JP7744828B2 - 放射性金属錯体の製造方法 - Google Patents

放射性金属錯体の製造方法

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Publication number
JP7744828B2
JP7744828B2 JP2021540709A JP2021540709A JP7744828B2 JP 7744828 B2 JP7744828 B2 JP 7744828B2 JP 2021540709 A JP2021540709 A JP 2021540709A JP 2021540709 A JP2021540709 A JP 2021540709A JP 7744828 B2 JP7744828 B2 JP 7744828B2
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ligand
radioactive metal
water
reaction solution
organic solvent
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JPWO2021033530A1 (https=
Inventor
智之 今井
真登 桐生
彰宏 井澤
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Nihon Medi Physics Co Ltd
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Nihon Medi Physics Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2021540709A 2019-08-21 2020-08-04 放射性金属錯体の製造方法 Active JP7744828B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025085833A JP2025116040A (ja) 2019-08-21 2025-05-22 放射性金属錯体の製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019151480 2019-08-21
JP2019151480 2019-08-21
PCT/JP2020/029757 WO2021033530A1 (ja) 2019-08-21 2020-08-04 放射性金属錯体の製造方法

Related Child Applications (1)

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JP2025085833A Division JP2025116040A (ja) 2019-08-21 2025-05-22 放射性金属錯体の製造方法

Publications (2)

Publication Number Publication Date
JPWO2021033530A1 JPWO2021033530A1 (https=) 2021-02-25
JP7744828B2 true JP7744828B2 (ja) 2025-09-26

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JP2021540709A Active JP7744828B2 (ja) 2019-08-21 2020-08-04 放射性金属錯体の製造方法
JP2025085833A Pending JP2025116040A (ja) 2019-08-21 2025-05-22 放射性金属錯体の製造方法

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JP2025085833A Pending JP2025116040A (ja) 2019-08-21 2025-05-22 放射性金属錯体の製造方法

Country Status (9)

Country Link
US (1) US20220259160A1 (https=)
EP (1) EP4019502A4 (https=)
JP (2) JP7744828B2 (https=)
KR (1) KR20220047974A (https=)
CN (1) CN114269724A (https=)
AU (1) AU2020332618A1 (https=)
CA (1) CA3148288A1 (https=)
TW (1) TW202120483A (https=)
WO (1) WO2021033530A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022149578A1 (ja) 2021-01-08 2022-07-14 日本メジフィジックス株式会社 Ａｃ－２２５溶液の製造方法およびＡｃ－２２５溶液を用いた医薬の製造方法
EP4442285A1 (en) 2021-11-30 2024-10-09 Nihon Medi-Physics Co., Ltd. Stabilized radiopharmaceutical composition

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532820A (ja) 2001-02-28 2004-10-28 ダウ グローバル テクノロジーズ インコーポレイティド 標的放射線療法のためのアクチニウム−２２５錯体および複合体
JP2007535492A (ja) 2003-12-01 2007-12-06 イムノメディクス， インコーポレイテッド タンパク質とキレート剤とのコンジュゲートを調製するための改良された方法
JP2017503763A (ja) 2013-12-03 2017-02-02 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｇｃｃ発現細胞を撮像するための化合物及び組成物
WO2018187631A1 (en) 2017-04-05 2018-10-11 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
WO2021019983A1 (ja) 2019-07-30 2021-02-04 Ｊｆｅエンジニアリング株式会社 ジルコニウム錯体の合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7597876B2 (en) * 2007-01-11 2009-10-06 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
WO2008009444A1 (en) * 2006-07-19 2008-01-24 Van Dulmen, Adrianus, A. Use of ethanol for stabilizing a single-vial liquid formulation of a radiolabeled peptide
AU2010326004B2 (en) * 2009-12-04 2016-04-21 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
DE102012019714B4 (de) * 2012-10-08 2022-04-28 Johannes Gutenberg-Universität Mainz Verfahren zur Herstellung von pharmakologischen Metall-Ligand-Konjugaten
US20140147381A1 (en) * 2012-11-29 2014-05-29 Gregory David Espenan 89zr compounds, to include somatostatin, apparatus and products comprising such compounds, methods of making same, and methods of using same for radio imaging and/or treatment
WO2017161356A1 (en) * 2016-03-18 2017-09-21 Wake Forest University Compounds, compositions and associated methods using zirconium-89 in immuno-positron emission tomography
JP2019151480A (ja) 2018-03-06 2019-09-12 富士ゼロックス株式会社 検知装置及び画像形成装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532820A (ja) 2001-02-28 2004-10-28 ダウ グローバル テクノロジーズ インコーポレイティド 標的放射線療法のためのアクチニウム−２２５錯体および複合体
JP2007535492A (ja) 2003-12-01 2007-12-06 イムノメディクス， インコーポレイテッド タンパク質とキレート剤とのコンジュゲートを調製するための改良された方法
JP2017503763A (ja) 2013-12-03 2017-02-02 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｇｃｃ発現細胞を撮像するための化合物及び組成物
WO2018187631A1 (en) 2017-04-05 2018-10-11 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
WO2021019983A1 (ja) 2019-07-30 2021-02-04 Ｊｆｅエンジニアリング株式会社 ジルコニウム錯体の合成方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GHAI, Anchal et al.，Optimizing the radiosynthesis of [68Ga] DOTA-MLN6907 peptide containing three disulfide cyclization，Applied Radiation and Isotopes，2018年，140，pp.333-341，ISSN 0969-8043
HASEGAWA, Koki et al.，Improved 68Ga-labeling method using ethanol addition: Application to the α-helical peptide DOTA-FAM，J Label Compd Radiopharm，2017年，60，pp. 55-61，ISSN 1099-1344
PEREZ-MALO, Marylaine et al.，Improved Efficacy of Synthesizing *MIII-Labeled DOTA Complexes in Binary Mixtures of Water and Organ，Inorganic Chemistry，2018年，57，pp.6107-6117，ISSN 0020-1669

Also Published As

Publication number Publication date
EP4019502A1 (en) 2022-06-29
US20220259160A1 (en) 2022-08-18
CA3148288A1 (en) 2021-02-25
EP4019502A4 (en) 2023-08-16
CN114269724A (zh) 2022-04-01
TW202120483A (zh) 2021-06-01
JP2025116040A (ja) 2025-08-07
JPWO2021033530A1 (https=) 2021-02-25
AU2020332618A1 (en) 2022-02-24
WO2021033530A1 (ja) 2021-02-25
KR20220047974A (ko) 2022-04-19

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