JP7546299B2 - Ｉｒｅ１小分子阻害物質 - Google Patents

Ｉｒｅ１小分子阻害物質 Download PDF

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JP7546299B2
JP7546299B2 JP2021531523A JP2021531523A JP7546299B2 JP 7546299 B2 JP7546299 B2 JP 7546299B2 JP 2021531523 A JP2021531523 A JP 2021531523A JP 2021531523 A JP2021531523 A JP 2021531523A JP 7546299 B2 JP7546299 B2 JP 7546299B2
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JPWO2020117635A5 (enExample
JP2022511477A (ja
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ジョセフ ピー． ヴァッカ
サラ ベティゴール
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Cornell University
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Cornell University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021531523A 2018-12-03 2019-12-02 Ｉｒｅ１小分子阻害物質 Active JP7546299B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862774794P 2018-12-03 2018-12-03
US62/774,794 2018-12-03
PCT/US2019/063921 WO2020117635A1 (en) 2018-12-03 2019-12-02 Ire1 small molecule inhibitors

Publications (3)

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JP2022511477A JP2022511477A (ja) 2022-01-31
JPWO2020117635A5 JPWO2020117635A5 (enExample) 2022-12-02
JP7546299B2 true JP7546299B2 (ja) 2024-09-06

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JP2021531523A Active JP7546299B2 (ja) 2018-12-03 2019-12-02 Ｉｒｅ１小分子阻害物質

Country Status (8)

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US (1) US12071426B2 (enExample)
EP (1) EP3891137B1 (enExample)
JP (1) JP7546299B2 (enExample)
AU (1) AU2019393754A1 (enExample)
CA (1) CA3121755A1 (enExample)
IL (1) IL283433A (enExample)
SG (1) SG11202105690TA (enExample)
WO (1) WO2020117635A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
SG11202105690TA (en) 2018-12-03 2021-06-29 Univ Cornell Ire1 small molecule inhibitors
EP3941919B1 (en) 2019-01-03 2025-12-24 Genentech, Inc. Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases.
CN113795307A (zh) * 2019-02-18 2021-12-14 基因泰克公司 吡啶并嘧啶基化合物及其使用方法
WO2020232403A1 (en) * 2019-05-15 2020-11-19 Cornell University Treatment of fibrosis with ire1 small molecule inhibitors
EP3983400B1 (en) * 2019-06-11 2025-05-28 Genentech, Inc. Quinazolinyl compounds and methods of use
US11840523B2 (en) * 2020-11-13 2023-12-12 The Regents Of The University Of California IRE1α inhibitors and uses thereof
AU2021381949A1 (en) 2020-11-18 2023-06-15 Deciphera Pharmaceuticals, Llc Gcn2 and perk kinase inhibitors and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018102751A1 (en) 2016-12-02 2018-06-07 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
WO2018166528A1 (en) 2017-03-17 2018-09-20 Genentech, Inc. Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8664230B2 (en) * 2011-03-17 2014-03-04 The Asan Foundation Pyridopyrimidine derivatives and use thereof
CN108239074B (zh) 2016-12-26 2021-07-06 中国医学科学院药物研究所 喹唑啉类化合物及其制备方法、用途和药物组合物
US20180346446A1 (en) 2017-06-01 2018-12-06 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
CN111566089B (zh) 2017-11-10 2023-11-17 康奈尔大学 Ire1小分子抑制剂
SG11202105690TA (en) 2018-12-03 2021-06-29 Univ Cornell Ire1 small molecule inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018102751A1 (en) 2016-12-02 2018-06-07 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
WO2018166528A1 (en) 2017-03-17 2018-09-20 Genentech, Inc. Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders

Also Published As

Publication number Publication date
SG11202105690TA (en) 2021-06-29
EP3891137A1 (en) 2021-10-13
AU2019393754A1 (en) 2021-07-22
US20220356168A1 (en) 2022-11-10
WO2020117635A1 (en) 2020-06-11
US12071426B2 (en) 2024-08-27
IL283433A (en) 2021-07-29
JP2022511477A (ja) 2022-01-31
EP3891137B1 (en) 2024-10-09
CA3121755A1 (en) 2020-06-11

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