IL264730B2 - PHARMACEUTICAL COMPOSITION COMPRISING TGFbetaRII AND ANOTHER ANTI-CANCER AGENT - Google Patents
PHARMACEUTICAL COMPOSITION COMPRISING TGFbetaRII AND ANOTHER ANTI-CANCER AGENTInfo
- Publication number
- IL264730B2 IL264730B2 IL264730A IL26473019A IL264730B2 IL 264730 B2 IL264730 B2 IL 264730B2 IL 264730 A IL264730 A IL 264730A IL 26473019 A IL26473019 A IL 26473019A IL 264730 B2 IL264730 B2 IL 264730B2
- Authority
- IL
- Israel
- Prior art keywords
- antibody
- tumor
- protein
- hvr
- seq
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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| US201662374621P | 2016-08-12 | 2016-08-12 | |
| PCT/EP2017/070513 WO2018029367A1 (en) | 2016-08-12 | 2017-08-11 | Combination therapy for cancer |
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| IL264730A IL264730A (en) | 2019-03-31 |
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| SG (1) | SG11201901126UA (OSRAM) |
| WO (1) | WO2018029367A1 (OSRAM) |
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| HK1225740A1 (zh) | 2013-08-22 | 2017-09-15 | Acceleron Pharma Inc. | TGF-β受体II型变体及其用途 |
| EP3331550B1 (en) | 2015-08-04 | 2022-11-02 | Acceleron Pharma Inc. | Composition for treating myeloproliferative disorders |
| SI3628049T1 (sl) | 2017-05-04 | 2023-10-30 | Acceleron Pharma Inc. | Fuzijske beljakovine receptorja TGF-beta tipa II in njihova uporaba |
| US20210015857A1 (en) * | 2018-03-23 | 2021-01-21 | The University Of Western Australia | Method for immunotherapy drug treatment |
| JP2021522298A (ja) * | 2018-05-04 | 2021-08-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 癌治療のためのＰＤ−１／ＰＤ−Ｌ１、ＴＧＦβおよびＤＮＡ−ＰＫの同時阻害 |
| CN112118858A (zh) * | 2018-05-15 | 2020-12-22 | 默克专利有限公司 | 用于未经治疗对象中癌症治疗的靶向tgf-β抑制的给药方案 |
| SG11202012426WA (en) * | 2018-06-13 | 2021-01-28 | Merck Patent Gmbh | Treatment of stage iii nsclc and mitigation of pathological conditions associated with the treatment |
| BR112020026902A2 (pt) * | 2018-07-02 | 2021-03-30 | Merck Patent Gmbh | Terapia combinada com inibição direcionada de tgf-b para o tratamento de câncer de pulmão de células não pequenas avançado |
| SG11202100208VA (en) * | 2018-07-09 | 2021-02-25 | Precigen Inc | Fusion constructs and methods of using thereof |
| CN112969714B (zh) * | 2018-11-30 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 抗cd40抗体、其抗原结合片段及其医药用途 |
| MX2021009175A (es) | 2019-01-30 | 2021-09-14 | Scholar Rock Inc | Inhibidores especificos del complejo de ltbp de tgf? y usos de los mismos. |
| EP3693974A1 (en) * | 2019-02-07 | 2020-08-12 | Koninklijke Philips N.V. | Identifying responsiveness to radio-immuno combination therapy |
| AU2020290119B2 (en) * | 2019-06-10 | 2024-07-18 | Shandong Boan Biotechnology Co., Ltd. | Bifunctional fusion protein against PDL1 and TGFβ and use thereof |
| EP3990116A1 (en) * | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| CN112442132A (zh) * | 2019-09-05 | 2021-03-05 | 复旦大学 | 靶向肿瘤的重组双功能融合蛋白及其应用 |
| BR112022004563A2 (pt) * | 2019-09-12 | 2022-06-07 | Sirnaomics Inc | Coliberação de sirna tgf-ß e sirna pdl1 para tratar câncer |
| CN112574314A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 一种融合蛋白及其应用 |
| WO2021078123A1 (en) | 2019-10-21 | 2021-04-29 | Nanjing Leads Biolabs Co., Ltd. | RECOMBINANT PROTEIN TARGETING PD-1 AND TGFβ |
| WO2021084124A1 (en) | 2019-11-01 | 2021-05-06 | Ares Trading S.A. | COMBINED INHIBITION OF PD-1, TGFβ AND ATM TOGETHER WITH RADIOTHERAPY FOR THE TREATMENT OF CANCER |
| KR20220097443A (ko) * | 2019-11-05 | 2022-07-07 | 메르크 파텐트 게엠베하 | 암의 치료를 위한 PD-1, TGFβ 및 TIGIT의 조합 억제 |
| US20230035169A1 (en) * | 2019-12-11 | 2023-02-02 | WuXi Biologics Ireland Limited | BI-FUNCTIONAL ANTIBODY AGAINST PD-L1 AND TGF-Beta |
| EP3838260A1 (en) | 2019-12-20 | 2021-06-23 | Ares Trading S.A. | Igg:tgf rii fusion protein composition |
| CN115135302A (zh) | 2019-12-20 | 2022-09-30 | 阿雷斯贸易股份有限公司 | IgG:TGFβRII融合蛋白组合物 |
| AU2021205440A1 (en) | 2020-01-11 | 2022-09-01 | Scholar Rock,Inc. | TGF-beta inhibitors and use thereof |
| MX2022008609A (es) | 2020-01-11 | 2022-11-10 | Scholar Rock Inc | Inhibidores de tgf¿ y uso de los mismos. |
| EP4093779A4 (en) * | 2020-02-25 | 2024-03-06 | Wuxi Biologics Ireland Limited | BIFUNCTIONAL FUSION PROTEIN AND USES THEREOF |
| WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
| WO2021209358A1 (en) * | 2020-04-14 | 2021-10-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer based upon an icos antibody and a pd-l1 antibody tgf-beta-receptor fusion protein |
| WO2022011256A1 (en) | 2020-07-10 | 2022-01-13 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| WO2022017487A1 (zh) * | 2020-07-24 | 2022-01-27 | 迈威(上海)生物科技股份有限公司 | TGF-β RII突变体及其融合蛋白 |
| CN116323657B (zh) * | 2020-09-24 | 2023-12-08 | 上海齐鲁制药研究中心有限公司 | 同时靶向PD-L1和TGFβ的双功能分子及其医药用途 |
| AU2021370991A1 (en) | 2020-11-02 | 2023-06-22 | Ares Trading S.A. | Combination treatment of cancer |
| CA3196557A1 (en) | 2020-11-02 | 2022-05-05 | Ada SALA-HOJMAN | Combination treatment of cancer |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| AU2022270880A1 (en) | 2021-05-03 | 2023-09-28 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
| CA3221411A1 (en) | 2021-05-25 | 2022-12-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
| WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| JP2024520764A (ja) | 2021-06-07 | 2024-05-24 | アレス トレーディング ソシエテ アノニム | 癌の組み合わせ処置 |
| GB202215997D0 (en) * | 2022-10-28 | 2022-12-14 | Io Biotech Aps | Therapy |
| WO2024149237A1 (zh) | 2023-01-09 | 2024-07-18 | 北京拓界生物医药科技有限公司 | TGFβ1结合分子、GARP-TGFβ1结合分子及其医药用途 |
| WO2024187051A1 (en) | 2023-03-07 | 2024-09-12 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
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| WO2013079174A1 (en) * | 2011-11-28 | 2013-06-06 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
| WO2015118175A2 (en) * | 2014-02-10 | 2015-08-13 | Merck Patent Gmbh | TARGETED TGFβ INHIBITION |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU4314801A (en) | 2000-02-11 | 2001-08-20 | Lexigen Pharm Corp | Enhancing the circulating half-life of antibody-based fusion proteins |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| KR101607288B1 (ko) | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| TWI729512B (zh) | 2008-12-09 | 2021-06-01 | 美商建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
| PT3489254T (pt) * | 2012-04-30 | 2022-12-30 | Biocon Ltd | Proteínas de fusão direcionadas/imunomoduladoras e seus métodos de fabrico |
| EP2855528B1 (en) | 2012-05-31 | 2019-06-19 | Genentech, Inc. | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
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2017
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2021
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2024
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013079174A1 (en) * | 2011-11-28 | 2013-06-06 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
| WO2015118175A2 (en) * | 2014-02-10 | 2015-08-13 | Merck Patent Gmbh | TARGETED TGFβ INHIBITION |
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| IL264730B1 (en) | 2024-05-01 |
| JP7573365B2 (ja) | 2024-10-25 |
| EP3497130B1 (en) | 2021-10-27 |
| WO2018029367A1 (en) | 2018-02-15 |
| KR20190039200A (ko) | 2019-04-10 |
| US20180118832A1 (en) | 2018-05-03 |
| MX2019001503A (es) | 2019-06-03 |
| EP3497130A1 (en) | 2019-06-19 |
| CA3031168A1 (en) | 2018-02-15 |
| AU2017310027A1 (en) | 2019-01-31 |
| KR20250028537A (ko) | 2025-02-28 |
| CL2019000277A1 (es) | 2019-07-05 |
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| KR20230125859A (ko) | 2023-08-29 |
| PH12019500270A1 (en) | 2019-07-01 |
| RU2019106663A (ru) | 2020-09-14 |
| RU2019106663A3 (OSRAM) | 2020-11-26 |
| IL264730A (en) | 2019-03-31 |
| ES2905663T3 (es) | 2022-04-11 |
| CN109641963A (zh) | 2019-04-16 |
| US20220017621A1 (en) | 2022-01-20 |
| JP2019527706A (ja) | 2019-10-03 |
| BR112019001818A2 (pt) | 2019-05-07 |
| AU2024219446A1 (en) | 2024-09-26 |
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