JP7808963B2 - ＨＩＦ－２アルファ（ＥＰＡＳ１）の発現を阻害するためのＲＮＡｉ剤、その組成物及び使用方法 - Google Patents

ＨＩＦ－２アルファ（ＥＰＡＳ１）の発現を阻害するためのＲＮＡｉ剤、その組成物及び使用方法

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JP7808963B2
JP7808963B2 JP2021540037A JP2021540037A JP7808963B2 JP 7808963 B2 JP7808963 B2 JP 7808963B2 JP 2021540037 A JP2021540037 A JP 2021540037A JP 2021540037 A JP2021540037 A JP 2021540037A JP 7808963 B2 JP7808963 B2 JP 7808963B2
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hif
rnai agent
nucleotide
nucleotides
antisense strand
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JP2022518384A5 (https=
JPWO2020146521A5 (https=
JP2022518384A (ja
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リー チェン
シュー トンシュイ
ニコラス アントニー
チュー ルイ
カールソン ジェフリー
ワン ソ
リー シアオカイ
アルテンホーファー エーリヒ
ファウラー－ワッターズ マシュー
チェン ポー
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アローヘッド ファーマシューティカルズ インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A01K2207/12—Animals modified by administration of exogenous cells
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2021540037A 2019-01-09 2020-01-08 ＨＩＦ－２アルファ（ＥＰＡＳ１）の発現を阻害するためのＲＮＡｉ剤、その組成物及び使用方法 Active JP7808963B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962790360P 2019-01-09 2019-01-09
US62/790,360 2019-01-09
US201962827564P 2019-04-01 2019-04-01
US62/827,564 2019-04-01
US201962839381P 2019-04-26 2019-04-26
US62/839,381 2019-04-26
PCT/US2020/012775 WO2020146521A2 (en) 2019-01-09 2020-01-08 Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use

Publications (4)

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JP2022518384A JP2022518384A (ja) 2022-03-15
JP2022518384A5 JP2022518384A5 (https=) 2023-01-20
JPWO2020146521A5 JPWO2020146521A5 (https=) 2023-01-20
JP7808963B2 true JP7808963B2 (ja) 2026-01-30

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US (1) US12221610B2 (https=)
EP (1) EP3908288A4 (https=)
JP (1) JP7808963B2 (https=)
KR (1) KR20210113273A (https=)
CN (1) CN113613661B (https=)
AU (1) AU2020207050A1 (https=)
BR (1) BR112021013362A2 (https=)
CA (1) CA3120580A1 (https=)
IL (1) IL284696A (https=)
MX (1) MX2021008261A (https=)
SG (1) SG11202105577TA (https=)
TW (1) TW202043470A (https=)
UY (1) UY38539A (https=)
WO (1) WO2020146521A2 (https=)

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CN114053426B (zh) * 2020-07-30 2024-06-18 成都科岭源医药技术有限公司 一种双药链接组装单元及双药靶向接头-药物偶联物
CN116323633A (zh) * 2020-09-11 2023-06-23 箭头药业股份有限公司 骨骼肌递送平台及使用方法
WO2022086882A1 (en) 2020-10-21 2022-04-28 Nikang Therapeutics, Inc. Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor
CN115105607B (zh) * 2021-03-22 2024-12-20 成都科岭源医药技术有限公司 一种用于adc的双药-接头的制备方法及其用途
CN113304274B (zh) * 2021-04-23 2025-03-04 天津全和诚生物技术有限公司 缀合物及其制备方法和用途
US20250003952A1 (en) * 2021-09-07 2025-01-02 Kyoto University Senolytic drug screening method and senolytic drug

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JP2018516595A (ja) 2015-05-29 2018-06-28 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｈｉｆ２αの遺伝子発現を阻害する組成物及び方法

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