JPH0124767B2 - - Google Patents
Info
- Publication number
- JPH0124767B2 JPH0124767B2 JP7517779A JP7517779A JPH0124767B2 JP H0124767 B2 JPH0124767 B2 JP H0124767B2 JP 7517779 A JP7517779 A JP 7517779A JP 7517779 A JP7517779 A JP 7517779A JP H0124767 B2 JPH0124767 B2 JP H0124767B2
- Authority
- JP
- Japan
- Prior art keywords
- peak
- water
- compound
- absorption
- shows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920000642 polymer Polymers 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 21
- 238000010521 absorption reaction Methods 0.000 claims description 15
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims description 10
- 238000001228 spectrum Methods 0.000 claims description 10
- 229910052732 germanium Inorganic materials 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000004455 differential thermal analysis Methods 0.000 claims description 8
- 206010020772 Hypertension Diseases 0.000 claims description 7
- 238000001237 Raman spectrum Methods 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 230000003595 spectral effect Effects 0.000 claims description 5
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 claims description 4
- 230000001631 hypertensive effect Effects 0.000 claims description 4
- 230000000704 physical effect Effects 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229940119177 germanium dioxide Drugs 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000013078 crystal Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 150000002291 germanium compounds Chemical class 0.000 description 7
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 7
- 238000000862 absorption spectrum Methods 0.000 description 6
- 206010003119 arrhythmia Diseases 0.000 description 6
- 230000006793 arrhythmia Effects 0.000 description 6
- 206010002383 Angina Pectoris Diseases 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000282414 Homo sapiens Species 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- NLIJOIUVZBYQRS-UHFFFAOYSA-N 3-trichlorogermylpropanoic acid Chemical compound OC(=O)CC[Ge](Cl)(Cl)Cl NLIJOIUVZBYQRS-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 208000005053 encephalomalacia Diseases 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- -1 organogermanium compound Chemical class 0.000 description 1
- 125000000082 organogermanium group Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7517779A JPS55167222A (en) | 1979-06-16 | 1979-06-16 | Drug for warm-blooded animal comprising organogermanium polymer as main constituent |
| AU59304/80A AU533001B2 (en) | 1979-06-16 | 1980-06-13 | Germanium-containing organic polymers and pharmaceutical preparation containing same |
| CA000354057A CA1162546A (en) | 1979-06-16 | 1980-06-16 | Medicine effective for warmblooded animals comprising, as an essential ingredient, a germanium- containing organic polymer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7517779A JPS55167222A (en) | 1979-06-16 | 1979-06-16 | Drug for warm-blooded animal comprising organogermanium polymer as main constituent |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1295983A Division JPS5916829A (ja) | 1983-01-31 | 1983-01-31 | 有機ゲルマニウム重合体を主剤としたウイルス用薬剤 |
| JP1296183A Division JPS5916825A (ja) | 1983-01-31 | 1983-01-31 | 有機ゲルマニウム重合体を主剤とする癌用薬剤 |
| JP1296083A Division JPS5916824A (ja) | 1983-01-31 | 1983-01-31 | 有機ゲルマニウム重合体を主剤とした白内障用薬剤 |
| JP1296283A Division JPS5916826A (ja) | 1983-01-31 | 1983-01-31 | 有機ゲルマニウム重合体を主剤とした慢性呼吸器疾患用薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55167222A JPS55167222A (en) | 1980-12-26 |
| JPH0124767B2 true JPH0124767B2 (enrdf_load_stackoverflow) | 1989-05-15 |
Family
ID=13568655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7517779A Granted JPS55167222A (en) | 1979-06-16 | 1979-06-16 | Drug for warm-blooded animal comprising organogermanium polymer as main constituent |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS55167222A (enrdf_load_stackoverflow) |
| AU (1) | AU533001B2 (enrdf_load_stackoverflow) |
| CA (1) | CA1162546A (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260056A (en) * | 1988-11-15 | 1993-11-09 | Sanwa Kagaku Kenkyusho Co. Ltd. | Composition for enhancing biosynthesis of interferon |
| AU635045B2 (en) * | 1989-07-20 | 1993-03-11 | Asai Germanium Research Institute Co., Ltd | Agent for preventing and treating opacity of lens |
| JP4620169B1 (ja) | 2010-01-28 | 2011-01-26 | 株式会社三和化学研究所 | 有機酸重合体を有効成分とするクローン病の予防又は治療剤 |
| JPWO2015020040A1 (ja) | 2013-08-06 | 2017-03-02 | 国立大学法人九州大学 | 有機酸重合体を有効成分とする癌細胞の生着予防又は生着抑制のための医薬 |
-
1979
- 1979-06-16 JP JP7517779A patent/JPS55167222A/ja active Granted
-
1980
- 1980-06-13 AU AU59304/80A patent/AU533001B2/en not_active Ceased
- 1980-06-16 CA CA000354057A patent/CA1162546A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU533001B2 (en) | 1983-10-27 |
| JPS55167222A (en) | 1980-12-26 |
| AU5930480A (en) | 1981-01-08 |
| CA1162546A (en) | 1984-02-21 |
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