JP7736431B2 - サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬 - Google Patents

サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬

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Publication number
JP7736431B2
JP7736431B2 JP2020543559A JP2020543559A JP7736431B2 JP 7736431 B2 JP7736431 B2 JP 7736431B2 JP 2020543559 A JP2020543559 A JP 2020543559A JP 2020543559 A JP2020543559 A JP 2020543559A JP 7736431 B2 JP7736431 B2 JP 7736431B2
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Japan
Prior art keywords
compound
jak1
pharmaceutically acceptable
cytokine
acceptable salt
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JP2020543559A
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English (en)
Japanese (ja)
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JP2021513981A (ja
JP2021513981A5 (https=
Inventor
マイケル・オニール・モンゴメリー
アーマッド・ナイム
スーザン・スノッドグラス
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Incyte Corp
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Incyte Corp
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Publication of JP2021513981A publication Critical patent/JP2021513981A/ja
Publication of JP2021513981A5 publication Critical patent/JP2021513981A5/ja
Priority to JP2023187800A priority Critical patent/JP2024023213A/ja
Application granted granted Critical
Publication of JP7736431B2 publication Critical patent/JP7736431B2/ja
Priority to JP2025249075A priority patent/JP2026048833A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2020543559A 2018-02-16 2019-02-14 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬 Active JP7736431B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023187800A JP2024023213A (ja) 2018-02-16 2023-11-01 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬
JP2025249075A JP2026048833A (ja) 2018-02-16 2025-12-15 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862710446P 2018-02-16 2018-02-16
US62/710,446 2018-02-16
US201862631825P 2018-02-18 2018-02-18
US62/631,825 2018-02-18
PCT/US2019/018066 WO2019161098A1 (en) 2018-02-16 2019-02-14 Jak1 pathway inhibitors for the treatment of cytokine-related disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023187800A Division JP2024023213A (ja) 2018-02-16 2023-11-01 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬

Publications (3)

Publication Number Publication Date
JP2021513981A JP2021513981A (ja) 2021-06-03
JP2021513981A5 JP2021513981A5 (https=) 2022-02-21
JP7736431B2 true JP7736431B2 (ja) 2025-09-09

Family

ID=65529906

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020543559A Active JP7736431B2 (ja) 2018-02-16 2019-02-14 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬
JP2023187800A Pending JP2024023213A (ja) 2018-02-16 2023-11-01 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬
JP2025249075A Pending JP2026048833A (ja) 2018-02-16 2025-12-15 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023187800A Pending JP2024023213A (ja) 2018-02-16 2023-11-01 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬
JP2025249075A Pending JP2026048833A (ja) 2018-02-16 2025-12-15 サイトカイン関連障害を治療するためのｊａｋ１経路阻害薬

Country Status (20)

Country Link
US (4) US11103510B2 (https=)
EP (1) EP3752146A1 (https=)
JP (3) JP7736431B2 (https=)
KR (3) KR102925957B1 (https=)
CN (4) CN111936135A (https=)
AU (2) AU2019221667B2 (https=)
BR (3) BR122023022247A2 (https=)
CA (1) CA3091339A1 (https=)
CL (1) CL2020002102A1 (https=)
CO (1) CO2020011388A2 (https=)
EC (1) ECSP20057643A (https=)
IL (3) IL276725B2 (https=)
MA (1) MA51829A (https=)
MX (2) MX2020008521A (https=)
PE (1) PE20212186A1 (https=)
PH (1) PH12020551251A1 (https=)
SG (1) SG11202007805SA (https=)
TW (2) TWI910423B (https=)
UA (1) UA127519C2 (https=)
WO (1) WO2019161098A1 (https=)

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MX2022001596A (es) * 2019-08-08 2022-03-11 Rigel Pharmaceuticals Inc Compuestos y metodos para tratar sindrome de liberacion de citocinas.
WO2021072098A1 (en) 2019-10-10 2021-04-15 Incyte Corporation Biomarkers for graft-versus-host disease
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JP2022090856A (ja) * 2020-12-08 2022-06-20 ソニーセミコンダクタソリューションズ株式会社 測距装置、および測距方法、並びにプログラム
CA3204374A1 (en) * 2020-12-08 2022-06-16 Incyte Corporation Jak1 pathway inhibitors for the treatment of vitiligo
UA129643C2 (uk) * 2021-05-03 2025-06-18 Інсайт Корпорейшн Інгібітори шляху jak1 для лікування вузлуватого свербця
CN117858709A (zh) * 2022-08-08 2024-04-09 石药集团中奇制药技术（石家庄）有限公司 一种含有三环杂芳基的化合物的用途
CN120053657B (zh) * 2025-02-28 2025-09-09 东莞市第八人民医院（东莞市儿童医院） 用于治疗aplaid的药物及药物组合物

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