JP7617005B2 - Ａｋｔ阻害剤 - Google Patents

Ａｋｔ阻害剤 Download PDF

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Publication number
JP7617005B2
JP7617005B2 JP2021543533A JP2021543533A JP7617005B2 JP 7617005 B2 JP7617005 B2 JP 7617005B2 JP 2021543533 A JP2021543533 A JP 2021543533A JP 2021543533 A JP2021543533 A JP 2021543533A JP 7617005 B2 JP7617005 B2 JP 7617005B2
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group
compound
formula
pharma
acceptable salt
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Japanese (ja)
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JPWO2020156437A5 (https=
JP2022517866A5 (https=
JP2022517866A (ja
Inventor
昌友 馬
禾 田
杰 安
建良 趙
東暉 陳
艦 呉
丹 徐
春霞 朱
舟山 田
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Nanjing Chia Tai Tianqing Pharmaceutical Co Ltd
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Nanjing Chia Tai Tianqing Pharmaceutical Co Ltd
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Publication of JP2022517866A5 publication Critical patent/JP2022517866A5/ja
Priority to JP2024161770A priority Critical patent/JP2024175091A/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2021543533A 2019-01-29 2020-01-22 Ａｋｔ阻害剤 Active JP7617005B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024161770A JP2024175091A (ja) 2019-01-29 2024-09-19 Ａｋｔ阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910084801.3 2019-01-29
CN201910084801 2019-01-29
PCT/CN2020/073798 WO2020156437A1 (zh) 2019-01-29 2020-01-22 Akt抑制剂

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024161770A Division JP2024175091A (ja) 2019-01-29 2024-09-19 Ａｋｔ阻害剤

Publications (4)

Publication Number Publication Date
JP2022517866A JP2022517866A (ja) 2022-03-10
JPWO2020156437A5 JPWO2020156437A5 (https=) 2023-02-01
JP2022517866A5 JP2022517866A5 (https=) 2023-02-01
JP7617005B2 true JP7617005B2 (ja) 2025-01-17

Family

ID=71841634

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021543533A Active JP7617005B2 (ja) 2019-01-29 2020-01-22 Ａｋｔ阻害剤
JP2024161770A Withdrawn JP2024175091A (ja) 2019-01-29 2024-09-19 Ａｋｔ阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024161770A Withdrawn JP2024175091A (ja) 2019-01-29 2024-09-19 Ａｋｔ阻害剤

Country Status (10)

Country Link
US (1) US20220144821A1 (https=)
EP (1) EP3919491B1 (https=)
JP (2) JP7617005B2 (https=)
KR (1) KR102892239B1 (https=)
CN (2) CN117964620A (https=)
AU (1) AU2020214258B2 (https=)
CA (1) CA3127884A1 (https=)
ES (1) ES3037595T3 (https=)
PL (1) PL3919491T3 (https=)
WO (1) WO2020156437A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI908780B (zh) * 2020-03-17 2025-12-21 大陸商江蘇恆瑞醫藥股份有限公司 稠合二環類衍生物、其製備方法及其在醫藥上的應用
CN115485276B (zh) * 2020-05-15 2024-05-31 南京正大天晴制药有限公司 氘代akt激酶抑制剂
CN119302960A (zh) * 2020-07-22 2025-01-14 南京正大天晴制药有限公司 Akt抑制剂的单位剂量组合物
WO2022017448A1 (zh) * 2020-07-22 2022-01-27 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐及晶型
CN115836069B (zh) * 2020-07-22 2024-02-06 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐、其制备方法及用途
CN116478156A (zh) * 2022-01-17 2023-07-25 南京正大天晴制药有限公司 一种akt抑制剂化合物的富马酸盐晶型及其制备方法
WO2024146599A1 (zh) * 2023-01-06 2024-07-11 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮的衍生物、其制备方法以及医药用途
CN121586576A (zh) 2023-06-14 2026-02-27 南京正大天晴制药有限公司 Akt抑制剂在制备预防或治疗乳腺癌药物中的用途
CN120157686A (zh) * 2023-12-14 2025-06-17 南京正大天晴制药有限公司 一种具有降解akt激酶活性的化合物及其制备方法和药学上的应用
CN121177294B (zh) * 2025-11-27 2026-02-27 四川省医学科学院·四川省人民医院 Akt抑制剂在制备诱导胰岛移植免疫耐受药物中的应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007512364A (ja) 2003-11-21 2007-05-17 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼインヒビター
JP2011509309A (ja) 2008-01-09 2011-03-24 アレイ バイオファーマ、インコーポレイテッド ＡＫＴタンパク質キナーゼ阻害剤としての５Ｈ−シクロペンタ［ｄ］ピリミジン
JP2013508382A (ja) 2009-10-23 2013-03-07 イーライ リリー アンド カンパニー Ａｋｔ阻害剤
JP2016500064A (ja) 2012-11-16 2016-01-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ キナーゼ活性のモジュレーターとしての新規イミダゾール−ピペリジニル誘導体
JP2016500065A (ja) 2012-11-16 2016-01-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ キナーゼ活性のモジュレーターとしての新規複素環式誘導体
JP2017526698A (ja) 2014-09-05 2017-09-14 アークル インコーポレイテッド 増殖性障害を処置するための組成物および方法
CN108503645A (zh) 2018-03-01 2018-09-07 山东大学 含氨甲基的哌嗪酮类化合物及其制备方法和应用
JP2021522237A (ja) 2018-04-24 2021-08-30 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ プテリジノン化合物およびその使用

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* Cited by examiner, † Cited by third party
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US20130065908A1 (en) * 2009-12-07 2013-03-14 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
UA95641C2 (xx) 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
EP2049500B1 (en) 2006-07-06 2011-09-07 Array Biopharma, Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CN109020957B (zh) * 2017-06-12 2023-01-13 南京天印健华医药科技有限公司 作为mnk抑制剂的杂环化合物

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007512364A (ja) 2003-11-21 2007-05-17 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼインヒビター
JP2011509309A (ja) 2008-01-09 2011-03-24 アレイ バイオファーマ、インコーポレイテッド ＡＫＴタンパク質キナーゼ阻害剤としての５Ｈ−シクロペンタ［ｄ］ピリミジン
JP2013508382A (ja) 2009-10-23 2013-03-07 イーライ リリー アンド カンパニー Ａｋｔ阻害剤
JP2016500064A (ja) 2012-11-16 2016-01-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ キナーゼ活性のモジュレーターとしての新規イミダゾール−ピペリジニル誘導体
JP2016500065A (ja) 2012-11-16 2016-01-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ キナーゼ活性のモジュレーターとしての新規複素環式誘導体
JP2017526698A (ja) 2014-09-05 2017-09-14 アークル インコーポレイテッド 増殖性障害を処置するための組成物および方法
CN108503645A (zh) 2018-03-01 2018-09-07 山东大学 含氨甲基的哌嗪酮类化合物及其制备方法和应用
JP2021522237A (ja) 2018-04-24 2021-08-30 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ プテリジノン化合物およびその使用

Also Published As

Publication number Publication date
US20220144821A1 (en) 2022-05-12
CN113272304B (zh) 2024-03-29
KR102892239B1 (ko) 2025-11-26
EP3919491A1 (en) 2021-12-08
EP3919491A4 (en) 2022-10-19
WO2020156437A1 (zh) 2020-08-06
PL3919491T3 (pl) 2025-10-20
EP3919491C0 (en) 2025-05-28
CN117964620A (zh) 2024-05-03
KR20210120054A (ko) 2021-10-06
EP3919491B1 (en) 2025-05-28
CN113272304A (zh) 2021-08-17
AU2020214258A1 (en) 2021-09-16
CA3127884A1 (en) 2020-08-06
ES3037595T3 (en) 2025-10-03
JP2024175091A (ja) 2024-12-17
AU2020214258B2 (en) 2025-08-28
JP2022517866A (ja) 2022-03-10

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