DE3267355D1 - Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids - Google Patents
Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoidsInfo
- Publication number
- DE3267355D1 DE3267355D1 DE8282730023T DE3267355T DE3267355D1 DE 3267355 D1 DE3267355 D1 DE 3267355D1 DE 8282730023 T DE8282730023 T DE 8282730023T DE 3267355 T DE3267355 T DE 3267355T DE 3267355 D1 DE3267355 D1 DE 3267355D1
- Authority
- DE
- Germany
- Prior art keywords
- delta
- homopregnane
- pregnane
- intermediates
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE8282730023T DE3267355D1 (en) | 1981-03-09 | 1982-03-05 | Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813109459 DE3109459A1 (de) | 1981-03-09 | 1981-03-09 | (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden |
DE8282730023T DE3267355D1 (en) | 1981-03-09 | 1982-03-05 | Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3267355D1 true DE3267355D1 (en) | 1985-12-19 |
Family
ID=6127032
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19813109459 Withdrawn DE3109459A1 (de) | 1981-03-09 | 1981-03-09 | (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden |
DE8282730023T Expired DE3267355D1 (en) | 1981-03-09 | 1982-03-05 | Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19813109459 Withdrawn DE3109459A1 (de) | 1981-03-09 | 1981-03-09 | (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden |
Country Status (4)
Country | Link |
---|---|
US (1) | US4404141A (de) |
EP (1) | EP0061416B1 (de) |
JP (1) | JPS57159799A (de) |
DE (2) | DE3109459A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0123735A1 (de) * | 1983-04-29 | 1984-11-07 | Gist-Brocades N.V. | Verfahren zur Herstellung von 20-keto-delta-16-Steroiden und in diesem Verfahren erhaltene Zwischenprodukte |
FR2677029B1 (fr) * | 1991-05-23 | 1994-01-21 | Roussel Uclaf | Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one. |
FR2676740B1 (fr) * | 1991-05-23 | 1993-11-05 | Roussel Uclaf | Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires. |
KR101591482B1 (ko) * | 2008-05-28 | 2016-02-03 | 레베라겐 바이오파마 인코포레이티드 | 질환의 치료를 위한 NF-κB 의 비호르몬성 스테로이드 조절제 |
WO2010079594A1 (ja) | 2009-01-07 | 2010-07-15 | 三菱化学株式会社 | ステロール側鎖切断酵素蛋白質およびその利用 |
EP2556083A4 (de) | 2010-04-05 | 2013-12-04 | Validus Biopharma Inc | Nichthormonale steroide modulatoren von nf-kappa-b zur krankheitsbehandlung |
CN101875681B (zh) * | 2010-06-22 | 2012-08-08 | 浙江工业大学 | 一种16α-羟基泼尼松龙的合成方法 |
US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
CN113493486B (zh) * | 2020-04-02 | 2024-05-24 | 河南利华制药有限公司 | 一种哈西奈德及其中间体的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2000229C3 (de) * | 1970-01-03 | 1973-09-20 | Syntex Corp., Panama | Verfahren zur Herstellung von 9alpha, 1 lbeta Dichlorsteroiden |
DE2236115A1 (de) * | 1972-07-20 | 1974-02-07 | Schering Ag | Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden |
US3892857A (en) * | 1972-11-24 | 1975-07-01 | Squibb & Sons Inc | Steroid formulation |
US4021459A (en) * | 1975-08-14 | 1977-05-03 | Schering Corporation | Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes |
US4277409A (en) * | 1977-03-18 | 1981-07-07 | Roussel Uclaf | Preparation of 9α-fluoro-16α-methyl-21-acetoxy-Δ1,4 -pregnadiene-11β-ol-3,20-dione |
US4113722A (en) * | 1977-11-11 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Steroidal[16α,17-b]benzodioxins |
US4116978A (en) * | 1977-07-20 | 1978-09-26 | E. R. Squibb & Sons, Inc. | D-homo oxasteroids |
US4265815A (en) * | 1980-03-31 | 1981-05-05 | E. R. Squibb & Sons, Inc. | 17-(Substituted thio)androst-4-ene[16,17,-b]-[1,4]benzodioxin-3-ones |
-
1981
- 1981-03-09 DE DE19813109459 patent/DE3109459A1/de not_active Withdrawn
-
1982
- 1982-03-05 EP EP82730023A patent/EP0061416B1/de not_active Expired
- 1982-03-05 DE DE8282730023T patent/DE3267355D1/de not_active Expired
- 1982-03-09 JP JP57035998A patent/JPS57159799A/ja active Granted
- 1982-03-09 US US06/356,615 patent/US4404141A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0061416B1 (de) | 1985-11-13 |
JPS57159799A (en) | 1982-10-01 |
JPH033680B2 (de) | 1991-01-21 |
EP0061416A1 (de) | 1982-09-29 |
US4404141A (en) | 1983-09-13 |
DE3109459A1 (de) | 1982-09-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SCHERING AG, 13353 BERLIN, DE |
|
8339 | Ceased/non-payment of the annual fee |