GR3019342T3 - 4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives - Google Patents

4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives

Info

Publication number
GR3019342T3
GR3019342T3 GR960400737T GR960400737T GR3019342T3 GR 3019342 T3 GR3019342 T3 GR 3019342T3 GR 960400737 T GR960400737 T GR 960400737T GR 960400737 T GR960400737 T GR 960400737T GR 3019342 T3 GR3019342 T3 GR 3019342T3
Authority
GR
Greece
Prior art keywords
amido
fluorophenyl
phenyl
piperidine derivatives
piperidine
Prior art date
Application number
GR960400737T
Other languages
English (en)
Inventor
Linas V Kudzma
H Kenneth Spencer
Sherry A Severnak
Original Assignee
Ohmeda Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohmeda Pharma Prod filed Critical Ohmeda Pharma Prod
Publication of GR3019342T3 publication Critical patent/GR3019342T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
GR960400737T 1987-11-02 1996-03-19 4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives GR3019342T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/115,284 US4791121A (en) 1987-11-02 1987-11-02 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds

Publications (1)

Publication Number Publication Date
GR3019342T3 true GR3019342T3 (en) 1996-06-30

Family

ID=22360366

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960400737T GR3019342T3 (en) 1987-11-02 1996-03-19 4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives

Country Status (16)

Country Link
US (1) US4791121A (el)
EP (1) EP0315405B1 (el)
JP (2) JPH02152963A (el)
KR (1) KR970008313B1 (el)
CN (1) CN1020723C (el)
AU (1) AU611728B2 (el)
CA (1) CA1334416C (el)
DE (1) DE3854938T2 (el)
DK (1) DK172787B1 (el)
ES (1) ES2081810T3 (el)
FI (1) FI885035A (el)
GR (1) GR3019342T3 (el)
IL (1) IL88140A0 (el)
MX (1) MX9203140A (el)
NO (1) NO172691C (el)
NZ (1) NZ226634A (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871749A (en) * 1987-12-31 1989-10-03 Boc, Inc. 4-heteropentacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharamaceutical compositions and method employing such compounds
US4868194A (en) * 1988-09-23 1989-09-19 Merrell Dow Pharmaceuticals Inc. Imidazole antiarrhythmics
KR900016129A (ko) * 1989-04-20 1990-11-12 테리 아아르 커세트 4-알콕시알킬-4-아미노페닐피페리딘 및 그들의 유도체의 제조 방법
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
FR2678267B1 (fr) * 1991-06-25 1994-02-04 Elf Sanofi Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2725986B1 (fr) * 1994-10-21 1996-11-29 Adir Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
WO2007061555A1 (en) * 2005-11-17 2007-05-31 Mallinckrodt Inc. Process for synthesizing remifentanil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161637A (en) * 1961-10-10 1964-12-15 Res Lab Dr C Janssen N V 1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds
NL284196A (el) * 1961-10-10
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4196210A (en) * 1975-09-23 1980-04-01 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne

Also Published As

Publication number Publication date
IL88140A0 (en) 1989-06-30
CN1041585A (zh) 1990-04-25
NZ226634A (en) 1990-07-26
CN1020723C (zh) 1993-05-19
NO172691B (no) 1993-05-18
KR890008094A (ko) 1989-07-08
FI885035A0 (fi) 1988-11-01
EP0315405A1 (en) 1989-05-10
DK607988A (da) 1989-05-03
DE3854938D1 (de) 1996-03-07
NO172691C (no) 1993-08-25
JPH0552834B2 (el) 1993-08-06
DK607988D0 (da) 1988-11-01
US4791121A (en) 1988-12-13
AU611728B2 (en) 1991-06-20
JPH02152963A (ja) 1990-06-12
MX9203140A (es) 1992-07-01
JPH0215061A (ja) 1990-01-18
CA1334416C (en) 1995-02-14
EP0315405B1 (en) 1996-01-24
KR970008313B1 (ko) 1997-05-23
DE3854938T2 (de) 1996-05-30
NO884842D0 (no) 1988-10-31
DK172787B1 (da) 1999-07-19
NO884842L (no) 1989-05-03
AU2455888A (en) 1989-05-04
ES2081810T3 (es) 1996-03-16
FI885035A (fi) 1989-05-03

Similar Documents

Publication Publication Date Title
PH25048A (en) N-substituted benzamides
EP0277794A3 (en) N-heterocyclic-n-(4-piperidyl) amides
EP0289919A3 (en) N-substituted azoles
DK475286A (da) N-substituerede piperidiner
GR3019342T3 (en) 4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives
ZA865484B (en) Novel n-(2-fluorophenyl)-azolidines
IL88645A0 (en) 4-heteropentacyclyl-4-(n-(phenyl)amido)-piperidine derivatives and pharmaceutical compositions containing them
ZA872429B (en) N-substituted benzamides
GB2163158B (en) N-substituted tetra-alkyl piperidines
ZA875491B (en) N-(2-cyano-2-oximinoacetyl)-aminonitriles
ZA888444B (en) N-substituted dichloromaleimides
DK432689A (da) Lactamderivater
DK490188A (da) Lactamderivater
DK288988A (da) Amider
DK432789D0 (da) Lactamderivater
DK432889A (da) Lactamderivater
GB8709447D0 (en) Dihydropyridines
HK1000211A1 (en) N-substituted hindered amine stabilizers
ZA887006B (en) N-substituted hindered amine stabilizers
SE8406185D0 (sv) Novel n-substituted dihydropyridines
ZA892948B (en) N-substituted n-amino-pyrroles
GB2143236B (en) Triacetonamine hydrochloride
PH25118A (en) Cyclic amine derivatives
ATA239689A (de) Neue n-substituierte piperidin- oder 3-pyrrolidinderivate
ATE88702T1 (de) P-phenoxy-phenoxymethyl-fuenfring-heteroaromaten