JP7627042B2 - Ｏ－メチルリッチ完全安定化オリゴヌクレオチド - Google Patents

Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Download PDF

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JP7627042B2
JP7627042B2 JP2021509991A JP2021509991A JP7627042B2 JP 7627042 B2 JP7627042 B2 JP 7627042B2 JP 2021509991 A JP2021509991 A JP 2021509991A JP 2021509991 A JP2021509991 A JP 2021509991A JP 7627042 B2 JP7627042 B2 JP 7627042B2
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nucleotides
strand
sirna
oligonucleotide
antisense strand
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JP2021533804A (ja
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アナスタシア・コボロバ
ジュリア・オルターマン
サラ・デイビス
アントン・トゥラノフ
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University of Massachusetts Amherst
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JP2021509991A 2018-08-23 2019-08-23 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Active JP7627042B2 (ja)

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US201862721993P 2018-08-23 2018-08-23
US62/721,993 2018-08-23
PCT/US2019/048027 WO2020041769A1 (en) 2018-08-23 2019-08-23 O-methyl rich fully stabilized oligonucleotides

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JP2021533804A JP2021533804A (ja) 2021-12-09
JP2021533804A5 JP2021533804A5 (https=) 2022-08-31
JPWO2020041769A5 JPWO2020041769A5 (https=) 2022-08-31
JP7627042B2 true JP7627042B2 (ja) 2025-02-05

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US (2) US11279930B2 (https=)
EP (1) EP3840759A4 (https=)
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WO (1) WO2020041769A1 (https=)

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EP3277811B1 (en) 2015-04-03 2020-12-23 University of Massachusetts Fully stabilized asymmetric sirna
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
WO2017132669A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
JP7627042B2 (ja) 2018-08-23 2025-02-05 ユニバーシティー オブ マサチューセッツ Ｏ－メチルリッチ完全安定化オリゴヌクレオチド
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
MX2022001710A (es) 2019-08-09 2022-05-10 Univ Massachusetts Oligonucleótidos modificados químicamente dirigidos a los snp.
JP2022545118A (ja) * 2019-08-23 2022-10-25 ユニバーシティー オブ マサチューセッツ Ｏ－メチルリッチ完全安定化オリゴヌクレオチド
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
WO2021173984A2 (en) * 2020-02-28 2021-09-02 University Of Massachusetts Oligonucleotides for prnp modulation
AU2021238319A1 (en) * 2020-03-18 2022-10-06 University Of Massachusetts Oligonucleotides for MAPT modulation
JP7837560B2 (ja) * 2020-03-26 2026-03-31 ユニバーシティー オブ マサチューセッツ 安定性の向上を有する修飾オリゴヌクレオチドの合成
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WO2023014654A2 (en) * 2021-08-02 2023-02-09 University Of Massachusetts Oligonucleotides for htt-1a modulation
EP4433595A1 (en) * 2021-11-18 2024-09-25 Resonance Health Analysis Services Pty Ltd Method for treating cyclophilin b associated diseases
KR20240161967A (ko) * 2022-03-16 2024-11-13 다이이찌 산쿄 가부시키가이샤 트랜스페린 수용체 2 의 발현을 억제하는 siRNA
WO2025063238A1 (ja) * 2023-09-20 2025-03-27 第一三共株式会社 ホスホランバンの発現を抑制するｓｉＲＮＡ

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