CN113613661B - 用于抑制HIF-2α(EPAS1)的表达的RNAi试剂、其组合物和使用方法 - Google Patents

用于抑制HIF-2α(EPAS1)的表达的RNAi试剂、其组合物和使用方法

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Publication number
CN113613661B
CN113613661B CN202080008795.4A CN202080008795A CN113613661B CN 113613661 B CN113613661 B CN 113613661B CN 202080008795 A CN202080008795 A CN 202080008795A CN 113613661 B CN113613661 B CN 113613661B
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China
Prior art keywords
hif
rnai agent
certain embodiments
sense strand
targeting
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CN202080008795.4A
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Chinese (zh)
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CN113613661A (zh
Inventor
李珍
舒东旭
A·尼古拉斯
朱锐
J·卡尔森
S·黃
李晓恺
E·阿尔滕霍费尔
M·福勒-沃特斯
陈波
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Arrowhead Pharmaceuticals Inc
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Arrowhead Pharmaceuticals Inc
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CN202080008795.4A 2019-01-09 2020-01-08 用于抑制HIF-2α(EPAS1)的表达的RNAi试剂、其组合物和使用方法 Active CN113613661B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962790360P 2019-01-09 2019-01-09
US62/790360 2019-01-09
US201962827564P 2019-04-01 2019-04-01
US62/827564 2019-04-01
US201962839381P 2019-04-26 2019-04-26
US62/839381 2019-04-26
PCT/US2020/012775 WO2020146521A2 (en) 2019-01-09 2020-01-08 Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use

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Publication Number Publication Date
CN113613661A CN113613661A (zh) 2021-11-05
CN113613661B true CN113613661B (zh) 2025-11-14

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US (1) US12221610B2 (https=)
EP (1) EP3908288A4 (https=)
JP (1) JP7808963B2 (https=)
KR (1) KR20210113273A (https=)
CN (1) CN113613661B (https=)
AU (1) AU2020207050A1 (https=)
BR (1) BR112021013362A2 (https=)
CA (1) CA3120580A1 (https=)
IL (1) IL284696A (https=)
MX (1) MX2021008261A (https=)
SG (1) SG11202105577TA (https=)
TW (1) TW202043470A (https=)
UY (1) UY38539A (https=)
WO (1) WO2020146521A2 (https=)

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CN116323633A (zh) * 2020-09-11 2023-06-23 箭头药业股份有限公司 骨骼肌递送平台及使用方法
WO2022086882A1 (en) 2020-10-21 2022-04-28 Nikang Therapeutics, Inc. Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor
CN115105607B (zh) * 2021-03-22 2024-12-20 成都科岭源医药技术有限公司 一种用于adc的双药-接头的制备方法及其用途
CN113304274B (zh) * 2021-04-23 2025-03-04 天津全和诚生物技术有限公司 缀合物及其制备方法和用途
US20250003952A1 (en) * 2021-09-07 2025-01-02 Kyoto University Senolytic drug screening method and senolytic drug

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