska | Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen |
| US20080286228A1 (en) * | 1995-10-20 | 2008-11-20 | Tarantolo Stefano R | Compositions and methods for enhancing immune responses mediated by antigen-presenting cells |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US5935824A (en) * | 1996-01-31 | 1999-08-10 | Technologene, Inc. | Protein expression system |
| CA2198966C (en) * | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
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| RU2369404C2 (ru) * | 2004-02-09 | 2009-10-10 | Хьюман Дженом Сайенсиз, Инк. | Слитые белки альбумина |
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| US4828994A (en) * | 1984-09-21 | 1989-05-09 | Genex Corporation | Bacillus strains with reduced extracellular protease levels |
| DE3679343D1 (de) * | 1985-03-28 | 1991-06-27 | Chiron Corp | Expression durch verwendung von fusionsgenen fuer proteinproduktion. |
| JP2862870B2 (ja) * | 1986-09-12 | 1999-03-03 | 協和醗酵工業株式会社 | 新規ペプチド |
| DE3851117T2 (de) * | 1987-10-16 | 1995-03-30 | Genencor Int | Sequenzspezifische saure E.coli-Protease. |
| JPH01191683A (ja) * | 1988-01-27 | 1989-08-01 | M D Res Kk | 新規なプロテアーゼ |
| JPH0249585A (ja) * | 1988-08-12 | 1990-02-19 | M D Res Kk | 新規なプロテアーゼ |
| EP0336056B1 (en) * | 1988-01-27 | 1995-04-05 | M & D RESEARCH CO., LTD. | Protease |
| JP2643968B2 (ja) * | 1988-02-03 | 1997-08-25 | サントリー株式会社 | Ｋｅｘ２エンドプロテアーゼ及びその製造方法 |
| JPH02271880A (ja) * | 1989-04-13 | 1990-11-06 | Suzuki Gakki Seisakusho:Kk | 呼吸器官鍛練器 |
-
1990
- 1990-10-09 JP JP2271880A patent/JPH07108232B2/ja not_active Expired - Lifetime
-
1991
- 1991-02-25 WO PCT/JP1991/000239 patent/WO1992006211A1/ja not_active Ceased
- 1991-02-25 EP EP91904654A patent/EP0591524A1/en not_active Ceased
- 1991-02-25 CA CA002070781A patent/CA2070781A1/en not_active Abandoned
-
1994
- 1994-05-16 US US08/243,082 patent/US5506120A/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Ｊ．Ｂａｃｔｅｒｉｏｌ．，Ｖｏｌ．１７０，Ｐ．５６２５−５６３２（１９８８） |
| Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，Ｖｏｌ．２６２，Ｎｏ．２０，Ｐ．９６１５−９６２０（１９８７） |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992006211A1 (en) | 1992-04-16 |
| US5506120A (en) | 1996-04-09 |
| EP0591524A4 (enExample) | 1994-08-03 |
| JPH04148694A (ja) | 1992-05-21 |
| EP0591524A1 (en) | 1994-04-13 |
| CA2070781A1 (en) | 1992-04-10 |
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