JPH0459287B2 - - Google Patents
Info
- Publication number
- JPH0459287B2 JPH0459287B2 JP59036766A JP3676684A JPH0459287B2 JP H0459287 B2 JPH0459287 B2 JP H0459287B2 JP 59036766 A JP59036766 A JP 59036766A JP 3676684 A JP3676684 A JP 3676684A JP H0459287 B2 JPH0459287 B2 JP H0459287B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- hair
- minoxidil
- glycerin
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004209 hair Anatomy 0.000 claims description 21
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims description 18
- 229960003632 minoxidil Drugs 0.000 claims description 18
- 229940088597 hormone Drugs 0.000 claims description 11
- 239000005556 hormone Substances 0.000 claims description 11
- 239000002537 cosmetic Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 235000011187 glycerol Nutrition 0.000 description 17
- 239000012153 distilled water Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 230000003779 hair growth Effects 0.000 description 10
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 6
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 5
- 229960001348 estriol Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 4
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 229940053934 norethindrone Drugs 0.000 description 3
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 3
- 229960003387 progesterone Drugs 0.000 description 3
- 239000000186 progesterone Substances 0.000 description 3
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229960001616 chlormadinone acetate Drugs 0.000 description 2
- 229950002007 estradiol benzoate Drugs 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940062452 progesterone 25 mg Drugs 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 235000015961 tonic Nutrition 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000208293 Capsicum Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 229960003996 chlormadinone Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
Description
本発明は公知化合物を二種組み合せることによ
つて特異的に有効な毛髪の生長促進作用を示す養
毛化粧料に関するものである。本発明者は頭髪の
脱毛が男性に多いことに着目し、女性ホルモンと
降圧剤ミノキシジル（２，４−ジアミノ−６−ピ
ペリジノピリミジン−３−オキサイド）を配合し
て毛根部に塗布したところ、各々単独塗布に比べ
てさらに優れた養毛作用を示すのを見い出し、本
発明を完成するにいたつたものである。女性ホル
モンに属するものとしては、卵胞ホルモンと黄体
ホルモンがある。卵胞ホルモンには、エストラジ
オール系、エストリオール系、及びスチルベスト
ロール系がある。又、黄体ホルモンには、プロゲ
ステロン系、クロルマジノン、ノルエチステロン
などがある。女性ホルモン、ミノキシジル共にア
ルコール類、水などを溶媒として用いこれにヘア
ローシヨン、ヘアトニツクなどの製造上通常用い
られる香料、湿潤剤、清涼剤、頭皮刺戟剤などを
加えて成る溶液１中に、通常女性ホルモン（エ
ストリオールなど）0.1〜1.0ｇ、ミノキシジル１
〜10ｇの範囲で溶存せしめることにより、十分に
目的を達成することができる。本願養毛化粧料は
その性質上ヘアローシヨンタイプが最も効果的で
あるが、ヘアクリーム、ポマード等の整髪料とし
て用いることも可能である。
以下に女性ホルモン及びミノキシジル配合の養
毛効果を検討した試験例および、同じく毛髪化粧
料の製造実施例を掲げるが、本剤塗布に基く皮膚
の発赤発疹その他の副作用は一切認められなかつ
た。
試験例
マウスに対する女性ホルモン・ミノキシジル配
合養毛剤の効果
BDF1〓マウス（６週齢、平均30ｇ）の背部を
安全カミソリで剃つたマウス12匹を３匹ずつ４群
に分かち、各群に対して以下の混合溶液を剃毛翌
日から１日２回朝夕塗布し、定期的に各マウスか
ら５本あて抜毛し、長さを測定した。
第１群：エタノール５ml＋グリセリン0.5ml＋蒸
留水4.5ml
第２群：エストリオール５mg＋エタノール５ml＋
グリセリン0.5ml＋蒸留水4.5ml
第３群：ミノキシジル50mg＋エタノール５ml＋グ
リセリン0.5ml＋蒸留水4.5ml
第４群：エストリオール５mg＋ミノキシジル50mg
＋エタノール５ml＋グリセリン0.5ml＋
蒸留水4.5ml
剃毛後14日目の肉眼観察による発毛情況と抜毛
15本の測定値を以下に示す。
The present invention relates to a hair nourishing cosmetic that exhibits a specifically effective hair growth promoting effect by combining two types of known compounds. The present inventor focused on the fact that hair loss is more common in men, and applied a mixture of female hormones and an antihypertensive agent minoxidil (2,4-diamino-6-piperidinopyrimidine-3-oxide) to the hair roots. The present invention was completed based on the discovery that each of these agents exhibits a more excellent hair-nourishing effect than when applied alone. Female hormones include follicular hormone and progesterone. Follicular hormones include estradiol, estriol, and stilbestrol. In addition, progesterone hormones include progesterone, chlormadinone, norethisterone, and the like. Female hormones and minoxidil are usually mixed in a solution 1 made by using alcohol, water, etc. as a solvent, and adding fragrances, humectants, cooling agents, scalp stimulants, etc. commonly used in the production of hair lotions, hair tonics, etc. (estriol etc.) 0.1-1.0g, minoxidil 1
By dissolving the amount in the range of ~10 g, the purpose can be fully achieved. Due to its nature, the hair nourishing cosmetic composition of the present application is most effective as a hair lotion type, but it can also be used as a hair styling product such as a hair cream or pomade. Below are test examples examining the hair growth effect of a combination of female hormones and minoxidil, as well as manufacturing examples of hair cosmetics. No redness, rash, or other side effects were observed on the skin due to the application of this drug. Test Example: Effect of hair tonic containing female hormone minoxidil on mice BDF 1 12 mice (6 weeks old, average 30g) whose backs were shaved with a safety razor were divided into 4 groups of 3 mice each, and each group was given the following treatment. A mixed solution was applied twice a day, morning and evening, starting the day after shaving, and five hairs were removed from each mouse at regular intervals to measure the length. Group 1: 5 ml of ethanol + 0.5 ml of glycerin + 4.5 ml of distilled water Group 2: 5 mg of estriol + 5 ml of ethanol +
Glycerin 0.5ml + distilled water 4.5ml Group 3: Minoxidil 50mg + Ethanol 5ml + Glycerin 0.5ml + Distilled water 4.5ml Group 4: Estriol 5mg + Minoxidil 50mg
+ 5 ml of ethanol + 0.5 ml of glycerin +
Distilled water 4.5ml Hair growth and hair removal by visual observation 14 days after shaving
The measured values of the 15 pieces are shown below.
【表】
又、第１群〜第４群の抜毛15本の測定データ
は、以下の通りである。
各個体毛長（mm） 平均毛長 標準偏差
第１群
1.6 1.8 1.6 1.7 1.7
1.9 1.9 2.0 1.9 1.9 1.8 0.13
1.7 1.6 1.9 1.9 1.9
第２群
2.2 2.1 2.3 2.1 2.0
2.3 2.2 2.4 2.3 2.1 2.3 0.17
2.3 2.6 2.5 2.5 2.5
第３群
3.2 3.1 3.1 3.0 2.8
2.8 3.0 3.0 2.8 2.8 3.0 0.16
3.3 3.2 3.0 2.9 2.9
第４群
4.3 4.3 4.4 4.4 4.3
4.1 3.9 3.9 4.2 4.1 4.1 0.19
4.0 3.9 3.9 3.9 3.9
女性ホルモンによる養毛効果は、2.3−1.8＝0.5
mm、ミノキシジルによる効果は、3.0−1.8＝1.7mm
で、これら両者の相加効果は、0.5＋1.2＝1.7であ
る。
然るに、両者を併用した場合における養毛効果
は、4.1−1.8＝2.3である。
この二つの場合について、有意性を検討する
と、両者の期待される相加効果(A)は、
（1.8＋0.5＋1.2）±（0.17＋0.16）＝3.5
±0.33両者併用によつて得られる効果(B)は、
4.1±0.19であるので、これら(A)と(B)について、
ｔ検定を行えば、ｔ＝6.12となり、0.001％以下
の危険率で、有意の差が、認められる。
上記試験例に準じて、以下の実験を行つた。
BDF1〓マウス（６週齢、平均28ｇ）の背部を安
全カミソリで剃つた36匹を、３匹ずつ12群に分か
ち、各群に対して、以下の混合溶液を剃毛翌日か
ら一日２回朝夕塗布し、定期的に、各マウスから
５本あて抜毛し、長さを測定した。
第１群：エタノール５ml＋グリセリン0.5ml＋蒸
留水4.5ml
第２群：エタノール５mg＋ミノキシジル50mg＋グ
リセリン0.5ml＋蒸留水4.5ml
第３群：エタノール５ml＋安息香酸エストラジオ
ール２mg＋グリセリン0.5ml＋蒸留水4.5
ml
第４群：エタノール５ml＋フオスフエストロール
100mg＋グリセリン0.5ml＋蒸留水4.5ml
第５群：エタノール５ml＋プロゲステロン25mg＋
グリセリン0.5ml＋蒸留水4.5ml
第６群：エタノール５ml＋酢酸クロルマジノン20
mg＋グリセリン0.5ml＋蒸留水4.5ml
第７群：エタノール５ml＋ノルエチステロン５mg
＋グリセリン0.5ml＋蒸留水4.5ml
第８群：エタノール５ml＋ミノキシジル50mg＋安
息香酸エストラジオール２mg＋グリセリ
ン0.5ml＋蒸留水4.5ml
第９群：エタノール５ml＋ミノキシジル50mg＋フ
オスフエストロール100mg＋グリセリン
0.5ml＋蒸留水4.5ml
第10群：エタノール５ml＋ミノキシジル50mg＋プ
ロゲステロン25mg＋グリセリン0.5ml＋
蒸留水4.5ml
第11群：エタノール５ml＋ミノキシジル50mg＋酢
酸クロルマジノン20mg＋グリセリン0.5
ml＋蒸留水4.5ml
第12群：エタノール５ml＋ミノキシジル50mg＋ノ
ルエチステロン５ml＋グリセリン0.5ml
＋蒸留水4.5ml
剃毛後14日目の抜毛15本の平均値を次表に示
す。
平均毛長（mm）
第１群 1.8
第２群 2.9
第３群 2.1
第４群 2.3
第５群 2.1
第６群 2.1
第７群 2.2
第８群 4.0
第９群 4.4
第10群 4.2
第11群 4.1
第12群 4.2
第１群の平均毛長に対して、第２群および、第
３、４、５、６群は、それぞれ養毛効果が認めら
れるが、夫々の養毛効果の相加効果即ち、（第２
群−第１群）＋（第３群−第１群）、（第２群−第１
群）＋（第４群−第１群）、（第２群−第１群）＋（第
５群−第１群）、（第２群−第１群）＋（第６群−第
１群）、（第２群−第１群）＋（第７群−第１群）
は、
夫々、1.4mm、1.6mm、1.4mm、1.4mm、1.5mmであ
るのに対して、ミノキシジル＋各女性ホルモン併
用の相乗効果、即ち、（第８群−第１群）、（第９
群−第１群）、（第10群−第１群）、（第11群−第１
群）、（第12群−第１群）は、夫々、2.2mm、2.6
mm、2.4mm、2.3mm、2.4mmであり、明らかに有意の
差がみとめられる。
以上の試験から、本願養毛化粧料は、現在用い
られている夫々の系の女性ホルモンと、ミノキシ
ジルとの併用による相乗的な養毛効果を有するこ
とが明らかである。
また、本願養毛剤は、肉眼観察所見から明らか
なように養毛効果にむらが無く、優れた養毛効果
が期待できるものである。
以下に実施例を掲げる。
実施例
ヘアローシヨン
95％エタノール 50％（重量％）
グリセリン ５％
エストリオール 0.05％
ミノキシジル 0.5％
ｌ−メントール 0.4％
トウガラシチンキ 1.0％
レゾルシン 0.5％
香 料 1.5％
着色料 適量
精製水 全体を100％にするための適量
以上を混合溶解して製品とする。[Table] The measurement data for the 15 hairs of the first to fourth groups are as follows. Individual hair length (mm) Average hair length Standard deviation Group 1 1.6 1.8 1.6 1.7 1.7 1.9 1.9 2.0 1.9 1.9 1.8 0.13 1.7 1.6 1.9 1.9 1.9 Group 2 2.2 2.1 2.3 2.1 2.0 2.3 2.2 2.4 2.3 2.1 2.3 0.17 2.3 2.6 2.5 2.5 2.5 Group 3 3.2 3.1 3.1 3.0 2.8 2.8 3.0 3.0 2.8 2.8 3.0 0.16 3.3 3.2 3.0 2.9 2.9 Group 4 4.3 4.3 4.4 4.4 4.3 4.1 3.9 3.9 4.2 4.1 4.1 0. 19 4.0 3.9 3.9 3.9 3.9 The hair growth effect of female hormones is 2.3 −1.8=0.5
mm, the effect of minoxidil is 3.0−1.8=1.7 mm
The additive effect of these two is 0.5+1.2=1.7. However, the hair growth effect when both are used together is 4.1-1.8=2.3. Considering the significance of these two cases, the expected additive effect (A) of both is (1.8 + 0.5 + 1.2) ± (0.17 + 0.16) = 3.5 ± 0.33. The effect (B) is 4.1±0.19, so for these (A) and (B),
If a t-test is performed, t=6.12, and a significant difference is recognized with a risk rate of 0.001% or less. The following experiment was conducted according to the above test example.
BDF 1 = The backs of 36 mice (6 weeks old, average 28 g) were shaved with a safety razor, divided into 12 groups of 3 mice, and each group was given the following mixed solution twice a day from the day after shaving. The solution was applied twice in the morning and evening, and five hairs were removed from each mouse periodically to measure the length. Group 1: 5 ml of ethanol + 0.5 ml of glycerin + 4.5 ml of distilled water Group 2: 5 mg of ethanol + 50 mg of minoxidil + 0.5 ml of glycerin + 4.5 ml of distilled water Group 3: 5 ml of ethanol + 2 mg of estradiol benzoate + 0.5 ml of glycerin + 4.5 ml of distilled water
ml Group 4: ethanol 5ml + fusfestrol
100mg + glycerin 0.5ml + distilled water 4.5ml Group 5: ethanol 5ml + progesterone 25mg +
Glycerin 0.5ml + distilled water 4.5ml Group 6: Ethanol 5ml + Chlormadinone acetate 20
mg + glycerin 0.5ml + distilled water 4.5ml Group 7: ethanol 5ml + norethisterone 5mg
+ Glycerin 0.5ml + Distilled water 4.5ml Group 8: Ethanol 5ml + Minoxidil 50mg + Estradiol benzoate 2mg + Glycerin 0.5ml + Distilled water 4.5ml Group 9: Ethanol 5ml + Minoxidil 50mg + Fuosfuestrol 100mg + Glycerin
0.5ml + distilled water 4.5ml Group 10: ethanol 5ml + minoxidil 50mg + progesterone 25mg + glycerin 0.5ml +
Distilled water 4.5ml Group 11: ethanol 5ml + minoxidil 50mg + chlormadinone acetate 20mg + glycerin 0.5
ml + distilled water 4.5ml Group 12: ethanol 5ml + minoxidil 50mg + norethisterone 5ml + glycerin 0.5ml
+ 4.5 ml of distilled water The following table shows the average value of the 15 hairs removed on the 14th day after shaving. Average hair length (mm) Group 1 1.8 Group 2 2.9 Group 3 2.1 Group 4 2.3 Group 5 2.1 Group 6 2.1 Group 7 2.2 Group 8 4.0 Group 9 4.4 Group 10 4.2 Group 11 4.1 Group 12 4.2 Groups 2, 3, 4, 5, and 6 each have a hair-nurturing effect relative to the average hair length of group 1, but the additive effect of each hair-nurturing effect, i.e. , (second
group - 1st group) + (3rd group - 1st group), (2nd group - 1st group)
group) + (4th group - 1st group), (2nd group - 1st group) + (5th group - 1st group), (2nd group - 1st group) + (6th group - 1st group) group), (2nd group - 1st group) + (7th group - 1st group)
are 1.4 mm, 1.6 mm, 1.4 mm, 1.4 mm, and 1.5 mm, respectively, whereas the synergistic effect of minoxidil + each female hormone combination, that is, (group 8 - group 1), (group 9)
group - 1st group), (10th group - 1st group), (11th group - 1st group)
group), (12th group - 1st group) are 2.2 mm and 2.6, respectively.
mm, 2.4 mm, 2.3 mm, and 2.4 mm, and a clearly significant difference can be seen. From the above tests, it is clear that the hair-growth cosmetic of the present application has a synergistic hair-growth effect when used in combination with currently used female hormones and minoxidil. In addition, the hair growth agent of the present application has a uniform hair growth effect, as is clear from the macroscopic findings, and can be expected to have an excellent hair growth effect. Examples are listed below. Example Hair lotion 95% ethanol 50% (wt%) Glycerin 5% Estriol 0.05% Minoxidil 0.5% L-menthol 0.4% Capsicum tincture 1.0% Resorcinol 0.5% Fragrance 1.5% Coloring agent Appropriate amount Purified water To make the total 100% A suitable amount or more is mixed and dissolved to make a product.
Claims (1)
して含有する毛髪化粧料。1. A hair cosmetic containing female hormones and minoxidil as hair nourishing ingredients.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3676684A JPS60181008A (en) | 1984-02-27 | 1984-02-27 | Hair tonic cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3676684A JPS60181008A (en) | 1984-02-27 | 1984-02-27 | Hair tonic cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60181008A JPS60181008A (en) | 1985-09-14 |
| JPH0459287B2 true JPH0459287B2 (en) | 1992-09-21 |
Family
ID=12478877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3676684A Granted JPS60181008A (en) | 1984-02-27 | 1984-02-27 | Hair tonic cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60181008A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0676299B2 (en) * | 1986-06-16 | 1994-09-28 | 鐘紡株式会社 | Hair nourishment |
| JP2003012468A (en) * | 2001-06-28 | 2003-01-15 | Kaminomoto Co Ltd | Promoter for restoration and growth of hair |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5238035A (en) * | 1975-09-13 | 1977-03-24 | Hoechst Ag | Hair tonic |
| JPS5888307A (en) * | 1981-11-19 | 1983-05-26 | Takeo Kinji | Minoxidil-containing hair tonic |
-
1984
- 1984-02-27 JP JP3676684A patent/JPS60181008A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5238035A (en) * | 1975-09-13 | 1977-03-24 | Hoechst Ag | Hair tonic |
| JPS5888307A (en) * | 1981-11-19 | 1983-05-26 | Takeo Kinji | Minoxidil-containing hair tonic |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60181008A (en) | 1985-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3563449B2 (en) | Hair restoration cosmetics | |
| JPS61165311A (en) | Hair tonic cosmetic | |
| JP2001288047A (en) | Composition for scalp and hair | |
| JPH0853327A (en) | Hair tonic composed of allantoin or its derivative | |
| EP1810695A1 (en) | Non-aqueous liquid shampoo composition | |
| JP4162823B2 (en) | Hair cosmetics | |
| JPS5888306A (en) | Hair tonic cosmetic | |
| JP2001288046A (en) | Composition for scalp and hair | |
| JPH05286835A (en) | Hair-raising cosmetic | |
| JPH0459287B2 (en) | ||
| JPH11269043A (en) | Cosmetic for scalp and hair | |
| JP2546813B2 (en) | Hair nourishing cosmetics | |
| JP3133532B2 (en) | Hair restoration cosmetics | |
| JPH11302133A (en) | Cosmetic for scalp and hair | |
| JPS61165310A (en) | Gray hair-preventing cosmetic | |
| JPH10273424A (en) | Cosmetic for hair | |
| JP3193544B2 (en) | Hair restoration cosmetics | |
| JPS62242608A (en) | Hair tonic cosmetic | |
| JP3014215B2 (en) | Hair restoration cosmetics | |
| JP3717676B2 (en) | Hair nourishing | |
| JP3639389B2 (en) | Hair nourishing | |
| JP3624318B2 (en) | Hair nourishing agent | |
| JPS61165312A (en) | Hair tonic cosmetic | |
| JPH0566927B2 (en) | ||
| JPS62190116A (en) | Hair-tonic cosmetic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |