JPH07108232B2 - ペプチド又は蛋白質の製造方法 - Google Patents
ペプチド又は蛋白質の製造方法Info
- Publication number
- JPH07108232B2 JPH07108232B2 JP2271880A JP27188090A JPH07108232B2 JP H07108232 B2 JPH07108232 B2 JP H07108232B2 JP 2271880 A JP2271880 A JP 2271880A JP 27188090 A JP27188090 A JP 27188090A JP H07108232 B2 JPH07108232 B2 JP H07108232B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- peptide
- protease
- arg
- dipeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2271880A JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
| EP91904654A EP0591524A1 (en) | 1990-10-09 | 1991-02-25 | Process for producing peptide or protein |
| CA002070781A CA2070781A1 (en) | 1990-10-09 | 1991-02-25 | Method of producing peptides or proteins |
| PCT/JP1991/000239 WO1992006211A1 (en) | 1990-10-09 | 1991-02-25 | Process for producing peptide or protein |
| US08/243,082 US5506120A (en) | 1990-10-09 | 1994-05-16 | Method of producing peptides or proteins as fusion proteins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2271880A JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04148694A JPH04148694A (ja) | 1992-05-21 |
| JPH07108232B2 true JPH07108232B2 (ja) | 1995-11-22 |
Family
ID=17506194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2271880A Expired - Lifetime JPH07108232B2 (ja) | 1990-10-09 | 1990-10-09 | ペプチド又は蛋白質の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5506120A (enExample) |
| EP (1) | EP0591524A1 (enExample) |
| JP (1) | JPH07108232B2 (enExample) |
| CA (1) | CA2070781A1 (enExample) |
| WO (1) | WO1992006211A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2090969C (en) * | 1990-09-04 | 2001-08-21 | Russell Arthur Brierley | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
| WO1992017595A1 (en) * | 1991-04-01 | 1992-10-15 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Genes which influence pichia proteolytic activity, and uses therefor |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FR2701953B1 (fr) * | 1993-02-22 | 1995-05-24 | Centre Nat Rech Scient | Protéine de fusion multi-VIP et procédé de préparation de VIP recombinant. |
| EP0645454A3 (en) * | 1993-06-22 | 1997-01-15 | Vladimir Glebovich Lunin | Protein containing a chimeric somatostatin, coding DNA, immunogenic compositions, and method for improving the productivity of farmes animals. |
| US5888775A (en) * | 1994-04-29 | 1999-03-30 | Dade International Inc | Peptide synthesis and purification by fusion to penI protein or precipitation effective portion thereof |
| US6037145A (en) * | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
| CN1193998A (zh) * | 1995-04-11 | 1998-09-23 | 麦克公司 | 以二肽基础的化合物生产的生物方法 |
| WO1996034958A1 (en) * | 1995-05-03 | 1996-11-07 | Biostar Inc. | Vasoactive intestinal peptide |
| US6037321A (en) * | 1995-05-03 | 2000-03-14 | Biostar Inc. | Fusion proteins comprising vasoactive intestinal peptide or PACAP |
| WO1997001627A1 (en) * | 1995-06-27 | 1997-01-16 | Igen International, Inc. | High-level expression and efficient recovery of ubiquitin fusion proteins from escherichia coli |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| US20080286228A1 (en) * | 1995-10-20 | 2008-11-20 | Tarantolo Stefano R | Compositions and methods for enhancing immune responses mediated by antigen-presenting cells |
| EP0859625B1 (en) * | 1995-10-20 | 2008-06-25 | University Of Nebraska Board Of Regents | Composition and methods for enhancing immune responses mediated by antigen-presenting cells |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US5935824A (en) * | 1996-01-31 | 1999-08-10 | Technologene, Inc. | Protein expression system |
| CA2198966C (en) * | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| US6265204B1 (en) | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
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| KR100368073B1 (ko) * | 1999-03-09 | 2003-01-24 | 한국생명공학연구원 | 융합파트너를 이용한 재조합 단백질의 제조방법 |
| EP1274720A4 (en) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | ALBUMIN FUSED PROTEINS |
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| ATE512674T1 (de) * | 2003-01-06 | 2011-07-15 | Angiochem Inc | Angiopep-1, verwandte verbindungen, und deren verwnedungen |
| AU2004276687B2 (en) * | 2003-09-30 | 2011-07-14 | Asubio Pharma Co., Ltd. | Method of cleaving polypeptide by using OmpT protease mutant |
| RU2369404C2 (ru) * | 2004-02-09 | 2009-10-10 | Хьюман Дженом Сайенсиз, Инк. | Слитые белки альбумина |
| HUE027902T2 (en) * | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| US8334365B2 (en) | 2006-06-07 | 2012-12-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| WO2009158704A2 (en) | 2008-06-27 | 2009-12-30 | Duke University | Therapeutic agents comprising elastin-like peptides |
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| JP6824888B2 (ja) | 2015-02-09 | 2021-02-03 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 筋肉の疾患および障害を治療するための方法および組成物 |
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| US4703004A (en) * | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
| CA1213537A (en) * | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
| US4828994A (en) * | 1984-09-21 | 1989-05-09 | Genex Corporation | Bacillus strains with reduced extracellular protease levels |
| DE3679343D1 (de) * | 1985-03-28 | 1991-06-27 | Chiron Corp | Expression durch verwendung von fusionsgenen fuer proteinproduktion. |
| JP2862870B2 (ja) * | 1986-09-12 | 1999-03-03 | 協和醗酵工業株式会社 | 新規ペプチド |
| EP0312346B1 (en) * | 1987-10-16 | 1994-08-17 | Genencor International, Inc. | E. coli sequence specific acid protease |
| JPH01191683A (ja) * | 1988-01-27 | 1989-08-01 | M D Res Kk | 新規なプロテアーゼ |
| DE68922014T2 (de) * | 1988-01-27 | 1995-08-03 | M & D Research Co | Protease. |
| JPH0249585A (ja) * | 1988-08-12 | 1990-02-19 | M D Res Kk | 新規なプロテアーゼ |
| JP2643968B2 (ja) * | 1988-02-03 | 1997-08-25 | サントリー株式会社 | Ｋｅｘ２エンドプロテアーゼ及びその製造方法 |
| JPH02271880A (ja) * | 1989-04-13 | 1990-11-06 | Suzuki Gakki Seisakusho:Kk | 呼吸器官鍛練器 |
-
1990
- 1990-10-09 JP JP2271880A patent/JPH07108232B2/ja not_active Expired - Lifetime
-
1991
- 1991-02-25 EP EP91904654A patent/EP0591524A1/en not_active Ceased
- 1991-02-25 WO PCT/JP1991/000239 patent/WO1992006211A1/ja not_active Ceased
- 1991-02-25 CA CA002070781A patent/CA2070781A1/en not_active Abandoned
-
1994
- 1994-05-16 US US08/243,082 patent/US5506120A/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Ｊ．Ｂａｃｔｅｒｉｏｌ．，Ｖｏｌ．１７０，Ｐ．５６２５−５６３２（１９８８） |
| Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，Ｖｏｌ．２６２，Ｎｏ．２０，Ｐ．９６１５−９６２０（１９８７） |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992006211A1 (en) | 1992-04-16 |
| US5506120A (en) | 1996-04-09 |
| JPH04148694A (ja) | 1992-05-21 |
| EP0591524A1 (en) | 1994-04-13 |
| CA2070781A1 (en) | 1992-04-10 |
| EP0591524A4 (enExample) | 1994-08-03 |
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