JPH04330008A - ５α−リダクターゼ阻害剤 - Google Patents
５α−リダクターゼ阻害剤Info
- Publication number
- JPH04330008A JPH04330008A JP2414964A JP41496490A JPH04330008A JP H04330008 A JPH04330008 A JP H04330008A JP 2414964 A JP2414964 A JP 2414964A JP 41496490 A JP41496490 A JP 41496490A JP H04330008 A JPH04330008 A JP H04330008A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- acid
- hair
- reductase
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 title claims abstract description 9
- 239000002677 5-alpha reductase inhibitor Substances 0.000 title claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- 201000004384 Alopecia Diseases 0.000 claims description 16
- 206010000496 acne Diseases 0.000 claims description 16
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 15
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 claims description 15
- 239000004480 active ingredient Substances 0.000 claims description 6
- 231100000360 alopecia Toxicity 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 229940123934 Reductase inhibitor Drugs 0.000 claims description 2
- 244000121765 Lansium domesticum Species 0.000 abstract description 12
- 229960003473 androstanolone Drugs 0.000 abstract description 10
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 abstract description 9
- 235000006686 Lansium domesticum Nutrition 0.000 abstract description 8
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- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- SYTWWAZKYVYTTQ-SUAVODKESA-N lansic acid Chemical group OC(=O)CC[C@@]1(C)[C@H](C(=C)C)CCC(=C)[C@@H]1CC[C@@H]1[C@](CCC(O)=O)(C)[C@H](C(C)=C)CC=C1C SYTWWAZKYVYTTQ-SUAVODKESA-N 0.000 abstract description 2
- ZSWPCPFSALDZBI-UHFFFAOYSA-N Lansioside A Natural products CC(=O)NCC1OC(OC2CCC3(C)C(CCC4C(=CCC(C(=C)C)C4(C)CCC(=O)O)C)C(=C)CCC3C2(C)C)C(O)C(O)C1O ZSWPCPFSALDZBI-UHFFFAOYSA-N 0.000 abstract 1
- VTWINLUFYLXPHU-UHFFFAOYSA-N Lansioside B Natural products CC(=C)C1CC=C(C)C(CCC2C(=C)CCC3C(C)(C)C(CCC23C)OCC4OC(O)C(O)C(O)C4O)C1(C)CCC(=O)O VTWINLUFYLXPHU-UHFFFAOYSA-N 0.000 abstract 1
- LESZSAQXPRFCAF-UHFFFAOYSA-N Lansioside B Chemical compound OC(=O)CCC1(C)C(C(=C)C)CC=C(C)C1CCC1C2(C)CCC(OC3C(C(O)C(O)C(CO)O3)O)C(C)(C)C2CCC1=C LESZSAQXPRFCAF-UHFFFAOYSA-N 0.000 abstract 1
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- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- 125000000188 beta-D-glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- SRBFZHDQGSBBOR-KKQCNMDGSA-N beta-D-xylose Chemical group O[C@@H]1CO[C@@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-KKQCNMDGSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- DPUBTAIUQYXFDA-RAWPCXBLSA-N lansioside A Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1C(C)(C)[C@@H]2CCC(=C)[C@H](CC[C@@H]3[C@@]([C@H](C(C)=C)CC=C3C)(C)CCC(O)=O)[C@@]2(C)CC1 DPUBTAIUQYXFDA-RAWPCXBLSA-N 0.000 abstract 1
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- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2414964A JPH04330008A (ja) | 1990-12-27 | 1990-12-27 | ５α−リダクターゼ阻害剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2414964A JPH04330008A (ja) | 1990-12-27 | 1990-12-27 | ５α−リダクターゼ阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59087818A Division JPS60243020A (ja) | 1984-05-02 | 1984-05-02 | ５α−リダクタ−ゼ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04330008A true JPH04330008A (ja) | 1992-11-18 |
| JPH0524126B2 JPH0524126B2 (enrdf_load_stackoverflow) | 1993-04-06 |
Family
ID=18523382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2414964A Granted JPH04330008A (ja) | 1990-12-27 | 1990-12-27 | ５α−リダクターゼ阻害剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04330008A (enrdf_load_stackoverflow) |
-
1990
- 1990-12-27 JP JP2414964A patent/JPH04330008A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0524126B2 (enrdf_load_stackoverflow) | 1993-04-06 |
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