BR112021019772A2 - Reconstituição de cd3 em células efetoras imunes e ipsc geneticamente modificadas - Google Patents

Reconstituição de cd3 em células efetoras imunes e ipsc geneticamente modificadas

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Publication number
BR112021019772A2
BR112021019772A2 BR112021019772A BR112021019772A BR112021019772A2 BR 112021019772 A2 BR112021019772 A2 BR 112021019772A2 BR 112021019772 A BR112021019772 A BR 112021019772A BR 112021019772 A BR112021019772 A BR 112021019772A BR 112021019772 A2 BR112021019772 A2 BR 112021019772A2
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BR
Brazil
Prior art keywords
effector cells
ipsc
genetically modified
reconstitution
enhanced
Prior art date
Application number
BR112021019772A
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English (en)
Inventor
Alec Witty
Bahram Valamehr
Mochtar Pribadi
Tong Lee Tom
Original Assignee
Fate Therapeutics Inc
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Publication date
Application filed by Fate Therapeutics Inc filed Critical Fate Therapeutics Inc
Publication of BR112021019772A2 publication Critical patent/BR112021019772A2/pt

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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

reconstituição de cd3 em células efetoras imunes e ipsc geneticamente modificadas. trata-se de métodos e composições para a obtenção de células efetoras derivadas funcionalmente aprimoradas obtidas a partir da diferenciação alvejada de ipscs geneticamente modificadas por genoma. as células derivadas de ipsc fornecidas no presente documento têm edição de genoma estável e funcional que entrega efeitos terapêuticos melhorados ou aprimorados. também são fornecidas composições terapêuticas e o uso das mesmas que compreendem as células efetoras derivadas funcionalmente aprimoradas sozinhas ou com anticorpos ou inibidores de via de sinalização em terapias de combinação.
BR112021019772A 2019-04-11 2020-04-08 Reconstituição de cd3 em células efetoras imunes e ipsc geneticamente modificadas BR112021019772A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962832622P 2019-04-11 2019-04-11
PCT/US2020/027327 WO2020210398A1 (en) 2019-04-11 2020-04-08 CD3 RECONSTITUTION IN ENGINEERED iPSC AND IMMUNE EFFECTOR CELLS

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BR112021019772A2 true BR112021019772A2 (pt) 2022-01-04

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US (1) US20220184142A1 (pt)
EP (1) EP3953453A4 (pt)
JP (1) JP2022527405A (pt)
KR (1) KR20210139472A (pt)
CN (1) CN113906133A (pt)
AU (1) AU2020271523A1 (pt)
BR (1) BR112021019772A2 (pt)
CA (1) CA3135224A1 (pt)
IL (1) IL286858A (pt)
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WO (1) WO2020210398A1 (pt)

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CN114525259A (zh) * 2020-11-03 2022-05-24 南京北恒生物科技有限公司 靶向cd7的嵌合抗原受体及其用途
AU2021376382A1 (en) * 2020-11-04 2023-06-15 Fate Therapeutics, Inc. Multiplexed engineered ipsc and immune effector cells targeting solid tumors
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス，インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
EP4284918A1 (en) * 2021-01-29 2023-12-06 Allogene Therapeutics, Inc. Knockdown or knockout of one or more of tap2, nlrc5, beta2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products
CN113528453B (zh) * 2021-07-07 2023-05-12 金宇保灵生物药品有限公司 一种永生化猪巨噬细胞株及其构建方法和应用
GB202110363D0 (en) * 2021-07-19 2021-09-01 Celyad S A NKG2D CAR cells expressing IL-18 for adoptive cell therapy
WO2023233342A2 (en) * 2022-06-01 2023-12-07 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2024047561A1 (en) * 2022-09-02 2024-03-07 Janssen Biotech, Inc. Biomaterials and processes for immune synapse modulation of hypoimmunogenicity

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CA2945393C (en) * 2014-04-24 2021-03-23 Board Of Regents, The University Of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
JP6928604B2 (ja) * 2015-11-04 2021-09-01 フェイト セラピューティクス，インコーポレイテッド 万能性細胞のゲノム改変
EP4180519A1 (en) * 2016-04-15 2023-05-17 Memorial Sloan Kettering Cancer Center Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
EP3559214A1 (en) * 2016-12-21 2019-10-30 UCL Business PLC Therapeutic cells
CN111556892A (zh) * 2017-12-08 2020-08-18 菲特治疗公司 使用增强的iPSC衍生的效应细胞的免疫疗法

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EP3953453A1 (en) 2022-02-16
EP3953453A4 (en) 2022-12-28
IL286858A (en) 2021-12-01
US20220184142A1 (en) 2022-06-16
CN113906133A (zh) 2022-01-07
KR20210139472A (ko) 2021-11-22
SG11202110601UA (en) 2021-10-28
WO2020210398A1 (en) 2020-10-15
CA3135224A1 (en) 2020-10-15
AU2020271523A1 (en) 2021-10-14
MX2021012054A (es) 2022-01-18

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