JPH0144714B2 - - Google Patents

Info

Publication number
JPH0144714B2
JPH0144714B2 JP54136824A JP13682479A JPH0144714B2 JP H0144714 B2 JPH0144714 B2 JP H0144714B2 JP 54136824 A JP54136824 A JP 54136824A JP 13682479 A JP13682479 A JP 13682479A JP H0144714 B2 JPH0144714 B2 JP H0144714B2
Authority
JP
Japan
Prior art keywords
group
carbonyloxymethyl
carboxylic acid
methyl
piperazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54136824A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5559195A (en
Inventor
Ikuo Ueda
Masakazu Kobayashi
Choji Yamada
Hiroki Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS5559195A publication Critical patent/JPS5559195A/ja
Publication of JPH0144714B2 publication Critical patent/JPH0144714B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP13682479A 1978-10-24 1979-10-22 3,7-disubstituted-2 or 3-cephem-4-carboxylic acid compound or its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents Granted JPS5559195A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7841754 1978-10-24

Publications (2)

Publication Number Publication Date
JPS5559195A JPS5559195A (en) 1980-05-02
JPH0144714B2 true JPH0144714B2 (en, 2012) 1989-09-29

Family

ID=10500550

Family Applications (2)

Application Number Title Priority Date Filing Date
JP13682479A Granted JPS5559195A (en) 1978-10-24 1979-10-22 3,7-disubstituted-2 or 3-cephem-4-carboxylic acid compound or its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
JP63196258A Granted JPS6479188A (en) 1978-10-24 1988-08-05 3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP63196258A Granted JPS6479188A (en) 1978-10-24 1988-08-05 3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof

Country Status (5)

Country Link
US (2) US4327093A (en, 2012)
EP (1) EP0010313B1 (en, 2012)
JP (2) JPS5559195A (en, 2012)
AT (1) ATE2330T1 (en, 2012)
DE (1) DE2964634D1 (en, 2012)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
IL99898A (en) * 1990-11-09 1996-10-31 Eisai Co Ltd 7-Acyl-3-substituted carbamoyloxy cephem compounds their preparation and antibacterial compositions containing them
JPH05230068A (ja) * 1992-02-07 1993-09-07 Kyoto Yakuhin Kogyo Kk ３−ジ置換カルバモイルオキシメチルセファロスポリン化合物、その製造法および中間体化合物
SI3616695T1 (sl) 2011-09-09 2025-01-31 Merck Sharp & Dohme Llc Ceftolozan/tazobaktam za zdravljenje intrapulmonalnih okužb
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274997A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
MX387913B (es) 2013-03-15 2025-03-19 Merck Sharp & Dohme Llc Composiciones antibioticas de ceftolozano
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
BR112022010382A2 (pt) * 2019-11-29 2022-08-16 Molsid Substrato de beta-lactamase fluorogênica e método de detecção associado

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36281A (en) 1970-03-13 1977-04-29 Merck & Co Inc Cephalosporin derivatives antibiotic mixtures containing them and process for their preparation
SE376250B (en, 2012) 1970-05-05 1975-05-12 Basf Ag
US3966717A (en) * 1971-05-14 1976-06-29 Glaxo Laboratories Limited 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
NL178005C (nl) * 1972-11-06 1986-01-02 Merck & Co Inc Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum.
SE7503274L (sv) * 1974-04-11 1975-10-13 Ciba Geigy Ag Cefalosporin
US4011215A (en) * 1974-08-15 1977-03-08 Glaxo Laboratories Limited 3-Chloroalkylcarbamoyloxymethyl-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acids and physiologically acceptable salts or oxides thereof
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2619243C2 (de) * 1975-05-06 1985-07-04 Takeda Chemical Industries, Ltd., Osaka Verfahren zur Herstellung von 3-Acyloxymethyl-cephem-Verbindungen
JPS5278891A (en) * 1975-12-24 1977-07-02 Asahi Chem Ind Co Ltd Synthesis of cephalosporin antibiotics
US4061630A (en) * 1976-02-20 1977-12-06 Eli Lilly And Company 7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiotics
JPS52125188A (en) * 1976-04-14 1977-10-20 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
US4292427A (en) * 1976-11-17 1981-09-29 Merck & Co., Inc. Cephalosporin compounds
PT69450A (en) * 1978-04-07 1979-05-01 Glaxo Group Ltd Improvements in or relating to cephalosporin compounds
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds

Also Published As

Publication number Publication date
JPS6479188A (en) 1989-03-24
EP0010313A1 (en) 1980-04-30
US4399278A (en) 1983-08-16
JPH0369354B2 (en, 2012) 1991-10-31
DE2964634D1 (en) 1983-03-03
US4327093A (en) 1982-04-27
ATE2330T1 (de) 1983-02-15
JPS5559195A (en) 1980-05-02
EP0010313B1 (en) 1983-01-26

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