AU2020240015B2 - Nicorandil derivatives - Google Patents

Nicorandil derivatives

Info

Publication number
AU2020240015B2
AU2020240015B2 AU2020240015A AU2020240015A AU2020240015B2 AU 2020240015 B2 AU2020240015 B2 AU 2020240015B2 AU 2020240015 A AU2020240015 A AU 2020240015A AU 2020240015 A AU2020240015 A AU 2020240015A AU 2020240015 B2 AU2020240015 B2 AU 2020240015B2
Authority
AU
Australia
Prior art keywords
compound
aki
disease
formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020240015A
Other languages
English (en)
Other versions
AU2020240015A1 (en
Inventor
Sundeep Dugar
Shalabh Gupta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unicycive Therapeutics Inc
Original Assignee
Unicycive Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unicycive Therapeutics Inc filed Critical Unicycive Therapeutics Inc
Publication of AU2020240015A1 publication Critical patent/AU2020240015A1/en
Application granted granted Critical
Publication of AU2020240015B2 publication Critical patent/AU2020240015B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2020240015A 2019-03-15 2020-03-16 Nicorandil derivatives Active AU2020240015B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962819372P 2019-03-15 2019-03-15
US62/819,372 2019-03-15
PCT/US2020/023016 WO2020190890A1 (en) 2019-03-15 2020-03-16 Nicorandil derivatives

Publications (2)

Publication Number Publication Date
AU2020240015A1 AU2020240015A1 (en) 2021-10-07
AU2020240015B2 true AU2020240015B2 (en) 2025-10-09

Family

ID=70296016

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020240015A Active AU2020240015B2 (en) 2019-03-15 2020-03-16 Nicorandil derivatives

Country Status (13)

Country Link
US (5) US12377082B2 (https=)
EP (1) EP3937938B1 (https=)
JP (1) JP7664862B2 (https=)
KR (1) KR102878883B1 (https=)
CN (1) CN114144178A (https=)
AU (1) AU2020240015B2 (https=)
BR (1) BR112021018254A2 (https=)
CA (1) CA3133093A1 (https=)
ES (1) ES3064585T3 (https=)
IL (1) IL286434B2 (https=)
MX (1) MX2021011081A (https=)
SG (1) SG11202109899VA (https=)
WO (1) WO2020190890A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117835982A (zh) 2021-07-10 2024-04-05 奥克西利斯制药有限公司 调节释放型尼可地尔化合物制剂
WO2024151489A1 (en) 2023-01-09 2024-07-18 Unicycive Therapeutics Inc. Pharmaceutical pyridyl compositions and methods for use
US20250002458A1 (en) 2023-05-24 2025-01-02 Unicycive Therapeutics Inc. Salt forms of nicorandil derivative
US20250145571A1 (en) 2023-09-26 2025-05-08 Unicycive Therapeutics, Inc. Amino acid prodrugs of nicorandil
US20250161282A1 (en) 2023-11-16 2025-05-22 Unicycive Therapeutics, Inc. Pharmaceutical pyridyl compositions for treating and preventing delayed graft function
WO2025194102A1 (en) 2024-03-15 2025-09-18 Unicycive Therapeutics, Inc. Pyridine modified nicorandil derivatives
CN118845679B (zh) * 2024-07-04 2025-11-25 山东中医药大学 一种快速溶出的尼可地尔片剂及其制备方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2012137225A1 (en) * 2011-04-08 2012-10-11 Sphaera Pharma Pvt. Ltd Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds

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WO2012137225A1 (en) * 2011-04-08 2012-10-11 Sphaera Pharma Pvt. Ltd Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds

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Also Published As

Publication number Publication date
WO2020190890A8 (en) 2021-09-10
SG11202109899VA (en) 2021-10-28
AU2020240015A1 (en) 2021-10-07
US20220265630A1 (en) 2022-08-25
BR112021018254A8 (pt) 2021-11-23
ES3064585T3 (en) 2026-04-27
CA3133093A1 (en) 2020-09-24
EP3937938A1 (en) 2022-01-19
MX2021011081A (es) 2022-01-18
US20240390348A1 (en) 2024-11-28
JP2022524243A (ja) 2022-04-28
EP3937938B1 (en) 2026-01-28
CN114144178A (zh) 2022-03-04
US12036211B2 (en) 2024-07-16
JP7664862B2 (ja) 2025-04-18
US12396989B2 (en) 2025-08-26
BR112021018254A2 (pt) 2022-03-15
US20260115175A1 (en) 2026-04-30
WO2020190890A1 (en) 2020-09-24
US12377082B2 (en) 2025-08-05
KR102878883B1 (ko) 2025-10-30
KR20220009373A (ko) 2022-01-24
IL286434B2 (en) 2026-02-01
IL286434B1 (en) 2025-10-01
EP3937938C0 (en) 2026-01-28
US20220079927A1 (en) 2022-03-17
US20230310398A1 (en) 2023-10-05
IL286434A (en) 2021-10-31

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Legal Events

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