JPH0569507B2 - - Google Patents

Info

Publication number
JPH0569507B2
JPH0569507B2 JP59035894A JP3589484A JPH0569507B2 JP H0569507 B2 JPH0569507 B2 JP H0569507B2 JP 59035894 A JP59035894 A JP 59035894A JP 3589484 A JP3589484 A JP 3589484A JP H0569507 B2 JPH0569507 B2 JP H0569507B2
Authority
JP
Japan
Prior art keywords
plasminogen activator
lysine
tissue
present
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59035894A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60181028A (ja
Inventor
Akio Hasegawa
Shuhei Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP59035894A priority Critical patent/JPS60181028A/ja
Priority to DE8585102058T priority patent/DE3584902D1/de
Priority to EP85102058A priority patent/EP0156169B1/en
Priority to US06/705,896 priority patent/US4568544A/en
Publication of JPS60181028A publication Critical patent/JPS60181028A/ja
Publication of JPH0569507B2 publication Critical patent/JPH0569507B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP59035894A 1984-02-29 1984-02-29 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法 Granted JPS60181028A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59035894A JPS60181028A (ja) 1984-02-29 1984-02-29 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法
DE8585102058T DE3584902D1 (de) 1984-02-29 1985-02-25 Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
EP85102058A EP0156169B1 (en) 1984-02-29 1985-02-25 An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
US06/705,896 US4568544A (en) 1984-02-29 1985-02-26 Aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59035894A JPS60181028A (ja) 1984-02-29 1984-02-29 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法

Publications (2)

Publication Number Publication Date
JPS60181028A JPS60181028A (ja) 1985-09-14
JPH0569507B2 true JPH0569507B2 (cs) 1993-10-01

Family

ID=12454730

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59035894A Granted JPS60181028A (ja) 1984-02-29 1984-02-29 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法

Country Status (1)

Country Link
JP (1) JPS60181028A (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
JPS62120321A (ja) * 1985-11-20 1987-06-01 Eisai Co Ltd ｔＰＡ含有医薬組成物
DE3718889A1 (de) * 1987-06-05 1988-12-22 Behringwerke Ag Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤

Also Published As

Publication number Publication date
JPS60181028A (ja) 1985-09-14

Similar Documents

Publication Publication Date Title
EP0100982B1 (en) Novel purified plasminogen activator, process for its production and thrombolytic composition containing it
EP0156169B1 (en) An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
CA1206434A (en) Method for stabilizing tissue plasminogen activator and a stable aqueous solution or powder containing the same
EP0217379B1 (en) Thrombolytic composition and a process for production thereof
JPH05227962A (ja) ウイルス安全性精製ヒトトロンビン
JP2010540432A (ja) ヒト組織型プラスミノーゲンアクチベータの精製方法
US4020268A (en) Agarose containing affinity matrix materials
SE406913B (sv) Forfarande for rening eller lagning av ett enzym genom kontakt med affinitelsmatrismaterial
JPH0569507B2 (cs)
JPS60184026A (ja) 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助方法
US4550080A (en) Process for the preparation of a plasminogen activator
EP0151996B1 (en) Process for the preparation of a double-chain plasminogen activator
JPS6360938A (ja) 修飾組織型プラスミノ−ゲン活性化因子およびその製造方法
EP0163751A1 (en) Process for the preparation of a plasminogen activator
JPS60248621A (ja) 一本鎖組織プラスミノ−ゲンアクチベ−タ−の安定化方法
JP2861655B2 (ja) ヒト尿性トリプシンインヒビター含有液状製剤及びその製造方法
JPS60174727A (ja) 新規なプラスミノ−ゲン・アクチベ−タ−の安定化方法
CA1206903A (en) Process for the preparation of a plasminogen activator
JPH0521551B2 (cs)
JPS62283932A (ja) 組織プラスミノ−ゲンアクチベ−タの乾燥製剤
JPH0558910A (ja) トリプシンインヒビター含有凍結乾燥製剤
JPS63174934A (ja) ウロキナ−ゼ前駆体乾燥製剤
JP2714817B2 (ja) ウロキナーゼ前駆体の製造方法
JPS60158116A (ja) 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPH0329390B2 (cs)

Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term