JP7664862B2 - ニコランジル誘導体 - Google Patents

ニコランジル誘導体 Download PDF

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Publication number
JP7664862B2
JP7664862B2 JP2021578168A JP2021578168A JP7664862B2 JP 7664862 B2 JP7664862 B2 JP 7664862B2 JP 2021578168 A JP2021578168 A JP 2021578168A JP 2021578168 A JP2021578168 A JP 2021578168A JP 7664862 B2 JP7664862 B2 JP 7664862B2
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compound
pharmaceutical composition
disease
formula
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JP2022524243A5 (https=
JP2022524243A (ja
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グプタ，シャラブ
デュガー，サンディープ
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ユニサイシブ セラピューティクス インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2021578168A 2019-03-15 2020-03-16 ニコランジル誘導体 Active JP7664862B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962819372P 2019-03-15 2019-03-15
US62/819,372 2019-03-15
PCT/US2020/023016 WO2020190890A1 (en) 2019-03-15 2020-03-16 Nicorandil derivatives

Publications (3)

Publication Number Publication Date
JP2022524243A JP2022524243A (ja) 2022-04-28
JP2022524243A5 JP2022524243A5 (https=) 2023-03-13
JP7664862B2 true JP7664862B2 (ja) 2025-04-18

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ID=70296016

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021578168A Active JP7664862B2 (ja) 2019-03-15 2020-03-16 ニコランジル誘導体

Country Status (13)

Country Link
US (5) US12377082B2 (https=)
EP (1) EP3937938B1 (https=)
JP (1) JP7664862B2 (https=)
KR (1) KR102878883B1 (https=)
CN (1) CN114144178A (https=)
AU (1) AU2020240015B2 (https=)
BR (1) BR112021018254A2 (https=)
CA (1) CA3133093A1 (https=)
ES (1) ES3064585T3 (https=)
IL (1) IL286434B2 (https=)
MX (1) MX2021011081A (https=)
SG (1) SG11202109899VA (https=)
WO (1) WO2020190890A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117835982A (zh) 2021-07-10 2024-04-05 奥克西利斯制药有限公司 调节释放型尼可地尔化合物制剂
WO2024151489A1 (en) 2023-01-09 2024-07-18 Unicycive Therapeutics Inc. Pharmaceutical pyridyl compositions and methods for use
US20250002458A1 (en) 2023-05-24 2025-01-02 Unicycive Therapeutics Inc. Salt forms of nicorandil derivative
US20250145571A1 (en) 2023-09-26 2025-05-08 Unicycive Therapeutics, Inc. Amino acid prodrugs of nicorandil
US20250161282A1 (en) 2023-11-16 2025-05-22 Unicycive Therapeutics, Inc. Pharmaceutical pyridyl compositions for treating and preventing delayed graft function
WO2025194102A1 (en) 2024-03-15 2025-09-18 Unicycive Therapeutics, Inc. Pyridine modified nicorandil derivatives
CN118845679B (zh) * 2024-07-04 2025-11-25 山东中医药大学 一种快速溶出的尼可地尔片剂及其制备方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2014514300A (ja) 2011-04-08 2014-06-19 スファエラ ファーマ ピーティーイー リミテッド 置換メチルホルミル試薬並びに化合物の物理化学的性質及び／又は薬物動態学的性質を改質するためのそれらの使用方法

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Also Published As

Publication number Publication date
WO2020190890A8 (en) 2021-09-10
SG11202109899VA (en) 2021-10-28
AU2020240015A1 (en) 2021-10-07
US20220265630A1 (en) 2022-08-25
BR112021018254A8 (pt) 2021-11-23
ES3064585T3 (en) 2026-04-27
CA3133093A1 (en) 2020-09-24
EP3937938A1 (en) 2022-01-19
MX2021011081A (es) 2022-01-18
US20240390348A1 (en) 2024-11-28
JP2022524243A (ja) 2022-04-28
EP3937938B1 (en) 2026-01-28
CN114144178A (zh) 2022-03-04
US12036211B2 (en) 2024-07-16
US12396989B2 (en) 2025-08-26
BR112021018254A2 (pt) 2022-03-15
US20260115175A1 (en) 2026-04-30
WO2020190890A1 (en) 2020-09-24
US12377082B2 (en) 2025-08-05
KR102878883B1 (ko) 2025-10-30
KR20220009373A (ko) 2022-01-24
IL286434B2 (en) 2026-02-01
IL286434B1 (en) 2025-10-01
EP3937938C0 (en) 2026-01-28
US20220079927A1 (en) 2022-03-17
US20230310398A1 (en) 2023-10-05
IL286434A (en) 2021-10-31
AU2020240015B2 (en) 2025-10-09

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