JPH0364498B2 - - Google Patents

Info

Publication number
JPH0364498B2
JPH0364498B2 JP59502223A JP50222384A JPH0364498B2 JP H0364498 B2 JPH0364498 B2 JP H0364498B2 JP 59502223 A JP59502223 A JP 59502223A JP 50222384 A JP50222384 A JP 50222384A JP H0364498 B2 JPH0364498 B2 JP H0364498B2
Authority
JP
Japan
Prior art keywords
compound
vitamin
bone
compounds
dihydroxyvitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59502223A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60501261A (ja
Inventor
Hekutaa Efu Deruuka
Hainritsuhi Kee Shunoozu
Rafuaru Aaru Shishinsukii
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of JPS60501261A publication Critical patent/JPS60501261A/ja
Publication of JPH0364498B2 publication Critical patent/JPH0364498B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dram (AREA)
JP59502223A 1983-05-09 1984-05-09 １α，２５―ジヒドロキシル化ビタミンＤ↓２化合物及びその製造方法 Granted JPS60501261A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US492863 1983-05-09
US607327 1984-05-04

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP1338025A Division JPH0610188B2 (ja) 1983-05-09 1989-12-26 １α，２５―ジヒドロキシル化ビタミンＤ▼下２▲化合物の前駆体
JP1338023A Division JPH0651624B2 (ja) 1983-05-09 1989-12-26 骨の損耗の予防又は再生不調症の治療又は予防用薬剤
JP1338024A Division JPH02288873A (ja) 1983-05-09 1989-12-26 シクロビタミンｄ化合物

Publications (2)

Publication Number Publication Date
JPS60501261A JPS60501261A (ja) 1985-08-08
JPH0364498B2 true JPH0364498B2 (en, 2012) 1991-10-07

Family

ID=23957917

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59502223A Granted JPS60501261A (ja) 1983-05-09 1984-05-09 １α，２５―ジヒドロキシル化ビタミンＤ↓２化合物及びその製造方法

Country Status (5)

Country Link
JP (1) JPS60501261A (en, 2012)
BE (1) BE899612A (en, 2012)
FR (1) FR2545824B1 (en, 2012)
GB (3) GB2139627B (en, 2012)
IE (1) IE58277B1 (en, 2012)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
JP2608322B2 (ja) * 1988-04-11 1997-05-07 日清製粉株式会社 １α，２５‐ジヒドロキシビタミンＤ▲下２▼類の製造法
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
JPH08507073A (ja) * 1993-02-19 1996-07-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン カルシウム代謝障害の治療のための２６，２６，２６，２７，２７，２７−ヘキサフルオロ−１アルファ，２５−ジヒドロキシコレカルシフェロールの使用
EP0981514B1 (en) * 1997-05-16 2006-04-05 Woman & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
CA2289209C (en) 1997-05-16 2006-07-25 Women & Infants Hospital Cyclic ether vitamin d3 compounds, 1.alpha. (oh) 3-epi-vitamin d3 compounds and uses thereof
WO2002030430A1 (en) * 2000-10-06 2002-04-18 Abbott Laboratories Use of vitamin d2 compounds for alopecia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE877356R (fr) * 1978-01-16 1979-10-15 Wisconsin Alumni Res Found Procede de preparation de composes 1alpha-hydroxyles
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4264513A (en) * 1979-05-21 1981-04-28 Wisconsin Alumni Research Foundation 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same

Also Published As

Publication number Publication date
GB2158442B (en) 1987-02-04
JPS60501261A (ja) 1985-08-08
GB2158443B (en) 1987-02-04
GB2139627B (en) 1987-02-04
GB8411794D0 (en) 1984-06-13
GB2158442A (en) 1985-11-13
FR2545824B1 (fr) 1987-11-20
GB2139627A (en) 1984-11-14
BE899612A (fr) 1984-08-31
FR2545824A1 (fr) 1984-11-16
IE841149L (en) 1984-11-09
GB8507475D0 (en) 1985-05-01
GB2158443A (en) 1985-11-13
GB8507474D0 (en) 1985-05-01
IE58277B1 (en) 1993-08-25

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