JP7514025B2 - Ｊａｋ阻害剤化合物及びその使用 - Google Patents

Ｊａｋ阻害剤化合物及びその使用 Download PDF

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JP7514025B2
JP7514025B2 JP2021572695A JP2021572695A JP7514025B2 JP 7514025 B2 JP7514025 B2 JP 7514025B2 JP 2021572695 A JP2021572695 A JP 2021572695A JP 2021572695 A JP2021572695 A JP 2021572695A JP 7514025 B2 JP7514025 B2 JP 7514025B2
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alkyl
ethyl
cycloalkyl
indazol
membered
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JP2022523274A (ja
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リャン ルー
ハイ ファン
ロンジェン ジャン
サイサイ チャオ
ジシュアン ジャン
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Henan Medinno Pharmaceutical Technology Co Ltd
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Henan Medinno Pharmaceutical Technology Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
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  • Transplantation (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
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JP2021572695A 2019-02-25 2020-02-21 Ｊａｋ阻害剤化合物及びその使用 Active JP7514025B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201910137984 2019-02-25
CN201910137984.0 2019-02-25
CN201910877661 2019-09-17
CN201910877661.5 2019-09-17
PCT/CN2020/076231 WO2020173400A1 (zh) 2019-02-25 2020-02-21 Jak抑制剂化合物及其用途

Publications (2)

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JP2022523274A JP2022523274A (ja) 2022-04-21
JP7514025B2 true JP7514025B2 (ja) 2024-07-10

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US (2) US11629148B2 (de)
EP (1) EP3932919B1 (de)
JP (1) JP7514025B2 (de)
KR (1) KR20210132666A (de)
CN (2) CN111606908B (de)
AU (1) AU2020228799A1 (de)
BR (1) BR112021016751B8 (de)
CA (1) CA3131293A1 (de)
CL (1) CL2021002244A1 (de)
DK (1) DK3932919T3 (de)
FI (1) FI3932919T3 (de)
IL (1) IL285783B1 (de)
MX (1) MX2021010242A (de)
PE (1) PE20212069A1 (de)
PT (1) PT3932919T (de)
WO (1) WO2020173400A1 (de)
ZA (1) ZA202106511B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10836763B2 (en) 2018-09-04 2020-11-17 Theravance Biopharma R&D Ip, Llc 5 to 7 membered heterocyclic amides as JAK inhibitors
TWI791886B (zh) 2018-09-04 2023-02-11 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之二甲基胺基氮雜環丁烷醯胺
CA3108848A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
US10968222B2 (en) 2018-10-29 2021-04-06 Theravance Biopharma R&D Ip, Llc 2-azabicyclo hexane JAK inhibitor compound
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
EP3932919B1 (de) * 2019-02-25 2024-06-26 Henan Medinno Pharmaceutical Technology Co., Ltd. Jak inhibitorverbindung und verwendung davon
CN114075199A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
JP7530128B2 (ja) * 2021-01-15 2024-08-07 シェンチェン カンスー ファーマシューティカル テクノロジー カンパニー リミテッド Ｆｇｆｒ阻害剤化合物及びその使用
WO2022178215A1 (en) 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
CN115043844B (zh) * 2021-06-21 2024-05-17 河南迈英诺医药科技有限公司 Trk激酶抑制剂化合物及其用途
CN117343063A (zh) * 2022-07-04 2024-01-05 河南迈英诺医药科技有限公司 作为trk抑制剂和/或ret抑制剂的化合物及其用途
WO2024032598A1 (zh) * 2022-08-08 2024-02-15 河南迈英诺医药科技有限公司 TGF-β抑制剂化合物及其用途

Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2014522865A (ja) 2011-07-27 2014-09-08 ファイザー・リミテッド インダゾール
WO2017077288A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
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