JPH0627070B2 - ウイルス感染の予防治療およびインターフェロン生成誘導用医薬組成物 - Google Patents
ウイルス感染の予防治療およびインターフェロン生成誘導用医薬組成物Info
- Publication number
- JPH0627070B2 JPH0627070B2 JP3201754A JP20175491A JPH0627070B2 JP H0627070 B2 JPH0627070 B2 JP H0627070B2 JP 3201754 A JP3201754 A JP 3201754A JP 20175491 A JP20175491 A JP 20175491A JP H0627070 B2 JPH0627070 B2 JP H0627070B2
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidinol
- phenyl
- amino
- bromo
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 210000000822 natural killer cell Anatomy 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940042126 oral powder Drugs 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000002962 plaque-reduction assay Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000009491 slugging Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2220579A | 1979-03-19 | 1979-03-19 | |
| US7985079A | 1979-09-28 | 1979-09-28 | |
| US79850 | 1979-09-28 | ||
| US22205 | 1979-09-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3572980A Division JPS55127378A (en) | 1979-03-19 | 1980-03-19 | 66arylpyrimidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0517451A JPH0517451A (ja) | 1993-01-26 |
| JPH0627070B2 true JPH0627070B2 (ja) | 1994-04-13 |
Family
ID=26695670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3201754A Expired - Lifetime JPH0627070B2 (ja) | 1979-03-19 | 1991-08-12 | ウイルス感染の予防治療およびインターフェロン生成誘導用医薬組成物 |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPH0627070B2 (cs) |
| CH (1) | CH646958A5 (cs) |
| DE (1) | DE3008693A1 (cs) |
| FR (1) | FR2451918A1 (cs) |
| GB (1) | GB2048250B (cs) |
| IT (1) | IT1143012B (cs) |
| NL (1) | NL8001568A (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0111440A1 (en) * | 1982-10-15 | 1984-06-20 | Ciba-Geigy Ag | 2-Aminopyrimidines, their production and use |
| US4795812A (en) * | 1985-02-05 | 1989-01-03 | The Upjohn Company | 4-substituted-6-aryl-pyrimidine compounds |
| GB9012311D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
| EP0948331A2 (en) * | 1996-12-12 | 1999-10-13 | PHARMACIA & UPJOHN COMPANY | Method for treating multiple sclerosis |
| AU768201B2 (en) * | 1999-01-22 | 2003-12-04 | Amgen, Inc. | Kinase inhibitors |
| US6495558B1 (en) | 1999-01-22 | 2002-12-17 | Amgen Inc. | Kinase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2688019A (en) * | 1951-08-25 | 1954-08-31 | Burroughs Wellcome Co | 6-aryl-2,4-diamino pyrimidines and process of preparing same |
| US2723977A (en) * | 1953-07-29 | 1955-11-15 | Searle & Co | 5, 6-disubstituted 2-amino-4-pyrimidols |
| US2723978A (en) * | 1954-01-14 | 1955-11-15 | Searle & Co | 2-amino-5-alkenyl-6-phenyl-4-pyrimidols |
| US2710867A (en) * | 1954-03-12 | 1955-06-14 | Searle & Co | New 2-amino-4-pyrimidol derivatives |
| US2748121A (en) * | 1954-06-17 | 1956-05-29 | Searle & Co | 6-nitroaryl derivatives of 2-amino-4-pyrimidols |
| US2704285A (en) * | 1954-06-17 | 1955-03-15 | Searle & Co | 2-amino-5-(lower alkyl)-6-substituted phenyl-4-pyrimidols |
| US3281420A (en) * | 1966-01-27 | 1966-10-25 | Searle & Co | Carboxylic acid [2-(2-amino-4-azido-6-phenyl-5-pyrimidinyl)-1-methylethylidene] hydrazides and intermediate |
| US3412094A (en) * | 1967-06-21 | 1968-11-19 | Searle & Co | 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners |
| US3932617A (en) * | 1974-05-24 | 1976-01-13 | The Upjohn Company | Interferon induction |
-
1980
- 1980-03-06 DE DE19803008693 patent/DE3008693A1/de active Granted
- 1980-03-10 IT IT48119/80A patent/IT1143012B/it active
- 1980-03-14 CH CH204380A patent/CH646958A5/de not_active IP Right Cessation
- 1980-03-17 GB GB8008979A patent/GB2048250B/en not_active Expired
- 1980-03-17 NL NL8001568A patent/NL8001568A/nl active Search and Examination
- 1980-03-18 FR FR8006015A patent/FR2451918A1/fr active Granted
-
1991
- 1991-08-12 JP JP3201754A patent/JPH0627070B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2451918A1 (fr) | 1980-10-17 |
| DE3008693A1 (de) | 1980-10-02 |
| GB2048250B (en) | 1983-04-27 |
| FR2451918B1 (cs) | 1984-01-06 |
| CH646958A5 (de) | 1984-12-28 |
| IT1143012B (it) | 1986-10-22 |
| NL8001568A (nl) | 1980-09-23 |
| GB2048250A (en) | 1980-12-10 |
| JPH0517451A (ja) | 1993-01-26 |
| IT8048119A0 (it) | 1980-03-10 |
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