JPH05502882A - アルコール含有水性ゲル状リン脂質組成物、該リン脂質組成物を希釈するリポソーム溶液の製造方法及び該リン脂質組成物を含有する局所適用調製物 - Google Patents
アルコール含有水性ゲル状リン脂質組成物、該リン脂質組成物を希釈するリポソーム溶液の製造方法及び該リン脂質組成物を含有する局所適用調製物Info
- Publication number
- JPH05502882A JPH05502882A JP3503437A JP50343791A JPH05502882A JP H05502882 A JPH05502882 A JP H05502882A JP 3503437 A JP3503437 A JP 3503437A JP 50343791 A JP50343791 A JP 50343791A JP H05502882 A JPH05502882 A JP H05502882A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- parts
- phospholipid
- gel
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Fats And Perfumes (AREA)
Abstract
Description
Claims (8)
- 1.アルコールとしてエタノール、1−プロパノール、2−アロパノール、また はこれらの混合物を含有するアルコール含有水性ゲル状リン脂質組成物であって 、成分として −70.00〜80.00重量部のホスファチジルコリンと、15.00〜5. 00重量部の酸性リン脂質と、5.00〜25.00重量部のその他のリン脂質 とから成り、そのうえリンを有しない随伴脂質も前記リン脂質100重量部当た り1〜15重量部の量で含有するリン脂質濃縮物を15.00〜30.00重量 部、−アルコールを20.00〜14.00重量部、及び−水溶液を50.00 〜71.00重量部含有するリボソームゲルであることを特徴とするリン脂質組 成物。
- 2.リン脂質濃縮物が 80重量部のホスファチジルコリンと、5〜15重量部の酸性リン脂質と、 15〜5重量部のその他のリン脂質と から成り、そのうえリンを有しない随伴脂質も前記リン脂質100重量部当たり 1〜9重量部の量で含有することを特徴とする請求項1に記載のリン脂質組成物 。
- 3.リボソームゲルの最終生成段階でのアルコール含量が約16重量%であるこ とを特徴とする請求項1及び2に記載のリン脂質組成物。
- 4.請求項1から3に記載のリン脂質組成物の、水含有溶液での稀釈によるリボ ソーム溶液製造への使用。
- 5.水含有溶液が少なくとも1種の生物活性作用物質も含有することを特徴とす る請求項4に記載の使用。
- 6.作用物質が消炎薬、抗凝血剤、抗真菌剤、鎮痙薬もしくは血行促進剤、また は角質層に浸透する手入れ用薬剤であることを特徴とする請求項5に記載の使用 。
- 7.請求項1から3に記載のリン脂質組成物1種以上を少なくとも1種の生物活 性作用物質、並びに通常の補助物質及び添加物質と組み合わせて含有する局所適 用可能な医薬品調製物または化粧品調製物。
- 8.作用物質が消炎薬、抗凝血剤、抗真菌剤、鎮痙薬、血行促進剤、または角質 層に浸透する手入れ用薬剤であることを特徴とする請求項7に記載の調製物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4003783.5 | 1990-02-08 | ||
DE19904003782 DE4003782C2 (de) | 1990-02-08 | 1990-02-08 | Liposomales System und Verfahren zu dessen Herstellung |
DE4003782.7 | 1990-02-08 | ||
DE19904003783 DE4003783C2 (de) | 1990-02-08 | 1990-02-08 | Phospholipidhaltiges Gel, Verfahren zu dessen Herstellung und Verwendung |
PCT/EP1991/000229 WO1991011993A1 (de) | 1990-02-08 | 1991-02-06 | Alkohol enthaltende wässrige gelartige phospholipidzusammensetzung, ihre verwendung und topische zubereitungen, die diese enthalten |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05502882A true JPH05502882A (ja) | 1993-05-20 |
JPH07112969B2 JPH07112969B2 (ja) | 1995-12-06 |
Family
ID=25889876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3503437A Expired - Lifetime JPH07112969B2 (ja) | 1990-02-08 | 1991-02-06 | アルコール含有水性ゲル状リン脂質組成物、該リン脂質組成物を希釈するリポソーム溶液の製造方法及び該リン脂質組成物を含有する局所適用調製物 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0514435B1 (ja) |
JP (1) | JPH07112969B2 (ja) |
AT (1) | ATE95419T1 (ja) |
CA (1) | CA2067807C (ja) |
DE (1) | DE59100466D1 (ja) |
DK (1) | DK0514435T3 (ja) |
ES (1) | ES2060365T3 (ja) |
HK (1) | HK24294A (ja) |
WO (1) | WO1991011993A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008007430A (ja) * | 2006-06-27 | 2008-01-17 | Kracie Home Products Kk | ゲル状化粧料及びその製造方法 |
JP2012140395A (ja) * | 2011-01-05 | 2012-07-26 | Livon Laboratories | リポソームの製造方法、該方法によって製造されるリポソーム組成物、及び該リポソーム組成物の使用方法 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1251840B (it) * | 1991-09-20 | 1995-05-26 | Schiena Ricerche | Uso di formulazioni liposomiali contenenti papaverina nel trattamento della impotenza maschile |
DE4407995C2 (de) * | 1994-03-10 | 1996-07-11 | Byk Gulden Lomberg Chem Fab | Topische Zubereitungen |
US5540934A (en) * | 1994-06-22 | 1996-07-30 | Touitou; Elka | Compositions for applying active substances to or through the skin |
EP0914159A1 (de) * | 1996-07-13 | 1999-05-12 | ratiopharm GmbH | Topische phospholipidhaltige aciclovirzubereitung |
DE10203923B4 (de) * | 2002-01-31 | 2011-06-01 | Klinipharm Gmbh | Verfahren zur Erhöhung der Wasserlöslichkeit lipophiler Wirkstoffe, Herstellung von hochkonzentrierten wässrigen Zusammensetzungen dieser Wirkstoffe, derartige Produkte und ihre Verwendung |
US20060078580A1 (en) | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
US7740875B2 (en) | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
LT3600435T (lt) | 2017-03-23 | 2024-04-25 | Lipid Systems Sp. Z.O.O. | Hidrofilinių junginių aukšto efektyvumo įkapsuliavimas vienasluoksnėse liposomose |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3042365A1 (de) * | 1980-11-10 | 1982-06-03 | Harsanyi, Dr., Eugen, 5014 Kerpen | Fluessige lecithin-haltige einphasige mehrstoffsysteme |
DE3269611D1 (en) * | 1981-07-02 | 1986-04-10 | Hoffmann La Roche | Process for preparing liposome solutions |
JPS5910511A (ja) * | 1982-07-07 | 1984-01-20 | Eisai Co Ltd | 脂溶性物質含有水性液 |
US5064655A (en) * | 1989-02-24 | 1991-11-12 | Liposome Technology, Inc. | Liposome gel composition and method |
-
1991
- 1991-02-06 AT AT91903667T patent/ATE95419T1/de not_active IP Right Cessation
- 1991-02-06 ES ES91903667T patent/ES2060365T3/es not_active Expired - Lifetime
- 1991-02-06 DE DE91903667T patent/DE59100466D1/de not_active Expired - Lifetime
- 1991-02-06 WO PCT/EP1991/000229 patent/WO1991011993A1/de active IP Right Grant
- 1991-02-06 CA CA002067807A patent/CA2067807C/en not_active Expired - Lifetime
- 1991-02-06 EP EP91903667A patent/EP0514435B1/de not_active Expired - Lifetime
- 1991-02-06 DK DK91903667.3T patent/DK0514435T3/da active
- 1991-02-06 JP JP3503437A patent/JPH07112969B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-17 HK HK242/94A patent/HK24294A/xx not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008007430A (ja) * | 2006-06-27 | 2008-01-17 | Kracie Home Products Kk | ゲル状化粧料及びその製造方法 |
JP2012140395A (ja) * | 2011-01-05 | 2012-07-26 | Livon Laboratories | リポソームの製造方法、該方法によって製造されるリポソーム組成物、及び該リポソーム組成物の使用方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2060365T3 (es) | 1994-11-16 |
ATE95419T1 (de) | 1993-10-15 |
WO1991011993A1 (de) | 1991-08-22 |
DE59100466D1 (de) | 1993-11-11 |
DK0514435T3 (da) | 1993-11-29 |
EP0514435A1 (de) | 1992-11-25 |
CA2067807C (en) | 1998-11-03 |
CA2067807A1 (en) | 1991-08-09 |
HK24294A (en) | 1994-03-25 |
EP0514435B1 (de) | 1993-10-06 |
JPH07112969B2 (ja) | 1995-12-06 |
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