JP7607559B2 - 脂質代謝調節不全の治療方法 - Google Patents

脂質代謝調節不全の治療方法 Download PDF

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Publication number
JP7607559B2
JP7607559B2 JP2021528981A JP2021528981A JP7607559B2 JP 7607559 B2 JP7607559 B2 JP 7607559B2 JP 2021528981 A JP2021528981 A JP 2021528981A JP 2021528981 A JP2021528981 A JP 2021528981A JP 7607559 B2 JP7607559 B2 JP 7607559B2
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trem2
antibody
mammal
certain embodiments
cells
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JP2022513114A5 (https=
JP2022513114A (ja
JPWO2020112889A5 (https=
Inventor
ジュゼッペ アスタリタ，
パオロ， ギルバート ディ
カイ リン リン，
キャスリン エム． モンロー，
アリシア エー． ニュージェント，
レンゲリッチ， ベッティーナ ヴァン
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Denali Therapeutics Inc
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Denali Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021528981A 2018-11-26 2019-11-26 脂質代謝調節不全の治療方法 Active JP7607559B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862771456P 2018-11-26 2018-11-26
US62/771,456 2018-11-26
US201962817955P 2019-03-13 2019-03-13
US62/817,955 2019-03-13
US201962890506P 2019-08-22 2019-08-22
US62/890,506 2019-08-22
PCT/US2019/063427 WO2020112889A2 (en) 2018-11-26 2019-11-26 Methods for treating dysregulated lipid metabolism

Publications (4)

Publication Number Publication Date
JP2022513114A JP2022513114A (ja) 2022-02-07
JP2022513114A5 JP2022513114A5 (https=) 2022-12-02
JPWO2020112889A5 JPWO2020112889A5 (https=) 2022-12-02
JP7607559B2 true JP7607559B2 (ja) 2024-12-27

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JP2021528981A Active JP7607559B2 (ja) 2018-11-26 2019-11-26 脂質代謝調節不全の治療方法

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US (1) US20230132366A9 (https=)
EP (1) EP3887401A2 (https=)
JP (1) JP7607559B2 (https=)
CN (1) CN113302206A (https=)
CA (1) CA3120970A1 (https=)
MA (1) MA54296A (https=)
WO (1) WO2020112889A2 (https=)

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WO2020117715A1 (en) 2018-12-03 2020-06-11 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
PH12021552002A1 (en) 2019-02-20 2022-09-19 Denali Therapeutics Inc Anti-trem2 antibodies and methods of use thereof
PE20221465A1 (es) 2020-01-13 2022-09-21 Denali Therapeutics Inc Anticuerpos anti-trem2 y metodos para utilizarlos
TWI890727B (zh) 2020-01-13 2025-07-21 美商戴納立製藥公司 抗trem2 抗體及其使用方法
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
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US20250101101A1 (en) 2023-09-01 2025-03-27 iTeos Belgium SA Anti-trem2 antibodies and methods of use
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Also Published As

Publication number Publication date
WO2020112889A2 (en) 2020-06-04
JP2022513114A (ja) 2022-02-07
CN113302206A (zh) 2021-08-24
WO2020112889A3 (en) 2020-07-30
CA3120970A1 (en) 2020-06-04
WO2020112889A9 (en) 2021-06-10
EP3887401A2 (en) 2021-10-06
US20230132366A9 (en) 2023-04-27
US20220025039A1 (en) 2022-01-27
MA54296A (fr) 2021-10-06

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