CN113302206A - 治疗脂质代谢失调的方法 - Google Patents

治疗脂质代谢失调的方法 Download PDF

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Publication number
CN113302206A
CN113302206A CN201980089105.XA CN201980089105A CN113302206A CN 113302206 A CN113302206 A CN 113302206A CN 201980089105 A CN201980089105 A CN 201980089105A CN 113302206 A CN113302206 A CN 113302206A
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antibody
trem2
mammal
trem
cell
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CN201980089105.XA
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English (en)
Chinese (zh)
Inventor
G·阿斯塔里塔
G·迪保罗
林凯琳
K·M·门罗
A·A·纽金特
B·范伦格里奇
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Denali Therapeutics Inc
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Denali Therapeutics Inc
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Publication of CN113302206A publication Critical patent/CN113302206A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980089105.XA 2018-11-26 2019-11-26 治疗脂质代谢失调的方法 Pending CN113302206A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862771456P 2018-11-26 2018-11-26
US62/771,456 2018-11-26
US201962817955P 2019-03-13 2019-03-13
US62/817,955 2019-03-13
US201962890506P 2019-08-22 2019-08-22
US62/890,506 2019-08-22
PCT/US2019/063427 WO2020112889A2 (en) 2018-11-26 2019-11-26 Methods for treating dysregulated lipid metabolism

Publications (1)

Publication Number Publication Date
CN113302206A true CN113302206A (zh) 2021-08-24

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ID=68988303

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CN201980089105.XA Pending CN113302206A (zh) 2018-11-26 2019-11-26 治疗脂质代谢失调的方法

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US (1) US20230132366A9 (https=)
EP (1) EP3887401A2 (https=)
JP (1) JP7607559B2 (https=)
CN (1) CN113302206A (https=)
CA (1) CA3120970A1 (https=)
MA (1) MA54296A (https=)
WO (1) WO2020112889A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117771226A (zh) * 2023-12-28 2024-03-29 山东博森医学工程技术有限公司 一种加快骨关节炎损伤修复的促进剂

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019016989A2 (pt) 2017-02-17 2020-05-26 Denali Therapeutics Inc. Polipeptídeos de ligação ao receptor de transferrina manipulados
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
WO2020117715A1 (en) 2018-12-03 2020-06-11 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
PH12021552002A1 (en) 2019-02-20 2022-09-19 Denali Therapeutics Inc Anti-trem2 antibodies and methods of use thereof
PE20221465A1 (es) 2020-01-13 2022-09-21 Denali Therapeutics Inc Anticuerpos anti-trem2 y metodos para utilizarlos
TWI890727B (zh) 2020-01-13 2025-07-21 美商戴納立製藥公司 抗trem2 抗體及其使用方法
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
AU2021289144A1 (en) * 2020-06-11 2022-12-15 King's College London TREM2 chimeric receptor
MX2023001546A (es) * 2020-08-05 2023-05-03 Vigil Neuroscience Inc Tratamiento de enfermedades relacionadas con la disfunción del receptor del factor 1 estimulante de colonias con agonistas trem2.
CN115015412B (zh) * 2022-05-26 2024-07-05 江苏独步生物科技有限公司 一种与中枢神经损伤修复相关的分子靶标及其应用
US20250101101A1 (en) 2023-09-01 2025-03-27 iTeos Belgium SA Anti-trem2 antibodies and methods of use
WO2025064933A1 (en) * 2023-09-22 2025-03-27 The Trustees Of Columbia University In The City Of New York Restoring tim4 in liver macrophages to treat non-alcoholic steatohepatitis (nash)
WO2025194147A1 (en) * 2024-03-15 2025-09-18 The Children's Medical Center Corporation Therapeutic modulation of trem2 and uses thereof in retinal degeneration
CN118983095A (zh) * 2024-08-01 2024-11-19 中国人民解放军总医院第五医学中心 脂质在hiv感染者抗逆转录病毒治疗后免疫重建结果预测中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005128010A (ja) * 2003-10-03 2005-05-19 Takeda Chem Ind Ltd インスリン抵抗性改善剤のスクリーニング方法
CN102307899A (zh) * 2009-01-28 2012-01-04 特拉维夫医学中心医学研究,基础设施及健康服务基金 炎症、自身免疫疾病和心血管疾病的嗜酸细胞活化趋化因子-2(ccl24)抑制剂
CN108738323A (zh) * 2015-10-06 2018-11-02 艾利妥 抗trem2抗体及其使用方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR14523E (fr) 1911-02-06 1911-12-30 Daniel German Caswell Perfectionnements dans les vélocipèdes
US4326055A (en) 1977-12-22 1982-04-20 Hoffmann-La Roche Inc. Stilbene derivatives
DE3202100A1 (de) 1982-01-23 1983-08-04 Basf Ag, 6700 Ludwigshafen Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
DE69224660C5 (de) 1991-12-18 2010-06-02 The Salk Institute For Biological Studies, La Jolla Mitteln zur modulierung von verfahren durch retinoid rezeptoren und dafür nützliche verbindungen
DE10199033I2 (de) 1992-04-22 2003-01-09 Ligand Parmaceuticals Inc Retinoid-x Rezeptor selektive Verbindungen
US5780676A (en) 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5466861A (en) 1992-11-25 1995-11-14 Sri International Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
JPH08511027A (ja) 1993-01-11 1996-11-19 リガンド・ファーマシューティカルズ・インコーポレーテッド レチノイドｘレセプターに対して選択的な活性を有する化合物、およびレチノイドｘレセプターによって媒体されたプロセスの調節手段
ATE187434T1 (de) 1993-01-11 1999-12-15 Ligand Pharm Inc Selektivitaet fuer retinoid x rezeptoren enthaltende verbindungen
US5399586A (en) 1993-03-11 1995-03-21 Allergan, Inc. Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity
EP0694078A4 (en) 1993-04-07 1997-06-25 Ligand Pharm Inc SORTING PROCESS RELATING TO RECEPTOR AGONISTS
ES2133798T3 (es) 1994-08-10 1999-09-16 Hoffmann La Roche Ligandos del receptor x del acido retinoico.
CA2208981C (en) 1994-12-30 2008-08-26 Ligand Pharmaceuticals Incorporated Novel trienoic retinoid compounds and methods
US5721103A (en) 1994-12-30 1998-02-24 Ligand Pharmaceuticals Incorporated Trienoic retinoid compounds and methods
JPH09330101A (ja) 1996-06-13 1997-12-22 Kokusai Chodendo Sangyo Gijutsu Kenkyu Center 制御装置及び方法
IT1286031B1 (it) 1996-10-24 1998-07-07 Enichem Spa Procedimento per la produzione di polimeri vinilaromatici ad elevato grado di sindiotassia
US6969711B2 (en) 1997-05-26 2005-11-29 Kowa Company, Ltd. Cyclic diamine compounds and medicine containing the same
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
WO2001041704A2 (en) 1999-12-13 2001-06-14 Merck & Co., Inc. Method for the prevention and/or treatment of atherosclerosis
US20030086923A1 (en) 1999-12-13 2003-05-08 Sparrow Carl P. Method for the prevention and/or treatment of atherosclerosis
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
WO2003059884A1 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
US6828446B2 (en) 2001-12-21 2004-12-07 Pharmacia Corporation Aromatic thioether liver X-receptor modulators
AU2003217276A1 (en) 2002-02-28 2003-09-16 Eli Lilly And Company Method of treating atherosclerosis and hypercholesterolemia
MXPA04011691A (es) 2002-05-24 2005-09-12 Pharmacia Corp Moduladores del receptor x anilino hepaticos.
MXPA04011690A (es) 2002-05-24 2005-03-31 Pharmacia Corp Moduladores de receptor x de higado de sulfona.
MXPA05002914A (es) 2002-09-17 2005-05-27 Pharmacia Corp Moduladores de los receptores x hepaticos aromaticos.
WO2004058175A2 (en) 2002-12-23 2004-07-15 Irm Llc Novel use of liver x receptor agonists
US20050009837A1 (en) 2003-05-20 2005-01-13 City Of Hope Modulators of lipid metabolism and methods of use
RU2006124843A (ru) 2003-12-12 2008-01-20 Уайт (Us) Хинолины, пригодные для лечения сердечно-сосудистого заболевания
JP2008509138A (ja) 2004-08-03 2008-03-27 ワイス 心臓血管疾患の治療に有用なインダゾール類
BRPI0716833A2 (pt) 2006-09-19 2013-11-05 Wyeth Corp Uso de agonistas de lxr para o tratamento de osteoartrite
US9149492B2 (en) 2008-10-08 2015-10-06 Trustees Of Dartmouth College Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
JP5719340B2 (ja) 2009-03-20 2015-05-20 レティーナ インプラント アーゲー 能動型網膜インプラント
WO2013056232A2 (en) 2011-10-13 2013-04-18 Case Western Reserve University Rxr agonists compounds and methods
MX352727B (es) 2011-12-13 2017-12-06 Dartmouth College Tratamiento de trastorno autoinmune al usar agonistas de rxr.
WO2015038585A1 (en) 2013-09-11 2015-03-19 Trustees Of Dartmouth College Method for selectively inhibiting acat1 in the treatment of alzheimer's disease
US10286000B2 (en) 2013-10-25 2019-05-14 St. Jude Children's Research Hospital, Inc. Retinoid X receptor-gamma agonists and retinoid X receptor-alpha antagonists for treatment of cancer
US10100308B2 (en) 2014-05-29 2018-10-16 Trustees Of Dartmouth College Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
EP3177322A4 (en) * 2014-08-08 2018-07-18 Alector LLC Anti-trem2 antibodies and methods of use thereof
CN107708696B (zh) 2015-06-30 2021-05-28 国立大学法人冈山大学 炎症性肠病的预防或治疗用药剂
WO2017058866A1 (en) 2015-09-28 2017-04-06 Precision Immune, Inc. Anti-trem2 antibodies and uses thereof
EP3368160B1 (en) 2015-10-31 2023-05-17 IO Therapeutics, Inc. Treatment of nervous system disorders using thyroid hormone neutral doses of rxr agonists
US20190367623A1 (en) * 2017-01-17 2019-12-05 Yeda Research And Development Co. Ltd. Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells
JOP20190248A1 (ar) * 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
BR112019022752A2 (pt) 2017-08-03 2020-05-19 Alector Llc anticorpos anti-trem2 e métodos de uso dos mesmos
WO2019118513A1 (en) 2017-12-12 2019-06-20 Pionyr Immunotherapeutics, Inc. Anti-trem2 antibodies and related methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005128010A (ja) * 2003-10-03 2005-05-19 Takeda Chem Ind Ltd インスリン抵抗性改善剤のスクリーニング方法
CN102307899A (zh) * 2009-01-28 2012-01-04 特拉维夫医学中心医学研究,基础设施及健康服务基金 炎症、自身免疫疾病和心血管疾病的嗜酸细胞活化趋化因子-2(ccl24)抑制剂
CN108738323A (zh) * 2015-10-06 2018-11-02 艾利妥 抗trem2抗体及其使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MIN PARK等: "Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity", 《DIABETES 》, vol. 64, no. 1, pages 117 - 127, XP055671908, DOI: 10.2337/db13-1869 *
秦涛: "TREM-1、TREM-2在非酒精性脂肪性肝炎时肝组织表达的研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》, no. 09, pages 1 - 40 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117771226A (zh) * 2023-12-28 2024-03-29 山东博森医学工程技术有限公司 一种加快骨关节炎损伤修复的促进剂

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WO2020112889A2 (en) 2020-06-04
JP2022513114A (ja) 2022-02-07
WO2020112889A3 (en) 2020-07-30
CA3120970A1 (en) 2020-06-04
WO2020112889A9 (en) 2021-06-10
JP7607559B2 (ja) 2024-12-27
EP3887401A2 (en) 2021-10-06
US20230132366A9 (en) 2023-04-27
US20220025039A1 (en) 2022-01-27
MA54296A (fr) 2021-10-06

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