GB727336A - Improvements in or relating to chemotherapeutic agents - Google Patents

Improvements in or relating to chemotherapeutic agents

Info

Publication number
GB727336A
GB727336A GB29401/52A GB2940152A GB727336A GB 727336 A GB727336 A GB 727336A GB 29401/52 A GB29401/52 A GB 29401/52A GB 2940152 A GB2940152 A GB 2940152A GB 727336 A GB727336 A GB 727336A
Authority
GB
United Kingdom
Prior art keywords
relating
butyrates
aminophenyl
ethyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29401/52A
Inventor
Walter Charles Joseph Ross
James Lionel Everett
John James Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Publication of GB727336A publication Critical patent/GB727336A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0727336/IV (b)/1> where R1 is hydrogen or alkyl (preferably up to C8), and their preparation by the action of phosphorus oxychloride on alkyl N : N-di-(2-hydroxyethyl)-aminophenylbutyrates, followed by hydrolysis of the ester group if desired. Examples are given of the preparation of the p-compounds where R1 is H, methyl and ethyl. The hydroxyethylamino esters are obtained from methyl and ethyl g -(p-aminophenyl)-butyrates and ethylene oxide. The g -(p-aminophenyl)-butyrates are prepared from g -(p-nitrophenyl)-butyric acid by esterification (via the acid chloride) and reduction of the nitro group.
GB29401/52A 1952-11-20 1952-11-20 Improvements in or relating to chemotherapeutic agents Expired GB727336A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB322814X 1952-11-20

Publications (1)

Publication Number Publication Date
GB727336A true GB727336A (en) 1955-03-30

Family

ID=10336169

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29401/52A Expired GB727336A (en) 1952-11-20 1952-11-20 Improvements in or relating to chemotherapeutic agents

Country Status (5)

Country Link
US (1) US2944079A (en)
CH (1) CH322814A (en)
DE (1) DE939507C (en)
FR (1) FR1093021A (en)
GB (1) GB727336A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304341A2 (en) * 1987-08-21 1989-02-22 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Ramified alkyl esters of 4-bis(chloroethyl)aminophenyl-alkyl carboxylic acids

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3335176A (en) * 1962-04-13 1967-08-08 Allied Chem Aminomethyl carboxy dibenzyl amines and preparation thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB128912A (en) * 1918-06-26 1919-10-30 Ste Chim Usines Rhone Manufacture of New Substituted Benzoic Acid Esters.
GB653452A (en) * 1947-04-12 1951-05-16 Goodrich Co B F Improvements in or relating to a method of preparing an (n,n-diaryl) amino acid ester

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304341A2 (en) * 1987-08-21 1989-02-22 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Ramified alkyl esters of 4-bis(chloroethyl)aminophenyl-alkyl carboxylic acids
WO1989001331A1 (en) * 1987-08-21 1989-02-23 The United States Of America, As Represented By Th Enhancing drug delivery to the brain
US4835182A (en) * 1987-08-21 1989-05-30 The United States Of America As Represented By The Department Of Health And Human Services Enhancing drug delivery to the brain
EP0304341A3 (en) * 1987-08-21 1989-11-23 Us Health Ramified alkyl esters of 4-bis(chloroethyl)aminophenyl-alkyl carboxylic acids
JPH0655700B2 (en) * 1987-08-21 1994-07-27 アメリカ合衆国 Improved drug delivery to the brain

Also Published As

Publication number Publication date
DE939507C (en) 1956-02-23
US2944079A (en) 1960-07-05
CH322814A (en) 1957-06-30
FR1093021A (en) 1955-04-29

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