JP7573365B2 - 癌の併用療法 - Google Patents
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- JP7573365B2 JP7573365B2 JP2019506349A JP2019506349A JP7573365B2 JP 7573365 B2 JP7573365 B2 JP 7573365B2 JP 2019506349 A JP2019506349 A JP 2019506349A JP 2019506349 A JP2019506349 A JP 2019506349A JP 7573365 B2 JP7573365 B2 JP 7573365B2
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| EP3331550B1 (en) | 2015-08-04 | 2022-11-02 | Acceleron Pharma Inc. | Composition for treating myeloproliferative disorders |
| EP4241848A3 (en) | 2017-05-04 | 2023-11-01 | Acceleron Pharma Inc. | Tgf-beta receptor type ii fusion proteins and uses thereof |
| WO2019178650A1 (en) * | 2018-03-23 | 2019-09-26 | The University Of Western Australia | Method for immunotherapy drug treatment |
| KR20210006405A (ko) * | 2018-05-04 | 2021-01-18 | 메르크 파텐트 게엠베하 | 암의 치료를 위한 PD-1/PD-L1, TGFβ 및 DNA-PK의 조합 억제 |
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| AU2019299318A1 (en) * | 2018-07-02 | 2021-01-21 | Merck Patent Gmbh | Combination therapy with targeted TGF-B inhibition for treatment of advanced non-small cell lung cancer |
| KR20210042909A (ko) * | 2018-07-09 | 2021-04-20 | 프레시전 인코포레이티드 | 융합 구조물 및 그의 이용 방법 |
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| TW202043267A (zh) | 2019-01-30 | 2020-12-01 | 美商供石公司 | TGFβ之LTBP複合物專一性抑制劑及其用途 |
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| EP3929215A4 (en) * | 2019-06-10 | 2022-06-22 | Shandong Boan Biotechnology Co., Ltd. | BIFUNCTIONAL FUSION PROTEIN AGAINST PDL1 AND TGF? AND ITS USE |
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| CN112442132A (zh) * | 2019-09-05 | 2021-03-05 | 复旦大学 | 靶向肿瘤的重组双功能融合蛋白及其应用 |
| WO2021061437A1 (en) * | 2019-09-12 | 2021-04-01 | Sirnaomics, Inc. | CO-DELIVERY OF TGF-β SIRNA AND PDL1 SIRNA TO TREAT CANCER |
| CN112574314A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 一种融合蛋白及其应用 |
| EP4048704A4 (en) | 2019-10-21 | 2023-11-22 | Nanjing Leads Biolabs Co., Ltd. | RECOMBINANT PROTEIN TARGETING PD-1 AND TGFß |
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| KR20220097443A (ko) * | 2019-11-05 | 2022-07-07 | 메르크 파텐트 게엠베하 | 암의 치료를 위한 PD-1, TGFβ 및 TIGIT의 조합 억제 |
| CA3158047A1 (en) * | 2019-12-11 | 2021-06-17 | Yunying CHEN | Bi-functional antibody against pd-l1 and tgf? |
| CA3161504A1 (en) | 2019-12-20 | 2021-06-24 | Chiara IORIO | Igg:tgf.beta.rii fusion protein composition |
| EP3838260A1 (en) | 2019-12-20 | 2021-06-23 | Ares Trading S.A. | Igg:tgf rii fusion protein composition |
| JP2023511255A (ja) | 2020-01-11 | 2023-03-17 | スカラー ロック インコーポレイテッド | ＴＧＦ－β阻害剤及びその使用 |
| WO2021142427A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | TGFβ INHIBITORS AND USE THEREOF |
| TWI813951B (zh) * | 2020-02-25 | 2023-09-01 | 大陸商上海藥明生物技術有限公司 | 一種雙功能融合蛋白及其用途 |
| WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
| US20230149543A1 (en) * | 2020-04-14 | 2023-05-18 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer based upon an icos antbody and a pd-l1 antibody tgf-bets-receptor fusion protein |
| AU2021305234A1 (en) | 2020-07-10 | 2023-02-09 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| WO2022017487A1 (zh) * | 2020-07-24 | 2022-01-27 | 迈威(上海)生物科技股份有限公司 | TGF-β RII突变体及其融合蛋白 |
| WO2022063193A1 (zh) * | 2020-09-24 | 2022-03-31 | 上海齐鲁制药研究中心有限公司 | 同时靶向PD-L1和TGFβ的双功能分子及其医药用途 |
| WO2022090529A1 (en) | 2020-11-02 | 2022-05-05 | Ares Trading S.A. | Combination treatment of cancer |
| JP2023553257A (ja) | 2020-11-02 | 2023-12-21 | アレス トレーディング ソシエテ アノニム | がんの組み合わせ治療 |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| CA3218697A1 (en) | 2021-05-03 | 2022-11-10 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
| CA3221411A1 (en) | 2021-05-25 | 2022-12-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
| WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| CA3220380A1 (en) | 2021-06-07 | 2022-12-15 | Rinat ZAYNAGETDINOV | Combination treatment of cancer |
| GB202215997D0 (en) * | 2022-10-28 | 2022-12-14 | Io Biotech Aps | Therapy |
| CN120418286A (zh) | 2023-01-09 | 2025-08-01 | 北京拓界生物医药科技有限公司 | TGFβ1结合分子、GARP-TGFβ1结合分子及其医药用途 |
| WO2024187051A1 (en) | 2023-03-07 | 2024-09-12 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
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| JP2015500207A (ja) | 2011-11-28 | 2015-01-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテ | 抗ｐｄ−ｌ１抗体及びその使用 |
| JP2015519372A (ja) | 2012-05-31 | 2015-07-09 | ジェネンテック， インコーポレイテッド | Ｐｄ−１系結合アンタゴニスト及びｖｅｇｆアンタゴニストを用いた癌の治療方法 |
| WO2015118175A2 (en) | 2014-02-10 | 2015-08-13 | Merck Patent Gmbh | TARGETED TGFβ INHIBITION |
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| CN1406249B (zh) | 2000-02-11 | 2010-06-16 | 默克专利股份有限公司 | 增加基于抗体的融合蛋白的循环半衰期 |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| KR101888321B1 (ko) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
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| NZ701821A (en) * | 2012-04-30 | 2016-06-24 | Biocon Ltd | Targeted/immunomodulatory fusion proteins and methods for making same |
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| JP2015500207A (ja) | 2011-11-28 | 2015-01-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテ | 抗ｐｄ−ｌ１抗体及びその使用 |
| JP2015519372A (ja) | 2012-05-31 | 2015-07-09 | ジェネンテック， インコーポレイテッド | Ｐｄ−１系結合アンタゴニスト及びｖｅｇｆアンタゴニストを用いた癌の治療方法 |
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| CN109641963A (zh) | 2019-04-16 |
| KR20190039200A (ko) | 2019-04-10 |
| US20220017621A1 (en) | 2022-01-20 |
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