JPH0355492B2 - - Google Patents

Info

Publication number
JPH0355492B2
JPH0355492B2 JP1248233A JP24823389A JPH0355492B2 JP H0355492 B2 JPH0355492 B2 JP H0355492B2 JP 1248233 A JP1248233 A JP 1248233A JP 24823389 A JP24823389 A JP 24823389A JP H0355492 B2 JPH0355492 B2 JP H0355492B2
Authority
JP
Japan
Prior art keywords
polymer
grams
moles
polyols
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1248233A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02218719A (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPH02218719A publication Critical patent/JPH02218719A/ja
Publication of JPH0355492B2 publication Critical patent/JPH0355492B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Finishing Walls (AREA)
  • Fencing (AREA)
  • Floor Finish (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
JP1248233A 1980-05-15 1989-09-26 ポリ(オルトエステル)の製造方法 Granted JPH02218719A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US150052 1980-05-15
US06/150,052 US4304767A (en) 1980-05-15 1980-05-15 Polymers of di- (and higher functionality) ketene acetals and polyols

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP59269669A Division JPS60221424A (ja) 1980-05-15 1984-12-22 ポリ(オルトエステル)の製造方法

Publications (2)

Publication Number Publication Date
JPH02218719A JPH02218719A (ja) 1990-08-31
JPH0355492B2 true JPH0355492B2 (cg-RX-API-DMAC10.html) 1991-08-23

Family

ID=22532907

Family Applications (5)

Application Number Title Priority Date Filing Date
JP56501812A Expired - Lifetime JPH039127B2 (cg-RX-API-DMAC10.html) 1980-05-15 1981-05-08
JP59269669A Granted JPS60221424A (ja) 1980-05-15 1984-12-22 ポリ(オルトエステル)の製造方法
JP59269670A Granted JPS60214745A (ja) 1980-05-15 1984-12-22 ポリマーが生物学的に活性な薬剤と混合されてなる組成物
JP1248233A Granted JPH02218719A (ja) 1980-05-15 1989-09-26 ポリ(オルトエステル)の製造方法
JP2096580A Pending JPH03732A (ja) 1980-05-15 1990-04-13 ポリケテンアセタールとポリオールとの生分解性ポリマー

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP56501812A Expired - Lifetime JPH039127B2 (cg-RX-API-DMAC10.html) 1980-05-15 1981-05-08
JP59269669A Granted JPS60221424A (ja) 1980-05-15 1984-12-22 ポリ(オルトエステル)の製造方法
JP59269670A Granted JPS60214745A (ja) 1980-05-15 1984-12-22 ポリマーが生物学的に活性な薬剤と混合されてなる組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2096580A Pending JPH03732A (ja) 1980-05-15 1990-04-13 ポリケテンアセタールとポリオールとの生分解性ポリマー

Country Status (20)

Country Link
US (1) US4304767A (cg-RX-API-DMAC10.html)
EP (1) EP0051667B1 (cg-RX-API-DMAC10.html)
JP (5) JPH039127B2 (cg-RX-API-DMAC10.html)
AT (1) AT384615B (cg-RX-API-DMAC10.html)
AU (1) AU543991B2 (cg-RX-API-DMAC10.html)
BE (1) BE888829A (cg-RX-API-DMAC10.html)
CA (1) CA1186438A (cg-RX-API-DMAC10.html)
CH (1) CH657369A5 (cg-RX-API-DMAC10.html)
DE (1) DE3148618A1 (cg-RX-API-DMAC10.html)
DK (1) DK16082A (cg-RX-API-DMAC10.html)
ES (1) ES502255A0 (cg-RX-API-DMAC10.html)
GB (1) GB2086404B (cg-RX-API-DMAC10.html)
GR (1) GR74902B (cg-RX-API-DMAC10.html)
IE (1) IE51287B1 (cg-RX-API-DMAC10.html)
NL (1) NL188166C (cg-RX-API-DMAC10.html)
NZ (1) NZ197036A (cg-RX-API-DMAC10.html)
PT (1) PT73035B (cg-RX-API-DMAC10.html)
SE (1) SE455791B (cg-RX-API-DMAC10.html)
WO (1) WO1981003278A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA813269B (cg-RX-API-DMAC10.html)

Families Citing this family (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
US4513143A (en) * 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) * 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
US4639366A (en) * 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4549010A (en) * 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4754745A (en) * 1984-11-21 1988-07-05 Horowitz Bruce S Conformable sheet material for use in brachytherapy
US4697575A (en) * 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US4780319A (en) * 1985-07-08 1988-10-25 Merck & Co., Inc. Organic acids as catalysts for the erosion of polymers
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4855132A (en) * 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4763642A (en) * 1986-04-07 1988-08-16 Horowitz Bruce S Intracavitational brachytherapy
ATE97929T1 (de) * 1986-05-15 1993-12-15 Hoechst Ag Biologisch abbaubare polymere fuer depotzubereitungen mit kontrollierter wirkstoffabgabe.
US4713441A (en) * 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4842868A (en) * 1986-09-26 1989-06-27 Helwing Robert F Covalently bonded active agents with carbonium ion base groups
DE3700128A1 (de) * 1987-01-03 1988-07-14 Hoechst Ag Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US4913903A (en) * 1987-02-04 1990-04-03 Alza Corporation Post-surgical applications for bioerodible polymers
US4957986A (en) * 1988-08-02 1990-09-18 E. I. Du Pont De Nemours And Company Partially fluorinated polyesters from ketene acetals and fluorine monomers
US4906714A (en) * 1988-08-02 1990-03-06 E. I. Du Pont De Nemours And Company Partially fluorinated polyesters from ketene acetals and fluorinated vinyl monomers
US4957998A (en) * 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US4946931A (en) * 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
US5013821A (en) * 1989-06-15 1991-05-07 Pharmaceutical Delivery Systems, Inc. Ortho and thio-ortho ester polymer
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
EP0489843A4 (en) * 1989-08-28 1992-08-12 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5047464A (en) * 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
US5217712A (en) * 1989-09-20 1993-06-08 Merck & Co., Inc. Bioerodible thermoset elastomers
DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
NZ239370A (en) * 1990-08-22 1994-04-27 Merck & Co Inc Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone
JPH04120376U (ja) * 1991-04-16 1992-10-28 横河電機株式会社 リレ−検査回路
US5211951A (en) * 1991-07-24 1993-05-18 Merck & Co., Inc. Process for the manufacture of bioerodible poly (orthoester)s and polyacetals
US5254345A (en) * 1991-10-11 1993-10-19 Merck & Co., Inc. Poly(orthocarbonate acetal) bioerodible polymers
US5461140A (en) * 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
KR950702217A (ko) * 1993-05-03 1995-06-19 에드워드 케이. 웰치 2세 전자부화 알켄-티올 폴리머내의 폴리머 분산액정(polymer dispersed liquid crystals in electron-rich alkene-thiol polymers)
US5401885A (en) * 1993-06-01 1995-03-28 Huls America, Inc. Method of preparing ortho esters and 1.1-dialkoxycycloalkanes
US5442033A (en) * 1993-07-20 1995-08-15 Ethicon, Inc. Liquid copolymers of epsilon-caprolactone and lactide
ES2109136B1 (es) * 1994-04-22 1998-07-01 Vita Invest Sa Polimeros biodegradables de esqueleto carbonado de acetales de centeno y alcoholes, procedimiento para su obtencion y composicion y utilizacion correspondientes.
US5811510A (en) * 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
FI98136C (fi) * 1995-09-27 1997-04-25 Biocon Oy Kudosolosuhteissa hajoava materiaali ja menetelmä sen valmistamiseksi
US5968543A (en) * 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
NZ509797A (en) * 1998-07-10 2003-11-28 Univ Sydney Prophylactic treatments of neovascularisation in macular degeneration using a steroid
AUPQ496500A0 (en) * 2000-01-06 2000-02-03 University Of Sydney, The Kit
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
CA2453050A1 (en) 2000-09-06 2002-03-14 A.P. Pharma, Inc. Degradable polyacetal polymers
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
WO2002092661A1 (en) * 2001-05-11 2002-11-21 Ap Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US6524606B1 (en) 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040062778A1 (en) * 2002-09-26 2004-04-01 Adi Shefer Surface dissolution and/or bulk erosion controlled release compositions and devices
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US6863782B2 (en) * 2002-11-15 2005-03-08 A.P. Pharma, Inc. Method of preparing di(ketene acetals)
CL2004000698A1 (es) * 2003-03-31 2005-05-20 Alza Corp Comosicion farmaceutica no acuosa que comprende al menos un ingrediente activo y un vehiculo de fase unica que contiene al menos un polimero y al menos un solvente, siendo el vehiculo miscible en agua; procedimiento para su preparacion; dispositivo d
US7056591B1 (en) 2003-07-30 2006-06-06 Advanced Cardiovascular Systems, Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US7083802B2 (en) * 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US7083803B2 (en) * 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7329413B1 (en) 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
US7220816B2 (en) 2003-12-16 2007-05-22 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same
US7435788B2 (en) 2003-12-19 2008-10-14 Advanced Cardiovascular Systems, Inc. Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
JP2007520496A (ja) * 2004-02-04 2007-07-26 レットメッド ピーティーワイ リミテッド 徐放性ステロイド組成物
JP2007523911A (ja) * 2004-02-26 2007-08-23 アドバンスト アキュラー システムズ リミテッド 眼病変治療用テトラサイクリン誘導体
US20050192257A1 (en) * 2004-02-26 2005-09-01 Peyman Gholam A. Predictors for patients at risk for glaucoma from steroid therapy
US8685431B2 (en) 2004-03-16 2014-04-01 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same
US8778014B1 (en) 2004-03-31 2014-07-15 Advanced Cardiovascular Systems, Inc. Coatings for preventing balloon damage to polymer coated stents
US20050245497A1 (en) * 2004-04-08 2005-11-03 Penfold Philip L Treatment of ophthalmic conditions
US20050261243A1 (en) * 2004-04-21 2005-11-24 Peyman Gholam A Antiprostaglandins for the treatment of ocular pathologies
US7820732B2 (en) 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US20050288481A1 (en) * 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
US20050271700A1 (en) * 2004-06-03 2005-12-08 Desnoyer Jessica R Poly(ester amide) coating composition for implantable devices
US20050287184A1 (en) 2004-06-29 2005-12-29 Hossainy Syed F A Drug-delivery stent formulations for restenosis and vulnerable plaque
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US7166680B2 (en) 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
US7390497B2 (en) 2004-10-29 2008-06-24 Advanced Cardiovascular Systems, Inc. Poly(ester amide) filler blends for modulation of coating properties
US8609123B2 (en) 2004-11-29 2013-12-17 Advanced Cardiovascular Systems, Inc. Derivatized poly(ester amide) as a biobeneficial coating
US20060122152A1 (en) * 2004-12-03 2006-06-08 Peyman Gholam A Heparin for the treatment of ocular pathologies
US7419504B2 (en) 2004-12-27 2008-09-02 Advanced Cardiovascular Systems, Inc. Poly(ester amide) block copolymers
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
US7202325B2 (en) 2005-01-14 2007-04-10 Advanced Cardiovascular Systems, Inc. Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles
WO2006105123A2 (en) * 2005-03-31 2006-10-05 Ap Pharma, Inc. Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions
JP2008537757A (ja) * 2005-03-31 2008-09-25 エーピー ファーマ, インコーポレイテッド Peg−ポリ(オルトエステル)グラフトコポリマーおよび医薬組成物
US20070014760A1 (en) 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
EP1904056B1 (en) * 2005-07-18 2009-04-29 Minu, L.L.C. Use of a macrolide to restore corneal sensation
US20070020312A1 (en) * 2005-07-20 2007-01-25 Desnoyer Jessica R Method of fabricating a bioactive agent-releasing implantable medical device
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US8377462B2 (en) * 2005-07-29 2013-02-19 Advanced Cardiovascular Systems, Inc. PEA-TEMPO/PEA-BZ coatings for controlled delivery of drug from implantable medical devices
US7713916B2 (en) 2005-09-22 2010-05-11 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
US20070066493A1 (en) * 2005-09-22 2007-03-22 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
CN101287739B (zh) * 2005-10-11 2011-05-25 富士胶片株式会社 含氟螺缩醛化合物及其制备方法
EP1948271B1 (en) 2005-11-17 2013-10-02 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
US7910152B2 (en) * 2006-02-28 2011-03-22 Advanced Cardiovascular Systems, Inc. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology
SI1854477T1 (sl) 2006-03-16 2017-01-31 Dyax Corp. Peptidi, ki inhibirajo plazma kalikrein za uporabo pri zdravljenju očesnih motenj
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US20070265329A1 (en) * 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
US20070281870A1 (en) * 2006-06-02 2007-12-06 Halliburton Energy Services, Inc. Stimuli-degradable gels
US7306040B1 (en) * 2006-06-02 2007-12-11 Halliburton Energy Services, Inc. Stimuli-degradable gels
US20090258028A1 (en) * 2006-06-05 2009-10-15 Abbott Cardiovascular Systems Inc. Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug
US8323676B2 (en) * 2008-06-30 2012-12-04 Abbott Cardiovascular Systems Inc. Poly(ester-amide) and poly(amide) coatings for implantable medical devices for controlled release of a protein or peptide and a hydrophobic drug
US7458953B2 (en) * 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US7875697B2 (en) 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US7771739B2 (en) * 2006-06-30 2010-08-10 Abbott Cardiovascular Systems Inc. Implantable medical devices comprising semi-crystalline poly(ester-amide)
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
JP2009542232A (ja) 2006-07-10 2009-12-03 エスバテック・アーゲー 上皮および/または内皮層を通過するscFv抗体
US20090181063A1 (en) * 2006-07-13 2009-07-16 Michael Huy Ngo Implantable medical device comprising a pro-healing poly(ester-amide)
US7731987B2 (en) * 2006-07-13 2010-06-08 Advanced Cardiovascular Systems, Inc. Implantable medical device comprising a pro-healing poly(ester-amide)
US8030436B2 (en) * 2006-07-13 2011-10-04 Advanced Cardiovascular Systems, Inc. Poly(ester-amide) elastomers and their use with implantable medical devices
US20080014245A1 (en) * 2006-07-14 2008-01-17 Stephen Pacetti Drug-eluting implantable medical device with free radical scavenger for protecting drugs during sterilization and related method
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
ZA200902587B (en) 2006-11-09 2010-06-30 Alcon Res Ltd Water insoluble polymer matrix for drug delivery
US20080114076A1 (en) * 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
US20080175882A1 (en) * 2007-01-23 2008-07-24 Trollsas Mikael O Polymers of aliphatic thioester
US8252361B2 (en) * 2007-06-05 2012-08-28 Abbott Cardiovascular Systems Inc. Implantable medical devices for local and regional treatment
US20080306584A1 (en) * 2007-06-05 2008-12-11 Pamela Kramer-Brown Implantable medical devices for local and regional treatment
US9737638B2 (en) * 2007-06-20 2017-08-22 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
US7927621B2 (en) * 2007-06-25 2011-04-19 Abbott Cardiovascular Systems Inc. Thioester-ester-amide copolymers
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
CA2722743A1 (en) 2008-04-28 2009-11-05 Zogenix, Inc. Novel formulations for treatment of migraine
US8889172B1 (en) 2008-04-30 2014-11-18 Abbott Cardiovascular Systems Inc. Amorphous or semi-crystalline poly(ester amide) polymer with a high glass transition temperature
EP2303393A4 (en) * 2008-05-07 2011-10-19 Obj Ltd METHOD AND APPARATUS FOR ENHANCED TRANSDERMAL DIFFUSION
US8765162B2 (en) 2008-06-30 2014-07-01 Abbott Cardiovascular Systems Inc. Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
US20100047319A1 (en) * 2008-08-21 2010-02-25 Michael Huy Ngo Biodegradable Poly(Ester-Amide) And Poly(Amide) Coatings For Implantable Medical Devices With Enhanced Bioabsorption Times
BRPI0922189A2 (pt) * 2008-12-11 2018-10-23 A P Pharma Inc "métodos para aumentar a estabilidade de poliortoésteres e suas formulações".
US20120207770A1 (en) 2009-10-14 2012-08-16 Nanyang Technological University Antiproliferative agent
EP2343046A1 (en) 2010-01-08 2011-07-13 Nirvana's Tree House B.V. Functionalised triblock copolymers and compositions containing such polymers
US9452037B2 (en) 2010-05-25 2016-09-27 International Scientific Pty Ltd Delivery of oral care products
WO2011156869A1 (en) 2010-06-17 2011-12-22 International Scientific Pty Ltd Delivery of skin care products
CA2827330A1 (en) 2011-02-23 2012-08-30 Ams Research Corporation Pelvic implant and therapeutic agent system and method
AU2012220564A1 (en) 2011-02-23 2013-08-29 Ams Research Corporation Drug releasing pelvic treatment system and method
MX362286B (es) 2011-11-18 2019-01-10 Regeneron Pharma Microparticulas de polimero y proteina.
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
US9849180B2 (en) 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
KR102370470B1 (ko) 2013-03-15 2022-03-04 헤론 테라퓨틱스 인코포레이티드 폴리오르토에스테르 및 비프로톤성 용매의 조성물
EP3509601A1 (en) 2014-04-21 2019-07-17 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
BR112016024665B1 (pt) 2014-04-21 2023-04-11 Heron Therapeutics, Inc Composição, composição semissólida e seu uso
EP3134070B1 (en) 2014-04-21 2020-09-23 Heron Therapeutics, Inc. Compositions of a polyorthoester and an organic acid excipient
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
EP3154552B1 (en) 2014-06-11 2021-03-24 International Scientific Pty Ltd Device and method to treat or prevent joint degeneration
AU2016342374B2 (en) 2015-10-23 2022-08-04 Nortiva Bio, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
SG11201804384UA (en) 2015-12-08 2018-06-28 Lyndra Inc Geometric configurations for gastric residence systems
WO2017106716A1 (en) 2015-12-16 2017-06-22 Regeneron Pharmaceuticals, Inc. Compositions and methods of manufacturing protein microparticles
US12109305B2 (en) 2016-05-27 2024-10-08 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems
EP3518902A4 (en) 2016-09-30 2020-07-08 Lyndra, Inc. GASTRIC RESIDENCE SYSTEMS FOR LONG-TERM ADMINISTRATION OF ADAMANTANE CLASS MEDICINES
PL3615545T3 (pl) 2017-04-24 2022-01-10 Cocrystal Pharma, Inc. Pochodne pirolopirymidyny użyteczne jako inhibitory replikacji wirusa grypy
WO2018227147A1 (en) 2017-06-09 2018-12-13 Lyndra, Inc. Gastric residence systems with release rate-modulating films
SG11201912185XA (en) 2017-06-16 2020-01-30 Avery Therapeutics Inc Three dimensional tissue compositions and methods of use
CA3076330A1 (en) 2017-09-20 2019-03-28 Lyndra, Inc. Encapsulation of gastric residence systems
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US12357631B2 (en) 2018-07-27 2025-07-15 Cocrystal Pharma, Inc. Pyrrolo[2,3-B]pyridin derivatives as inhibitors of influenza virus replication
WO2020055858A1 (en) 2018-09-10 2020-03-19 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication
FI3866778T3 (fi) 2018-10-17 2023-03-21 Cocrystal Pharma Inc Influenssa viruksen replikaation estäjien yhdistelmät
EP3887355A1 (en) 2018-11-26 2021-10-06 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
MY207613A (en) 2019-11-25 2025-03-06 Regeneron Pharma Sustained release formulations using non-aqueous emulsions
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
WO2021188620A1 (en) 2020-03-17 2021-09-23 Cocrystal Pharma Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
AU2021254045A1 (en) 2020-04-10 2022-10-13 Cocrystal Pharma, Inc. Inhibitors of norovirus and coronavirus replication
WO2021211748A1 (en) 2020-04-14 2021-10-21 The Regents Of The University Of California Pan-coronavirus vaccine compositions
IL303027A (en) 2020-11-25 2023-07-01 Regeneron Pharma Sustained release formulations by creating a non-aqueous membrane emulsion
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
IL310394A (en) 2021-08-03 2024-03-01 Cocrystal Pharma Inc Corona virus inhibitors
KR20250174945A (ko) 2023-04-12 2025-12-15 센테니얼 테라퓨틱스, 엘엘씨 케토헥소키나아제 억제를 위한 이치환 피리미딘 화합물
AU2024278772A1 (en) 2023-05-31 2025-11-06 Centennial Therapeutics, Llc Bicyclic compounds for ketohexokinase inhibition
WO2025175208A1 (en) 2024-02-16 2025-08-21 The Regents Of The University Of California Intra-vascular drug delivery device and method for focal drug delivery by vascular perfusion

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2687407A (en) * 1951-07-18 1954-08-24 Dynamit Nobel Ag Production of resins from diallylidene pentaerythritol and a polyhydroxy alcohol
US2909506A (en) * 1956-07-10 1959-10-20 Union Carbide Corp Modified acrolein-pentaerythritol resins
US3087918A (en) * 1957-08-01 1963-04-30 Union Carbide Corp Modified acrolein-pentaerythritol resins
US2957856A (en) * 1958-08-29 1960-10-25 Union Carbide Corp Phosphorus-containing spirobi(metadioxane) resins
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4180646A (en) * 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4066747A (en) * 1976-04-08 1978-01-03 Alza Corporation Polymeric orthoesters housing beneficial drug for controlled release therefrom

Also Published As

Publication number Publication date
AU7175381A (en) 1981-12-07
SE8200068L (sv) 1982-01-08
SE455791B (sv) 1988-08-08
NL8120177A (nl) 1982-04-01
ZA813269B (en) 1982-06-30
BE888829A (fr) 1981-08-28
EP0051667A4 (en) 1982-09-15
JPS60214745A (ja) 1985-10-28
JPH047729B2 (cg-RX-API-DMAC10.html) 1992-02-12
CA1186438A (en) 1985-04-30
JPH0216930B2 (cg-RX-API-DMAC10.html) 1990-04-18
GB2086404A (en) 1982-05-12
NL188166C (nl) 1992-04-16
IE51287B1 (en) 1986-11-26
IE811098L (en) 1981-11-15
EP0051667A1 (en) 1982-05-19
DK16082A (da) 1982-01-15
ATA904081A (de) 1987-05-15
PT73035B (en) 1984-10-22
AT384615B (de) 1987-12-10
PT73035A (en) 1981-06-01
DE3148618A1 (en) 1982-07-15
JPH02218719A (ja) 1990-08-31
EP0051667B1 (en) 1986-03-05
ES8207564A1 (es) 1982-10-01
GR74902B (cg-RX-API-DMAC10.html) 1984-07-12
GB2086404B (en) 1984-06-27
ES502255A0 (es) 1982-10-01
US4304767A (en) 1981-12-08
DE3148618C2 (cg-RX-API-DMAC10.html) 1990-10-18
WO1981003278A1 (en) 1981-11-26
NZ197036A (en) 1984-02-03
JPH03732A (ja) 1991-01-07
JPS60221424A (ja) 1985-11-06
JPH039127B2 (cg-RX-API-DMAC10.html) 1991-02-07
JPS57500613A (cg-RX-API-DMAC10.html) 1982-04-08
CH657369A5 (de) 1986-08-29
AU543991B2 (en) 1985-05-09

Similar Documents

Publication Publication Date Title
JPH0355492B2 (cg-RX-API-DMAC10.html)
US4079038A (en) Poly(carbonates)
US4155992A (en) Pharmaceutical composition of poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality with drug
US5968543A (en) Polymers with controlled physical state and bioerodibility
US4119579A (en) Polymeric orthoesters
US12187844B2 (en) Block copolymers of lactones and poly(propylene fumarate)
DE2602994A1 (de) Orthoesterpolymere und verfahren zu deren herstellung
US7045589B2 (en) Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
EP0869986B1 (en) Polymers with controlled physical state and bioerodibility
JPH0730177B2 (ja) ポリ(オルトカーボネートアセタール)生体分解性ポリマー
US4186185A (en) Compositions comprising arylene substituted poly(orthoesters) containing useful agents
EP0215543A1 (en) A new process for making polyesters, polyamides and polyketones
IT8148606A1 (it) Polimeri di polioli e cheten-acetali aventi una funzionalita' di due o piu' e metodo per produrli