JPH04211384A - 細菌ベクター - Google Patents
細菌ベクターInfo
- Publication number
- JPH04211384A JPH04211384A JP3056889A JP5688991A JPH04211384A JP H04211384 A JPH04211384 A JP H04211384A JP 3056889 A JP3056889 A JP 3056889A JP 5688991 A JP5688991 A JP 5688991A JP H04211384 A JPH04211384 A JP H04211384A
- Authority
- JP
- Japan
- Prior art keywords
- plasmid
- lactis
- msp
- hybrid vector
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 108010033670 threonyl-aspartyl-tyrosine Proteins 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 108010073452 tryptophyl-glycyl-histidyl-glutamic acid Proteins 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB90064007 | 1990-03-22 | ||
| GB909006400A GB9006400D0 (en) | 1990-03-22 | 1990-03-22 | Bacterial vectors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04211384A true JPH04211384A (ja) | 1992-08-03 |
Family
ID=10673033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3056889A Pending JPH04211384A (ja) | 1990-03-22 | 1991-03-20 | 細菌ベクター |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5559007A (xx) |
| EP (1) | EP0449770B1 (xx) |
| JP (1) | JPH04211384A (xx) |
| KR (1) | KR910016930A (xx) |
| AR (1) | AR245504A1 (xx) |
| AT (1) | ATE174055T1 (xx) |
| AU (1) | AU643511B2 (xx) |
| BR (1) | BR9101137A (xx) |
| CA (1) | CA2038706A1 (xx) |
| DE (1) | DE69130544T2 (xx) |
| DK (1) | DK0449770T3 (xx) |
| ES (1) | ES2125864T3 (xx) |
| FI (1) | FI911367A (xx) |
| GB (1) | GB9006400D0 (xx) |
| HU (1) | HUT57263A (xx) |
| IE (1) | IE910948A1 (xx) |
| MX (1) | MX25027A (xx) |
| NO (1) | NO911138L (xx) |
| NZ (1) | NZ237506A (xx) |
| PT (1) | PT97081B (xx) |
| TW (1) | TW213488B (xx) |
| ZA (1) | ZA912114B (xx) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008067708A (ja) * | 1995-10-20 | 2008-03-27 | Actogenix Nv | 生物学的に活性のあるポリペプチドのデリバリー |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5286361A (en) * | 1992-10-19 | 1994-02-15 | Regents Of The University Of California | Magnetically attached sputter targets |
| AU2149495A (en) * | 1995-04-11 | 1996-10-30 | Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno | Method for the construction of vectors for lactic acid bacte ria like lactobacillus such that the bacteria can efficientl y express, secrete and display proteins at the surface |
| CA2264495C (en) * | 1996-09-06 | 2007-04-17 | Bioteknologisk Institut | A lactic acid bacterial regulatable expression system |
| EP1239032A1 (en) * | 2001-03-02 | 2002-09-11 | Société des Produits Nestlé S.A. | Lactic acid bacteria as agents for treating and preventing allergy |
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| EP1513545B1 (en) | 2002-06-19 | 2008-03-19 | Actogenix N.V. | Methods and means to promote gut absorption |
| CA2506031A1 (en) * | 2002-11-15 | 2004-06-03 | Vib Vzw | Self-containing lactobacillus strain comprising a thya mutation and therapeutic applications thereof |
| EP1957100B1 (en) | 2005-11-29 | 2016-07-13 | Intrexon Actobiotics NV | Induction of mucosal tolerance to antigens |
| AU2008204442B2 (en) | 2007-01-12 | 2013-03-14 | Intrexon Actobiotics Nv | Lactococcus promoters and uses thereof |
| EP2125010B1 (en) | 2007-01-25 | 2014-06-04 | Actogenix N.V. | Treatment of immune disease by mucosal delivery of antigens using genetically modified lactobacillus |
| JP5126879B2 (ja) * | 2007-07-13 | 2013-01-23 | 独立行政法人海洋研究開発機構 | 新規ｄｎａ断片およびそれを含む組換えベクター、それらによって形質転換された形質転換体、ならびにそれらの利用 |
| JP2012504116A (ja) | 2008-09-29 | 2012-02-16 | アクトジェニックス・エヌブイ | 粘膜での微生物のコロニー形成の低減 |
| DK2424972T3 (da) | 2009-04-30 | 2013-10-14 | Actogenix Nv | Kryobeskyttende midler til frysetørring af mælkesyrebakterier |
| EP2275527A1 (en) | 2009-07-17 | 2011-01-19 | ActoGeniX NV | Animal component-free culture medium for bacterial fermentation |
| EP3192873A1 (en) | 2009-09-29 | 2017-07-19 | Intrexon Actobiotics NV | Lactobacillus and streptococcus promoters and uses thereof |
| AU2011268146A1 (en) | 2010-06-17 | 2013-01-10 | Actogenix Nv | Compositions and methods for treating inflammatory conditions |
| JP6175428B2 (ja) | 2011-06-01 | 2017-08-02 | イントレクソン・アクトバイオテイクス・エヌブイＩｎｔｒｅｘｏｎ Ａｃｔｏｂｉｏｔｉｃｓ ＮＶ | 細菌のポリシストロン性発現系 |
| ES2676707T3 (es) | 2011-09-23 | 2018-07-24 | Intrexon Actobiotics Nv | Bacterias gram positivas modificadas y usos de las mismas |
| HUE038336T2 (hu) | 2011-09-23 | 2018-10-29 | Intrexon Actobiotics Nv | Módosított gram-pozitív baktériumok és alkalmazásaik |
| DK3402499T3 (da) | 2016-01-14 | 2021-09-27 | Intrexon Actobiotics Nv | Sammensætninger og fremgangsmåder til behandlingen af type 1 diabetes |
| EP3601572A4 (en) * | 2017-03-22 | 2021-01-06 | Agency for Science, Technology and Research | PROTEIN EXPRESSION CONSTRUCTION AND RELATED PROCESSES |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8400687A (nl) | 1984-03-02 | 1985-10-01 | Unilever Nv | Recombinant plasmiden; recombinant plasmiden bevattende bacterien; werkwijze voor het bereiden of vervaardigen van een zuivelproduct; werkwijze voor het bereiden van een eiwit. |
| EP0168342B1 (de) | 1984-06-14 | 1991-07-03 | Ciba-Geigy Ag | Verfahren zur Herstellung von Thrombin-Inhibitoren |
| NL8503316A (nl) * | 1985-11-29 | 1987-06-16 | Stichting Nl I Zuivelonderzoek | Werkwijze voor het bereiden van proteinen met behulp van gastheer-organismen, in het bijzonder melkzuurbacterien, welke recombinant dna-plasmiden met een hoge replicon-aktiviteit en een hoge promotor-aktiviteit voor het betreffende proteine-coderende gen bevatten, de van dergelijke recombinant dna-plasmiden voorziene gastheerorganismen, de recombinant dna-plasmiden zelve, de replicon-aktiviteit en promotor-aktiviteit coderende dna-fragmenten, alsmede de verkregen proteinen. |
| EP0316677A3 (en) | 1987-11-13 | 1990-04-25 | Miles Inc. | Method for cloning in lactic acid bacteria |
| NL9000753A (nl) * | 1990-03-30 | 1991-10-16 | Nl Zuivelonderzoek Inst | Dna-fragment, ten minste coderend voor een deel van het extracellulaire eiwit met een schijnbaar molecuulgewicht van 60 kda van lactococcus lactis stammen zoals de lactococcus lactis ssp. lactis stam mg1363, combinaties hiervan met voor homologe of heterologe eiwitten coderende dna-sequenties alsmede de hiermee verkregen homologe en heterologe eiwitten. |
-
1990
- 1990-03-22 GB GB909006400A patent/GB9006400D0/en active Pending
-
1991
- 1991-03-13 DE DE69130544T patent/DE69130544T2/de not_active Expired - Fee Related
- 1991-03-13 AT AT91810167T patent/ATE174055T1/de not_active IP Right Cessation
- 1991-03-13 ES ES91810167T patent/ES2125864T3/es not_active Expired - Lifetime
- 1991-03-13 EP EP91810167A patent/EP0449770B1/en not_active Expired - Lifetime
- 1991-03-13 DK DK91810167T patent/DK0449770T3/da active
- 1991-03-15 AU AU73558/91A patent/AU643511B2/en not_active Ceased
- 1991-03-20 PT PT97081A patent/PT97081B/pt not_active IP Right Cessation
- 1991-03-20 TW TW080102185A patent/TW213488B/zh active
- 1991-03-20 CA CA002038706A patent/CA2038706A1/en not_active Abandoned
- 1991-03-20 NZ NZ237506A patent/NZ237506A/en unknown
- 1991-03-20 FI FI911367A patent/FI911367A/fi not_active Application Discontinuation
- 1991-03-20 JP JP3056889A patent/JPH04211384A/ja active Pending
- 1991-03-21 NO NO91911138A patent/NO911138L/no unknown
- 1991-03-21 ZA ZA912114A patent/ZA912114B/xx unknown
- 1991-03-21 HU HU91958A patent/HUT57263A/hu unknown
- 1991-03-21 IE IE094891A patent/IE910948A1/en unknown
- 1991-03-21 KR KR1019910004439A patent/KR910016930A/ko not_active Application Discontinuation
- 1991-03-22 BR BR919101137A patent/BR9101137A/pt unknown
- 1991-03-22 MX MX2502791A patent/MX25027A/es unknown
- 1991-03-22 AR AR91319296A patent/AR245504A1/es active
-
1994
- 1994-01-21 US US08/186,222 patent/US5559007A/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008067708A (ja) * | 1995-10-20 | 2008-03-27 | Actogenix Nv | 生物学的に活性のあるポリペプチドのデリバリー |
Also Published As
| Publication number | Publication date |
|---|---|
| FI911367A0 (fi) | 1991-03-20 |
| NO911138D0 (no) | 1991-03-21 |
| DE69130544D1 (de) | 1999-01-14 |
| FI911367A (fi) | 1991-09-23 |
| ATE174055T1 (de) | 1998-12-15 |
| PT97081A (pt) | 1991-11-29 |
| IE910948A1 (en) | 1991-09-25 |
| EP0449770B1 (en) | 1998-12-02 |
| AU643511B2 (en) | 1993-11-18 |
| KR910016930A (ko) | 1991-11-05 |
| PT97081B (pt) | 1998-07-31 |
| NO911138L (no) | 1991-09-23 |
| ZA912114B (en) | 1992-01-29 |
| DK0449770T3 (da) | 1999-06-23 |
| HU910958D0 (en) | 1991-10-28 |
| DE69130544T2 (de) | 1999-04-29 |
| ES2125864T3 (es) | 1999-03-16 |
| EP0449770A3 (en) | 1992-07-01 |
| AR245504A1 (es) | 1994-01-31 |
| BR9101137A (pt) | 1991-11-05 |
| AU7355891A (en) | 1991-10-03 |
| MX25027A (es) | 1993-12-01 |
| TW213488B (xx) | 1993-09-21 |
| CA2038706A1 (en) | 1991-09-23 |
| GB9006400D0 (en) | 1990-05-23 |
| HUT57263A (en) | 1991-11-28 |
| EP0449770A2 (en) | 1991-10-02 |
| NZ237506A (en) | 1992-12-23 |
| US5559007A (en) | 1996-09-24 |
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