JPH046164B2 - - Google Patents
Info
- Publication number
- JPH046164B2 JPH046164B2 JP58175618A JP17561883A JPH046164B2 JP H046164 B2 JPH046164 B2 JP H046164B2 JP 58175618 A JP58175618 A JP 58175618A JP 17561883 A JP17561883 A JP 17561883A JP H046164 B2 JPH046164 B2 JP H046164B2
- Authority
- JP
- Japan
- Prior art keywords
- monomer
- drug
- meth
- adhesive layer
- acrylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000178 monomer Substances 0.000 claims description 49
- 229940079593 drug Drugs 0.000 claims description 47
- 239000003814 drug Substances 0.000 claims description 47
- 239000000126 substance Substances 0.000 claims description 29
- 239000012790 adhesive layer Substances 0.000 claims description 23
- 229920001577 copolymer Polymers 0.000 claims description 19
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 15
- 238000013329 compounding Methods 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 229920001519 homopolymer Polymers 0.000 claims description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000000962 organic group Chemical group 0.000 claims description 3
- -1 acryloyl amino acid Chemical class 0.000 description 23
- 230000001070 adhesive effect Effects 0.000 description 21
- 239000000853 adhesive Substances 0.000 description 20
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 12
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 8
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 6
- 229920002554 vinyl polymer Polymers 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 239000012298 atmosphere Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 239000011261 inert gas Substances 0.000 description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 239000005060 rubber Substances 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 3
- 229960000201 isosorbide dinitrate Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229960003712 propranolol Drugs 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 2
- XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- ZNIFSRGNXRYGHF-UHFFFAOYSA-N Clonidine hydrochloride Chemical compound Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1 ZNIFSRGNXRYGHF-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 244000043261 Hevea brasiliensis Species 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 description 2
- 229960005274 benzocaine Drugs 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229960002925 clonidine hydrochloride Drugs 0.000 description 2
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 2
- 229960004022 clotrimazole Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 2
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229960001047 methyl salicylate Drugs 0.000 description 2
- 229920003052 natural elastomer Polymers 0.000 description 2
- 229920001194 natural rubber Polymers 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 239000000123 paper Substances 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920006255 plastic film Polymers 0.000 description 2
- 229920001083 polybutene Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- QJBZDBLBQWFTPZ-UHFFFAOYSA-N pyrrolnitrin Chemical compound [O-][N+](=O)C1=C(Cl)C=CC=C1C1=CNC=C1Cl QJBZDBLBQWFTPZ-UHFFFAOYSA-N 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- BFUXUGOZJVHVMR-UHFFFAOYSA-N 1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound N1CNS(=O)(=O)C2=CC(S(=O)(=O)N)=CC=C21 BFUXUGOZJVHVMR-UHFFFAOYSA-N 0.000 description 1
- BDHGFCVQWMDIQX-UHFFFAOYSA-N 1-ethenyl-2-methylimidazole Chemical compound CC1=NC=CN1C=C BDHGFCVQWMDIQX-UHFFFAOYSA-N 0.000 description 1
- HAWZITGJTUAVQW-UHFFFAOYSA-N 1-ethenyl-2-phenylimidazole Chemical compound C=CN1C=CN=C1C1=CC=CC=C1 HAWZITGJTUAVQW-UHFFFAOYSA-N 0.000 description 1
- HQGPZXPTJWUDQR-UHFFFAOYSA-N 1-ethenyl-5-methylpyrrolidin-2-one Chemical compound CC1CCC(=O)N1C=C HQGPZXPTJWUDQR-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- QHVBLSNVXDSMEB-UHFFFAOYSA-N 2-(diethylamino)ethyl prop-2-enoate Chemical compound CCN(CC)CCOC(=O)C=C QHVBLSNVXDSMEB-UHFFFAOYSA-N 0.000 description 1
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 1
- MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 description 1
- MXRGSJAOLKBZLU-UHFFFAOYSA-N 3-ethenylazepan-2-one Chemical compound C=CC1CCCCNC1=O MXRGSJAOLKBZLU-UHFFFAOYSA-N 0.000 description 1
- CPHGOBGXZQKCKI-UHFFFAOYSA-N 4,5-diphenyl-1h-imidazole Chemical compound N1C=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 CPHGOBGXZQKCKI-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 description 1
- BKYKPTRYDKTTJY-UHFFFAOYSA-N 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1CCCC1 BKYKPTRYDKTTJY-UHFFFAOYSA-N 0.000 description 1
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 1
- AGJUUQSLGVCRQA-SWOUQTJZSA-N Fungichromin Chemical compound CCCCC[C@@H](O)[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O AGJUUQSLGVCRQA-SWOUQTJZSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- 239000000006 Nitroglycerin Substances 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- TZRXHJWUDPFEEY-UHFFFAOYSA-N Pentaerythritol Tetranitrate Chemical compound [O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O TZRXHJWUDPFEEY-UHFFFAOYSA-N 0.000 description 1
- 239000000026 Pentaerythritol tetranitrate Substances 0.000 description 1
- AGJUUQSLGVCRQA-UHFFFAOYSA-N Pentamycin Natural products CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(O)C(O)C(C)=CC=CC=CC=CC=CC(O)C(C)OC1=O AGJUUQSLGVCRQA-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- PPTYJKAXVCCBDU-UHFFFAOYSA-N Rohypnol Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1F PPTYJKAXVCCBDU-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229920000800 acrylic rubber Polymers 0.000 description 1
- ARHWPKZXBHOEEE-UHFFFAOYSA-N alclofenac Chemical compound OC(=O)CC1=CC=C(OCC=C)C(Cl)=C1 ARHWPKZXBHOEEE-UHFFFAOYSA-N 0.000 description 1
- 229960005142 alclofenac Drugs 0.000 description 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 229960001301 amobarbital Drugs 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- CIJVBYRUFLGDHY-UHFFFAOYSA-N bucumolol Chemical compound O1C(=O)C=CC2=C1C(OCC(O)CNC(C)(C)C)=CC=C2C CIJVBYRUFLGDHY-UHFFFAOYSA-N 0.000 description 1
- 229950002568 bucumolol Drugs 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 description 1
- 229960003291 chlorphenamine Drugs 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 229960001076 chlorpromazine Drugs 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229960004703 clobetasol propionate Drugs 0.000 description 1
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 description 1
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 1
- 229960003120 clonazepam Drugs 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- WTYGAUXICFETTC-UHFFFAOYSA-N cyclobarbital Chemical compound C=1CCCCC=1C1(CC)C(=O)NC(=O)NC1=O WTYGAUXICFETTC-UHFFFAOYSA-N 0.000 description 1
- 229960004138 cyclobarbital Drugs 0.000 description 1
- 229960003206 cyclopenthiazide Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229960004281 desmopressin Drugs 0.000 description 1
- NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 description 1
- 229960001985 dextromethorphan Drugs 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960001193 diclofenac sodium Drugs 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
- HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 description 1
- 229960004704 dihydroergotamine Drugs 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 1
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 description 1
- 229960005426 doxepin Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- GFJVXXWOPWLRNU-UHFFFAOYSA-N ethenyl formate Chemical compound C=COC=O GFJVXXWOPWLRNU-UHFFFAOYSA-N 0.000 description 1
- 125000005670 ethenylalkyl group Chemical group 0.000 description 1
- UQXKXGWGFRWILX-UHFFFAOYSA-N ethylene glycol dinitrate Chemical compound O=N(=O)OCCON(=O)=O UQXKXGWGFRWILX-UHFFFAOYSA-N 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- 229960004369 flufenamic acid Drugs 0.000 description 1
- LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 description 1
- 229960003469 flumetasone Drugs 0.000 description 1
- WXURHACBFYSXBI-GQKYHHCASA-N flumethasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O WXURHACBFYSXBI-GQKYHHCASA-N 0.000 description 1
- 229960002200 flunitrazepam Drugs 0.000 description 1
- 229940043075 fluocinolone Drugs 0.000 description 1
- 229960001347 fluocinolone acetonide Drugs 0.000 description 1
- 229960000785 fluocinonide Drugs 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 229960002690 fluphenazine Drugs 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 229960003878 haloperidol Drugs 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- MSYBLBLAMDYKKZ-UHFFFAOYSA-N hydron;pyridine-3-carbonyl chloride;chloride Chemical compound Cl.ClC(=O)C1=CC=CN=C1 MSYBLBLAMDYKKZ-UHFFFAOYSA-N 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- MPGBPFMOOXKQRX-UHFFFAOYSA-N indenolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1C=CC2 MPGBPFMOOXKQRX-UHFFFAOYSA-N 0.000 description 1
- 229950008838 indenolol Drugs 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000005001 laminate film Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 229960004391 lorazepam Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229960003464 mefenamic acid Drugs 0.000 description 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- UKIKQWUFUHMMML-UHFFFAOYSA-N n,n-dimethyl-2-propan-2-ylidenehexanamide Chemical compound CCCCC(=C(C)C)C(=O)N(C)C UKIKQWUFUHMMML-UHFFFAOYSA-N 0.000 description 1
- YRVUCYWJQFRCOB-UHFFFAOYSA-N n-butylprop-2-enamide Chemical compound CCCCNC(=O)C=C YRVUCYWJQFRCOB-UHFFFAOYSA-N 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- OIXVKQDWLFHVGR-WQDIDPJDSA-N neomycin B sulfate Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO OIXVKQDWLFHVGR-WQDIDPJDSA-N 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- 229960001597 nifedipine Drugs 0.000 description 1
- 229960001454 nitrazepam Drugs 0.000 description 1
- KJONHKAYOJNZEC-UHFFFAOYSA-N nitrazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1 KJONHKAYOJNZEC-UHFFFAOYSA-N 0.000 description 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- 229960001907 nitrofurazone Drugs 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
- 229960000649 oxyphenbutazone Drugs 0.000 description 1
- HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229960004321 pentaerithrityl tetranitrate Drugs 0.000 description 1
- 229960000339 pentamycin Drugs 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920006122 polyamide resin Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920005672 polyolefin resin Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 229960004604 propranolol hydrochloride Drugs 0.000 description 1
- JNTOKFNBDFMTIV-UHFFFAOYSA-N propyl nitrate Chemical compound CCCO[N+]([O-])=O JNTOKFNBDFMTIV-UHFFFAOYSA-N 0.000 description 1
- 229960002132 pyrrolnitrin Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 229960004499 scopolamine hydrobromide Drugs 0.000 description 1
- WTGQALLALWYDJH-MOUKNHLCSA-N scopolamine hydrobromide (anhydrous) Chemical compound Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 WTGQALLALWYDJH-MOUKNHLCSA-N 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- SKIVFJLNDNKQPD-UHFFFAOYSA-N sulfacetamide Chemical compound CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 SKIVFJLNDNKQPD-UHFFFAOYSA-N 0.000 description 1
- 229960002673 sulfacetamide Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000003106 tissue adhesive Substances 0.000 description 1
- 229960002044 tolmetin sodium Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Description
æ¬çºæã¯ç®èé¢ã«çŽæ¥è²Œãä»ããããæãã¯ä»
ã®è£å©æ段ãä»ããŠè²Œãä»ããŠè¬ç©ãç®èãéã
ãŠäœå ã«æäžããå±ææ§åã¯å šèº«æ§ã®çŸæ£ãæ²»ç
ããããããã®å»è¬è£œå€ã«é¢ãããã®ã§ããã åŸæ¥ã倩ç¶ãŽã ãäž»äœãšãããµãªãã«é žã¡ãã«
å«æ貌çå€ããã¡ã³ããŒã³å«æ貌çå€ãªã©ã®è¬ç©
å«æã®ããŒãç¶åã³ã·ãŒãç¶ç©ãææ¡ãããŠãã
ãããããã¯ããããç®èæ¥çæ§ãåéæ§ãç®è
åºæ¿æ§ãéææ§ãè¬ç©å®å®æ§ãªã©ã®ç¹ã«ãããŠå
åãªãã®ãšã¯ãããªãããããã®æ¹è¯ã¿ã€ããšã
ãŠã¢ã¯ãªã«é žã¢ã«ãã«ãšã¹ãã«ãšæ¥µæ§åéäœãšã®
å ±éåäœãäž»äœãšããè¬ç©å«æã®è²Œçå€ãæ°å€ã
ææ¡ãããŠãããã倧éæäžãå¿ èŠãšããè¬ç©ã
çšããå Žåè©²å ±éåäœã«å¯Ÿãã溶解æ§ãéããã
æéå ã«ãããæå¹éã®è¬ç©ã®æŸåºæ§ã«ãããŠæª
ã å åã«æºè¶³ããããã®ã§ã¯ãªãã€ããæŽã«äžèš
貌çå€ã¯æ±è ºãªã©ããçãã湿åãåžåããèœå
ã«æ¬ ããããã«ãç®èé¢ã«è²Œä»é©çšããéãå å
ãªç®èå¯çæ§ãåŸãããçŸæ£æ²»çã«å åãªè¬çå¹
æãçºæ®ããããšãåºæ¥ãªããã®ã§ãã€ãã æ¬çºæè ãã¯ããããã®æ¬ ç¹ã解æ¶ããããã«
éæç 究ãéããçµæãè¬ç©å«æã®è²Œçå€å±€ãç¹
å®ã®æ°Žå¯æº¶æ§åéäœã®åç¬éåäœåã³ïŒåã¯è©²å
éäœãšå ±éåå¯èœãªåéäœãšã®å ±éåäœãšãå«æ
è¬ç©ãæå¹ã«æ©èœãããé åå©å€ããæ§æãããŠ
ããå»è¬è£œå€ãç®èé¢ã«é©çšãããšã該å»è¬è£œå€
ã¯ç®èå¯çæ§ãè¯å¥œã§ãäžã€è¬ç©ã®æº¶è§£æ§ãéåžž
ã«é«ãå åãªè¬çå¹æãçºæ®ããããšãèŠãåº
ããæ¬çºæã«è³ã€ããã®ã§ããã å³ã¡ãæ¬çºæã¯æ æäœãšè©²æ°Žäžæº¶æ§æ æäœäžã«
çŽæ¥çåã¯éæ¥çã«åœ¢æãããè¬ç©å«æã®è²Œçå€
å±€ãšãç©å±€ããå»è¬è£œå€ã«ãããŠã該貌çå€å±€ã
åéäœ(a)äžè¬åŒ
ã®è£å©æ段ãä»ããŠè²Œãä»ããŠè¬ç©ãç®èãéã
ãŠäœå ã«æäžããå±ææ§åã¯å šèº«æ§ã®çŸæ£ãæ²»ç
ããããããã®å»è¬è£œå€ã«é¢ãããã®ã§ããã åŸæ¥ã倩ç¶ãŽã ãäž»äœãšãããµãªãã«é žã¡ãã«
å«æ貌çå€ããã¡ã³ããŒã³å«æ貌çå€ãªã©ã®è¬ç©
å«æã®ããŒãç¶åã³ã·ãŒãç¶ç©ãææ¡ãããŠãã
ãããããã¯ããããç®èæ¥çæ§ãåéæ§ãç®è
åºæ¿æ§ãéææ§ãè¬ç©å®å®æ§ãªã©ã®ç¹ã«ãããŠå
åãªãã®ãšã¯ãããªãããããã®æ¹è¯ã¿ã€ããšã
ãŠã¢ã¯ãªã«é žã¢ã«ãã«ãšã¹ãã«ãšæ¥µæ§åéäœãšã®
å ±éåäœãäž»äœãšããè¬ç©å«æã®è²Œçå€ãæ°å€ã
ææ¡ãããŠãããã倧éæäžãå¿ èŠãšããè¬ç©ã
çšããå Žåè©²å ±éåäœã«å¯Ÿãã溶解æ§ãéããã
æéå ã«ãããæå¹éã®è¬ç©ã®æŸåºæ§ã«ãããŠæª
ã å åã«æºè¶³ããããã®ã§ã¯ãªãã€ããæŽã«äžèš
貌çå€ã¯æ±è ºãªã©ããçãã湿åãåžåããèœå
ã«æ¬ ããããã«ãç®èé¢ã«è²Œä»é©çšããéãå å
ãªç®èå¯çæ§ãåŸãããçŸæ£æ²»çã«å åãªè¬çå¹
æãçºæ®ããããšãåºæ¥ãªããã®ã§ãã€ãã æ¬çºæè ãã¯ããããã®æ¬ ç¹ã解æ¶ããããã«
éæç 究ãéããçµæãè¬ç©å«æã®è²Œçå€å±€ãç¹
å®ã®æ°Žå¯æº¶æ§åéäœã®åç¬éåäœåã³ïŒåã¯è©²å
éäœãšå ±éåå¯èœãªåéäœãšã®å ±éåäœãšãå«æ
è¬ç©ãæå¹ã«æ©èœãããé åå©å€ããæ§æãããŠ
ããå»è¬è£œå€ãç®èé¢ã«é©çšãããšã該å»è¬è£œå€
ã¯ç®èå¯çæ§ãè¯å¥œã§ãäžã€è¬ç©ã®æº¶è§£æ§ãéåžž
ã«é«ãå åãªè¬çå¹æãçºæ®ããããšãèŠãåº
ããæ¬çºæã«è³ã€ããã®ã§ããã å³ã¡ãæ¬çºæã¯æ æäœãšè©²æ°Žäžæº¶æ§æ æäœäžã«
çŽæ¥çåã¯éæ¥çã«åœ¢æãããè¬ç©å«æã®è²Œçå€
å±€ãšãç©å±€ããå»è¬è£œå€ã«ãããŠã該貌çå€å±€ã
åéäœ(a)äžè¬åŒ
ãåŒãåã³ïŒåã¯
ãåŒã
ïŒäœããã¯æ°ŽçŽ åã¯ã¡ãã«åºãã¯å°ãªããšã
ïŒåã®çªçŽ åååã¯çªçŽ åã³é žçŽ ååãæããæ
æ©åºã瀺ããïŒ ã§ç€ºãããæ°Žå¯æº¶æ§åéäœã®åç¬éåäœåã³ïŒå
ã¯è©²åéäœãšå ±éåå¯èœãªåéäœãšã®å ±éåäœ
ãšãé åå©å€ãšããŠã®åžžæž©ã§ç²çæ§ãæããç²ç
æ§ç©è³ªãšãè¬ç©ãå¿ é æåãšããŠæ§æãããŠãã
ããšãç¹åŸŽãšããå»è¬è£œå€ãæäŸãããã®ã§ã
ãã æ¬çºæã«çšããããæ æäœãšããŠåçš®ãã©ã¹ã
ãã¯ãã€ã«ã ãçŽé¡ãäžç¹åžãç¹åžãéå±ç®ãå
ã¯ããããšãã©ã¹ããã¯ãã€ã«ã ãšã®ç©å±€ãã€ã«
ã ãªã©ãããªãæ°Žäžæº¶æ§ã®æ æäœãçšãããã該
æ æäœäžã«çŽæ¥çåã¯äžå¡ãææãªã©ãä»ããŠé
æ¥çã«è¬ç©å«æã®è²Œçå€å±€ãèšããããã ãŸãæ¬çºæã§äœ¿çšãããåéäœ(a)äžè¬åŒ
ïŒåã®çªçŽ åååã¯çªçŽ åã³é žçŽ ååãæããæ
æ©åºã瀺ããïŒ ã§ç€ºãããæ°Žå¯æº¶æ§åéäœã®åç¬éåäœåã³ïŒå
ã¯è©²åéäœãšå ±éåå¯èœãªåéäœãšã®å ±éåäœ
ãšãé åå©å€ãšããŠã®åžžæž©ã§ç²çæ§ãæããç²ç
æ§ç©è³ªãšãè¬ç©ãå¿ é æåãšããŠæ§æãããŠãã
ããšãç¹åŸŽãšããå»è¬è£œå€ãæäŸãããã®ã§ã
ãã æ¬çºæã«çšããããæ æäœãšããŠåçš®ãã©ã¹ã
ãã¯ãã€ã«ã ãçŽé¡ãäžç¹åžãç¹åžãéå±ç®ãå
ã¯ããããšãã©ã¹ããã¯ãã€ã«ã ãšã®ç©å±€ãã€ã«
ã ãªã©ãããªãæ°Žäžæº¶æ§ã®æ æäœãçšãããã該
æ æäœäžã«çŽæ¥çåã¯äžå¡ãææãªã©ãä»ããŠé
æ¥çã«è¬ç©å«æã®è²Œçå€å±€ãèšããããã ãŸãæ¬çºæã§äœ¿çšãããåéäœ(a)äžè¬åŒ
ãåŒãåã³ïŒåã¯
ãåŒã
ïŒäœããã¯æ°ŽçŽ åã¯ã¡ãã«åºãã¯å°ãªããšã
ïŒåã®çªçŽ åååã¯çªçŽ åã³é žçŽ ååãæããæ
æ©åºã瀺ããïŒ ã§ç€ºãããæ°Žå¯æº¶æ§ã®åéäœã¯ã宀枩äžã§æ°Ž100
ïœã«å¯ŸããŠ10ïœä»¥äžå¯æº¶ãªå¡©åºæ§åéäœãæé©ã§
ãããäŸãã°ããã«ã«ããã©ã¯ã¿ã ãïŒâããã«
ã€ãããŸãŒã«ãïŒâããã«âïŒâã¡ãã«ã€ãããŸ
ãŒã«ãïŒâããã«âïŒâããšãã«ã€ãããŸãŒã«ã
ïŒâããã«ãããªãã³ãïŒâããã«âïŒâã¡ãã«
âïŒâãããªãã³ãïŒâããã«ïŒâãããªãã³ã
ïŒâããã«ããªãžã³ãïŒâããã«ããªãžã³ãã¢ã¯
ãªãã€ã«ã¢ã«ããªã³ã®åŠãçªçŽ ååå«æã®é£œåå
ã³äžé£œåè€çŽ ç°åºå«æããã«ç³»åéäœãïŒã¡ã¿ïŒ
ã¢ã¯ãªã«ã¢ããããžã¡ãã«ïŒã¡ã¿ïŒã¢ã¯ãªã«ã¢ã
ããâããã«ã¢ã¯ãªã«ã¢ãããããã©ã¡ãã«ã
ãã«ã¢ã¯ãªã«ã¢ããã®åŠãã¢ããåºå«æããã«ç³»
åéäœãâïŒã¡ã¿ïŒã¢ã¯ãªãã€ã«ã¢ããé žã®åŠ
ãããã«ç³»åéäœãåã³ïŒåã¯ïŒã¡ã¿ïŒã¢ã¯ãªã«
é žïœâããã«ã¢ãããšãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢
ã¯ãªã«é žãžã¡ãã«ã¢ãããšãã«ãšã¹ãã«ãïŒã¡ã¿ïŒ
ã¢ã¯ãªã«é žãžãšãã«ã¢ãããšãã«ãšã¹ãã«ã®åŠã
ã¢ã«ãã«ã¢ããã¢ã«ãã«åºå«æã¢ã¯ãªã«ç³»åé
äœãïŒã¡ã¿ïŒã¢ã¯ãªã«é žã®ãŠã¬ã¿ã³ãå°¿çŽ ãã€ãœ
ã·ã¢ããŒããšã¹ãã«ã®åŠãã¢ã¯ãªã«ç³»åéäœãæ
ããããšãåºæ¥ãããããã¯æœåšçã«å¡©åºæ§ãå
ããåéäœã§ããã該åéäœã貌çå€å±€æåãšã
ãŠäœ¿çšããŠããããå»è¬è£œå€èªäœãè¥å¹²ã®å¡©åºæ§
ãæœåšçã«æããŠãããåŒ±é žæ§ãåããç®èé¢äž
ã«è©²å»è¬è£œå€ã貌ä»é©çšããéã«å«æçªçŽ ååã
ãããã³åããŠæ£è·é»ãæããã®ã§ãé©çšç®èè¡š
é¢äžã掻æ§åãããããã«ãŒãºåãè¬ç©ã®çµç®åž
åæ§ãåäžããçŸæ£æ²»çã«å åãªéã®è¬ç©ãåžå
ãããããšãåºæ¥ããã®ã§ããããŸã該塩åºæ§å
éäœäžã«å°ãªããšãïŒåã®çªçŽ åååã¯çªçŽ åã³
é žçŽ ååãæããŠããããå ±éåäœã®æ¥µæ§ãé«ãŸ
ããè¬ç©ã®æº¶è§£æ§åã³ç®èæ¥çæ§ãåäžãããã
ãšãåºæ¥ããäžèšåéäœã¯è²Œçå€å±€äžã«åç¬éå
äœåã³ïŒåã¯è©²åéäœãšå ±éåå¯èœãªåéäœãšã®
å ±éåäœãšããŠé åãããå«æããè¬ç©ã®æº¶è§£æ§
ãé«ãã該è¬ç©ã®äœå ãžã®å€éæäžãå¯èœãšãã
ãããŸãæ°Žå¯æº¶æ§åéäœãåºçºåæãšãããã貌
çå€å±€ã®èŠªæ°Žæ§ãåäžããç®èé¢ã«åæ³ããã湿
åãåžåããã®ã§å»è¬è£œå€ã®ç®èå¯çæ§ãç¶æã
æºè¶³ããè¬çå¹æãå åã«åŸããããå ±éåäœã«
çšããããå ±éåå¯èœãªåéäœã¯è¬ç©åã³åéäœ
(a)ã®éåäœãšçžæº¶ããããæãã¯çœæ¿ãããçšåºŠ
ã«çžæº¶ããéåäœã圢æãããã®ã§ãããäžã€é
åå©å€ãšãå åçžæº¶ãããéåäœã圢æãããã®
ãçšããããäŸãã°ïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žãã³ãã«ãšã¹ãã«ã
ïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢
ã¯ãªã«é žãããã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é ž
ãªã¯ãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žãã·ã«ãšã¹ãã«ãïŒã¡
ã¿ïŒã¢ã¯ãªã«é žããã·ã«ãšã¹ãã«ã®åŠãççŽ æ°ã
ïŒä»¥äžã®ã¢ã«ãã«åºãæããïŒã¡ã¿ïŒã¢ã¯ãªã«é ž
ã¢ã«ãã«ãšã¹ãã«ãæãããããããã®åéäœã®
ã¢ã«ãã«åºã¯çŽéç¶åã¯åå²ç¶ã§ãã€ãŠãããã
ä»ã®å ±éåå¯èœãªåéäœãšããŠã¯ã®é žããã«ãé ¢
é žããã«ãããããªã³é žããã«ã®åŠãããã«ãšã¹
ãã«é¡ããããã«ã¢ã«ãã«ãšãŒãã«é¡ãæããã
ããåèšã«æ²ããåéäœ(a)ãšå ±éåå¯èœãªåéäœ
ã®å ±éåæã®é åæ¯ã¯40ã100ïŒ60ãïŒã§ããã
çš®é¡åã³æ·»å éã¯åéäœã®æ§è³ªåã³ç®çã«å¿ããŠ
ä»»æã«éžæããããšãåºæ¥ããäžèšã®åéäœ(a)ã®
åç¬éåäœåã³ïŒåã¯è©²åéäœãšå ±éåå¯èœãªå
éäœãšã®å ±éåäœã®è²Œçå€å±€äžãžã®é åçã¯ïŒã
75ééïŒ ã®ç¯å²ãæãŸãããïŒééïŒ ä»¥äžã§ã¯è¬
ç©ã®æº¶è§£æ§ãäžå åã§ã貌çå€å±€äžã§è¬ç©ã®çµæ¶
åãçããŠæŸåºæ§ã«æ¯éããããæããããããŸ
ã75ééïŒ ä»¥äžã§ã¯è¬ç©ã®æº¶è§£æ§ãæŸåºæ§ã¯è¯å¥œ
ã§ããããç®èæ¥çæ§ãå¯çæ§ãäžå åãšãªãã
æãŸããè¬çå¹æãåŸãããå Žåãããã æ¬çºæã«ãããŠäœ¿çšãããè¬ç©ã¯ãå»è¬è£œå€ã
ç®èé¢äžã«è²Œä»é©çšããéã«è©²è¬ç©ãçµç®çã«äœ
å ã«åžåããããã®ã§ããã°ç¹ã«å¶éã¯ãªããäŸ
ãã° (ã€) ã³ã«ãã³ã¹ããã€ãé¡ïŒäŸãã°ãã€ããã³ãŒ
ããŸã³ããã¬ãããŸãã³ããã¯ãã¡ã¿ãŸã³ãã
ããªããŒãããã«ã¡ã¿ãŸã³ãããªã¢ã ã·ãã
ã³ãããªã¢ã ã·ããã³ã¢ã»ãããããã«ãªã·ã
ãã³ããã«ãªã·ããã³ã¢ã»ãããããã«ãªã·ã
ãã³ã¢ã»ãããã¢ã»ããŒããããããªã³é žã¯ã
ãã¿ãŸãŒã«ãªã©ã (ã) é®çæ¶çå€ïŒäŸãã°ã¢ã»ãã¢ããããšã³ãã¡
ããšãã é žããã«ããšãã é žãã€ã³ãã¡ã¿ã·
ã³ããžã¯ãããšããã¯ããžã¯ãããšããã¯ãã
ãªãŠã ãã¢ã«ã¯ãããšããã¯ããªãã·ããšã³ã
ã¿ãŸã³ãããšãã«ãã¿ãŸã³ãã€ãããããšã³ã
ãã«ã«ãããããšã³ããµãªãã«é žããµãªãã«é ž
ã¡ãã«ãïœâã¡ã³ããŒã«ãã«ã³ãã¢ãŒãã¹ãªã³
ããã¯ããã«ã¡ãã³ãããªãŠã ãããããã»
ã³ãããšã³ãããšã³ãªã©ã (ã) å¬ç é®éå€ïŒäŸãã°ããšããã«ãã¿ãŒã«ãã¢
ã¢ãã«ãã¿ãŒã«ãã·ã¯ããã«ãã¿ãŒã«ããã©ãŒ
ãã ãããããªããŒã«ãªã©ã (ã) 粟ç¥å®å®å€ïŒäŸãã°ãã«ããšããžã³ãããªãª
ããžã³ããžã¢ãŒãã ããã«ããã©ãŒãã ãã¯ã
ã«ããããžã³ãªã©ã (ã) æé«è¡å§å€ïŒäŸãã°ã¯ãããžã³ãå¡©é žã¯ãã
ãžã³ããã³ãããŒã«ããããã©ãããŒã«ãå¡©é ž
ãããã©ãããŒã«ãããã©ããŒã«ãã€ã³ããã
ãŒã«ããã¯ã¢ããŒã«ããããšãžãã³ãªã©ã (ã) éå§å©å°¿å€ïŒäŸãã°ãã€ãããµã€ã¢ã¶ã€ãã
ãã³ãããã«ãµã€ã¢ã¶ã€ããã·ã¯ããã³ãã¢ã¶
ã€ããªã© (ã) æçç©è³ªïŒäŸãã°ããã·ãªã³ãããã©ãµã€ã¯
ãªã³ããªãã·ããã©ãµã€ã¯ãªã³ãç¡«é žãã©ãžãª
ãã€ã·ã³ããšãªã¹ããã€ã·ã³ãã¯ãã©ã ããšã
ã³ãŒã«ãªã©ã (ã) 麻é å€ïŒäŸãã°ãªãã«ã€ã³ããã³ãŸã«ã€ã³ã
ã¢ããå®æ¯éŠé žãšãã«ãªã©ã (ãª) æèæ§ç©è³ªïŒäŸãã°å¡©åãã³ã¶ã«ã³ããŠã ã
ããããã©ãŸã³ããã€ã¹ã¿ãã³ãã¢ã»ãã¹ã«ã
ã¢ãã³ãã¯ãããªããŸãŒã«ãªã©ã (ã) æçèç©è³ªïŒäŸãã°ãã³ã¿ãã€ã·ã³ãã¢ã ã
ããªã·ã³ïŒ¢ããããŒã«ãããªã³ãã¯ãããªããŸ
ãŒã«ãªã©ã (ã«) ãã¿ãã³å€ïŒäŸãã°ãã¿ãã³ïŒ¡ããšã«ãŽã«
ã«ã·ããšããŒã«ãã³ã¬ã«ã«ã·ããšããŒã«ããªã¯
ããã¢ã·ã³ããªããã©ãã³é ªé žãšã¹ãã«ãªã©ã (ã²) æãŠãããå€ïŒäŸãã°ããã©ãŒãã ãã¡ã
ããã¡ãŒããã¯ãããŒãã ãªã©ã (ã¯) å è¡ç®¡æ¡åŒµå€ïŒäŸãã°ãããã°ãªã»ãª
ã³ããããã°ãªã³ãŒã«ãã€ãœãœã«ãããžãã€ã
ã¬ãŒãããšãªã¹ãªããŒã«ããã©ãã€ãã¬ãŒãã
ãã³ã¿ãšãªã¹ãªããŒã«ããã©ãã€ãã¬ãŒããã
ãããã«ãã€ãã¬ãŒããªã©ã ïŒã«ïŒ æãã¹ã¿ãã³å€ïŒããšãã°å¡©é žãžããšã³
ããã©ãã³ãã¯ãã«ããšãã©ãã³ããžããšãã«
ã€ãããŸãŒã«ãªã©ã (ãš) é®å³å€ïŒäŸãã°ããã¹ããã¡ãã«ãã¢ã³ã
ãã«ãã¿ãã³ããšããšããªã³ãå¡©é žãšããšããª
ã³ãªã©ã (ã¿) æ§ãã«ã¢ã³ïŒäŸãã°ããã²ã¹ããã³ããšã¹
ãã©ãžãªãŒã«ãªã©ã (ã¬) æ鬱å€ïŒäŸãã°ããã»ãã³ãªã©ã (ãœ) ãã®ä»ïŒäŸãã°ïŒâãã«ãªããŠã©ã·ã«ããž
ããããšã«ãŽã¿ãã³ãããšã³ã¿ããŒã«ããã¹ã¢
ãã¬ã·ã³ããžãŽãã·ã³ãã¡ãã¯ããã©ã·ããã
ã³ããªããã¹ã³ãã©ãã³ãèåæ°ŽçŽ é žã¹ã³ãã©
ãã³ãªã©ã ãæãããããããã®è¬ç©ã¯å¿ èŠã«å¿ããŠïŒçš®é¡
以äžäœµçšããããšãåºæ¥ããäžèšè¬ç©ã®æ·»å éã¯
ç®çãšããå»çåã³ïŒåã¯æäžå¹æã«ãã€ãŠç°ãª
ããã貌çå€å±€äžã«0.01ã30ééïŒ ã®ç¯å²ã§å«æ
ãããã å«æããè¬ç©ãæå¹ã«æ©èœãããé åå©å€ã®äž
ã€ãšããŠåžžæž©ã§ç²çæ§ãæããç²çæ§ç©è³ªãçšã
ããããã該ç©è³ªã¯æ¬çºæã®å»è¬è£œå€ãçŸæ£æ²»ç
ã®ããã«ç®èé¢ãžçŽæ¥çã«è²Œä»é©çšããéã«å å
ãªç®èæ¥çæ§ãšå¯å°å 垯å¹æïŒããããODTå¹
æïŒãäžããè¬ç©ã®æ¡æ£ç§»åãæºè¶³ããé床ã§å¯
èœãšããåºäœãæäŸããããšãç®çãšããŠããã
ãããã®ç²çæ§ç©è³ªã¯è¬ç©ãåéäœ(a)ã®åç¬éå
äœåã³ïŒåã¯è©²åéäœãšå ±éåå¯èœãªåéäœãšã®
å ±éåäœãšå åã«çžæº¶ãããããæãã¯çœæ¿ãã
ãçšåºŠã«çžæº¶ãããã®ã§ããã該ç²çæ§ç©è³ªãšã
ãŠãäŸãã°ã·ãªã³ãŒã³ãŽã ãããªã€ãœãã¬ã³ãŽ
ã ãã¹ãã¬ã³âãã¿ãžãšã³ãŽã ãã¹ãã¬ã³âã€ãœ
ãã¬ã³âã¹ãã¬ã³ãããã¯å ±éåäœãŽã ãã¢ã¯ãª
ã«ãŽã ã倩ç¶ãŽã ã®åŠããŽã ç³»ç²çæ§ç©è³ªãããª
ããã«ã¢ã«ãã«ãšãŒãã«ãããªããã«ã¢ã«ã³ãŒ
ã«ãããªé ¢é žããã«ã®åŠãããã«ç³»ç²çæ§ç©è³ªã
ã«ã«ããã·ã¡ãã«ã»ã«ããŒã¹ã®åŠãã»ã«ããŒã¹ç³»
ç²çæ§ç©è³ªãïŒã¡ã¿ïŒã¢ã¯ãªã«é žã¢ã«ãã«ãšã¹ã
ã«ãäž»æåãšããïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒãç³»ç²çæ§
ç©è³ªãªã©ãæãããããäžèšç²çæ§ç©è³ªã®ãã¡ã
å«æè¬ç©ã®å解ã«å¯Ÿããå®å®æ§ãå»è¬è£œå€ã®ç®è
æ¥çæ§ãèæ ®ãããšãç¹ã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒã
ç³»ç²çæ§ç©è³ªã奜ãŸããããããã圢æãããå
éäœãšããŠãäŸãã°ïŒã¡ã¿ïŒã¢ã¯ãªã«é žãšãã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãšã¹ãã«ãïŒã¡
ã¿ïŒã¢ã¯ãªã«é žãã³ãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯
ãªã«é žããã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žã
ããã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žãªã¯ãã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãšã¹ãã«ãïŒã¡
ã¿ïŒã¢ã¯ãªã«é žãã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãª
ã«é žããã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããª
ãã·ã«ãšã¹ãã«ã®åŠãççŽ æ°ãïŒä»¥äžã®ã¢ã«ãã«
åºãæããïŒã¡ã¿ïŒã¢ã¯ãªã«é žã¢ã«ãã«ãšã¹ãã«
ãæããããã¢ã«ãã«åºãçŽéç¶åã¯åå²ç¶ã®ã
ã®ãäžçš®åã¯äºçš®ä»¥äžäœµçšããŠãããããŸãäžèš
åéäœãšå ±éåå¯èœã§åéæ§åã³ç®èæ¥çæ§ãå
äžãããäžã€èŠªæ°Žæ§ãé«ããç®çã§ãïŒã¡ã¿ïŒã¢
ã¯ãªã«é žãã€ã¿ã³ã³é žããã¬ã€ã³é žãç¡æ°Žãã¬ã€
ã³é žãã¯ããã³é žãïŒã¡ã¿ïŒã¢ã¯ãªã«é žïŒâãã
ããã·ãšãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žïŒâ
ããããã·ãããã«ãšã¹ãã«ãã¢ã¯ãªããããªã«
ã®åŠãå®èœæ§åéäœããé ¢é žããã«ãããããªã³
é žããã«ã®åŠãããã«ç³»åéäœãå ±éåããããš
ãåºæ¥ããé åå©å€ãšããŠäžèšã®ç²çæ§ç©è³ªã䜿
çšããå Žåã®æ·»å éã¯ã貌çå€å±€äžã«25ã95éé
ïŒ ãæãŸããã25ééïŒ ä»¥äžã§ã¯ç®èæ¥çã«å å
ãªç²çæ§ãç¶æåºæ¥ããäžã€è²Œçå€å±€å šäœã®åé
æ§ãé«ããªããããããè¬ç©ã®æ¡æ£ç§»åã«æ¯éã
ããããæŸåºæ§ãå£ãåŸåã瀺ãããŸã95ééïŒ
以äžã§ã¯ç®èæ¥çæ§ã¯è¯å¥œã§ã¯ããããè¬ç©ã®æº¶
解æ§ã®åäžãè¬ç©ã®å€éæŸåºãªã©ã®åŠãåéäœ(a)
æåã«åž°å ããå¹æãå¥ããªãæããçããã è¬ç©ãæ¡æ£ç§»åã«ãã€ãŠè²Œçå€å±€äžããé©çšç®
èé¢ãžæŸåºããããšãåºæ¥ãä»ã®é åå©å€ãšã
ãŠãåžžæž©ã§ç²çæ§ãæããªãç©è³ªãäŸãã°è»è³ªã
ãªå¡©åããã«ãè»è³ªããªã¢ããæš¹èãããªããã«
ã¢ã«ã³ãŒã«ãããªãªã¬ãã€ã³æš¹èãç±ç¡¬ååã¯å®€
æž©å ç¡«ã¿ã€ãã®ã·ãªã³ãŒã³ãŽã ãããªã¢ã¯ãªã«ç³»
æš¹èãªã©ãæãããããããããã®ç©è³ªã䜿çšã
ãŠè²Œçå€å±€ãç²çæ§ãæããªãå Žåã¯ãå€ç§çšã
ãŒããªã©ã®è£å©æ段ãä»ããŠç®èé¢ã«å»è¬è£œå€ã
é©çšããããšãå¯èœã§ããã ãŸãä»ã®é åå©å€ãšããŠãå«æããè¬ç©ã®æŸåº
ãä¿é²ããæŸåºè£å©ç©è³ªãäŸãã°ãããã¬ã³ã°ãª
ã³ãŒã«ããžãšãã¬ã³ã°ãªã³ãŒã«ãããªãšãã¬ã³ã°
ãªã³ãŒã«ã®åŠãã°ãªã³ãŒã«é¡ããšãã«ã¢ã«ã³ãŒ
ã«ããµãªãã«é žãå°¿çŽ ãã¢ã©ã³ãã€ã³ããžã¡ãã«
ã¹ã«ããã·ãããžã¡ãã«ã¢ã»ãã¢ããããžã¡ãã«
ãã«ã ã¢ããããžã€ãœãããã«ã¢ãžããŒãããžãš
ãã«ã»ãã±ãŒãããšãã«ã©ãŠã¬ãŒããã©ããªã³ã
é±æ²¹ã®åŠãç©è³ªãå¿ èŠã«å¿ããŠäžçš®é¡ä»¥äžæ·»å ã
ãããšãåºæ¥ããæ·»å éã¯ç®èæ¥çååã³åéå
ãšã®ãã©ã³ã¹ãèæ ®ããŠãå šè²Œçå€å±€æå100é
ééšã«å¯ŸããŠïŒã30éééšã®ç¯å²ãæãŸãããäž
èšã®æ©èœãæããæŸåºè£å©ç©è³ªã¯åèšã®ç²çæ§ç©
質åã¯ç²çæ§ãæããªãç©è³ªãé åå©å€ãšããŠçš
ãã貌çå€å±€äžã«æ·»å ããŠãå«æããè¬ç©ã®æå¹
æ§ãããåäžããããããšãå¯èœã§ããã å«æããè¬ç©ãæå¹ã«æ©èœãããé åå©å€ã¯ã
åè¿°ããç©è³ªä»¥å€ã«æ··åç©ã®æµåå€åœ¢èœãæå¶ã
ãŠä¿åœ¢èœãä»äžããç©è³ªãäŸãã°ã¯ã¬ãŒãçé žã«
ã«ã·ãŠã ãªã©ãæãã¯ä¿æž©èœãä»äžããç©è³ªãäŸ
ãã°ã«ãªãªã³ããã³ããã€ããªã©ãåç¬åã¯ä»ã®
é åå©å€ãšäœµçšããŠäœ¿çšã§ããã åèšã«ç€ºããå¿ é æåããæã貌çå€å±€ã¯é å
ç©åã¯é åç©ã®æº¶æ¶²ãšããŠäœæãããã®ãåèšæ
æäœäžã«çŽæ¥çãåã¯äžå¡ãææãªã©ãä»ããŠé
æ¥çã«å¡åžä¹Ÿç¥ããããåã¯äºãå¥é¢ã©ã€ããŒäž
ã«å¡èšããåŸãæ æäœäžã«è»¢çããŠèšããŠãã
ãã 以äžã«ç€ºããããã«æ¬çºæã®å»è¬è£œå€ã¯èº«äœã®
ç®èé¢ã«çŽæ¥è²Œãä»ããããåã¯ç®èã«å¯ŸããŠç¡
åºæ¿æ§ã®è²Œçå€å±€ãæããå€ç§çšæ¥çããŒããå
垯ã®åŠãè£å©æ段ãä»ããŠè²Œä»ããããšã«ããå«
æããè¬ç©ãçµç®çã«äœå ã«åžåãããå±æç³»å
ã¯å šèº«ç³»çŸæ£ã®æ²»çãæå¹ã«è¡ãªãããšãåºæ¥
ããç¹ã«åéäœ(a)ã®åç¬éåäœåã³ïŒåã¯è©²åé
äœãšå ±éåå¯èœãªåéäœãšã®å ±éåäœãåã¯é å
å©å€ã¯è²Œçå€å±€äžã«å«æããè¬ç©ã®éãæŸåºã«å¿
èŠãªæå°é床ã§ãäœå ãžã®è¬ç©ã®äŸçµŠãæ倧éã«
çºæ®ããæ©èœãæããã 以äžã«æ¬çºæã®å®æœäŸã瀺ããæŽã«å ·äœçã«èª¬
æããããæ¬çºæã¯ãããã«éå®ããããã®ã§ã¯
ãªããæè¡çææ³ãéžè±ããªãç¯å²ã«ãããŠçš®ã
ã®å¿çšãå¯èœã§ããããªããå®æœäŸäžã§éšãšãã
ã®ã¯éééšã瀺ãã å®æœäŸ ïŒ ããªããã«ãããªãã³ïŒåååPVPKâ30ã
GAF瀟補ïŒ15éšãå¡©åã¡ãã¬ã³85éšã«æº¶è§£ãã
ããªããã«ãããªãã³æº¶æ¶²ãåŸãã 次ã«äžæŽ»æ§ã¬ã¹é°å²æ°äžã«ãããŠåã€å£ãã©ã¹
ã³å ã«ãã¢ã¯ãªã«é žïŒâãšãã«ããã·ã«ãšã¹ãã«
93éšãã¢ã¯ãªã«é žïŒâããããã·ãšãã«ãšã¹ãã«
ïŒéšããä»èŸŒã¿ãéåéå§å€ãšããŠã®ã¢ãŸãã¹ã€
ãœããããããªã«0.1éšãæ·»å ããå 济ã62ã65
âã§æ¹æããªããåå¿åžé溶å€ã®é ¢é žãšãã«ã滎
äžããŠåå¿ãæå¶ãã€ã€ïŒæééåãããæŽã«75
ã80âã«ææž©ããŠïŒæéçæããç²çæ§ç©è³ªæº¶æ¶²
ãåŸãã äžèšã§åŸãããããªããã«ãããªãã³æº¶æ¶²ãšç²
çæ§ç©è³ªæº¶æ¶²ãåã åºåœ¢åã§20éšåã³80éšãšãªã
ããã«é åããå¡©é žã¯ãããžã³ã®ã¡ã¿ããŒã«æº¶æ¶²
ãæ·»å æ··åãã12ÎŒïœåã®ããªãšã¹ãã«ãã€ã«ã
äžã«ä¹Ÿç¥åŸã®åã¿ã50ÎŒïœãšãªãããã«å¡åžãã
100âã§ïŒåé也ç¥ããŠå»è¬è£œå€ãåŸãã ïŒèšå®å¡©é žã¯ãããžã³å«é200ÎŒïœïŒcm2ïŒ å®æœäŸ ïŒ äžæŽ»æ§ã¬ã¹é°å²æ°äžã«ãããŠåã€å£ãã©ã¹ã³å
ã«ãã¢ã¯ãªã«é žã€ãœããã«ãšã¹ãã«50éšãã¢ã¯ãª
ãã€ã«ã¢ã«ããªã³50éšãé ¢é žãšãã«200éšãã¢ãŸ
ãã¹ã€ãœããããããªã«0.2éšãä»èŸŒã¿ãå 济ã
62ã65âã§æ¹æããªããå¶åŸ¡ãçŽïŒæééååŸã
æŽã«75ã80âã«ææž©ããŠïŒæéçæããå ±éåäœ
溶液ãåŸãã 次ã«äžæŽ»æ§ã¬ã¹é°å²æ°äžããã©ã¹ã³å ã§ã¹ãã¬
ã³âã€ãœãã¬ã³âã¹ãã¬ã³ãããã¯å ±éåäœãŽã
30éšãããªããã³20éšããŠããããžã³40éšããã«
ãšã³ã«ãŠå åã«æº¶è§£ãæ··åããŠç²çæ§ç©è³ªæº¶æ¶²ã
åŸãã äžèšã§åŸãããå ±éåäœæº¶æ¶²ãšç²çæ§ç©è³ªæº¶æ¶²
ãåã åºåœ¢åã§35éšåã³65éšãšãªãããã«é å
ãããããã©ãããŒã«8.7éšãæ·»å æ··åããããª
ãšãã¬ã³ãã€ã«ã äžã«ä¹Ÿç¥åŸã®åã¿ã50ÎŒïœãšãª
ãããã«å¡åžãã80âã§10åé也ç¥ããŠå»è¬è£œå€
ãåŸãã ïŒèšå®ãããã©ãããŒã«å«é400ÎŒïœïŒcm2ïŒ å®æœäŸ ïŒ äžæŽ»æ§ã¬ã¹é°å²æ°äžã«ãããŠåã€å£ãã©ã¹ã³å
ã«ãã¡ã¿ã¯ãªã«é žããã·ã«ãšã¹ãã«50éšãïŒâã
ãã«ã€ãããŸãŒã«50éšãé ¢é žãšãã«66.7éšãã¢ãŸ
ãã¹ã€ãœããããããªã«0.2éšãä»èŸŒã¿ãå 济ã
62ã65âã§æ¹æããªããåå¿åžé溶å€ã®é ¢é žãšã
ã«ã滎äžããŠåå¿ãå¶åŸ¡ãã€ã€ïŒæééåããã
æŽã«75ã80âã«ææž©ããŠïŒæéçæããå ±éåäœ
溶液ãåŸãã 次ã«ã¢ã¯ãªã«é žã€ãœããã«ãšã¹ãã«98éšãã¢ã¯
ãªã«é žïŒéšãã¢ãŸãã¹ã€ãœããããããªã«0.2éš
ãäžèšãšåæ§ã®æäœã«ãã€ãŠå ±éåãããç²çæ§
ç©è³ªæº¶æ¶²ãåŸãã äžèšã§åŸãããå ±éåäœæº¶æ¶²ãšç²çæ§ç©è³ªæº¶æ¶²
ãåã åºåœ¢åã§30éšåã³57.5éšãšãªãããã«é å
ããã€ãœãœã«ãããžãã€ãã¬ãŒã12.5éšãæ·»å æ··
åããã·ãªã³ãŒã³å¥é¢åŠçãæœãããçŽã«ä¹Ÿç¥åŸ
ã®åã¿ã40ÎŒïœãšãªãããã«å¡åžãã80âã§10å
é也ç¥ããåŸãããªãšã¹ãã«ïŒãšãã¬ã³âé ¢é žã
ãã«å ±éåäœç©å±€ãã€ã«ã ã«è»¢çãããŠå»è¬è£œå€
ãåŸããïŒèšå®ã€ãœãœã«ãããžãã€ãã¬ãŒãå«é
500ÎŒïœïŒcm2ïŒ æ¯èŒäŸ ïŒãïŒ æ¯èŒäŸïŒãïŒã¯å®æœäŸïŒãïŒã«å¯Ÿå¿ããŠããã
åå®æœäŸããããªããã«ãããªãã³æº¶æ¶²åã³å ±é
åäœæº¶æ¶²ãé€ãã以å€ã¯åå®æœäŸãšåæ§ã®æäœã
è¡ãªããç²çæ§ç©è³ªæº¶æ¶²ãšåè¬ç©ããæ§æããã
貌çå€å±€ãæããå»è¬è£œå€ãåŸãã åå®æœäŸåã³æ¯èŒäŸã«ãŠåŸãããå»è¬è£œå€ã®ç¹
æ§çµæã第ïŒè¡šåã³ç¬¬ïŒè¡šã«ç€ºããã
ïŒåã®çªçŽ åååã¯çªçŽ åã³é žçŽ ååãæããæ
æ©åºã瀺ããïŒ ã§ç€ºãããæ°Žå¯æº¶æ§ã®åéäœã¯ã宀枩äžã§æ°Ž100
ïœã«å¯ŸããŠ10ïœä»¥äžå¯æº¶ãªå¡©åºæ§åéäœãæé©ã§
ãããäŸãã°ããã«ã«ããã©ã¯ã¿ã ãïŒâããã«
ã€ãããŸãŒã«ãïŒâããã«âïŒâã¡ãã«ã€ãããŸ
ãŒã«ãïŒâããã«âïŒâããšãã«ã€ãããŸãŒã«ã
ïŒâããã«ãããªãã³ãïŒâããã«âïŒâã¡ãã«
âïŒâãããªãã³ãïŒâããã«ïŒâãããªãã³ã
ïŒâããã«ããªãžã³ãïŒâããã«ããªãžã³ãã¢ã¯
ãªãã€ã«ã¢ã«ããªã³ã®åŠãçªçŽ ååå«æã®é£œåå
ã³äžé£œåè€çŽ ç°åºå«æããã«ç³»åéäœãïŒã¡ã¿ïŒ
ã¢ã¯ãªã«ã¢ããããžã¡ãã«ïŒã¡ã¿ïŒã¢ã¯ãªã«ã¢ã
ããâããã«ã¢ã¯ãªã«ã¢ãããããã©ã¡ãã«ã
ãã«ã¢ã¯ãªã«ã¢ããã®åŠãã¢ããåºå«æããã«ç³»
åéäœãâïŒã¡ã¿ïŒã¢ã¯ãªãã€ã«ã¢ããé žã®åŠ
ãããã«ç³»åéäœãåã³ïŒåã¯ïŒã¡ã¿ïŒã¢ã¯ãªã«
é žïœâããã«ã¢ãããšãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢
ã¯ãªã«é žãžã¡ãã«ã¢ãããšãã«ãšã¹ãã«ãïŒã¡ã¿ïŒ
ã¢ã¯ãªã«é žãžãšãã«ã¢ãããšãã«ãšã¹ãã«ã®åŠã
ã¢ã«ãã«ã¢ããã¢ã«ãã«åºå«æã¢ã¯ãªã«ç³»åé
äœãïŒã¡ã¿ïŒã¢ã¯ãªã«é žã®ãŠã¬ã¿ã³ãå°¿çŽ ãã€ãœ
ã·ã¢ããŒããšã¹ãã«ã®åŠãã¢ã¯ãªã«ç³»åéäœãæ
ããããšãåºæ¥ãããããã¯æœåšçã«å¡©åºæ§ãå
ããåéäœã§ããã該åéäœã貌çå€å±€æåãšã
ãŠäœ¿çšããŠããããå»è¬è£œå€èªäœãè¥å¹²ã®å¡©åºæ§
ãæœåšçã«æããŠãããåŒ±é žæ§ãåããç®èé¢äž
ã«è©²å»è¬è£œå€ã貌ä»é©çšããéã«å«æçªçŽ ååã
ãããã³åããŠæ£è·é»ãæããã®ã§ãé©çšç®èè¡š
é¢äžã掻æ§åãããããã«ãŒãºåãè¬ç©ã®çµç®åž
åæ§ãåäžããçŸæ£æ²»çã«å åãªéã®è¬ç©ãåžå
ãããããšãåºæ¥ããã®ã§ããããŸã該塩åºæ§å
éäœäžã«å°ãªããšãïŒåã®çªçŽ åååã¯çªçŽ åã³
é žçŽ ååãæããŠããããå ±éåäœã®æ¥µæ§ãé«ãŸ
ããè¬ç©ã®æº¶è§£æ§åã³ç®èæ¥çæ§ãåäžãããã
ãšãåºæ¥ããäžèšåéäœã¯è²Œçå€å±€äžã«åç¬éå
äœåã³ïŒåã¯è©²åéäœãšå ±éåå¯èœãªåéäœãšã®
å ±éåäœãšããŠé åãããå«æããè¬ç©ã®æº¶è§£æ§
ãé«ãã該è¬ç©ã®äœå ãžã®å€éæäžãå¯èœãšãã
ãããŸãæ°Žå¯æº¶æ§åéäœãåºçºåæãšãããã貌
çå€å±€ã®èŠªæ°Žæ§ãåäžããç®èé¢ã«åæ³ããã湿
åãåžåããã®ã§å»è¬è£œå€ã®ç®èå¯çæ§ãç¶æã
æºè¶³ããè¬çå¹æãå åã«åŸããããå ±éåäœã«
çšããããå ±éåå¯èœãªåéäœã¯è¬ç©åã³åéäœ
(a)ã®éåäœãšçžæº¶ããããæãã¯çœæ¿ãããçšåºŠ
ã«çžæº¶ããéåäœã圢æãããã®ã§ãããäžã€é
åå©å€ãšãå åçžæº¶ãããéåäœã圢æãããã®
ãçšããããäŸãã°ïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žãã³ãã«ãšã¹ãã«ã
ïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢
ã¯ãªã«é žãããã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é ž
ãªã¯ãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žãã·ã«ãšã¹ãã«ãïŒã¡
ã¿ïŒã¢ã¯ãªã«é žããã·ã«ãšã¹ãã«ã®åŠãççŽ æ°ã
ïŒä»¥äžã®ã¢ã«ãã«åºãæããïŒã¡ã¿ïŒã¢ã¯ãªã«é ž
ã¢ã«ãã«ãšã¹ãã«ãæãããããããã®åéäœã®
ã¢ã«ãã«åºã¯çŽéç¶åã¯åå²ç¶ã§ãã€ãŠãããã
ä»ã®å ±éåå¯èœãªåéäœãšããŠã¯ã®é žããã«ãé ¢
é žããã«ãããããªã³é žããã«ã®åŠãããã«ãšã¹
ãã«é¡ããããã«ã¢ã«ãã«ãšãŒãã«é¡ãæããã
ããåèšã«æ²ããåéäœ(a)ãšå ±éåå¯èœãªåéäœ
ã®å ±éåæã®é åæ¯ã¯40ã100ïŒ60ãïŒã§ããã
çš®é¡åã³æ·»å éã¯åéäœã®æ§è³ªåã³ç®çã«å¿ããŠ
ä»»æã«éžæããããšãåºæ¥ããäžèšã®åéäœ(a)ã®
åç¬éåäœåã³ïŒåã¯è©²åéäœãšå ±éåå¯èœãªå
éäœãšã®å ±éåäœã®è²Œçå€å±€äžãžã®é åçã¯ïŒã
75ééïŒ ã®ç¯å²ãæãŸãããïŒééïŒ ä»¥äžã§ã¯è¬
ç©ã®æº¶è§£æ§ãäžå åã§ã貌çå€å±€äžã§è¬ç©ã®çµæ¶
åãçããŠæŸåºæ§ã«æ¯éããããæããããããŸ
ã75ééïŒ ä»¥äžã§ã¯è¬ç©ã®æº¶è§£æ§ãæŸåºæ§ã¯è¯å¥œ
ã§ããããç®èæ¥çæ§ãå¯çæ§ãäžå åãšãªãã
æãŸããè¬çå¹æãåŸãããå Žåãããã æ¬çºæã«ãããŠäœ¿çšãããè¬ç©ã¯ãå»è¬è£œå€ã
ç®èé¢äžã«è²Œä»é©çšããéã«è©²è¬ç©ãçµç®çã«äœ
å ã«åžåããããã®ã§ããã°ç¹ã«å¶éã¯ãªããäŸ
ãã° (ã€) ã³ã«ãã³ã¹ããã€ãé¡ïŒäŸãã°ãã€ããã³ãŒ
ããŸã³ããã¬ãããŸãã³ããã¯ãã¡ã¿ãŸã³ãã
ããªããŒãããã«ã¡ã¿ãŸã³ãããªã¢ã ã·ãã
ã³ãããªã¢ã ã·ããã³ã¢ã»ãããããã«ãªã·ã
ãã³ããã«ãªã·ããã³ã¢ã»ãããããã«ãªã·ã
ãã³ã¢ã»ãããã¢ã»ããŒããããããªã³é žã¯ã
ãã¿ãŸãŒã«ãªã©ã (ã) é®çæ¶çå€ïŒäŸãã°ã¢ã»ãã¢ããããšã³ãã¡
ããšãã é žããã«ããšãã é žãã€ã³ãã¡ã¿ã·
ã³ããžã¯ãããšããã¯ããžã¯ãããšããã¯ãã
ãªãŠã ãã¢ã«ã¯ãããšããã¯ããªãã·ããšã³ã
ã¿ãŸã³ãããšãã«ãã¿ãŸã³ãã€ãããããšã³ã
ãã«ã«ãããããšã³ããµãªãã«é žããµãªãã«é ž
ã¡ãã«ãïœâã¡ã³ããŒã«ãã«ã³ãã¢ãŒãã¹ãªã³
ããã¯ããã«ã¡ãã³ãããªãŠã ãããããã»
ã³ãããšã³ãããšã³ãªã©ã (ã) å¬ç é®éå€ïŒäŸãã°ããšããã«ãã¿ãŒã«ãã¢
ã¢ãã«ãã¿ãŒã«ãã·ã¯ããã«ãã¿ãŒã«ããã©ãŒ
ãã ãããããªããŒã«ãªã©ã (ã) 粟ç¥å®å®å€ïŒäŸãã°ãã«ããšããžã³ãããªãª
ããžã³ããžã¢ãŒãã ããã«ããã©ãŒãã ãã¯ã
ã«ããããžã³ãªã©ã (ã) æé«è¡å§å€ïŒäŸãã°ã¯ãããžã³ãå¡©é žã¯ãã
ãžã³ããã³ãããŒã«ããããã©ãããŒã«ãå¡©é ž
ãããã©ãããŒã«ãããã©ããŒã«ãã€ã³ããã
ãŒã«ããã¯ã¢ããŒã«ããããšãžãã³ãªã©ã (ã) éå§å©å°¿å€ïŒäŸãã°ãã€ãããµã€ã¢ã¶ã€ãã
ãã³ãããã«ãµã€ã¢ã¶ã€ããã·ã¯ããã³ãã¢ã¶
ã€ããªã© (ã) æçç©è³ªïŒäŸãã°ããã·ãªã³ãããã©ãµã€ã¯
ãªã³ããªãã·ããã©ãµã€ã¯ãªã³ãç¡«é žãã©ãžãª
ãã€ã·ã³ããšãªã¹ããã€ã·ã³ãã¯ãã©ã ããšã
ã³ãŒã«ãªã©ã (ã) 麻é å€ïŒäŸãã°ãªãã«ã€ã³ããã³ãŸã«ã€ã³ã
ã¢ããå®æ¯éŠé žãšãã«ãªã©ã (ãª) æèæ§ç©è³ªïŒäŸãã°å¡©åãã³ã¶ã«ã³ããŠã ã
ããããã©ãŸã³ããã€ã¹ã¿ãã³ãã¢ã»ãã¹ã«ã
ã¢ãã³ãã¯ãããªããŸãŒã«ãªã©ã (ã) æçèç©è³ªïŒäŸãã°ãã³ã¿ãã€ã·ã³ãã¢ã ã
ããªã·ã³ïŒ¢ããããŒã«ãããªã³ãã¯ãããªããŸ
ãŒã«ãªã©ã (ã«) ãã¿ãã³å€ïŒäŸãã°ãã¿ãã³ïŒ¡ããšã«ãŽã«
ã«ã·ããšããŒã«ãã³ã¬ã«ã«ã·ããšããŒã«ããªã¯
ããã¢ã·ã³ããªããã©ãã³é ªé žãšã¹ãã«ãªã©ã (ã²) æãŠãããå€ïŒäŸãã°ããã©ãŒãã ãã¡ã
ããã¡ãŒããã¯ãããŒãã ãªã©ã (ã¯) å è¡ç®¡æ¡åŒµå€ïŒäŸãã°ãããã°ãªã»ãª
ã³ããããã°ãªã³ãŒã«ãã€ãœãœã«ãããžãã€ã
ã¬ãŒãããšãªã¹ãªããŒã«ããã©ãã€ãã¬ãŒãã
ãã³ã¿ãšãªã¹ãªããŒã«ããã©ãã€ãã¬ãŒããã
ãããã«ãã€ãã¬ãŒããªã©ã ïŒã«ïŒ æãã¹ã¿ãã³å€ïŒããšãã°å¡©é žãžããšã³
ããã©ãã³ãã¯ãã«ããšãã©ãã³ããžããšãã«
ã€ãããŸãŒã«ãªã©ã (ãš) é®å³å€ïŒäŸãã°ããã¹ããã¡ãã«ãã¢ã³ã
ãã«ãã¿ãã³ããšããšããªã³ãå¡©é žãšããšããª
ã³ãªã©ã (ã¿) æ§ãã«ã¢ã³ïŒäŸãã°ããã²ã¹ããã³ããšã¹
ãã©ãžãªãŒã«ãªã©ã (ã¬) æ鬱å€ïŒäŸãã°ããã»ãã³ãªã©ã (ãœ) ãã®ä»ïŒäŸãã°ïŒâãã«ãªããŠã©ã·ã«ããž
ããããšã«ãŽã¿ãã³ãããšã³ã¿ããŒã«ããã¹ã¢
ãã¬ã·ã³ããžãŽãã·ã³ãã¡ãã¯ããã©ã·ããã
ã³ããªããã¹ã³ãã©ãã³ãèåæ°ŽçŽ é žã¹ã³ãã©
ãã³ãªã©ã ãæãããããããã®è¬ç©ã¯å¿ èŠã«å¿ããŠïŒçš®é¡
以äžäœµçšããããšãåºæ¥ããäžèšè¬ç©ã®æ·»å éã¯
ç®çãšããå»çåã³ïŒåã¯æäžå¹æã«ãã€ãŠç°ãª
ããã貌çå€å±€äžã«0.01ã30ééïŒ ã®ç¯å²ã§å«æ
ãããã å«æããè¬ç©ãæå¹ã«æ©èœãããé åå©å€ã®äž
ã€ãšããŠåžžæž©ã§ç²çæ§ãæããç²çæ§ç©è³ªãçšã
ããããã該ç©è³ªã¯æ¬çºæã®å»è¬è£œå€ãçŸæ£æ²»ç
ã®ããã«ç®èé¢ãžçŽæ¥çã«è²Œä»é©çšããéã«å å
ãªç®èæ¥çæ§ãšå¯å°å 垯å¹æïŒããããODTå¹
æïŒãäžããè¬ç©ã®æ¡æ£ç§»åãæºè¶³ããé床ã§å¯
èœãšããåºäœãæäŸããããšãç®çãšããŠããã
ãããã®ç²çæ§ç©è³ªã¯è¬ç©ãåéäœ(a)ã®åç¬éå
äœåã³ïŒåã¯è©²åéäœãšå ±éåå¯èœãªåéäœãšã®
å ±éåäœãšå åã«çžæº¶ãããããæãã¯çœæ¿ãã
ãçšåºŠã«çžæº¶ãããã®ã§ããã該ç²çæ§ç©è³ªãšã
ãŠãäŸãã°ã·ãªã³ãŒã³ãŽã ãããªã€ãœãã¬ã³ãŽ
ã ãã¹ãã¬ã³âãã¿ãžãšã³ãŽã ãã¹ãã¬ã³âã€ãœ
ãã¬ã³âã¹ãã¬ã³ãããã¯å ±éåäœãŽã ãã¢ã¯ãª
ã«ãŽã ã倩ç¶ãŽã ã®åŠããŽã ç³»ç²çæ§ç©è³ªãããª
ããã«ã¢ã«ãã«ãšãŒãã«ãããªããã«ã¢ã«ã³ãŒ
ã«ãããªé ¢é žããã«ã®åŠãããã«ç³»ç²çæ§ç©è³ªã
ã«ã«ããã·ã¡ãã«ã»ã«ããŒã¹ã®åŠãã»ã«ããŒã¹ç³»
ç²çæ§ç©è³ªãïŒã¡ã¿ïŒã¢ã¯ãªã«é žã¢ã«ãã«ãšã¹ã
ã«ãäž»æåãšããïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒãç³»ç²çæ§
ç©è³ªãªã©ãæãããããäžèšç²çæ§ç©è³ªã®ãã¡ã
å«æè¬ç©ã®å解ã«å¯Ÿããå®å®æ§ãå»è¬è£œå€ã®ç®è
æ¥çæ§ãèæ ®ãããšãç¹ã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒã
ç³»ç²çæ§ç©è³ªã奜ãŸããããããã圢æãããå
éäœãšããŠãäŸãã°ïŒã¡ã¿ïŒã¢ã¯ãªã«é žãšãã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãšã¹ãã«ãïŒã¡
ã¿ïŒã¢ã¯ãªã«é žãã³ãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯
ãªã«é žããã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žã
ããã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žãªã¯ãã«ãš
ã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããã«ãšã¹ãã«ãïŒã¡
ã¿ïŒã¢ã¯ãªã«é žãã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãª
ã«é žããã·ã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žããª
ãã·ã«ãšã¹ãã«ã®åŠãççŽ æ°ãïŒä»¥äžã®ã¢ã«ãã«
åºãæããïŒã¡ã¿ïŒã¢ã¯ãªã«é žã¢ã«ãã«ãšã¹ãã«
ãæããããã¢ã«ãã«åºãçŽéç¶åã¯åå²ç¶ã®ã
ã®ãäžçš®åã¯äºçš®ä»¥äžäœµçšããŠãããããŸãäžèš
åéäœãšå ±éåå¯èœã§åéæ§åã³ç®èæ¥çæ§ãå
äžãããäžã€èŠªæ°Žæ§ãé«ããç®çã§ãïŒã¡ã¿ïŒã¢
ã¯ãªã«é žãã€ã¿ã³ã³é žããã¬ã€ã³é žãç¡æ°Žãã¬ã€
ã³é žãã¯ããã³é žãïŒã¡ã¿ïŒã¢ã¯ãªã«é žïŒâãã
ããã·ãšãã«ãšã¹ãã«ãïŒã¡ã¿ïŒã¢ã¯ãªã«é žïŒâ
ããããã·ãããã«ãšã¹ãã«ãã¢ã¯ãªããããªã«
ã®åŠãå®èœæ§åéäœããé ¢é žããã«ãããããªã³
é žããã«ã®åŠãããã«ç³»åéäœãå ±éåããããš
ãåºæ¥ããé åå©å€ãšããŠäžèšã®ç²çæ§ç©è³ªã䜿
çšããå Žåã®æ·»å éã¯ã貌çå€å±€äžã«25ã95éé
ïŒ ãæãŸããã25ééïŒ ä»¥äžã§ã¯ç®èæ¥çã«å å
ãªç²çæ§ãç¶æåºæ¥ããäžã€è²Œçå€å±€å šäœã®åé
æ§ãé«ããªããããããè¬ç©ã®æ¡æ£ç§»åã«æ¯éã
ããããæŸåºæ§ãå£ãåŸåã瀺ãããŸã95ééïŒ
以äžã§ã¯ç®èæ¥çæ§ã¯è¯å¥œã§ã¯ããããè¬ç©ã®æº¶
解æ§ã®åäžãè¬ç©ã®å€éæŸåºãªã©ã®åŠãåéäœ(a)
æåã«åž°å ããå¹æãå¥ããªãæããçããã è¬ç©ãæ¡æ£ç§»åã«ãã€ãŠè²Œçå€å±€äžããé©çšç®
èé¢ãžæŸåºããããšãåºæ¥ãä»ã®é åå©å€ãšã
ãŠãåžžæž©ã§ç²çæ§ãæããªãç©è³ªãäŸãã°è»è³ªã
ãªå¡©åããã«ãè»è³ªããªã¢ããæš¹èãããªããã«
ã¢ã«ã³ãŒã«ãããªãªã¬ãã€ã³æš¹èãç±ç¡¬ååã¯å®€
æž©å ç¡«ã¿ã€ãã®ã·ãªã³ãŒã³ãŽã ãããªã¢ã¯ãªã«ç³»
æš¹èãªã©ãæãããããããããã®ç©è³ªã䜿çšã
ãŠè²Œçå€å±€ãç²çæ§ãæããªãå Žåã¯ãå€ç§çšã
ãŒããªã©ã®è£å©æ段ãä»ããŠç®èé¢ã«å»è¬è£œå€ã
é©çšããããšãå¯èœã§ããã ãŸãä»ã®é åå©å€ãšããŠãå«æããè¬ç©ã®æŸåº
ãä¿é²ããæŸåºè£å©ç©è³ªãäŸãã°ãããã¬ã³ã°ãª
ã³ãŒã«ããžãšãã¬ã³ã°ãªã³ãŒã«ãããªãšãã¬ã³ã°
ãªã³ãŒã«ã®åŠãã°ãªã³ãŒã«é¡ããšãã«ã¢ã«ã³ãŒ
ã«ããµãªãã«é žãå°¿çŽ ãã¢ã©ã³ãã€ã³ããžã¡ãã«
ã¹ã«ããã·ãããžã¡ãã«ã¢ã»ãã¢ããããžã¡ãã«
ãã«ã ã¢ããããžã€ãœãããã«ã¢ãžããŒãããžãš
ãã«ã»ãã±ãŒãããšãã«ã©ãŠã¬ãŒããã©ããªã³ã
é±æ²¹ã®åŠãç©è³ªãå¿ èŠã«å¿ããŠäžçš®é¡ä»¥äžæ·»å ã
ãããšãåºæ¥ããæ·»å éã¯ç®èæ¥çååã³åéå
ãšã®ãã©ã³ã¹ãèæ ®ããŠãå šè²Œçå€å±€æå100é
ééšã«å¯ŸããŠïŒã30éééšã®ç¯å²ãæãŸãããäž
èšã®æ©èœãæããæŸåºè£å©ç©è³ªã¯åèšã®ç²çæ§ç©
質åã¯ç²çæ§ãæããªãç©è³ªãé åå©å€ãšããŠçš
ãã貌çå€å±€äžã«æ·»å ããŠãå«æããè¬ç©ã®æå¹
æ§ãããåäžããããããšãå¯èœã§ããã å«æããè¬ç©ãæå¹ã«æ©èœãããé åå©å€ã¯ã
åè¿°ããç©è³ªä»¥å€ã«æ··åç©ã®æµåå€åœ¢èœãæå¶ã
ãŠä¿åœ¢èœãä»äžããç©è³ªãäŸãã°ã¯ã¬ãŒãçé žã«
ã«ã·ãŠã ãªã©ãæãã¯ä¿æž©èœãä»äžããç©è³ªãäŸ
ãã°ã«ãªãªã³ããã³ããã€ããªã©ãåç¬åã¯ä»ã®
é åå©å€ãšäœµçšããŠäœ¿çšã§ããã åèšã«ç€ºããå¿ é æåããæã貌çå€å±€ã¯é å
ç©åã¯é åç©ã®æº¶æ¶²ãšããŠäœæãããã®ãåèšæ
æäœäžã«çŽæ¥çãåã¯äžå¡ãææãªã©ãä»ããŠé
æ¥çã«å¡åžä¹Ÿç¥ããããåã¯äºãå¥é¢ã©ã€ããŒäž
ã«å¡èšããåŸãæ æäœäžã«è»¢çããŠèšããŠãã
ãã 以äžã«ç€ºããããã«æ¬çºæã®å»è¬è£œå€ã¯èº«äœã®
ç®èé¢ã«çŽæ¥è²Œãä»ããããåã¯ç®èã«å¯ŸããŠç¡
åºæ¿æ§ã®è²Œçå€å±€ãæããå€ç§çšæ¥çããŒããå
垯ã®åŠãè£å©æ段ãä»ããŠè²Œä»ããããšã«ããå«
æããè¬ç©ãçµç®çã«äœå ã«åžåãããå±æç³»å
ã¯å šèº«ç³»çŸæ£ã®æ²»çãæå¹ã«è¡ãªãããšãåºæ¥
ããç¹ã«åéäœ(a)ã®åç¬éåäœåã³ïŒåã¯è©²åé
äœãšå ±éåå¯èœãªåéäœãšã®å ±éåäœãåã¯é å
å©å€ã¯è²Œçå€å±€äžã«å«æããè¬ç©ã®éãæŸåºã«å¿
èŠãªæå°é床ã§ãäœå ãžã®è¬ç©ã®äŸçµŠãæ倧éã«
çºæ®ããæ©èœãæããã 以äžã«æ¬çºæã®å®æœäŸã瀺ããæŽã«å ·äœçã«èª¬
æããããæ¬çºæã¯ãããã«éå®ããããã®ã§ã¯
ãªããæè¡çææ³ãéžè±ããªãç¯å²ã«ãããŠçš®ã
ã®å¿çšãå¯èœã§ããããªããå®æœäŸäžã§éšãšãã
ã®ã¯éééšã瀺ãã å®æœäŸ ïŒ ããªããã«ãããªãã³ïŒåååPVPKâ30ã
GAF瀟補ïŒ15éšãå¡©åã¡ãã¬ã³85éšã«æº¶è§£ãã
ããªããã«ãããªãã³æº¶æ¶²ãåŸãã 次ã«äžæŽ»æ§ã¬ã¹é°å²æ°äžã«ãããŠåã€å£ãã©ã¹
ã³å ã«ãã¢ã¯ãªã«é žïŒâãšãã«ããã·ã«ãšã¹ãã«
93éšãã¢ã¯ãªã«é žïŒâããããã·ãšãã«ãšã¹ãã«
ïŒéšããä»èŸŒã¿ãéåéå§å€ãšããŠã®ã¢ãŸãã¹ã€
ãœããããããªã«0.1éšãæ·»å ããå 济ã62ã65
âã§æ¹æããªããåå¿åžé溶å€ã®é ¢é žãšãã«ã滎
äžããŠåå¿ãæå¶ãã€ã€ïŒæééåãããæŽã«75
ã80âã«ææž©ããŠïŒæéçæããç²çæ§ç©è³ªæº¶æ¶²
ãåŸãã äžèšã§åŸãããããªããã«ãããªãã³æº¶æ¶²ãšç²
çæ§ç©è³ªæº¶æ¶²ãåã åºåœ¢åã§20éšåã³80éšãšãªã
ããã«é åããå¡©é žã¯ãããžã³ã®ã¡ã¿ããŒã«æº¶æ¶²
ãæ·»å æ··åãã12ÎŒïœåã®ããªãšã¹ãã«ãã€ã«ã
äžã«ä¹Ÿç¥åŸã®åã¿ã50ÎŒïœãšãªãããã«å¡åžãã
100âã§ïŒåé也ç¥ããŠå»è¬è£œå€ãåŸãã ïŒèšå®å¡©é žã¯ãããžã³å«é200ÎŒïœïŒcm2ïŒ å®æœäŸ ïŒ äžæŽ»æ§ã¬ã¹é°å²æ°äžã«ãããŠåã€å£ãã©ã¹ã³å
ã«ãã¢ã¯ãªã«é žã€ãœããã«ãšã¹ãã«50éšãã¢ã¯ãª
ãã€ã«ã¢ã«ããªã³50éšãé ¢é žãšãã«200éšãã¢ãŸ
ãã¹ã€ãœããããããªã«0.2éšãä»èŸŒã¿ãå 济ã
62ã65âã§æ¹æããªããå¶åŸ¡ãçŽïŒæééååŸã
æŽã«75ã80âã«ææž©ããŠïŒæéçæããå ±éåäœ
溶液ãåŸãã 次ã«äžæŽ»æ§ã¬ã¹é°å²æ°äžããã©ã¹ã³å ã§ã¹ãã¬
ã³âã€ãœãã¬ã³âã¹ãã¬ã³ãããã¯å ±éåäœãŽã
30éšãããªããã³20éšããŠããããžã³40éšããã«
ãšã³ã«ãŠå åã«æº¶è§£ãæ··åããŠç²çæ§ç©è³ªæº¶æ¶²ã
åŸãã äžèšã§åŸãããå ±éåäœæº¶æ¶²ãšç²çæ§ç©è³ªæº¶æ¶²
ãåã åºåœ¢åã§35éšåã³65éšãšãªãããã«é å
ãããããã©ãããŒã«8.7éšãæ·»å æ··åããããª
ãšãã¬ã³ãã€ã«ã äžã«ä¹Ÿç¥åŸã®åã¿ã50ÎŒïœãšãª
ãããã«å¡åžãã80âã§10åé也ç¥ããŠå»è¬è£œå€
ãåŸãã ïŒèšå®ãããã©ãããŒã«å«é400ÎŒïœïŒcm2ïŒ å®æœäŸ ïŒ äžæŽ»æ§ã¬ã¹é°å²æ°äžã«ãããŠåã€å£ãã©ã¹ã³å
ã«ãã¡ã¿ã¯ãªã«é žããã·ã«ãšã¹ãã«50éšãïŒâã
ãã«ã€ãããŸãŒã«50éšãé ¢é žãšãã«66.7éšãã¢ãŸ
ãã¹ã€ãœããããããªã«0.2éšãä»èŸŒã¿ãå 济ã
62ã65âã§æ¹æããªããåå¿åžé溶å€ã®é ¢é žãšã
ã«ã滎äžããŠåå¿ãå¶åŸ¡ãã€ã€ïŒæééåããã
æŽã«75ã80âã«ææž©ããŠïŒæéçæããå ±éåäœ
溶液ãåŸãã 次ã«ã¢ã¯ãªã«é žã€ãœããã«ãšã¹ãã«98éšãã¢ã¯
ãªã«é žïŒéšãã¢ãŸãã¹ã€ãœããããããªã«0.2éš
ãäžèšãšåæ§ã®æäœã«ãã€ãŠå ±éåãããç²çæ§
ç©è³ªæº¶æ¶²ãåŸãã äžèšã§åŸãããå ±éåäœæº¶æ¶²ãšç²çæ§ç©è³ªæº¶æ¶²
ãåã åºåœ¢åã§30éšåã³57.5éšãšãªãããã«é å
ããã€ãœãœã«ãããžãã€ãã¬ãŒã12.5éšãæ·»å æ··
åããã·ãªã³ãŒã³å¥é¢åŠçãæœãããçŽã«ä¹Ÿç¥åŸ
ã®åã¿ã40ÎŒïœãšãªãããã«å¡åžãã80âã§10å
é也ç¥ããåŸãããªãšã¹ãã«ïŒãšãã¬ã³âé ¢é žã
ãã«å ±éåäœç©å±€ãã€ã«ã ã«è»¢çãããŠå»è¬è£œå€
ãåŸããïŒèšå®ã€ãœãœã«ãããžãã€ãã¬ãŒãå«é
500ÎŒïœïŒcm2ïŒ æ¯èŒäŸ ïŒãïŒ æ¯èŒäŸïŒãïŒã¯å®æœäŸïŒãïŒã«å¯Ÿå¿ããŠããã
åå®æœäŸããããªããã«ãããªãã³æº¶æ¶²åã³å ±é
åäœæº¶æ¶²ãé€ãã以å€ã¯åå®æœäŸãšåæ§ã®æäœã
è¡ãªããç²çæ§ç©è³ªæº¶æ¶²ãšåè¬ç©ããæ§æããã
貌çå€å±€ãæããå»è¬è£œå€ãåŸãã åå®æœäŸåã³æ¯èŒäŸã«ãŠåŸãããå»è¬è£œå€ã®ç¹
æ§çµæã第ïŒè¡šåã³ç¬¬ïŒè¡šã«ç€ºããã
ãè¡šã
ãè¡šã
第ïŒè¡šåã³ç¬¬ïŒè¡šäžã®åç¹æ§ã®æž¬å®æ¹æ³ã¯ä»¥äž
ã®éãã§ããã ãç®èæ¥çæ§ãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒãäžè
éšå åŽã«è²Œä»ãã24æéåŸã«ç®èãžã®æ¥çç¶æ
ãç®èŠã«ãŠå€å¥ãã端æ«ãã¬ã¬ããªããäœæ¯ã
ã»ãšãã©åŒãæããªãçšåºŠã®æ¥çãâãšãã端
æ«ãã¬ã¬ãçããããé€å»åŸç³æ®ããçããã
ã®ãâ³ãšããã ãçºæ±æã®æ¥çæ§ãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒã
äžè éšå åŽã«è²Œä»ã10åçµéåŸã40âã®æ枩宀
ã«20åéå ¥å®€ãããã®æã®å¯çç¶æ ãç®èŠã«ãŠ
å€å¥ããç®èæ¥çæ§ãšåäžã®å€å®åºæºã«ãŠå€å®
ããã ãåžæ°ŽçãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒã25âã®æ°Ž
äžã«æµžæŒ¬ããïŒæéåŸã®ééå¢å åã浞挬åã®
ééã«ãŠé€ãç®åºããã ãå ±éåäœäžã®è¬å€ã®çµæ¶åãïŒå®åœ¢ã«è£æãã
åè©ŠæçãïŒâã®æž©åºŠäžã«æŸçœ®ããåè©Šæçäœ
補åŸïŒæ¥ç®åã³ïŒæ¥ç®ã«100åã®æ¡å€§é¡ã«ãŠè©Š
æçè¡šé¢ã«ãããè¬å€ã®çµæ¶ã®æç¡ã調ã¹ãã ãæ°ŽäžæŸåºçãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒã30â
ã®æ°Ž200mlã«æµžæŒ¬ãæ¯çªããïŒæéåŸã«æ°ŽïŒml
ããµã³ããªã³ã°ããŠãã®è¬ç©ãå«æ液ãé«é液
äœã¯ãããã°ã©ããŒïŒUVæ€åºïŒã«ãã枬å®
ããåæè¬ç©å«æéã100ïŒ ãšããæã®æŸåºç
ãæ±ããã ãè¡äžæ¿åºŠãïŒåè©ŠæçïŒïŒcmÏïŒãããããã
é€æ¯ããã©ããã®è ¹éšã«è²Œä»ããïŒæéåŸã©ã
ãã®è¡æ¶²ãæãåããã¬ã¹ã¯ãããã°ã©ãã€
ãŒãé«é液äœã¯ãããã°ã©ãã€ãŒããããã¯ã¬
ã¹ã¯ãããã°ã©ãã€ãŒâãã¹ã¹ãã¯ãã«è£ 眮ã
çšããŠè¬ç©ã®è¡äžæ¿åºŠã枬å®ããã
ã®éãã§ããã ãç®èæ¥çæ§ãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒãäžè
éšå åŽã«è²Œä»ãã24æéåŸã«ç®èãžã®æ¥çç¶æ
ãç®èŠã«ãŠå€å¥ãã端æ«ãã¬ã¬ããªããäœæ¯ã
ã»ãšãã©åŒãæããªãçšåºŠã®æ¥çãâãšãã端
æ«ãã¬ã¬ãçããããé€å»åŸç³æ®ããçããã
ã®ãâ³ãšããã ãçºæ±æã®æ¥çæ§ãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒã
äžè éšå åŽã«è²Œä»ã10åçµéåŸã40âã®æ枩宀
ã«20åéå ¥å®€ãããã®æã®å¯çç¶æ ãç®èŠã«ãŠ
å€å¥ããç®èæ¥çæ§ãšåäžã®å€å®åºæºã«ãŠå€å®
ããã ãåžæ°ŽçãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒã25âã®æ°Ž
äžã«æµžæŒ¬ããïŒæéåŸã®ééå¢å åã浞挬åã®
ééã«ãŠé€ãç®åºããã ãå ±éåäœäžã®è¬å€ã®çµæ¶åãïŒå®åœ¢ã«è£æãã
åè©ŠæçãïŒâã®æž©åºŠäžã«æŸçœ®ããåè©Šæçäœ
補åŸïŒæ¥ç®åã³ïŒæ¥ç®ã«100åã®æ¡å€§é¡ã«ãŠè©Š
æçè¡šé¢ã«ãããè¬å€ã®çµæ¶ã®æç¡ã調ã¹ãã ãæ°ŽäžæŸåºçãïŒåè©ŠæçïŒïŒÃïŒcmè§ïŒã30â
ã®æ°Ž200mlã«æµžæŒ¬ãæ¯çªããïŒæéåŸã«æ°ŽïŒml
ããµã³ããªã³ã°ããŠãã®è¬ç©ãå«æ液ãé«é液
äœã¯ãããã°ã©ããŒïŒUVæ€åºïŒã«ãã枬å®
ããåæè¬ç©å«æéã100ïŒ ãšããæã®æŸåºç
ãæ±ããã ãè¡äžæ¿åºŠãïŒåè©ŠæçïŒïŒcmÏïŒãããããã
é€æ¯ããã©ããã®è ¹éšã«è²Œä»ããïŒæéåŸã©ã
ãã®è¡æ¶²ãæãåããã¬ã¹ã¯ãããã°ã©ãã€
ãŒãé«é液äœã¯ãããã°ã©ãã€ãŒããããã¯ã¬
ã¹ã¯ãããã°ã©ãã€ãŒâãã¹ã¹ãã¯ãã«è£ 眮ã
çšããŠè¬ç©ã®è¡äžæ¿åºŠã枬å®ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ æ°Žäžæº¶æ§æ æäœãšè©²æ æäœäžã«çŽæ¥åã¯éæ¥
çã«åœ¢æãããè¬ç©å«æã®è²Œçå€å±€ãšãç©å±€ãã
å»è¬è£œå€ã«ãããŠã該貌çå€å±€ãåéäœ(a)äžè¬åŒ ãåŒãåã³ïŒåã¯ãåŒã ïŒäœããã¯æ°ŽçŽ åã¯ã¡ãã«åºãã¯å°ãªããšã
ïŒåã®çªçŽ åååã¯çªçŽ åã³é žçŽ ååãæããæ
æ©åºã瀺ããïŒ ã§ç€ºãããæ°Žå¯æº¶æ§åéäœã®åç¬éåäœåã³ïŒå
ã¯è©²åéäœãšå ±éåå¯èœãªåéäœãšã®å ±éåäœ
ãšãé åå©å€ãšããŠã®åžžæž©ã§ç²çæ§ãæããç²ç
æ§ç©è³ªãšãè¬ç©ãå¿ é æåãšããŠæ§æãããŠãã
ããšãç¹åŸŽãšããå»è¬è£œå€ã ïŒ åéäœ(a)ã®åç¬éåäœåã³ïŒåã¯è©²åéäœãš
å ±éåå¯èœãªåéäœãšã®å ±éåäœã®è©²è²Œçå€å±€äž
ãžã®é åçãïŒã75ééïŒ ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®å»è¬è£œå€ã
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58175618A JPS6066759A (ja) | 1983-09-21 | 1983-09-21 | å»è¬è£œå€ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58175618A JPS6066759A (ja) | 1983-09-21 | 1983-09-21 | å»è¬è£œå€ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6066759A JPS6066759A (ja) | 1985-04-16 |
| JPH046164B2 true JPH046164B2 (ja) | 1992-02-05 |
Family
ID=15999231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58175618A Granted JPS6066759A (ja) | 1983-09-21 | 1983-09-21 | å»è¬è£œå€ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6066759A (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0745400B2 (ja) * | 1986-03-29 | 1995-05-17 | æ¥æ±é»å·¥æ ªåŒäŒç€Ÿ | å€çšå»è¬è£œå€ |
| JPH0791193B2 (ja) * | 1989-02-28 | 1995-10-04 | åžäžè£œè¬æ ªåŒäŒç€Ÿ | ãšã¹ãã©ãžãªãŒã«å«æ貌ä»å€ |
| US5252334A (en) * | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
| AU644815B2 (en) * | 1989-09-08 | 1993-12-23 | Ortho-Mcneil Pharmaceutical, Inc. | Solid matrix system for transdermal drug delivery |
| JP2647222B2 (ja) * | 1990-02-27 | 1997-08-27 | ç©æ°ŽååŠå·¥æ¥æ ªåŒäŒç€Ÿ | çµç®åžåè£œå€ |
| JP2820306B2 (ja) * | 1990-02-27 | 1998-11-05 | ç©æ°ŽååŠå·¥æ¥æ ªåŒäŒç€Ÿ | çµç®åžåè£œå€ |
| JP6171063B1 (ja) * | 2016-08-22 | 2017-07-26 | æ¥æ¬çŽç®¡å·¥æ¥æ ªåŒäŒç€Ÿ | çŽç®¡ã梱å è³æãå¡åžå€ãå¡åžå€ã®è£œé æ¹æ³äžŠã³ã«çŽç®¡ã®è£œé æ¹æ³ |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5238016A (en) * | 1975-09-17 | 1977-03-24 | Taiho Yakuhin Kogyo Kk | Preparation of poultices |
| JPS5470340A (en) * | 1977-11-16 | 1979-06-06 | Kao Corp | Pressure-sensitive adhesive tape or sheet |
| JPS54154511A (en) * | 1978-04-06 | 1979-12-05 | Vnii Ispytatel Med Tech | Antiiangina film |
| JPS5645412A (en) * | 1979-09-20 | 1981-04-25 | Nitto Electric Ind Co Ltd | Medicinal material |
| JPS56140927A (en) * | 1980-04-07 | 1981-11-04 | Nitto Electric Ind Co Ltd | Medical member |
| JPS56167620A (en) * | 1980-05-28 | 1981-12-23 | Nitto Electric Ind Co Ltd | Stabilized material containing active principle |
| JPS5742617A (en) * | 1980-08-27 | 1982-03-10 | Teikoku Seiyaku Kk | Flexible cataplasma |
| JPS5742618A (en) * | 1980-08-29 | 1982-03-10 | Lion Corp | Plaster and its preparation |
| JPS5756424A (en) * | 1980-09-22 | 1982-04-05 | Nitto Electric Ind Co Ltd | Medical material for external use |
| JPS5758617A (en) * | 1980-09-27 | 1982-04-08 | Nitto Electric Ind Co Ltd | Medical material for external use |
| JPS5821613A (ja) * | 1981-07-29 | 1983-02-08 | Taisho Pharmaceut Co Ltd | 湿åžå€èäœ |
| JPS58126809A (ja) * | 1982-01-22 | 1983-07-28 | Nitto Electric Ind Co Ltd | å€çšéšæ |
| JPS58154516A (ja) * | 1982-03-10 | 1983-09-14 | Sunstar Giken Kk | ãããå€çšèäœ |
| JPS59196817A (ja) * | 1983-04-21 | 1984-11-08 | Sekisui Chem Co Ltd | 貌ä»å€ |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50149682U (ja) * | 1974-05-30 | 1975-12-12 |
-
1983
- 1983-09-21 JP JP58175618A patent/JPS6066759A/ja active Granted
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5238016A (en) * | 1975-09-17 | 1977-03-24 | Taiho Yakuhin Kogyo Kk | Preparation of poultices |
| JPS5470340A (en) * | 1977-11-16 | 1979-06-06 | Kao Corp | Pressure-sensitive adhesive tape or sheet |
| JPS54154511A (en) * | 1978-04-06 | 1979-12-05 | Vnii Ispytatel Med Tech | Antiiangina film |
| JPS5645412A (en) * | 1979-09-20 | 1981-04-25 | Nitto Electric Ind Co Ltd | Medicinal material |
| JPS56140927A (en) * | 1980-04-07 | 1981-11-04 | Nitto Electric Ind Co Ltd | Medical member |
| JPS56167620A (en) * | 1980-05-28 | 1981-12-23 | Nitto Electric Ind Co Ltd | Stabilized material containing active principle |
| JPS5742617A (en) * | 1980-08-27 | 1982-03-10 | Teikoku Seiyaku Kk | Flexible cataplasma |
| JPS5742618A (en) * | 1980-08-29 | 1982-03-10 | Lion Corp | Plaster and its preparation |
| JPS5756424A (en) * | 1980-09-22 | 1982-04-05 | Nitto Electric Ind Co Ltd | Medical material for external use |
| JPS5758617A (en) * | 1980-09-27 | 1982-04-08 | Nitto Electric Ind Co Ltd | Medical material for external use |
| JPS5821613A (ja) * | 1981-07-29 | 1983-02-08 | Taisho Pharmaceut Co Ltd | 湿åžå€èäœ |
| JPS58126809A (ja) * | 1982-01-22 | 1983-07-28 | Nitto Electric Ind Co Ltd | å€çšéšæ |
| JPS58154516A (ja) * | 1982-03-10 | 1983-09-14 | Sunstar Giken Kk | ãããå€çšèäœ |
| JPS59196817A (ja) * | 1983-04-21 | 1984-11-08 | Sekisui Chem Co Ltd | 貌ä»å€ |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6066759A (ja) | 1985-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5232702A (en) | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices | |
| US8263680B2 (en) | Acrylic polymer-based adhesives | |
| JP2849950B2 (ja) | çµç®åžåè£œå€ | |
| US4954343A (en) | Dermal pharmaceutical preparations | |
| EP1148106B1 (en) | Pressure-sensitive adhesive composition and moisture-permeable pressure-sensitive adhesive tape, pressure-sensitive adhesive drug composition, and pressure-sensitive adhesive tape preparation each containing the composition | |
| EP1945685B1 (en) | Acrylic polymer-based adhesives | |
| JPS60123417A (ja) | è¬ç©æäžéšæ | |
| CA2041330C (en) | Percutaneously absorbable eperisone or tolperisone preparation | |
| JPH046164B2 (ja) | ||
| JPH0429927A (ja) | 貌ä»å€ | |
| JP2688778B2 (ja) | çŸæ£æ²»ççšè²Œä»å€ | |
| JPH0152362B2 (ja) | ||
| JP3055991B2 (ja) | å€çšå»è¬è£œå€ | |
| JPH05139961A (ja) | å»ççšæå§æ§æ¥çå€åã³ãããçšããå»ççšè£œå€ | |
| JP2565334B2 (ja) | è¬å€æŸåºæ§å¯å€å貌ä»è£œå€ | |
| JP3676567B2 (ja) | å»ççšç²çå€çµæç©åã³å»ççšè²Œä»å€ | |
| JPS596286B2 (ja) | ãâãè£œå€ | |
| JPS63270060A (ja) | æèæ§ç²çéšæ | |
| JPH0529006B2 (ja) | ||
| JPH05186371A (ja) | çµç®åžåè£œå€ | |
| JPH0526764B2 (ja) | ||
| JPH0587489B2 (ja) | ||
| JPH09309824A (ja) | ç²çå€çµæç©åã³ãããçšãã貌ä»å€ | |
| JPH0745400B2 (ja) | å€çšå»è¬è£œå€ | |
| TW202202147A (zh) | 貌éå |