JP7783746B2 - 操作されたｉＰＳＣおよび免疫エフェクター細胞におけるＣＤ３の再構成 - Google Patents

操作されたｉＰＳＣおよび免疫エフェクター細胞におけるＣＤ３の再構成

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Publication number
JP7783746B2
JP7783746B2 JP2021560206A JP2021560206A JP7783746B2 JP 7783746 B2 JP7783746 B2 JP 7783746B2 JP 2021560206 A JP2021560206 A JP 2021560206A JP 2021560206 A JP2021560206 A JP 2021560206A JP 7783746 B2 JP7783746 B2 JP 7783746B2
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cells
cell
tcr
tgcd3
receptor
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JPWO2020210398A5 (https=
JP2022527405A (ja
JP2022527405A5 (https=
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バラマール，バーラム
リー，トム，トング
ウイッティ，アレック
プリバディ，モフタル
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フェイト セラピューティクス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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JP2021560206A 2019-04-11 2020-04-08 操作されたｉＰＳＣおよび免疫エフェクター細胞におけるＣＤ３の再構成 Active JP7783746B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962832622P 2019-04-11 2019-04-11
US62/832,622 2019-04-11
PCT/US2020/027327 WO2020210398A1 (en) 2019-04-11 2020-04-08 CD3 RECONSTITUTION IN ENGINEERED iPSC AND IMMUNE EFFECTOR CELLS

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JP2022527405A JP2022527405A (ja) 2022-06-01
JPWO2020210398A5 JPWO2020210398A5 (https=) 2023-04-18
JP2022527405A5 JP2022527405A5 (https=) 2023-04-18
JP7783746B2 true JP7783746B2 (ja) 2025-12-10

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US (1) US20220184142A1 (https=)
EP (1) EP3953453A4 (https=)
JP (1) JP7783746B2 (https=)
KR (1) KR20210139472A (https=)
CN (1) CN113906133A (https=)
AU (1) AU2020271523A1 (https=)
BR (1) BR112021019772A2 (https=)
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MX (1) MX2021012054A (https=)
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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
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