JPH0655700B2 - 脳への薬物投与の向上 - Google Patents

脳への薬物投与の向上

Info

Publication number
JPH0655700B2
JPH0655700B2 JP63507717A JP50771788A JPH0655700B2 JP H0655700 B2 JPH0655700 B2 JP H0655700B2 JP 63507717 A JP63507717 A JP 63507717A JP 50771788 A JP50771788 A JP 50771788A JP H0655700 B2 JPH0655700 B2 JP H0655700B2
Authority
JP
Japan
Prior art keywords
alkyl
brain
different
same
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63507717A
Other languages
English (en)
Japanese (ja)
Other versions
JPH03500646A (ja
Inventor
エイチ． グリーグ，ニージェル
ジェー． スウィーニー，ダニエル
アイ． ラポポート，スタンレー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Energy
US Department of Health and Human Services
Original Assignee
US Department of Energy
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Energy, US Department of Health and Human Services filed Critical US Department of Energy
Publication of JPH03500646A publication Critical patent/JPH03500646A/ja
Publication of JPH0655700B2 publication Critical patent/JPH0655700B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP63507717A 1987-08-21 1988-08-19 脳への薬物投与の向上 Expired - Lifetime JPH0655700B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88,982 1987-08-21
US07/088,982 US4835182A (en) 1987-08-21 1987-08-21 Enhancing drug delivery to the brain
PCT/US1988/002836 WO1989001331A1 (en) 1987-08-21 1988-08-19 Enhancing drug delivery to the brain

Publications (2)

Publication Number Publication Date
JPH03500646A JPH03500646A (ja) 1991-02-14
JPH0655700B2 true JPH0655700B2 (ja) 1994-07-27

Family

ID=22214651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63507717A Expired - Lifetime JPH0655700B2 (ja) 1987-08-21 1988-08-19 脳への薬物投与の向上

Country Status (13)

Country Link
US (1) US4835182A (OSRAM)
EP (1) EP0304341B1 (OSRAM)
JP (1) JPH0655700B2 (OSRAM)
AT (1) ATE77078T1 (OSRAM)
AU (1) AU615003B2 (OSRAM)
CA (1) CA1327051C (OSRAM)
DE (1) DE3871879T2 (OSRAM)
DK (1) DK42590A (OSRAM)
ES (1) ES2042755T3 (OSRAM)
GR (1) GR3005338T3 (OSRAM)
IE (1) IE60689B1 (OSRAM)
PT (1) PT88309B (OSRAM)
WO (1) WO1989001331A1 (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227511A (en) * 1988-12-23 1993-07-13 Hodogaya Chemical Co., Ltd. Benzamide derivatives and plant growth regulants containing them
EP0514437A4 (en) * 1990-02-09 1993-03-10 Us Commerce Branched alkyl esters of 4-bis (chloroethyl) aminophenyl-alkyl carboxylic acids for treatment of primary and metastatic tumors of the lymphatic system, and of cancers of the breast and ovaries

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB727336A (en) * 1952-11-20 1955-03-30 Nat Res Dev Improvements in or relating to chemotherapeutic agents
GB750155A (en) * 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA573957A (en) * 1959-04-14 C. J. Ross Walter P-nn-di-(2-chloroethyl)-aminophenylbutyrates
DE1126399B (de) * 1959-10-22 1962-03-29 Nat Res Dev Verfahren zur Herstellung cytostatisch wirkender Derivate des p-[Bis-(2-chloraethyl)-amino]-phenylalanins
US4261910A (en) * 1978-08-14 1981-04-14 Kureha Kagaku Kogyo Kabushiki Kaisha Process for the preparation of Chlorambucil derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB727336A (en) * 1952-11-20 1955-03-30 Nat Res Dev Improvements in or relating to chemotherapeutic agents
GB750155A (en) * 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines

Also Published As

Publication number Publication date
US4835182A (en) 1989-05-30
EP0304341A3 (en) 1989-11-23
ATE77078T1 (de) 1992-06-15
CA1327051C (en) 1994-02-15
PT88309B (pt) 1994-07-29
US4835182B1 (OSRAM) 1991-11-05
WO1989001331A1 (en) 1989-02-23
GR3005338T3 (OSRAM) 1993-05-24
PT88309A (pt) 1989-06-30
EP0304341A2 (en) 1989-02-22
DK42590D0 (da) 1990-02-16
DE3871879D1 (de) 1992-07-16
AU615003B2 (en) 1991-09-19
JPH03500646A (ja) 1991-02-14
DK42590A (da) 1990-02-16
EP0304341B1 (en) 1992-06-10
ES2042755T3 (es) 1993-12-16
DE3871879T2 (de) 1993-01-14
IE60689B1 (en) 1994-08-10
IE882535L (en) 1989-02-21
AU2427188A (en) 1989-03-09

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