BR112022004563A2 - Coliberação de sirna tgf-ß e sirna pdl1 para tratar câncer - Google Patents
Coliberação de sirna tgf-ß e sirna pdl1 para tratar câncerInfo
- Publication number
- BR112022004563A2 BR112022004563A2 BR112022004563A BR112022004563A BR112022004563A2 BR 112022004563 A2 BR112022004563 A2 BR 112022004563A2 BR 112022004563 A BR112022004563 A BR 112022004563A BR 112022004563 A BR112022004563 A BR 112022004563A BR 112022004563 A2 BR112022004563 A2 BR 112022004563A2
- Authority
- BR
- Brazil
- Prior art keywords
- sirna
- tgf
- pdl1
- treat cancer
- collaboration
- Prior art date
Links
- 108020004459 Small interfering RNA Proteins 0.000 title abstract 8
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
coliberação de sirna tgf-ß e sirna pdl1 para tratar câncer. são fornecidas composições contendo uma molécula de sir-na anti-tgf-ß e uma molécula de sirna anti-pdl1. métodos de uso dessas composições para tratar câncer também são fornecidos. a molécula de srirna anti-tgf-ß pode conter uma molécula de sirna anti-tgf-ß1. uma ou ambas as moléculas podem compreender um oligonucleotídeo com um comprimento de 19 pares de base a 25 pares de base, e uma ou ambas podem ser quimicamente modificadas para aumentar a sua estabilidade.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962899535P | 2019-09-12 | 2019-09-12 | |
PCT/US2020/050777 WO2021061437A1 (en) | 2019-09-12 | 2020-09-14 | CO-DELIVERY OF TGF-β SIRNA AND PDL1 SIRNA TO TREAT CANCER |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022004563A2 true BR112022004563A2 (pt) | 2022-06-07 |
Family
ID=75166066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022004563A BR112022004563A2 (pt) | 2019-09-12 | 2020-09-14 | Coliberação de sirna tgf-ß e sirna pdl1 para tratar câncer |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220282258A1 (pt) |
EP (1) | EP4028011A4 (pt) |
JP (1) | JP2022548085A (pt) |
KR (1) | KR20220110723A (pt) |
CN (1) | CN114980903A (pt) |
AU (1) | AU2020352441A1 (pt) |
BR (1) | BR112022004563A2 (pt) |
CA (1) | CA3151030A1 (pt) |
IL (1) | IL291297A (pt) |
WO (1) | WO2021061437A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116421616A (zh) * | 2022-03-17 | 2023-07-14 | 圣诺生物医药技术(苏州)有限公司 | 一种核酸干扰药物组合物及用于治疗结直肠癌、胃癌、前列腺癌的药物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2555778A4 (en) * | 2010-04-06 | 2014-05-21 | Alnylam Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR INHIBITING CD274 / PD-L1 GENE EXPRESSION |
US9642873B2 (en) * | 2010-05-04 | 2017-05-09 | Sirnaomics, Inc. | Combinations of TGFβ and COX-2 inhibitors and methods for their therapeutic application |
CA3004695C (en) * | 2012-04-30 | 2020-08-04 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
WO2015148683A1 (en) * | 2014-03-26 | 2015-10-01 | Tocagen Inc. | A retroviral vector having immune-stimulating activity |
WO2016057933A1 (en) * | 2014-10-10 | 2016-04-14 | Global Biopharma, Inc. | Methods for treating and/or preventing a tumor growth, invasion and/or metastasis |
IL259576B (en) * | 2015-12-04 | 2022-09-01 | Novartis Ag | grna molecule containing tracr and crrna, pharmaceutical composition containing it and method for preparing cells for immunotherapy |
WO2017100127A1 (en) * | 2015-12-06 | 2017-06-15 | Boston Biomedical, Inc. | ASYMMETRIC INTERFERING RNAs, AND COMPOSITIONS, USE, OR PREPARATION THEREOF |
MX2019001503A (es) * | 2016-08-12 | 2019-06-03 | Merck Patent Gmbh | Tratamiento conjunto contra el cancer. |
WO2018208720A1 (en) * | 2017-05-09 | 2018-11-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination pdl1 and tgf-beta blockade in patients with hpv+ malignancies |
MX2019013023A (es) * | 2017-05-12 | 2019-12-18 | Jiangsu Hengrui Medicine Co | Proteina de fusion con receptor tgf-?, y uso farmaceutico de la misma. |
BR112021012715A2 (pt) * | 2018-12-27 | 2021-09-21 | Sirnaomics, Inc. | Silenciamento de tgf-beta 1 e cox2 usando sirnas entregues em combinação com inibidores imune checkpoint para tratar câncer |
-
2020
- 2020-09-14 BR BR112022004563A patent/BR112022004563A2/pt not_active Application Discontinuation
- 2020-09-14 CN CN202080070598.5A patent/CN114980903A/zh active Pending
- 2020-09-14 JP JP2022516330A patent/JP2022548085A/ja active Pending
- 2020-09-14 WO PCT/US2020/050777 patent/WO2021061437A1/en unknown
- 2020-09-14 AU AU2020352441A patent/AU2020352441A1/en active Pending
- 2020-09-14 EP EP20868645.1A patent/EP4028011A4/en active Pending
- 2020-09-14 KR KR1020227011766A patent/KR20220110723A/ko unknown
- 2020-09-14 CA CA3151030A patent/CA3151030A1/en active Pending
-
2022
- 2022-03-13 IL IL291297A patent/IL291297A/en unknown
- 2022-03-14 US US17/694,316 patent/US20220282258A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021061437A1 (en) | 2021-04-01 |
KR20220110723A (ko) | 2022-08-09 |
JP2022548085A (ja) | 2022-11-16 |
EP4028011A4 (en) | 2023-04-05 |
CN114980903A (zh) | 2022-08-30 |
AU2020352441A1 (en) | 2022-04-28 |
EP4028011A1 (en) | 2022-07-20 |
US20220282258A1 (en) | 2022-09-08 |
CA3151030A1 (en) | 2021-04-01 |
IL291297A (en) | 2022-05-01 |
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Legal Events
Date | Code | Title | Description |
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |