BR112022000641A2 - Modificação genética de célula efetora imune e uso da mesma - Google Patents

Modificação genética de célula efetora imune e uso da mesma

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Publication number
BR112022000641A2
BR112022000641A2 BR112022000641A BR112022000641A BR112022000641A2 BR 112022000641 A2 BR112022000641 A2 BR 112022000641A2 BR 112022000641 A BR112022000641 A BR 112022000641A BR 112022000641 A BR112022000641 A BR 112022000641A BR 112022000641 A2 BR112022000641 A2 BR 112022000641A2
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Brazil
Prior art keywords
genetic modification
enhanced
immune effector
effector cell
derivative
Prior art date
Application number
BR112022000641A
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English (en)
Inventor
Bahram Valamehr
Jode Goodridge
Ryan Bjordahl
Tong Lee Tom
Original Assignee
Fate Therapeutics Inc
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Publication date
Application filed by Fate Therapeutics Inc filed Critical Fate Therapeutics Inc
Publication of BR112022000641A2 publication Critical patent/BR112022000641A2/pt

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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Abstract

modificação genética de célula efetora imune e uso da mesma. trata se de métodos e composições para obtenção de células efetoras derivativas funcionalmente aprimoradas, obtidas a partir da diferenciação direcionada de ipscs modificadas genomicamente. as células derivativas fornecidas neste documento têm edição estável e funcional do genoma que entrega efeitos terapêuticos melhorados ou aprimorados. também são fornecidas composições terapêuticas e o uso das mesmas que compreendem as células efetoras derivativas funcionalmente aprimoradas sozinhas ou com anticorpos ou inibidores de ponto de verificação em terapias de combinação.
BR112022000641A 2019-07-17 2020-07-17 Modificação genética de célula efetora imune e uso da mesma BR112022000641A2 (pt)

Applications Claiming Priority (3)

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US201962875490P 2019-07-17 2019-07-17
US202063021560P 2020-05-07 2020-05-07
PCT/US2020/042657 WO2021011919A1 (en) 2019-07-17 2020-07-17 Immune effector cell engineering and use thereof

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BR112022000641A2 true BR112022000641A2 (pt) 2022-03-29

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US (2) US20220275333A1 (pt)
EP (1) EP3999628A4 (pt)
JP (1) JP2022541441A (pt)
KR (1) KR20220035190A (pt)
CN (1) CN114258429A (pt)
AU (1) AU2020314969A1 (pt)
BR (1) BR112022000641A2 (pt)
CA (1) CA3146967A1 (pt)
IL (1) IL289830A (pt)
MX (1) MX2022000553A (pt)
WO (1) WO2021011919A1 (pt)

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