CN114144178A - 尼可地尔衍生物 - Google Patents

尼可地尔衍生物 Download PDF

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Publication number
CN114144178A
CN114144178A CN202080030754.5A CN202080030754A CN114144178A CN 114144178 A CN114144178 A CN 114144178A CN 202080030754 A CN202080030754 A CN 202080030754A CN 114144178 A CN114144178 A CN 114144178A
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CN
China
Prior art keywords
compound
substituted
aki
unsubstituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080030754.5A
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English (en)
Chinese (zh)
Inventor
S·古普塔
S·杜加尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unisef Medical
Original Assignee
Unisef Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unisef Medical filed Critical Unisef Medical
Publication of CN114144178A publication Critical patent/CN114144178A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202080030754.5A 2019-03-15 2020-03-16 尼可地尔衍生物 Pending CN114144178A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962819372P 2019-03-15 2019-03-15
US62/819372 2019-03-15
PCT/US2020/023016 WO2020190890A1 (en) 2019-03-15 2020-03-16 Nicorandil derivatives

Publications (1)

Publication Number Publication Date
CN114144178A true CN114144178A (zh) 2022-03-04

Family

ID=70296016

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080030754.5A Pending CN114144178A (zh) 2019-03-15 2020-03-16 尼可地尔衍生物

Country Status (13)

Country Link
US (5) US12377082B2 (https=)
EP (1) EP3937938B1 (https=)
JP (1) JP7664862B2 (https=)
KR (1) KR102878883B1 (https=)
CN (1) CN114144178A (https=)
AU (1) AU2020240015B2 (https=)
BR (1) BR112021018254A2 (https=)
CA (1) CA3133093A1 (https=)
ES (1) ES3064585T3 (https=)
IL (1) IL286434B2 (https=)
MX (1) MX2021011081A (https=)
SG (1) SG11202109899VA (https=)
WO (1) WO2020190890A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118845679A (zh) * 2024-07-04 2024-10-29 山东中医药大学 一种快速溶出的尼可地尔片剂及其制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117835982A (zh) 2021-07-10 2024-04-05 奥克西利斯制药有限公司 调节释放型尼可地尔化合物制剂
WO2024151489A1 (en) 2023-01-09 2024-07-18 Unicycive Therapeutics Inc. Pharmaceutical pyridyl compositions and methods for use
US20250002458A1 (en) 2023-05-24 2025-01-02 Unicycive Therapeutics Inc. Salt forms of nicorandil derivative
US20250145571A1 (en) 2023-09-26 2025-05-08 Unicycive Therapeutics, Inc. Amino acid prodrugs of nicorandil
US20250161282A1 (en) 2023-11-16 2025-05-22 Unicycive Therapeutics, Inc. Pharmaceutical pyridyl compositions for treating and preventing delayed graft function
WO2025194102A1 (en) 2024-03-15 2025-09-18 Unicycive Therapeutics, Inc. Pyridine modified nicorandil derivatives

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CN103607888A (zh) * 2011-04-08 2014-02-26 斯法尔制药私人有限公司 取代的甲基甲酰基试剂以及使用所述试剂改进化合物的物理化学性质和/或药代动力学性质的方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118845679A (zh) * 2024-07-04 2024-10-29 山东中医药大学 一种快速溶出的尼可地尔片剂及其制备方法
CN118845679B (zh) * 2024-07-04 2025-11-25 山东中医药大学 一种快速溶出的尼可地尔片剂及其制备方法

Also Published As

Publication number Publication date
WO2020190890A8 (en) 2021-09-10
SG11202109899VA (en) 2021-10-28
AU2020240015A1 (en) 2021-10-07
US20220265630A1 (en) 2022-08-25
BR112021018254A8 (pt) 2021-11-23
ES3064585T3 (en) 2026-04-27
CA3133093A1 (en) 2020-09-24
EP3937938A1 (en) 2022-01-19
MX2021011081A (es) 2022-01-18
US20240390348A1 (en) 2024-11-28
JP2022524243A (ja) 2022-04-28
EP3937938B1 (en) 2026-01-28
US12036211B2 (en) 2024-07-16
JP7664862B2 (ja) 2025-04-18
US12396989B2 (en) 2025-08-26
BR112021018254A2 (pt) 2022-03-15
US20260115175A1 (en) 2026-04-30
WO2020190890A1 (en) 2020-09-24
US12377082B2 (en) 2025-08-05
KR102878883B1 (ko) 2025-10-30
KR20220009373A (ko) 2022-01-24
IL286434B2 (en) 2026-02-01
IL286434B1 (en) 2025-10-01
EP3937938C0 (en) 2026-01-28
US20220079927A1 (en) 2022-03-17
US20230310398A1 (en) 2023-10-05
IL286434A (en) 2021-10-31
AU2020240015B2 (en) 2025-10-09

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