CA3127408A1 - Benzothiazepine compounds and their use as bile acid modulators - Google Patents

Benzothiazepine compounds and their use as bile acid modulators Download PDF

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Publication number
CA3127408A1
CA3127408A1 CA3127408A CA3127408A CA3127408A1 CA 3127408 A1 CA3127408 A1 CA 3127408A1 CA 3127408 A CA3127408 A CA 3127408A CA 3127408 A CA3127408 A CA 3127408A CA 3127408 A1 CA3127408 A1 CA 3127408A1
Authority
CA
Canada
Prior art keywords
tetrahydro
benzothiazepin
dioxido
oxy
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3127408A
Other languages
English (en)
French (fr)
Inventor
Per-Goran Gillberg
Jan Mattsson
Ingemar Starke
Santosh S. Kulkarni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albireo AB
Original Assignee
Albireo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo AB filed Critical Albireo AB
Publication of CA3127408A1 publication Critical patent/CA3127408A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA3127408A 2019-02-06 2020-02-06 Benzothiazepine compounds and their use as bile acid modulators Pending CA3127408A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN201911004690 2019-02-06
IN201911004690 2019-02-06
SE1950463-8 2019-04-12
SE1950463 2019-04-12
IN201911049986 2019-12-04
IN201911049986 2019-12-04
PCT/EP2020/052940 WO2020161216A1 (en) 2019-02-06 2020-02-06 Benzothiazepine compounds and their use as bile acid modulators

Publications (1)

Publication Number Publication Date
CA3127408A1 true CA3127408A1 (en) 2020-08-13

Family

ID=69591607

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3127408A Pending CA3127408A1 (en) 2019-02-06 2020-02-06 Benzothiazepine compounds and their use as bile acid modulators

Country Status (7)

Country Link
EP (1) EP3921027B1 (https=)
JP (1) JP7504110B2 (https=)
CN (2) CN113453753B (https=)
CA (1) CA3127408A1 (https=)
ES (1) ES2955799T3 (https=)
TW (1) TWI835997B (https=)
WO (1) WO2020161216A1 (https=)

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Also Published As

Publication number Publication date
EP3921027B1 (en) 2023-07-19
TW202045482A (zh) 2020-12-16
EP3921027A1 (en) 2021-12-15
ES2955799T3 (es) 2023-12-07
CN113453753A (zh) 2021-09-28
CN118834175A (zh) 2024-10-25
CN113453753B (zh) 2024-07-23
JP2022519664A (ja) 2022-03-24
WO2020161216A1 (en) 2020-08-13
JP7504110B2 (ja) 2024-06-21
TWI835997B (zh) 2024-03-21

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