JP7504110B2 - ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 - Google Patents

ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 Download PDF

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JP7504110B2
JP7504110B2 JP2021545905A JP2021545905A JP7504110B2 JP 7504110 B2 JP7504110 B2 JP 7504110B2 JP 2021545905 A JP2021545905 A JP 2021545905A JP 2021545905 A JP2021545905 A JP 2021545905A JP 7504110 B2 JP7504110 B2 JP 7504110B2
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tetrahydro
dioxide
benzothiazepin
oxy
butyl
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JPWO2020161216A5 (https=
JP2022519664A (ja
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ペル－ヨーラン・ギルベリ
ヤン・マットソン
インゲマル・スタルケ
サントシュ・エス・クルカルニ
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アルビレオ・アクチボラグ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2021545905A 2019-02-06 2020-02-06 ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 Active JP7504110B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN201911004690 2019-02-06
IN201911004690 2019-02-06
SE1950463-8 2019-04-12
SE1950463 2019-04-12
IN201911049986 2019-12-04
IN201911049986 2019-12-04
PCT/EP2020/052940 WO2020161216A1 (en) 2019-02-06 2020-02-06 Benzothiazepine compounds and their use as bile acid modulators

Publications (4)

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JP2022519664A JP2022519664A (ja) 2022-03-24
JPWO2020161216A5 JPWO2020161216A5 (https=) 2023-02-02
JP2022519664A5 JP2022519664A5 (https=) 2023-02-02
JP7504110B2 true JP7504110B2 (ja) 2024-06-21

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EP (1) EP3921027B1 (https=)
JP (1) JP7504110B2 (https=)
CN (2) CN113453753B (https=)
CA (1) CA3127408A1 (https=)
ES (1) ES2955799T3 (https=)
TW (1) TWI835997B (https=)
WO (1) WO2020161216A1 (https=)

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JP7748451B2 (ja) 2020-08-03 2025-10-02 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用

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EP3921027B1 (en) 2023-07-19
TW202045482A (zh) 2020-12-16
EP3921027A1 (en) 2021-12-15
ES2955799T3 (es) 2023-12-07
CA3127408A1 (en) 2020-08-13
CN113453753A (zh) 2021-09-28
CN118834175A (zh) 2024-10-25
CN113453753B (zh) 2024-07-23
JP2022519664A (ja) 2022-03-24
WO2020161216A1 (en) 2020-08-13
TWI835997B (zh) 2024-03-21

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