JPH033680B2 - - Google Patents

Info

Publication number
JPH033680B2
JPH033680B2 JP57035998A JP3599882A JPH033680B2 JP H033680 B2 JPH033680 B2 JP H033680B2 JP 57035998 A JP57035998 A JP 57035998A JP 3599882 A JP3599882 A JP 3599882A JP H033680 B2 JPH033680 B2 JP H033680B2
Authority
JP
Japan
Prior art keywords
represents hydrogen
dione
fluorine
methyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57035998A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57159799A (en
Inventor
Anen Kurausu
Raurento Henrii
Hoofumaisutaa Herumuuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS57159799A publication Critical patent/JPS57159799A/ja
Publication of JPH033680B2 publication Critical patent/JPH033680B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
JP57035998A 1981-03-09 1982-03-09 Delta 9(11)- and delta 16-21-chloro-20- ketosteroid of pregnane and d-homo-pregnane series and manufacture Granted JPS57159799A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813109459 DE3109459A1 (de) 1981-03-09 1981-03-09 (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden

Publications (2)

Publication Number Publication Date
JPS57159799A JPS57159799A (en) 1982-10-01
JPH033680B2 true JPH033680B2 (en, 2012) 1991-01-21

Family

ID=6127032

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57035998A Granted JPS57159799A (en) 1981-03-09 1982-03-09 Delta 9(11)- and delta 16-21-chloro-20- ketosteroid of pregnane and d-homo-pregnane series and manufacture

Country Status (4)

Country Link
US (1) US4404141A (en, 2012)
EP (1) EP0061416B1 (en, 2012)
JP (1) JPS57159799A (en, 2012)
DE (2) DE3109459A1 (en, 2012)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123735A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 20-keto-delta-16-steroids and new intermediate compounds formed in this process
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
FR2677029B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
CN103536599A (zh) 2008-05-28 2014-01-29 雷沃根生物医药有限公司 用于治疗疾病的NF-κB的非激素甾体调节剂
CN102272304B (zh) 2009-01-07 2013-10-23 三菱化学株式会社 切断固醇侧链的酶蛋白质及其应用
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
CN101875681B (zh) * 2010-06-22 2012-08-08 浙江工业大学 一种16α-羟基泼尼松龙的合成方法
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
CN113493486B (zh) * 2020-04-02 2024-05-24 河南利华制药有限公司 一种哈西奈德及其中间体的制备方法
CN117229344A (zh) * 2022-06-08 2023-12-15 湖南中南制药有限责任公司 一种哈西奈德的制备方法
CN118420696A (zh) * 2024-04-25 2024-08-02 湖南玉新药业有限公司 一种哈西奈德中间体异构体杂质的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2000229C3 (de) * 1970-01-03 1973-09-20 Syntex Corp., Panama Verfahren zur Herstellung von 9alpha, 1 lbeta Dichlorsteroiden
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
US3892857A (en) * 1972-11-24 1975-07-01 Squibb & Sons Inc Steroid formulation
US4021459A (en) * 1975-08-14 1977-05-03 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes
US4277409A (en) * 1977-03-18 1981-07-07 Roussel Uclaf Preparation of 9α-fluoro-16α-methyl-21-acetoxy-Δ1,4 -pregnadiene-11β-ol-3,20-dione
US4113722A (en) * 1977-11-11 1978-09-12 E. R. Squibb & Sons, Inc. Steroidal[16α,17-b]benzodioxins
US4116978A (en) * 1977-07-20 1978-09-26 E. R. Squibb & Sons, Inc. D-homo oxasteroids
US4265815A (en) * 1980-03-31 1981-05-05 E. R. Squibb & Sons, Inc. 17-(Substituted thio)androst-4-ene[16,17,-b]-[1,4]benzodioxin-3-ones

Also Published As

Publication number Publication date
EP0061416A1 (en) 1982-09-29
DE3267355D1 (en) 1985-12-19
DE3109459A1 (de) 1982-09-23
EP0061416B1 (en) 1985-11-13
JPS57159799A (en) 1982-10-01
US4404141A (en) 1983-09-13

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