ES3037595T3 - Akt inhibitor - Google Patents
Akt inhibitorInfo
- Publication number
- ES3037595T3 ES3037595T3 ES20748221T ES20748221T ES3037595T3 ES 3037595 T3 ES3037595 T3 ES 3037595T3 ES 20748221 T ES20748221 T ES 20748221T ES 20748221 T ES20748221 T ES 20748221T ES 3037595 T3 ES3037595 T3 ES 3037595T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- methyl
- reaction
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910084801 | 2019-01-29 | ||
| PCT/CN2020/073798 WO2020156437A1 (zh) | 2019-01-29 | 2020-01-22 | Akt抑制剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES3037595T3 true ES3037595T3 (en) | 2025-10-03 |
Family
ID=71841634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES20748221T Active ES3037595T3 (en) | 2019-01-29 | 2020-01-22 | Akt inhibitor |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220144821A1 (https=) |
| EP (1) | EP3919491B1 (https=) |
| JP (2) | JP7617005B2 (https=) |
| KR (1) | KR102892239B1 (https=) |
| CN (2) | CN117964620A (https=) |
| AU (1) | AU2020214258B2 (https=) |
| CA (1) | CA3127884A1 (https=) |
| ES (1) | ES3037595T3 (https=) |
| PL (1) | PL3919491T3 (https=) |
| WO (1) | WO2020156437A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI908780B (zh) * | 2020-03-17 | 2025-12-21 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合二環類衍生物、其製備方法及其在醫藥上的應用 |
| CN115485276B (zh) * | 2020-05-15 | 2024-05-31 | 南京正大天晴制药有限公司 | 氘代akt激酶抑制剂 |
| CN119302960A (zh) * | 2020-07-22 | 2025-01-14 | 南京正大天晴制药有限公司 | Akt抑制剂的单位剂量组合物 |
| WO2022017448A1 (zh) * | 2020-07-22 | 2022-01-27 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐及晶型 |
| CN115836069B (zh) * | 2020-07-22 | 2024-02-06 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐、其制备方法及用途 |
| CN116478156A (zh) * | 2022-01-17 | 2023-07-25 | 南京正大天晴制药有限公司 | 一种akt抑制剂化合物的富马酸盐晶型及其制备方法 |
| WO2024146599A1 (zh) * | 2023-01-06 | 2024-07-11 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮的衍生物、其制备方法以及医药用途 |
| CN121586576A (zh) | 2023-06-14 | 2026-02-27 | 南京正大天晴制药有限公司 | Akt抑制剂在制备预防或治疗乳腺癌药物中的用途 |
| CN120157686A (zh) * | 2023-12-14 | 2025-06-17 | 南京正大天晴制药有限公司 | 一种具有降解akt激酶活性的化合物及其制备方法和药学上的应用 |
| CN121177294B (zh) * | 2025-11-27 | 2026-02-27 | 四川省医学科学院·四川省人民医院 | Akt抑制剂在制备诱导胰岛移植免疫耐受药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2546754A1 (en) * | 2003-11-21 | 2005-06-09 | Array Biopharma Inc. | Akt protein kinase inhibitors |
| US20130065908A1 (en) * | 2009-12-07 | 2013-03-14 | Array Biopharma Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
| UA95641C2 (xx) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| US8329701B2 (en) | 2006-07-06 | 2012-12-11 | Array Biopharma Inc. | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
| EP2049500B1 (en) | 2006-07-06 | 2011-09-07 | Array Biopharma, Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| CA2711782C (en) | 2008-01-09 | 2017-01-03 | Array Biopharma Inc. | 5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors |
| MX2012004780A (es) * | 2009-10-23 | 2012-08-23 | Lilly Co Eli | Inhibidores de akt. |
| CA2890288A1 (en) * | 2012-11-16 | 2014-05-22 | Merck Patent Gmbh | Novel heterocyclic derivatives as modulators of kinase activity |
| AR093511A1 (es) * | 2012-11-16 | 2015-06-10 | Merck Patent Gmbh | Derivados de imidazol-piperidinilo como moduladores de la actividad de cinasas |
| EP3189036B1 (en) * | 2014-09-05 | 2023-07-19 | ArQule, Inc. | Compositions and methods for treating proliferation disorders |
| CN109020957B (zh) * | 2017-06-12 | 2023-01-13 | 南京天印健华医药科技有限公司 | 作为mnk抑制剂的杂环化合物 |
| CN108503645A (zh) * | 2018-03-01 | 2018-09-07 | 山东大学 | 含氨甲基的哌嗪酮类化合物及其制备方法和应用 |
| ES2969982T3 (es) * | 2018-04-24 | 2024-05-23 | Vertex Pharma | Compuestos de pteridinona y usos de los mismos |
-
2020
- 2020-01-22 PL PL20748221.7T patent/PL3919491T3/pl unknown
- 2020-01-22 EP EP20748221.7A patent/EP3919491B1/en active Active
- 2020-01-22 CN CN202410142331.2A patent/CN117964620A/zh active Pending
- 2020-01-22 US US17/426,047 patent/US20220144821A1/en active Pending
- 2020-01-22 JP JP2021543533A patent/JP7617005B2/ja active Active
- 2020-01-22 CA CA3127884A patent/CA3127884A1/en active Pending
- 2020-01-22 WO PCT/CN2020/073798 patent/WO2020156437A1/zh not_active Ceased
- 2020-01-22 KR KR1020217027161A patent/KR102892239B1/ko active Active
- 2020-01-22 AU AU2020214258A patent/AU2020214258B2/en active Active
- 2020-01-22 CN CN202080005749.9A patent/CN113272304B/zh active Active
- 2020-01-22 ES ES20748221T patent/ES3037595T3/es active Active
-
2024
- 2024-09-19 JP JP2024161770A patent/JP2024175091A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20220144821A1 (en) | 2022-05-12 |
| CN113272304B (zh) | 2024-03-29 |
| KR102892239B1 (ko) | 2025-11-26 |
| EP3919491A1 (en) | 2021-12-08 |
| JP7617005B2 (ja) | 2025-01-17 |
| EP3919491A4 (en) | 2022-10-19 |
| WO2020156437A1 (zh) | 2020-08-06 |
| PL3919491T3 (pl) | 2025-10-20 |
| EP3919491C0 (en) | 2025-05-28 |
| CN117964620A (zh) | 2024-05-03 |
| KR20210120054A (ko) | 2021-10-06 |
| EP3919491B1 (en) | 2025-05-28 |
| CN113272304A (zh) | 2021-08-17 |
| AU2020214258A1 (en) | 2021-09-16 |
| CA3127884A1 (en) | 2020-08-06 |
| JP2024175091A (ja) | 2024-12-17 |
| AU2020214258B2 (en) | 2025-08-28 |
| JP2022517866A (ja) | 2022-03-10 |
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