CL2021002244A1 - Compuesto inhibidor de jak y uso del mismo - Google Patents
Compuesto inhibidor de jak y uso del mismoInfo
- Publication number
- CL2021002244A1 CL2021002244A1 CL2021002244A CL2021002244A CL2021002244A1 CL 2021002244 A1 CL2021002244 A1 CL 2021002244A1 CL 2021002244 A CL2021002244 A CL 2021002244A CL 2021002244 A CL2021002244 A CL 2021002244A CL 2021002244 A1 CL2021002244 A1 CL 2021002244A1
- Authority
- CL
- Chile
- Prior art keywords
- inhibitor compound
- present disclosure
- jak inhibitor
- compounds
- tautomer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
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- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
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- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
La presente descripción se refiere a una clase de compuestos inhibidores de JAK y usos de los mismos. Específicamente, la presente descripción describe un compuesto representado por la Fórmula (G), un compuesto marcado isotópicamente del mismo, o un isómero óptico del mismo, un isómero geométrico del mismo, un tautómero del mismo o una mezcla de varios isómeros, o una sal farmacéuticamente aceptable del mismo, o un profármaco del mismo o un metabolito del mismo. La presente descripción se refiere además a la aplicación de los compuestos en medicina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910137984 | 2019-02-25 | ||
CN201910877661 | 2019-09-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021002244A1 true CL2021002244A1 (es) | 2022-03-18 |
Family
ID=72205292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021002244A CL2021002244A1 (es) | 2019-02-25 | 2021-08-25 | Compuesto inhibidor de jak y uso del mismo |
Country Status (14)
Country | Link |
---|---|
US (2) | US11629148B2 (es) |
EP (1) | EP3932919B1 (es) |
JP (1) | JP7514025B2 (es) |
KR (1) | KR20210132666A (es) |
CN (2) | CN113563345A (es) |
AU (1) | AU2020228799A1 (es) |
BR (1) | BR112021016751B8 (es) |
CA (1) | CA3131293A1 (es) |
CL (1) | CL2021002244A1 (es) |
IL (1) | IL285783A (es) |
MX (1) | MX2021010242A (es) |
PE (1) | PE20212069A1 (es) |
WO (1) | WO2020173400A1 (es) |
ZA (1) | ZA202106511B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112638902A (zh) | 2018-09-04 | 2021-04-09 | 施万生物制药研发Ip有限责任公司 | 用于制备jak抑制剂的方法及其中间体 |
US10947229B2 (en) | 2018-09-04 | 2021-03-16 | Theravance Biopharma R&D Ip, Llc | Dimethyl amino azetidine amides as JAK inhibitors |
ES2955717T3 (es) | 2018-09-04 | 2023-12-05 | Theravance Biopharma R&D Ip Llc | Amidas heterocíclicas de 5 a 7 elementos como inhibidores de JAK |
CA3113667A1 (en) | 2018-10-29 | 2020-05-07 | Theravance Biopharma R&D Ip, Llc | 2-azabicyclo hexane compound as jak inhibitor |
CN114075200A (zh) * | 2020-08-14 | 2022-02-22 | 河南迈英诺医药科技有限公司 | 用于治疗重症肺炎的jak抑制剂化合物 |
BR112021016751B8 (pt) * | 2019-02-25 | 2023-11-21 | Henan Medinno Pharmaceutical Tech Co Ltd | Compostos, composições farmacêuticas e usos dos compostos |
CN114075199A (zh) * | 2020-08-14 | 2022-02-22 | 河南迈英诺医药科技有限公司 | Jak抑制剂化合物及其用途 |
TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
JP2023554506A (ja) * | 2021-01-15 | 2023-12-27 | シェンチェン カンスー ファーマシューティカル テクノロジー カンパニー リミテッド | Fgfr阻害剤化合物及びその使用 |
WO2022178215A1 (en) | 2021-02-19 | 2022-08-25 | Theravance Biopharma R&D Ip, Llc | Amino amide tetrahydro imidazo pyridines as jak inhibitors |
WO2022268080A1 (zh) * | 2021-06-21 | 2022-12-29 | 河南迈英诺医药科技有限公司 | Trk激酶抑制剂化合物及其用途 |
CN117343063A (zh) * | 2022-07-04 | 2024-01-05 | 河南迈英诺医药科技有限公司 | 作为trk抑制剂和/或ret抑制剂的化合物及其用途 |
CN117534686A (zh) * | 2022-08-08 | 2024-02-09 | 河南迈英诺医药科技有限公司 | TGF-β抑制剂化合物及其用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US129A (en) | 1837-02-16 | Improvement in the balance for weighing | ||
US6313A (en) | 1849-04-17 | Thomas kendall | ||
AU5682799A (en) | 1998-08-21 | 2000-03-14 | Parker Hughes Institute | Quinazoline derivatives |
US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
AU2015260905A1 (en) * | 2014-05-14 | 2016-12-01 | Pfizer Inc. | Pyrazolopyridines and pyrazolopyrimidines |
US10556901B2 (en) * | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
CA3001542C (en) * | 2015-11-03 | 2021-02-16 | Theravance Biopharma R&D Ip, Llc | Jak kinase inhibitor compounds for treatment of respiratory disease |
WO2017077283A1 (en) * | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
PT3592742T (pt) * | 2017-03-09 | 2021-07-30 | Theravance Biopharma R&D Ip Llc | Inibidores de jak contendo uma amida heterocíclica com 4 membros |
AR111495A1 (es) * | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
BR112021016751B8 (pt) * | 2019-02-25 | 2023-11-21 | Henan Medinno Pharmaceutical Tech Co Ltd | Compostos, composições farmacêuticas e usos dos compostos |
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2020
- 2020-02-21 BR BR112021016751A patent/BR112021016751B8/pt active IP Right Grant
- 2020-02-21 EP EP20763885.9A patent/EP3932919B1/en active Active
- 2020-02-21 AU AU2020228799A patent/AU2020228799A1/en active Pending
- 2020-02-21 KR KR1020217028077A patent/KR20210132666A/ko active Search and Examination
- 2020-02-21 CN CN202110884592.8A patent/CN113563345A/zh active Pending
- 2020-02-21 JP JP2021572695A patent/JP7514025B2/ja active Active
- 2020-02-21 CN CN202010110961.3A patent/CN111606908B/zh active Active
- 2020-02-21 CA CA3131293A patent/CA3131293A1/en active Pending
- 2020-02-21 WO PCT/CN2020/076231 patent/WO2020173400A1/zh unknown
- 2020-02-21 PE PE2021001397A patent/PE20212069A1/es unknown
- 2020-02-21 MX MX2021010242A patent/MX2021010242A/es unknown
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2021
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CN111606908A (zh) | 2020-09-01 |
EP3932919A1 (en) | 2022-01-05 |
BR112021016751A2 (pt) | 2021-10-19 |
BR112021016751B1 (pt) | 2023-11-07 |
JP2022523274A (ja) | 2022-04-21 |
US20220073524A1 (en) | 2022-03-10 |
US20230192711A1 (en) | 2023-06-22 |
IL285783A (en) | 2021-10-31 |
JP7514025B2 (ja) | 2024-07-10 |
US11629148B2 (en) | 2023-04-18 |
AU2020228799A1 (en) | 2021-10-07 |
EP3932919B1 (en) | 2024-06-26 |
CN111606908B (zh) | 2021-08-24 |
ZA202106511B (en) | 2022-08-31 |
KR20210132666A (ko) | 2021-11-04 |
CA3131293A1 (en) | 2020-09-03 |
WO2020173400A1 (zh) | 2020-09-03 |
CN113563345A (zh) | 2021-10-29 |
MX2021010242A (es) | 2021-09-21 |
BR112021016751B8 (pt) | 2023-11-21 |
PE20212069A1 (es) | 2021-10-26 |
EP3932919A4 (en) | 2022-12-14 |
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