JPH05199871A - グリコシルトランスフェラーゼの改良された製造方法 - Google Patents

グリコシルトランスフェラーゼの改良された製造方法

Info

Publication number
JPH05199871A
JPH05199871A JP4136822A JP13682292A JPH05199871A JP H05199871 A JPH05199871 A JP H05199871A JP 4136822 A JP4136822 A JP 4136822A JP 13682292 A JP13682292 A JP 13682292A JP H05199871 A JPH05199871 A JP H05199871A
Authority
JP
Japan
Prior art keywords
leu
sequence
promoter
pro
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4136822A
Other languages
English (en)
Japanese (ja)
Inventor
Gabriele Watzele
バツェル ガブリエル
Eric G Berger
ゲー．ベルガー エリック
Bernd Meyhack
メイハック ベルント
Manfred Watzele
バツェル マンフレット
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9208211A external-priority patent/GB2256197B/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of JPH05199871A publication Critical patent/JPH05199871A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP4136822A 1991-05-31 1992-05-28 グリコシルトランスフェラーゼの改良された製造方法 Pending JPH05199871A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP91810414 1991-05-31
EP92810167 1992-03-04
GB9208211A GB2256197B (en) 1991-05-31 1992-04-14 Yeast as host for expression of heterologous glycosyl transferase enzymes
GB9208211:4 1992-04-14
GB92810167:4 1992-04-14
GB91810414:2 1992-04-14

Publications (1)

Publication Number Publication Date
JPH05199871A true JPH05199871A (ja) 1993-08-10

Family

ID=27234292

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4136822A Pending JPH05199871A (ja) 1991-05-31 1992-05-28 グリコシルトランスフェラーゼの改良された製造方法

Country Status (19)

Country Link
JP (1) JPH05199871A (fr)
AT (1) AT401940B (fr)
AU (1) AU655470B2 (fr)
BE (1) BE1005579A5 (fr)
CA (1) CA2070057A1 (fr)
DK (1) DK71992A (fr)
ES (1) ES2046118B1 (fr)
FI (1) FI922515A (fr)
GR (1) GR920100250A (fr)
HU (1) HU212927B (fr)
IE (1) IE69059B1 (fr)
IL (1) IL102052A0 (fr)
IT (1) IT1255044B (fr)
LU (1) LU88123A1 (fr)
MX (1) MX9202583A (fr)
NO (1) NO922134L (fr)
NZ (1) NZ242958A (fr)
PT (1) PT100545A (fr)
SE (1) SE9201544L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530857A (ja) * 2000-04-13 2003-10-21 バイオティカ テクノロジー リミティド グリコシル化されたハイブリッド産物およびその産生方法と利用

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE7819584U1 (de) * 1978-06-30 1978-10-12 Howmedica International, Inc. Zweigniederlassung Kiel, 2301 Schoenkirchen Tubenartiger vorratsbehaelter fuer medizinisches spritzgeraet
EP0632831B1 (fr) * 1992-03-09 2002-11-27 The Regents Of The University Of California Acide nucleique, vecteur d'expression et compositions pour l'identification de sialyltransferases recombinantes
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
WO2004099231A2 (fr) 2003-04-09 2004-11-18 Neose Technologies, Inc. Methode de glycopegylation et proteines/peptides produits au moyen de ces methodes
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
EP1771066A2 (fr) 2004-07-13 2007-04-11 Neose Technologies, Inc. Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon glp-1
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (fr) 2005-04-08 2010-03-31 Biogenerix Ag Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (fr) 2005-11-03 2007-05-18 Neose Technologies, Inc. Purification de sucre de nucleotide en utilisant des membranes
US20080242607A1 (en) 2006-07-21 2008-10-02 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
DK2144923T3 (da) 2007-04-03 2013-05-13 Biogenerix Ag Behandlingsfremgangsmåder under anvendelse af glycopegyleret g-csf
WO2008154639A2 (fr) 2007-06-12 2008-12-18 Neose Technologies, Inc. Procédé amélioré pour la production de sucres de nucléotide
CA2715465C (fr) 2008-02-27 2017-03-21 Novo Nordisk A/S Molecules de facteur viii conjuguees

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
AU4751990A (en) * 1988-12-13 1990-07-10 La Jolla Cancer Research Foundation Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof
US5032519A (en) * 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes
ATE188999T1 (de) * 1990-02-14 2000-02-15 Univ Michigan Verfahren und produkte für die synthese von oligosaccharidstrukturen auf glykoproteinen, glykolipiden oder als freie moleküle
EP0485532A1 (fr) * 1990-04-27 1992-05-20 Biogen, Inc. Fucosyle transferases impliquees dans l'expression de molecules d'adhesion
DE4028800A1 (de) * 1990-09-11 1992-03-12 Behringwerke Ag Gentechnische sialylierung von glykoproteinen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530857A (ja) * 2000-04-13 2003-10-21 バイオティカ テクノロジー リミティド グリコシル化されたハイブリッド産物およびその産生方法と利用

Also Published As

Publication number Publication date
HUT65728A (en) 1994-07-28
SE9201544D0 (sv) 1992-05-15
GR920100250A (el) 1993-03-31
AU1705292A (en) 1992-12-03
SE9201544L (sv) 1992-12-01
DK71992A (da) 1992-12-01
NZ242958A (en) 1993-06-25
IE69059B1 (en) 1996-08-07
IE921769A1 (en) 1992-12-02
FI922515A0 (fi) 1992-05-29
IL102052A0 (en) 1992-12-30
LU88123A1 (de) 1993-12-06
NO922134L (no) 1992-12-01
ITRM920411A0 (it) 1992-05-29
ATA112792A (de) 1996-05-15
DK71992D0 (da) 1992-05-29
ITRM920411A1 (it) 1993-11-29
CA2070057A1 (fr) 1992-12-01
NO922134D0 (no) 1992-05-29
BE1005579A5 (fr) 1993-11-09
HU212927B (en) 1996-12-30
FI922515A (fi) 1992-12-01
PT100545A (pt) 1993-08-31
IT1255044B (it) 1995-10-17
ES2046118B1 (es) 1994-08-16
ES2046118A1 (es) 1994-01-16
AT401940B (de) 1996-12-27
AU655470B2 (en) 1994-12-22
HU9201787D0 (en) 1992-08-28
MX9202583A (es) 1992-11-01

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