JPH01166763A

JPH01166763A - 医科用および歯科用硬化性材料

医科用および歯科用硬化性材料

Info

Publication number: JPH01166763A
Authority: JP; Japan
Prior art keywords: collagen; calcium phosphate; powder; curing; tcp
Prior art date: 1987-12-22
Legal status : Granted

Application number

JP62326077A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0331470B2 (sv

Inventor

Hiroyasu Onishi

大西　啓靖

Takashi Ishii

孝石井

Gino Suzuki

鈴木　銀男

Current Assignee

Nitta Gelatin Inc

Original Assignee

Nitta Gelatin Inc

Priority date

1987-12-22

Filing date

1987-12-22

Publication date

1989-06-30

1987-12-22 Application filed by Nitta Gelatin Inc filed Critical Nitta Gelatin Inc

1987-12-22 Priority to JP62326077A priority Critical patent/JPH01166763A/ja

1989-06-30 Publication of JPH01166763A publication Critical patent/JPH01166763A/ja

1991-05-07 Publication of JPH0331470B2 publication Critical patent/JPH0331470B2/ja

Status Granted legal-status Critical Current

Links

239000000463 material Substances 0.000 title claims abstract description 50
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 65
108010035532 Collagen Proteins 0.000 claims abstract description 59
102000008186 Collagen Human genes 0.000 claims abstract description 59
229920001436 collagen Polymers 0.000 claims abstract description 59
239000000843 powder Substances 0.000 claims abstract description 54
239000001506 calcium phosphate Substances 0.000 claims abstract description 37
235000011010 calcium phosphates Nutrition 0.000 claims abstract description 37
229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 36
229920001864 tannin Polymers 0.000 claims abstract description 21
239000001648 tannin Substances 0.000 claims abstract description 21
235000018553 tannin Nutrition 0.000 claims abstract description 21
238000004898 kneading Methods 0.000 abstract description 21
239000000126 substance Substances 0.000 abstract description 9
229910052588 hydroxylapatite Inorganic materials 0.000 abstract description 4
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract description 4
LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 48
TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 46
239000001263 FEMA 3042 Substances 0.000 description 46
LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 46
150000007524 organic acids Chemical class 0.000 description 46
235000015523 tannic acid Nutrition 0.000 description 46
229920002258 tannic acid Polymers 0.000 description 46
229940033123 tannic acid Drugs 0.000 description 46
239000000243 solution Substances 0.000 description 38
239000000047 product Substances 0.000 description 20
230000036760 body temperature Effects 0.000 description 13
210000000988 bone and bone Anatomy 0.000 description 13
239000003795 chemical substances by application Substances 0.000 description 10
239000002639 bone cement Substances 0.000 description 9
239000013522 chelant Substances 0.000 description 9
238000006243 chemical reaction Methods 0.000 description 8
230000000052 comparative effect Effects 0.000 description 8
230000000694 effects Effects 0.000 description 8
235000005985 organic acids Nutrition 0.000 description 8
238000005259 measurement Methods 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
239000007788 liquid Substances 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
238000000862 absorption spectrum Methods 0.000 description 5
238000004458 analytical method Methods 0.000 description 5
239000011575 calcium Substances 0.000 description 5
238000000634 powder X-ray diffraction Methods 0.000 description 5
238000004626 scanning electron microscopy Methods 0.000 description 5
238000012360 testing method Methods 0.000 description 5
239000007864 aqueous solution Substances 0.000 description 4
239000003479 dental cement Substances 0.000 description 4
239000002631 root canal filling material Substances 0.000 description 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
238000011049 filling Methods 0.000 description 3
238000006703 hydration reaction Methods 0.000 description 3
238000002156 mixing Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
238000006386 neutralization reaction Methods 0.000 description 3
239000002245 particle Substances 0.000 description 3
235000019731 tricalcium phosphate Nutrition 0.000 description 3
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
102100034112 Alkyldihydroxyacetonephosphate synthase, peroxisomal Human genes 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
101000799143 Homo sapiens Alkyldihydroxyacetonephosphate synthase, peroxisomal Proteins 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
229920002125 Sokalan® Polymers 0.000 description 2
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
238000000848 angular dependent Auger electron spectroscopy Methods 0.000 description 2
229910052586 apatite Inorganic materials 0.000 description 2
108010045569 atelocollagen Proteins 0.000 description 2
210000002449 bone cell Anatomy 0.000 description 2
230000002308 calcification Effects 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
239000001630 malic acid Substances 0.000 description 2
235000011090 malic acid Nutrition 0.000 description 2
238000000034 method Methods 0.000 description 2
210000000214 mouth Anatomy 0.000 description 2
230000017074 necrotic cell death Effects 0.000 description 2
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
239000004584 polyacrylic acid Substances 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
238000002054 transplantation Methods 0.000 description 2
RBNPOMFGQQGHHO-UHFFFAOYSA-N -2,3-Dihydroxypropanoic acid Natural products OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
239000012620 biological material Substances 0.000 description 1
XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
239000004927 clay Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000002131 composite material Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000007547 defect Effects 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
239000005548 dental material Substances 0.000 description 1
235000019700 dicalcium phosphate Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000004821 effect on bone Effects 0.000 description 1
238000010828 elution Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
238000010304 firing Methods 0.000 description 1
230000035876 healing Effects 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000010354 integration Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000011164 ossification Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000010298 pulverizing process Methods 0.000 description 1
238000013102 re-test Methods 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1