ES2955799T3 - Compuestos de benzotiazepina y su uso como moduladores de los ácidos biliares - Google Patents

Compuestos de benzotiazepina y su uso como moduladores de los ácidos biliares Download PDF

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Publication number
ES2955799T3
ES2955799T3 ES20705304T ES20705304T ES2955799T3 ES 2955799 T3 ES2955799 T3 ES 2955799T3 ES 20705304 T ES20705304 T ES 20705304T ES 20705304 T ES20705304 T ES 20705304T ES 2955799 T3 ES2955799 T3 ES 2955799T3
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ES
Spain
Prior art keywords
acid
tetrahydro
dioxide
benzothiazepin
oxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20705304T
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English (en)
Spanish (es)
Inventor
Per-Göran Gillberg
Jan Mattsson
Ingemar Starke
Santosh S Kulkarni
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Albireo AB
Original Assignee
Albireo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Albireo AB filed Critical Albireo AB
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Publication of ES2955799T3 publication Critical patent/ES2955799T3/es
Active legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
ES20705304T 2019-02-06 2020-02-06 Compuestos de benzotiazepina y su uso como moduladores de los ácidos biliares Active ES2955799T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201911004690 2019-02-06
SE1950463 2019-04-12
IN201911049986 2019-12-04
PCT/EP2020/052940 WO2020161216A1 (en) 2019-02-06 2020-02-06 Benzothiazepine compounds and their use as bile acid modulators

Publications (1)

Publication Number Publication Date
ES2955799T3 true ES2955799T3 (es) 2023-12-07

Family

ID=69591607

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20705304T Active ES2955799T3 (es) 2019-02-06 2020-02-06 Compuestos de benzotiazepina y su uso como moduladores de los ácidos biliares

Country Status (7)

Country Link
EP (1) EP3921027B1 (https=)
JP (1) JP7504110B2 (https=)
CN (2) CN113453753B (https=)
CA (1) CA3127408A1 (https=)
ES (1) ES2955799T3 (https=)
TW (1) TWI835997B (https=)
WO (1) WO2020161216A1 (https=)

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Also Published As

Publication number Publication date
EP3921027B1 (en) 2023-07-19
TW202045482A (zh) 2020-12-16
EP3921027A1 (en) 2021-12-15
CA3127408A1 (en) 2020-08-13
CN113453753A (zh) 2021-09-28
CN118834175A (zh) 2024-10-25
CN113453753B (zh) 2024-07-23
JP2022519664A (ja) 2022-03-24
WO2020161216A1 (en) 2020-08-13
JP7504110B2 (ja) 2024-06-21
TWI835997B (zh) 2024-03-21

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