JPH02152963A - ４―フェニル―４―〔ｎ―（フェニル）アミド〕ピペリジン誘導体及びこの誘導体を含む製剤組成物 - Google Patents

４―フェニル―４―〔ｎ―（フェニル）アミド〕ピペリジン誘導体及びこの誘導体を含む製剤組成物

Info

Publication number
JPH02152963A
JPH02152963A JP63278512A JP27851288A JPH02152963A JP H02152963 A JPH02152963 A JP H02152963A JP 63278512 A JP63278512 A JP 63278512A JP 27851288 A JP27851288 A JP 27851288A JP H02152963 A JPH02152963 A JP H02152963A
Authority
JP
Japan
Prior art keywords
phenyl
lower alkyl
pharmaceutically acceptable
ethyl
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63278512A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0552834B2 (en, 2012
Inventor
Linas V Kudzma
リナス　ヴィー　クズマ
H Kenneth Spencer
エイチ　ケニス　スペンサー
Sherry A Severnak
シェリー　エイ　セヴァナク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Messer LLC
Original Assignee
BOC Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOC Group Inc filed Critical BOC Group Inc
Publication of JPH02152963A publication Critical patent/JPH02152963A/ja
Publication of JPH0552834B2 publication Critical patent/JPH0552834B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP63278512A 1987-11-02 1988-11-02 ４―フェニル―４―〔ｎ―（フェニル）アミド〕ピペリジン誘導体及びこの誘導体を含む製剤組成物 Granted JPH02152963A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US115284 1987-11-02
US07/115,284 US4791121A (en) 1987-11-02 1987-11-02 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds

Publications (2)

Publication Number Publication Date
JPH02152963A true JPH02152963A (ja) 1990-06-12
JPH0552834B2 JPH0552834B2 (en, 2012) 1993-08-06

Family

ID=22360366

Family Applications (2)

Application Number Title Priority Date Filing Date
JP63278512A Granted JPH02152963A (ja) 1987-11-02 1988-11-02 ４―フェニル―４―〔ｎ―（フェニル）アミド〕ピペリジン誘導体及びこの誘導体を含む製剤組成物
JP1097244A Pending JPH0215061A (ja) 1987-11-02 1989-04-17 ４―フェニル―４―〔ｎ―（フェニル）アミド〕ピペリジン誘導体及びこの誘導体を含む製剤組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP1097244A Pending JPH0215061A (ja) 1987-11-02 1989-04-17 ４―フェニル―４―〔ｎ―（フェニル）アミド〕ピペリジン誘導体及びこの誘導体を含む製剤組成物

Country Status (16)

Country Link
US (1) US4791121A (en, 2012)
EP (1) EP0315405B1 (en, 2012)
JP (2) JPH02152963A (en, 2012)
KR (1) KR970008313B1 (en, 2012)
CN (1) CN1020723C (en, 2012)
AU (1) AU611728B2 (en, 2012)
CA (1) CA1334416C (en, 2012)
DE (1) DE3854938T2 (en, 2012)
DK (1) DK172787B1 (en, 2012)
ES (1) ES2081810T3 (en, 2012)
FI (1) FI885035A7 (en, 2012)
GR (1) GR3019342T3 (en, 2012)
IL (1) IL88140A0 (en, 2012)
MX (1) MX9203140A (en, 2012)
NO (1) NO172691C (en, 2012)
NZ (1) NZ226634A (en, 2012)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871749A (en) * 1987-12-31 1989-10-03 Boc, Inc. 4-heteropentacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharamaceutical compositions and method employing such compounds
US4868194A (en) * 1988-09-23 1989-09-19 Merrell Dow Pharmaceuticals Inc. Imidazole antiarrhythmics
KR900016129A (ko) * 1989-04-20 1990-11-12 테리 아아르 커세트 4-알콕시알킬-4-아미노페닐피페리딘 및 그들의 유도체의 제조 방법
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
FR2678267B1 (fr) * 1991-06-25 1994-02-04 Elf Sanofi Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2725986B1 (fr) * 1994-10-21 1996-11-29 Adir Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
AR028948A1 (es) * 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
EP1966140A1 (en) * 2005-11-17 2008-09-10 Mallinckrodt, Inc. Process for synthesizing remifentanil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE623427A (en, 2012) * 1961-10-10
US3161637A (en) * 1961-10-10 1964-12-15 Res Lab Dr C Janssen N V 1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4196210A (en) * 1975-09-23 1980-04-01 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne

Also Published As

Publication number Publication date
FI885035L (fi) 1989-05-03
FI885035A7 (fi) 1989-05-03
MX9203140A (es) 1992-07-01
DK607988D0 (da) 1988-11-01
JPH0552834B2 (en, 2012) 1993-08-06
NO884842L (no) 1989-05-03
NO172691C (no) 1993-08-25
AU2455888A (en) 1989-05-04
DE3854938D1 (de) 1996-03-07
KR890008094A (ko) 1989-07-08
ES2081810T3 (es) 1996-03-16
DK172787B1 (da) 1999-07-19
GR3019342T3 (en) 1996-06-30
CN1020723C (zh) 1993-05-19
CA1334416C (en) 1995-02-14
IL88140A0 (en) 1989-06-30
JPH0215061A (ja) 1990-01-18
EP0315405B1 (en) 1996-01-24
NZ226634A (en) 1990-07-26
US4791121A (en) 1988-12-13
CN1041585A (zh) 1990-04-25
DK607988A (da) 1989-05-03
FI885035A0 (fi) 1988-11-01
NO172691B (no) 1993-05-18
NO884842D0 (no) 1988-10-31
KR970008313B1 (ko) 1997-05-23
DE3854938T2 (de) 1996-05-30
EP0315405A1 (en) 1989-05-10
AU611728B2 (en) 1991-06-20

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees