CL2020002102A1 - Inhibidores de la vía de jak1 para el tratamiento de trastornos relacionados con citoquinas. - Google Patents

Inhibidores de la vía de jak1 para el tratamiento de trastornos relacionados con citoquinas.

Info

Publication number
CL2020002102A1
CL2020002102A1 CL2020002102A CL2020002102A CL2020002102A1 CL 2020002102 A1 CL2020002102 A1 CL 2020002102A1 CL 2020002102 A CL2020002102 A CL 2020002102A CL 2020002102 A CL2020002102 A CL 2020002102A CL 2020002102 A1 CL2020002102 A1 CL 2020002102A1
Authority
CL
Chile
Prior art keywords
inhibitors
treatment
cytokine
related disorders
jak1 pathway
Prior art date
Application number
CL2020002102A
Other languages
English (en)
Inventor
Montgomery Michael O'neill
Ahmad Naim
Susan Snodgrass
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CL2020002102A1 publication Critical patent/CL2020002102A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Esta descripción se refiere a los inhibidores de la vía de JAK1 y su uso en el tratamiento de enfermedades o trastornos relacionados con citoquinas como el síndrome de liberación de citoquinas (CRS), la linfohistiocitosis hemofagocítica (HLH), el síndrome de activación de macrófagos (MAS) y el síndrome de encefalopatía relacionada con células T CAR (CRES).
CL2020002102A 2018-02-16 2020-08-14 Inhibidores de la vía de jak1 para el tratamiento de trastornos relacionados con citoquinas. CL2020002102A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862710446P 2018-02-16 2018-02-16
US201862631825P 2018-02-18 2018-02-18

Publications (1)

Publication Number Publication Date
CL2020002102A1 true CL2020002102A1 (es) 2021-01-29

Family

ID=65529906

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002102A CL2020002102A1 (es) 2018-02-16 2020-08-14 Inhibidores de la vía de jak1 para el tratamiento de trastornos relacionados con citoquinas.

Country Status (20)

Country Link
US (2) US11103510B2 (es)
EP (1) EP3752146A1 (es)
JP (2) JP2021513981A (es)
KR (1) KR20200128043A (es)
CN (1) CN111936135A (es)
AU (1) AU2019221667A1 (es)
BR (3) BR122023022189A2 (es)
CA (1) CA3091339A1 (es)
CL (1) CL2020002102A1 (es)
CO (1) CO2020011388A2 (es)
EC (1) ECSP20057643A (es)
IL (1) IL276725A (es)
MA (1) MA51829A (es)
MX (2) MX2020008521A (es)
PE (1) PE20212186A1 (es)
PH (1) PH12020551251A1 (es)
SG (1) SG11202007805SA (es)
TW (2) TW202342026A (es)
UA (1) UA127519C2 (es)
WO (1) WO2019161098A1 (es)

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Also Published As

Publication number Publication date
EP3752146A1 (en) 2020-12-23
SG11202007805SA (en) 2020-09-29
MA51829A (fr) 2020-12-23
TW202000203A (zh) 2020-01-01
AU2019221667A1 (en) 2020-10-01
JP2024023213A (ja) 2024-02-21
UA127519C2 (uk) 2023-09-20
MX2023003392A (es) 2023-06-16
KR20200128043A (ko) 2020-11-11
CO2020011388A2 (es) 2020-12-10
PH12020551251A1 (en) 2021-05-17
CA3091339A1 (en) 2019-08-22
BR122023022247A2 (pt) 2024-02-20
ECSP20057643A (es) 2020-12-31
JP2021513981A (ja) 2021-06-03
US20190255053A1 (en) 2019-08-22
TW202342026A (zh) 2023-11-01
IL276725A (en) 2020-09-30
CN111936135A (zh) 2020-11-13
US11103510B2 (en) 2021-08-31
MX2020008521A (es) 2020-12-03
BR112020016628A2 (pt) 2020-12-15
US11833152B2 (en) 2023-12-05
PE20212186A1 (es) 2021-11-11
US20220040187A1 (en) 2022-02-10
WO2019161098A1 (en) 2019-08-22
BR122023022189A2 (pt) 2024-02-20
TWI799513B (zh) 2023-04-21

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